Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF54_LEIDO

TriTrypDb:

LdBPK_333290.1 , LdCL_330040500 , LDHU3_33.4770

Length:

1005

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.498
CLV_NRD_NRD_1	107	109	PF00675	0.635
CLV_NRD_NRD_1	200	202	PF00675	0.395
CLV_NRD_NRD_1	26	28	PF00675	0.399
CLV_NRD_NRD_1	794	796	PF00675	0.555
CLV_NRD_NRD_1	926	928	PF00675	0.458
CLV_PCSK_KEX2_1	202	204	PF00082	0.391
CLV_PCSK_KEX2_1	611	613	PF00082	0.403
CLV_PCSK_KEX2_1	92	94	PF00082	0.473
CLV_PCSK_KEX2_1	926	928	PF00082	0.458
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.456
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.403
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.476
CLV_PCSK_SKI1_1	194	198	PF00082	0.390
CLV_PCSK_SKI1_1	264	268	PF00082	0.477
CLV_PCSK_SKI1_1	302	306	PF00082	0.323
CLV_PCSK_SKI1_1	667	671	PF00082	0.476
CLV_PCSK_SKI1_1	92	96	PF00082	0.515
DEG_APCC_DBOX_1	193	201	PF00400	0.391
DEG_ODPH_VHL_1	850	862	PF01847	0.428
DOC_CYCLIN_RxL_1	645	657	PF00134	0.490
DOC_CYCLIN_RxL_1	664	673	PF00134	0.249
DOC_CYCLIN_RxL_1	87	101	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	537	540	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.458
DOC_MAPK_gen_1	27	34	PF00069	0.396
DOC_MAPK_gen_1	611	618	PF00069	0.348
DOC_MAPK_MEF2A_6	116	124	PF00069	0.412
DOC_MAPK_MEF2A_6	189	197	PF00069	0.384
DOC_MAPK_MEF2A_6	635	643	PF00069	0.448
DOC_MAPK_RevD_3	597	612	PF00069	0.416
DOC_PP2B_LxvP_1	537	540	PF13499	0.326
DOC_USP7_MATH_1	204	208	PF00917	0.483
DOC_USP7_MATH_1	260	264	PF00917	0.529
DOC_USP7_MATH_1	290	294	PF00917	0.483
DOC_USP7_MATH_1	424	428	PF00917	0.447
DOC_USP7_MATH_1	622	626	PF00917	0.546
DOC_USP7_MATH_1	647	651	PF00917	0.506
DOC_USP7_MATH_1	676	680	PF00917	0.556
DOC_USP7_MATH_1	685	689	PF00917	0.333
DOC_USP7_MATH_1	722	726	PF00917	0.457
DOC_USP7_MATH_1	733	737	PF00917	0.483
DOC_USP7_MATH_1	971	975	PF00917	0.520
DOC_WW_Pin1_4	407	412	PF00397	0.524
DOC_WW_Pin1_4	55	60	PF00397	0.508
DOC_WW_Pin1_4	643	648	PF00397	0.463
DOC_WW_Pin1_4	811	816	PF00397	0.500
DOC_WW_Pin1_4	969	974	PF00397	0.454
LIG_14-3-3_CanoR_1	189	193	PF00244	0.462
LIG_14-3-3_CanoR_1	27	35	PF00244	0.505
LIG_14-3-3_CanoR_1	277	282	PF00244	0.380
LIG_14-3-3_CanoR_1	461	465	PF00244	0.464
LIG_14-3-3_CanoR_1	710	716	PF00244	0.403
LIG_14-3-3_CanoR_1	749	758	PF00244	0.326
LIG_14-3-3_CanoR_1	87	91	PF00244	0.434
LIG_14-3-3_CanoR_1	927	937	PF00244	0.414
LIG_Actin_WH2_2	176	191	PF00022	0.479
LIG_Actin_WH2_2	394	410	PF00022	0.544
LIG_Actin_WH2_2	445	463	PF00022	0.504
LIG_Actin_WH2_2	586	602	PF00022	0.479
LIG_APCC_ABBA_1	193	198	PF00400	0.448
LIG_APCC_ABBA_1	385	390	PF00400	0.453
LIG_APCC_ABBA_1	850	855	PF00400	0.398
LIG_BIR_II_1	1	5	PF00653	0.403
LIG_BIR_III_4	554	558	PF00653	0.434
LIG_BIR_III_4	826	830	PF00653	0.564
LIG_BRCT_BRCA1_1	247	251	PF00533	0.495
LIG_BRCT_BRCA1_1	272	276	PF00533	0.420
LIG_BRCT_BRCA1_1	278	282	PF00533	0.381
LIG_Clathr_ClatBox_1	66	70	PF01394	0.446
LIG_Clathr_ClatBox_1	945	949	PF01394	0.473
LIG_deltaCOP1_diTrp_1	130	134	PF00928	0.487
LIG_EH1_1	804	812	PF00400	0.417
LIG_eIF4E_1	519	525	PF01652	0.330
LIG_FHA_1	183	189	PF00498	0.545
LIG_FHA_1	303	309	PF00498	0.414
LIG_FHA_1	313	319	PF00498	0.421
LIG_FHA_1	416	422	PF00498	0.402
LIG_FHA_1	487	493	PF00498	0.443
LIG_FHA_1	605	611	PF00498	0.402
LIG_FHA_1	664	670	PF00498	0.449
LIG_FHA_1	761	767	PF00498	0.384
LIG_FHA_1	864	870	PF00498	0.512
LIG_FHA_1	89	95	PF00498	0.550
LIG_FHA_1	975	981	PF00498	0.428
LIG_FHA_2	265	271	PF00498	0.463
LIG_GBD_Chelix_1	520	528	PF00786	0.427
LIG_GBD_Chelix_1	602	610	PF00786	0.425
LIG_GBD_Chelix_1	803	811	PF00786	0.282
LIG_Integrin_RGD_1	19	21	PF01839	0.544
LIG_Integrin_RGD_1	671	673	PF01839	0.563
LIG_KLC1_Yacidic_2	386	390	PF13176	0.433
LIG_LIR_Gen_1	31	42	PF02991	0.410
LIG_LIR_Gen_1	714	722	PF02991	0.430
LIG_LIR_Gen_1	856	865	PF02991	0.334
LIG_LIR_Gen_1	949	960	PF02991	0.484
LIG_LIR_Nem_3	159	164	PF02991	0.462
LIG_LIR_Nem_3	279	284	PF02991	0.411
LIG_LIR_Nem_3	31	37	PF02991	0.418
LIG_LIR_Nem_3	541	545	PF02991	0.475
LIG_LIR_Nem_3	554	559	PF02991	0.403
LIG_LIR_Nem_3	714	718	PF02991	0.419
LIG_LIR_Nem_3	856	862	PF02991	0.301
LIG_LIR_Nem_3	949	955	PF02991	0.461
LIG_LYPXL_S_1	318	322	PF13949	0.479
LIG_LYPXL_yS_3	319	322	PF13949	0.475
LIG_MLH1_MIPbox_1	278	282	PF16413	0.435
LIG_NRBOX	229	235	PF00104	0.455
LIG_NRBOX	402	408	PF00104	0.462
LIG_NRBOX	490	496	PF00104	0.465
LIG_NRBOX	564	570	PF00104	0.453
LIG_NRBOX	62	68	PF00104	0.454
LIG_NRBOX	950	956	PF00104	0.515
LIG_PCNA_yPIPBox_3	162	170	PF02747	0.465
LIG_PCNA_yPIPBox_3	226	234	PF02747	0.458
LIG_REV1ctd_RIR_1	279	289	PF16727	0.410
LIG_RPA_C_Fungi	992	1004	PF08784	0.370
LIG_SH2_CRK	800	804	PF00017	0.459
LIG_SH2_PTP2	893	896	PF00017	0.475
LIG_SH2_SRC	388	391	PF00017	0.449
LIG_SH2_STAP1	698	702	PF00017	0.459
LIG_SH2_STAT3	480	483	PF00017	0.453
LIG_SH2_STAT3	744	747	PF00017	0.495
LIG_SH2_STAT5	103	106	PF00017	0.529
LIG_SH2_STAT5	164	167	PF00017	0.442
LIG_SH2_STAT5	338	341	PF00017	0.433
LIG_SH2_STAT5	361	364	PF00017	0.478
LIG_SH2_STAT5	388	391	PF00017	0.449
LIG_SH2_STAT5	519	522	PF00017	0.448
LIG_SH2_STAT5	861	864	PF00017	0.307
LIG_SH2_STAT5	893	896	PF00017	0.468
LIG_SH3_1	901	907	PF00018	0.564
LIG_SH3_3	679	685	PF00018	0.563
LIG_SH3_3	871	877	PF00018	0.477
LIG_SH3_3	901	907	PF00018	0.558
LIG_SUMO_SIM_anti_2	808	814	PF11976	0.430
LIG_SUMO_SIM_par_1	120	125	PF11976	0.448
LIG_SUMO_SIM_par_1	604	609	PF11976	0.481
LIG_SUMO_SIM_par_1	65	71	PF11976	0.452
LIG_SUMO_SIM_par_1	808	814	PF11976	0.470
LIG_SUMO_SIM_par_1	944	950	PF11976	0.505
LIG_TYR_ITIM	336	341	PF00017	0.330
LIG_UBA3_1	195	202	PF00899	0.457
LIG_UBA3_1	605	611	PF00899	0.468
LIG_UBA3_1	881	888	PF00899	0.485
LIG_WRC_WIRS_1	166	171	PF05994	0.445
LIG_WRC_WIRS_1	712	717	PF05994	0.418
MOD_CDC14_SPxK_1	648	651	PF00782	0.461
MOD_CDK_SPxK_1	645	651	PF00069	0.507
MOD_CDK_SPxxK_3	55	62	PF00069	0.494
MOD_CK1_1	2	8	PF00069	0.357
MOD_CK1_1	486	492	PF00069	0.443
MOD_CK1_1	560	566	PF00069	0.439
MOD_CK1_1	614	620	PF00069	0.525
MOD_CK1_1	760	766	PF00069	0.336
MOD_CK1_1	85	91	PF00069	0.454
MOD_CK1_1	929	935	PF00069	0.553
MOD_CK1_1	947	953	PF00069	0.402
MOD_CK1_1	959	965	PF00069	0.392
MOD_CK1_1	974	980	PF00069	0.435
MOD_CK2_1	264	270	PF00069	0.470
MOD_CK2_1	498	504	PF00069	0.451
MOD_CK2_1	678	684	PF00069	0.645
MOD_CK2_1	947	953	PF00069	0.458
MOD_CK2_1	969	975	PF00069	0.454
MOD_CMANNOS	131	134	PF00535	0.472
MOD_Cter_Amidation	793	796	PF01082	0.612
MOD_GlcNHglycan	213	216	PF01048	0.605
MOD_GlcNHglycan	221	224	PF01048	0.478
MOD_GlcNHglycan	238	242	PF01048	0.350
MOD_GlcNHglycan	270	273	PF01048	0.467
MOD_GlcNHglycan	28	31	PF01048	0.444
MOD_GlcNHglycan	292	295	PF01048	0.550
MOD_GlcNHglycan	354	357	PF01048	0.477
MOD_GlcNHglycan	373	376	PF01048	0.328
MOD_GlcNHglycan	392	395	PF01048	0.397
MOD_GlcNHglycan	54	58	PF01048	0.541
MOD_GlcNHglycan	559	562	PF01048	0.402
MOD_GlcNHglycan	574	577	PF01048	0.393
MOD_GlcNHglycan	613	616	PF01048	0.464
MOD_GlcNHglycan	620	623	PF01048	0.590
MOD_GlcNHglycan	729	732	PF01048	0.477
MOD_GlcNHglycan	735	738	PF01048	0.430
MOD_GlcNHglycan	820	823	PF01048	0.520
MOD_GlcNHglycan	826	830	PF01048	0.585
MOD_GlcNHglycan	896	899	PF01048	0.571
MOD_GSK3_1	237	244	PF00069	0.469
MOD_GSK3_1	260	267	PF00069	0.432
MOD_GSK3_1	479	486	PF00069	0.470
MOD_GSK3_1	498	505	PF00069	0.266
MOD_GSK3_1	557	564	PF00069	0.396
MOD_GSK3_1	614	621	PF00069	0.541
MOD_GSK3_1	643	650	PF00069	0.506
MOD_GSK3_1	676	683	PF00069	0.621
MOD_GSK3_1	722	729	PF00069	0.569
MOD_GSK3_1	733	740	PF00069	0.430
MOD_GSK3_1	749	756	PF00069	0.270
MOD_GSK3_1	82	89	PF00069	0.497
MOD_GSK3_1	956	963	PF00069	0.432
MOD_GSK3_1	969	976	PF00069	0.389
MOD_N-GLC_1	483	488	PF02516	0.458
MOD_N-GLC_2	163	165	PF02516	0.461
MOD_NEK2_1	188	193	PF00069	0.452
MOD_NEK2_1	219	224	PF00069	0.373
MOD_NEK2_1	243	248	PF00069	0.546
MOD_NEK2_1	276	281	PF00069	0.346
MOD_NEK2_1	312	317	PF00069	0.449
MOD_NEK2_1	479	484	PF00069	0.419
MOD_NEK2_1	498	503	PF00069	0.440
MOD_NEK2_1	606	611	PF00069	0.420
MOD_NEK2_1	805	810	PF00069	0.408
MOD_NEK2_1	818	823	PF00069	0.424
MOD_NEK2_1	853	858	PF00069	0.426
MOD_NEK2_1	860	865	PF00069	0.458
MOD_NEK2_1	960	965	PF00069	0.465
MOD_NEK2_2	68	73	PF00069	0.445
MOD_OFUCOSY	630	637	PF10250	0.471
MOD_OFUCOSY	757	764	PF10250	0.413
MOD_PIKK_1	450	456	PF00454	0.500
MOD_PIKK_1	479	485	PF00454	0.475
MOD_PIKK_1	486	492	PF00454	0.460
MOD_PIKK_1	588	594	PF00454	0.413
MOD_PIKK_1	749	755	PF00454	0.459
MOD_PIKK_1	765	771	PF00454	0.248
MOD_PKA_1	611	617	PF00069	0.434
MOD_PKA_1	926	932	PF00069	0.496
MOD_PKA_2	188	194	PF00069	0.456
MOD_PKA_2	204	210	PF00069	0.407
MOD_PKA_2	26	32	PF00069	0.489
MOD_PKA_2	276	282	PF00069	0.347
MOD_PKA_2	460	466	PF00069	0.511
MOD_PKA_2	611	617	PF00069	0.434
MOD_PKA_2	785	791	PF00069	0.419
MOD_PKA_2	86	92	PF00069	0.484
MOD_PKA_2	926	932	PF00069	0.517
MOD_Plk_1	483	489	PF00069	0.521
MOD_Plk_1	85	91	PF00069	0.460
MOD_Plk_4	188	194	PF00069	0.483
MOD_Plk_4	270	276	PF00069	0.431
MOD_Plk_4	277	283	PF00069	0.381
MOD_Plk_4	564	570	PF00069	0.343
MOD_Plk_4	68	74	PF00069	0.388
MOD_Plk_4	737	743	PF00069	0.439
MOD_Plk_4	947	953	PF00069	0.497
MOD_ProDKin_1	407	413	PF00069	0.523
MOD_ProDKin_1	55	61	PF00069	0.499
MOD_ProDKin_1	643	649	PF00069	0.469
MOD_ProDKin_1	811	817	PF00069	0.502
MOD_ProDKin_1	969	975	PF00069	0.453
TRG_DiLeu_BaEn_2	939	945	PF01217	0.469
TRG_DiLeu_BaEn_4	238	244	PF01217	0.516
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.463
TRG_ENDOCYTIC_2	319	322	PF00928	0.475
TRG_ENDOCYTIC_2	338	341	PF00928	0.193
TRG_ENDOCYTIC_2	800	803	PF00928	0.461
TRG_ENDOCYTIC_2	952	955	PF00928	0.455
TRG_ER_diArg_1	200	203	PF00400	0.384
TRG_ER_diArg_1	528	531	PF00400	0.436
TRG_ER_diArg_1	926	928	PF00400	0.458
TRG_NES_CRM1_1	112	125	PF08389	0.403
TRG_NES_CRM1_1	450	464	PF08389	0.468
TRG_NES_CRM1_1	490	504	PF08389	0.463
TRG_NLS_MonoCore_2	201	206	PF00514	0.538
TRG_NLS_MonoExtC_3	200	205	PF00514	0.464
TRG_NLS_MonoExtN_4	201	206	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I500	Leptomonas seymouri	55%	100%
A0A1X0NRQ6	Trypanosomatidae	29%	98%
A0A3R7JX66	Trypanosoma rangeli	29%	100%
A4I9F5	Leishmania infantum	100%	100%
C9ZJS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	93%
E9B4F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3M2	Leishmania major	92%	100%
V5AVU3	Trypanosoma cruzi	28%	99%