Adenylate cyclase associated (CAP) C terminal, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Adenylate cyclase associated (CAP) C terminal, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF57_LEIDO

TriTrypDb:

LdBPK_211110.1 , LdCL_210016100 , LDHU3_21.1310

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF57

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0097435	supramolecular fiber organization	4	5
GO:0007165	signal transduction	2	1
GO:0019932	second-messenger-mediated signaling	4	1
GO:0019933	cAMP-mediated signaling	6	1
GO:0019935	cyclic-nucleotide-mediated signaling	5	1
GO:0031279	regulation of cyclase activity	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0045761	regulation of adenylate cyclase activity	5	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051339	regulation of lyase activity	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0008179	adenylate cyclase binding	4	1
GO:0019899	enzyme binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	574	578	PF00656	0.323
CLV_NRD_NRD_1	244	246	PF00675	0.538
CLV_NRD_NRD_1	251	253	PF00675	0.594
CLV_NRD_NRD_1	337	339	PF00675	0.458
CLV_NRD_NRD_1	468	470	PF00675	0.654
CLV_NRD_NRD_1	682	684	PF00675	0.201
CLV_PCSK_FUR_1	249	253	PF00082	0.654
CLV_PCSK_KEX2_1	244	246	PF00082	0.538
CLV_PCSK_KEX2_1	251	253	PF00082	0.594
CLV_PCSK_KEX2_1	336	338	PF00082	0.451
CLV_PCSK_KEX2_1	468	470	PF00082	0.654
CLV_PCSK_KEX2_1	682	684	PF00082	0.201
CLV_PCSK_SKI1_1	26	30	PF00082	0.429
CLV_PCSK_SKI1_1	284	288	PF00082	0.340
CLV_PCSK_SKI1_1	380	384	PF00082	0.349
CLV_PCSK_SKI1_1	416	420	PF00082	0.388
CLV_PCSK_SKI1_1	421	425	PF00082	0.450
CLV_PCSK_SKI1_1	56	60	PF00082	0.441
CLV_PCSK_SKI1_1	704	708	PF00082	0.484
CLV_Separin_Metazoa	49	53	PF03568	0.332
DEG_APCC_DBOX_1	309	317	PF00400	0.445
DEG_APCC_DBOX_1	415	423	PF00400	0.336
DEG_SCF_FBW7_1	533	538	PF00400	0.503
DEG_SPOP_SBC_1	126	130	PF00917	0.500
DEG_SPOP_SBC_1	484	488	PF00917	0.629
DOC_CKS1_1	4	9	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.383
DOC_MAPK_gen_1	458	466	PF00069	0.642
DOC_MAPK_MEF2A_6	563	571	PF00069	0.323
DOC_MAPK_MEF2A_6	643	651	PF00069	0.282
DOC_PP1_RVXF_1	151	158	PF00149	0.501
DOC_PP2B_LxvP_1	35	38	PF13499	0.464
DOC_PP2B_LxvP_1	685	688	PF13499	0.278
DOC_PP4_FxxP_1	520	523	PF00568	0.578
DOC_PP4_MxPP_1	511	514	PF00568	0.600
DOC_USP7_MATH_1	120	124	PF00917	0.536
DOC_USP7_MATH_1	126	130	PF00917	0.436
DOC_USP7_MATH_1	197	201	PF00917	0.545
DOC_USP7_MATH_1	371	375	PF00917	0.386
DOC_USP7_MATH_1	528	532	PF00917	0.652
DOC_USP7_MATH_1	642	646	PF00917	0.255
DOC_WW_Pin1_4	193	198	PF00397	0.596
DOC_WW_Pin1_4	3	8	PF00397	0.566
DOC_WW_Pin1_4	531	536	PF00397	0.536
DOC_WW_Pin1_4	554	559	PF00397	0.255
DOC_WW_Pin1_4	654	659	PF00397	0.255
LIG_14-3-3_CanoR_1	119	125	PF00244	0.557
LIG_14-3-3_CanoR_1	187	197	PF00244	0.606
LIG_14-3-3_CanoR_1	301	307	PF00244	0.409
LIG_14-3-3_CanoR_1	446	451	PF00244	0.560
LIG_14-3-3_CanoR_1	468	478	PF00244	0.631
LIG_14-3-3_CanoR_1	56	61	PF00244	0.452
LIG_Actin_WH2_2	200	218	PF00022	0.439
LIG_Actin_WH2_2	275	290	PF00022	0.395
LIG_BIR_III_4	160	164	PF00653	0.385
LIG_BRCT_BRCA1_1	153	157	PF00533	0.519
LIG_FHA_1	292	298	PF00498	0.353
LIG_FHA_1	408	414	PF00498	0.326
LIG_FHA_1	543	549	PF00498	0.278
LIG_FHA_1	591	597	PF00498	0.323
LIG_FHA_1	646	652	PF00498	0.291
LIG_FHA_1	655	661	PF00498	0.303
LIG_FHA_1	668	674	PF00498	0.278
LIG_FHA_1	701	707	PF00498	0.278
LIG_FHA_1	88	94	PF00498	0.421
LIG_FHA_2	328	334	PF00498	0.369
LIG_FHA_2	358	364	PF00498	0.414
LIG_FHA_2	470	476	PF00498	0.630
LIG_FHA_2	57	63	PF00498	0.449
LIG_FHA_2	692	698	PF00498	0.278
LIG_FHA_2	73	79	PF00498	0.506
LIG_LIR_Apic_2	518	523	PF02991	0.607
LIG_LIR_Gen_1	261	271	PF02991	0.428
LIG_LIR_Gen_1	408	419	PF02991	0.347
LIG_LIR_Gen_1	590	598	PF02991	0.323
LIG_LIR_LC3C_4	565	570	PF02991	0.323
LIG_LIR_Nem_3	22	28	PF02991	0.386
LIG_LIR_Nem_3	261	267	PF02991	0.434
LIG_LIR_Nem_3	536	542	PF02991	0.473
LIG_LIR_Nem_3	586	591	PF02991	0.323
LIG_PCNA_yPIPBox_3	44	56	PF02747	0.363
LIG_REV1ctd_RIR_1	115	125	PF16727	0.484
LIG_SH2_CRK	428	432	PF00017	0.411
LIG_SH2_CRK	551	555	PF00017	0.278
LIG_SH2_PTP2	591	594	PF00017	0.278
LIG_SH2_STAP1	89	93	PF00017	0.441
LIG_SH2_STAT5	164	167	PF00017	0.421
LIG_SH2_STAT5	378	381	PF00017	0.365
LIG_SH2_STAT5	39	42	PF00017	0.372
LIG_SH2_STAT5	447	450	PF00017	0.627
LIG_SH2_STAT5	591	594	PF00017	0.278
LIG_SH2_STAT5	691	694	PF00017	0.323
LIG_SH2_STAT5	89	92	PF00017	0.439
LIG_SH3_1	231	237	PF00018	0.444
LIG_SH3_3	231	237	PF00018	0.444
LIG_SH3_3	448	454	PF00018	0.614
LIG_SH3_3	474	480	PF00018	0.597
LIG_SH3_3	492	498	PF00018	0.649
LIG_SH3_3	5	11	PF00018	0.638
LIG_SH3_3	566	572	PF00018	0.278
LIG_SH3_3	589	595	PF00018	0.278
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.323
LIG_SUMO_SIM_par_1	567	574	PF11976	0.323
LIG_TRAF2_1	46	49	PF00917	0.339
LIG_TRAF2_1	562	565	PF00917	0.279
LIG_WRC_WIRS_1	88	93	PF05994	0.392
LIG_WW_3	7	11	PF00397	0.635
MOD_CDK_SPxxK_3	3	10	PF00069	0.571
MOD_CK1_1	127	133	PF00069	0.466
MOD_CK1_1	173	179	PF00069	0.369
MOD_CK1_1	191	197	PF00069	0.562
MOD_CK1_1	223	229	PF00069	0.394
MOD_CK1_1	374	380	PF00069	0.354
MOD_CK1_1	439	445	PF00069	0.581
MOD_CK1_1	487	493	PF00069	0.605
MOD_CK1_1	515	521	PF00069	0.595
MOD_CK1_1	531	537	PF00069	0.508
MOD_CK1_1	557	563	PF00069	0.362
MOD_CK1_1	645	651	PF00069	0.305
MOD_CK2_1	128	134	PF00069	0.453
MOD_CK2_1	178	184	PF00069	0.475
MOD_CK2_1	357	363	PF00069	0.366
MOD_CK2_1	469	475	PF00069	0.629
MOD_CK2_1	56	62	PF00069	0.441
MOD_CK2_1	620	626	PF00069	0.278
MOD_CK2_1	691	697	PF00069	0.323
MOD_GlcNHglycan	172	175	PF01048	0.377
MOD_GlcNHglycan	180	183	PF01048	0.423
MOD_GlcNHglycan	373	376	PF01048	0.359
MOD_GlcNHglycan	559	562	PF01048	0.487
MOD_GlcNHglycan	633	637	PF01048	0.278
MOD_GlcNHglycan	644	647	PF01048	0.278
MOD_GlcNHglycan	72	75	PF01048	0.633
MOD_GSK3_1	120	127	PF00069	0.544
MOD_GSK3_1	151	158	PF00069	0.461
MOD_GSK3_1	170	177	PF00069	0.287
MOD_GSK3_1	186	193	PF00069	0.524
MOD_GSK3_1	223	230	PF00069	0.458
MOD_GSK3_1	353	360	PF00069	0.356
MOD_GSK3_1	479	486	PF00069	0.666
MOD_GSK3_1	531	538	PF00069	0.473
MOD_GSK3_1	540	547	PF00069	0.449
MOD_GSK3_1	56	63	PF00069	0.430
MOD_GSK3_1	654	661	PF00069	0.262
MOD_GSK3_1	700	707	PF00069	0.278
MOD_LATS_1	54	60	PF00433	0.439
MOD_N-GLC_1	320	325	PF02516	0.435
MOD_N-GLC_1	667	672	PF02516	0.282
MOD_N-GLC_2	395	397	PF02516	0.494
MOD_NEK2_1	124	129	PF00069	0.525
MOD_NEK2_1	143	148	PF00069	0.212
MOD_NEK2_1	151	156	PF00069	0.423
MOD_NEK2_1	190	195	PF00069	0.596
MOD_NEK2_1	320	325	PF00069	0.400
MOD_NEK2_1	613	618	PF00069	0.323
MOD_NEK2_1	631	636	PF00069	0.189
MOD_NEK2_2	669	674	PF00069	0.255
MOD_NEK2_2	691	696	PF00069	0.323
MOD_NEK2_2	87	92	PF00069	0.460
MOD_PIKK_1	291	297	PF00454	0.424
MOD_PIKK_1	467	473	PF00454	0.560
MOD_PIKK_1	499	505	PF00454	0.633
MOD_PIKK_1	540	546	PF00454	0.449
MOD_PK_1	452	458	PF00069	0.630
MOD_PKA_1	380	386	PF00069	0.348
MOD_PKA_2	186	192	PF00069	0.693
MOD_PKA_2	300	306	PF00069	0.471
MOD_PKA_2	467	473	PF00069	0.562
MOD_PKA_2	620	626	PF00069	0.278
MOD_PKB_1	252	260	PF00069	0.510
MOD_PKB_1	306	314	PF00069	0.387
MOD_Plk_1	11	17	PF00069	0.554
MOD_Plk_1	320	326	PF00069	0.400
MOD_Plk_1	535	541	PF00069	0.473
MOD_Plk_1	667	673	PF00069	0.282
MOD_Plk_1	704	710	PF00069	0.508
MOD_Plk_4	102	108	PF00069	0.428
MOD_Plk_4	263	269	PF00069	0.480
MOD_Plk_4	374	380	PF00069	0.354
MOD_Plk_4	56	62	PF00069	0.441
MOD_Plk_4	587	593	PF00069	0.323
MOD_ProDKin_1	193	199	PF00069	0.592
MOD_ProDKin_1	3	9	PF00069	0.564
MOD_ProDKin_1	531	537	PF00069	0.521
MOD_ProDKin_1	554	560	PF00069	0.255
MOD_ProDKin_1	654	660	PF00069	0.255
MOD_SUMO_for_1	562	565	PF00179	0.323
TRG_DiLeu_BaEn_1	420	425	PF01217	0.398
TRG_DiLeu_BaEn_1	53	58	PF01217	0.410
TRG_DiLeu_BaEn_1	697	702	PF01217	0.323
TRG_DiLeu_LyEn_5	53	58	PF01217	0.410
TRG_ENDOCYTIC_2	591	594	PF00928	0.278
TRG_ER_diArg_1	249	252	PF00400	0.648
TRG_ER_diArg_1	335	338	PF00400	0.492
TRG_ER_diArg_1	467	469	PF00400	0.661
TRG_NES_CRM1_1	13	27	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P826	Leptomonas seymouri	47%	100%
E9AGV5	Leishmania infantum	99%	100%
Q4QCB0	Leishmania major	91%	100%