Putative DUF572 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Family of unknown function (DUF572), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF48_LEIDO

TriTrypDb:

LdBPK_291310.1 , LdCL_290018200 , LDHU3_29.1800

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071006	U2-type catalytic step 1 spliceosome	4	1
GO:0071012	catalytic step 1 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IF48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF48

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.748
CLV_NRD_NRD_1	20	22	PF00675	0.343
CLV_NRD_NRD_1	203	205	PF00675	0.320
CLV_NRD_NRD_1	286	288	PF00675	0.343
CLV_NRD_NRD_1	321	323	PF00675	0.402
CLV_NRD_NRD_1	331	333	PF00675	0.305
CLV_NRD_NRD_1	34	36	PF00675	0.343
CLV_NRD_NRD_1	455	457	PF00675	0.709
CLV_NRD_NRD_1	464	466	PF00675	0.661
CLV_NRD_NRD_1	66	68	PF00675	0.353
CLV_NRD_NRD_1	78	80	PF00675	0.354
CLV_PCSK_FUR_1	201	205	PF00082	0.320
CLV_PCSK_FUR_1	32	36	PF00082	0.343
CLV_PCSK_KEX2_1	127	129	PF00082	0.343
CLV_PCSK_KEX2_1	203	205	PF00082	0.320
CLV_PCSK_KEX2_1	286	288	PF00082	0.343
CLV_PCSK_KEX2_1	321	323	PF00082	0.472
CLV_PCSK_KEX2_1	331	333	PF00082	0.340
CLV_PCSK_KEX2_1	34	36	PF00082	0.343
CLV_PCSK_KEX2_1	464	466	PF00082	0.730
CLV_PCSK_KEX2_1	49	51	PF00082	0.351
CLV_PCSK_KEX2_1	66	68	PF00082	0.394
CLV_PCSK_KEX2_1	78	80	PF00082	0.353
CLV_PCSK_KEX2_1	83	85	PF00082	0.353
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.320
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.343
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.343
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.480
CLV_PCSK_PC7_1	199	205	PF00082	0.320
CLV_PCSK_PC7_1	79	85	PF00082	0.480
CLV_PCSK_SKI1_1	253	257	PF00082	0.393
CLV_PCSK_SKI1_1	321	325	PF00082	0.480
CLV_PCSK_SKI1_1	331	335	PF00082	0.332
CLV_PCSK_SKI1_1	413	417	PF00082	0.619
CLV_PCSK_SKI1_1	441	445	PF00082	0.595
CLV_PCSK_SKI1_1	78	82	PF00082	0.307
DEG_SCF_FBW7_1	111	117	PF00400	0.343
DEG_SCF_FBW7_1	360	365	PF00400	0.396
DEG_SCF_TRCP1_1	222	228	PF00400	0.288
DEG_SPOP_SBC_1	229	233	PF00917	0.480
DEG_SPOP_SBC_1	241	245	PF00917	0.227
DEG_SPOP_SBC_1	337	341	PF00917	0.323
DEG_SPOP_SBC_1	362	366	PF00917	0.410
DOC_CKS1_1	111	116	PF01111	0.343
DOC_CKS1_1	442	447	PF01111	0.601
DOC_CYCLIN_yClb3_PxF_3	410	416	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.375
DOC_MAPK_gen_1	49	57	PF00069	0.343
DOC_MAPK_gen_1	83	91	PF00069	0.480
DOC_PP2B_LxvP_1	351	354	PF13499	0.375
DOC_PP4_FxxP_1	249	252	PF00568	0.480
DOC_PP4_FxxP_1	442	445	PF00568	0.788
DOC_PP4_FxxP_1	53	56	PF00568	0.343
DOC_USP7_MATH_1	220	224	PF00917	0.465
DOC_USP7_MATH_1	242	246	PF00917	0.385
DOC_USP7_MATH_1	355	359	PF00917	0.343
DOC_USP7_MATH_1	372	376	PF00917	0.693
DOC_USP7_MATH_1	398	402	PF00917	0.749
DOC_USP7_MATH_1	415	419	PF00917	0.575
DOC_USP7_MATH_1	446	450	PF00917	0.644
DOC_USP7_MATH_1	69	73	PF00917	0.343
DOC_USP7_UBL2_3	374	378	PF12436	0.684
DOC_WW_Pin1_4	110	115	PF00397	0.343
DOC_WW_Pin1_4	237	242	PF00397	0.410
DOC_WW_Pin1_4	358	363	PF00397	0.449
DOC_WW_Pin1_4	430	435	PF00397	0.636
DOC_WW_Pin1_4	441	446	PF00397	0.571
LIG_14-3-3_CanoR_1	286	292	PF00244	0.445
LIG_14-3-3_CanoR_1	331	338	PF00244	0.393
LIG_14-3-3_CanoR_1	421	428	PF00244	0.687
LIG_14-3-3_CanoR_1	50	54	PF00244	0.343
LIG_14-3-3_CanoR_1	78	86	PF00244	0.307
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BRCT_BRCA1_1	245	249	PF00533	0.480
LIG_FHA_1	337	343	PF00498	0.431
LIG_FHA_1	421	427	PF00498	0.719
LIG_FHA_1	50	56	PF00498	0.343
LIG_FHA_2	107	113	PF00498	0.343
LIG_FHA_2	231	237	PF00498	0.480
LIG_LIR_Apic_2	10	16	PF02991	0.343
LIG_LIR_Apic_2	246	252	PF02991	0.480
LIG_LIR_Apic_2	440	445	PF02991	0.785
LIG_LIR_Apic_2	52	56	PF02991	0.343
LIG_LIR_Nem_3	130	136	PF02991	0.431
LIG_LIR_Nem_3	17	23	PF02991	0.343
LIG_LIR_Nem_3	274	280	PF02991	0.343
LIG_LIR_Nem_3	285	291	PF02991	0.343
LIG_Pex14_2	53	57	PF04695	0.343
LIG_SH2_GRB2like	75	78	PF00017	0.343
LIG_SH2_PTP2	13	16	PF00017	0.343
LIG_SH2_SRC	85	88	PF00017	0.307
LIG_SH2_STAT5	106	109	PF00017	0.348
LIG_SH2_STAT5	120	123	PF00017	0.359
LIG_SH2_STAT5	13	16	PF00017	0.353
LIG_SH2_STAT5	85	88	PF00017	0.343
LIG_SH3_1	108	114	PF00018	0.343
LIG_SH3_2	451	456	PF14604	0.648
LIG_SH3_3	108	114	PF00018	0.343
LIG_SH3_3	406	412	PF00018	0.744
LIG_SH3_3	448	454	PF00018	0.721
LIG_SH3_CIN85_PxpxPR_1	451	456	PF14604	0.718
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.343
LIG_TRAF2_1	143	146	PF00917	0.338
LIG_TRAF2_1	182	185	PF00917	0.480
LIG_WW_3	453	457	PF00397	0.657
MOD_CDK_SPK_2	110	115	PF00069	0.343
MOD_CK1_1	231	237	PF00069	0.487
MOD_CK1_1	240	246	PF00069	0.268
MOD_CK1_1	358	364	PF00069	0.443
MOD_CK1_1	424	430	PF00069	0.713
MOD_CK2_1	106	112	PF00069	0.343
MOD_CK2_1	230	236	PF00069	0.480
MOD_CK2_1	261	267	PF00069	0.440
MOD_Cter_Amidation	32	35	PF01082	0.343
MOD_GlcNHglycan	221	225	PF01048	0.368
MOD_GlcNHglycan	233	236	PF01048	0.308
MOD_GlcNHglycan	262	266	PF01048	0.464
MOD_GlcNHglycan	355	358	PF01048	0.450
MOD_GlcNHglycan	365	368	PF01048	0.310
MOD_GlcNHglycan	417	420	PF01048	0.718
MOD_GlcNHglycan	423	426	PF01048	0.723
MOD_GlcNHglycan	9	12	PF01048	0.496
MOD_GSK3_1	106	113	PF00069	0.343
MOD_GSK3_1	193	200	PF00069	0.346
MOD_GSK3_1	225	232	PF00069	0.389
MOD_GSK3_1	236	243	PF00069	0.393
MOD_GSK3_1	358	365	PF00069	0.456
MOD_GSK3_1	420	427	PF00069	0.757
MOD_GSK3_1	437	444	PF00069	0.513
MOD_N-GLC_1	4	9	PF02516	0.520
MOD_NEK2_1	197	202	PF00069	0.343
MOD_NEK2_1	363	368	PF00069	0.482
MOD_NEK2_2	85	90	PF00069	0.333
MOD_PIKK_1	446	452	PF00454	0.784
MOD_PK_1	373	379	PF00069	0.687
MOD_PKA_1	331	337	PF00069	0.323
MOD_PKA_1	373	379	PF00069	0.687
MOD_PKA_1	49	55	PF00069	0.343
MOD_PKA_1	78	84	PF00069	0.333
MOD_PKA_2	202	208	PF00069	0.410
MOD_PKA_2	331	337	PF00069	0.323
MOD_PKA_2	420	426	PF00069	0.657
MOD_PKA_2	49	55	PF00069	0.343
MOD_PKA_2	69	75	PF00069	0.183
MOD_PKA_2	78	84	PF00069	0.343
MOD_Plk_1	309	315	PF00069	0.371
MOD_Plk_1	398	404	PF00069	0.722
MOD_Plk_1	4	10	PF00069	0.520
MOD_Plk_4	193	199	PF00069	0.343
MOD_Plk_4	303	309	PF00069	0.278
MOD_Plk_4	338	344	PF00069	0.375
MOD_Plk_4	398	404	PF00069	0.743
MOD_Plk_4	458	464	PF00069	0.783
MOD_ProDKin_1	110	116	PF00069	0.343
MOD_ProDKin_1	237	243	PF00069	0.410
MOD_ProDKin_1	358	364	PF00069	0.449
MOD_ProDKin_1	430	436	PF00069	0.637
MOD_ProDKin_1	441	447	PF00069	0.573
MOD_SUMO_for_1	150	153	PF00179	0.343
TRG_ER_diArg_1	198	201	PF00400	0.343
TRG_ER_diArg_1	202	204	PF00400	0.343
TRG_ER_diArg_1	286	288	PF00400	0.343
TRG_ER_diArg_1	320	322	PF00400	0.401
TRG_ER_diArg_1	463	465	PF00400	0.726
TRG_ER_diArg_1	66	68	PF00400	0.353
TRG_NLS_Bipartite_1	21	38	PF00514	0.343
TRG_NLS_MonoExtN_4	32	38	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY11	Leptomonas seymouri	55%	100%
A4HHD4	Leishmania braziliensis	77%	100%
A4I4H9	Leishmania infantum	100%	100%
E9ADY0	Leishmania major	90%	100%
E9ALV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%