Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF51_LEIDO

TriTrypDb:

LdBPK_303020.1 , LdCL_300035800 , LDHU3_30.4010

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.503
CLV_NRD_NRD_1	114	116	PF00675	0.448
CLV_PCSK_KEX2_1	114	116	PF00082	0.448
CLV_PCSK_SKI1_1	100	104	PF00082	0.348
CLV_PCSK_SKI1_1	115	119	PF00082	0.407
CLV_PCSK_SKI1_1	31	35	PF00082	0.468
CLV_PCSK_SKI1_1	91	95	PF00082	0.434
CLV_Separin_Metazoa	178	182	PF03568	0.552
DEG_APCC_DBOX_1	30	38	PF00400	0.458
DEG_APCC_DBOX_1	99	107	PF00400	0.409
DEG_SCF_FBW7_1	60	67	PF00400	0.635
DOC_CKS1_1	61	66	PF01111	0.639
DOC_CYCLIN_yCln2_LP_2	58	61	PF00134	0.561
DOC_MAPK_gen_1	158	166	PF00069	0.531
DOC_MAPK_MEF2A_6	160	168	PF00069	0.492
DOC_MAPK_MEF2A_6	189	197	PF00069	0.558
DOC_MAPK_MEF2A_6	27	36	PF00069	0.598
DOC_MAPK_MEF2A_6	86	94	PF00069	0.409
DOC_PP2B_LxvP_1	130	133	PF13499	0.578
DOC_PP2B_LxvP_1	4	7	PF13499	0.757
DOC_PP2B_LxvP_1	58	61	PF13499	0.609
DOC_USP7_MATH_1	14	18	PF00917	0.671
DOC_USP7_MATH_1	41	45	PF00917	0.485
DOC_USP7_MATH_1	64	68	PF00917	0.654
DOC_WW_Pin1_4	10	15	PF00397	0.585
DOC_WW_Pin1_4	2	7	PF00397	0.793
DOC_WW_Pin1_4	60	65	PF00397	0.664
LIG_14-3-3_CanoR_1	114	118	PF00244	0.498
LIG_14-3-3_CanoR_1	15	23	PF00244	0.734
LIG_14-3-3_CanoR_1	31	37	PF00244	0.449
LIG_Actin_WH2_2	165	183	PF00022	0.476
LIG_Actin_WH2_2	87	102	PF00022	0.436
LIG_FHA_1	175	181	PF00498	0.460
LIG_FHA_2	173	179	PF00498	0.488
LIG_FHA_2	20	26	PF00498	0.625
LIG_GBD_Chelix_1	140	148	PF00786	0.502
LIG_GSK3_LRP6_1	60	65	PF00069	0.628
LIG_LIR_Gen_1	116	126	PF02991	0.465
LIG_LIR_Gen_1	134	144	PF02991	0.288
LIG_LIR_Gen_1	35	42	PF02991	0.505
LIG_LIR_Nem_3	116	121	PF02991	0.436
LIG_LIR_Nem_3	134	140	PF02991	0.346
LIG_LIR_Nem_3	35	39	PF02991	0.502
LIG_LIR_Nem_3	84	90	PF02991	0.461
LIG_LYPXL_yS_3	87	90	PF13949	0.417
LIG_OCRL_FandH_1	117	129	PF00620	0.436
LIG_SH2_STAT5	98	101	PF00017	0.531
LIG_SH3_3	58	64	PF00018	0.594
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.419
LIG_WRC_WIRS_1	33	38	PF05994	0.525
MOD_CDK_SPK_2	10	15	PF00069	0.687
MOD_CK1_1	18	24	PF00069	0.604
MOD_CK1_1	69	75	PF00069	0.687
MOD_CK1_1	79	85	PF00069	0.488
MOD_CK2_1	148	154	PF00069	0.542
MOD_CK2_1	172	178	PF00069	0.468
MOD_CK2_1	70	76	PF00069	0.667
MOD_GlcNHglycan	39	42	PF01048	0.447
MOD_GlcNHglycan	48	51	PF01048	0.419
MOD_GlcNHglycan	66	69	PF01048	0.517
MOD_GlcNHglycan	78	81	PF01048	0.721
MOD_GlcNHglycan	83	86	PF01048	0.443
MOD_GSK3_1	10	17	PF00069	0.696
MOD_GSK3_1	180	187	PF00069	0.561
MOD_GSK3_1	37	44	PF00069	0.491
MOD_GSK3_1	60	67	PF00069	0.687
MOD_GSK3_1	70	77	PF00069	0.675
MOD_NEK2_1	180	185	PF00069	0.479
MOD_NEK2_2	113	118	PF00069	0.477
MOD_NEK2_2	191	196	PF00069	0.647
MOD_PIKK_1	172	178	PF00454	0.541
MOD_PKA_2	113	119	PF00069	0.458
MOD_PKA_2	14	20	PF00069	0.732
MOD_PKA_2	180	186	PF00069	0.531
MOD_Plk_4	32	38	PF00069	0.463
MOD_Plk_4	66	72	PF00069	0.559
MOD_ProDKin_1	10	16	PF00069	0.585
MOD_ProDKin_1	2	8	PF00069	0.792
MOD_ProDKin_1	60	66	PF00069	0.669
TRG_DiLeu_BaEn_1	89	94	PF01217	0.491
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.586
TRG_ENDOCYTIC_2	87	90	PF00928	0.417
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z8	Leptomonas seymouri	65%	91%
A0A1X0P230	Trypanosomatidae	29%	100%
A0A3R7N1I2	Trypanosoma rangeli	30%	100%
A4HIN2	Leishmania braziliensis	77%	100%
A4I5X9	Leishmania infantum	100%	100%
C9ZRA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q6Z2	Leishmania major	92%	100%