Poly(A)-binding protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF40_LEIDO

TriTrypDb:

LdBPK_250080.1 , LdCL_250005800 , LDHU3_25.0110

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IF40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF40

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0005515	protein binding	2	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0031369	translation initiation factor binding	3	1
GO:0031370	eukaryotic initiation factor 4G binding	4	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.492
CLV_NRD_NRD_1	175	177	PF00675	0.443
CLV_NRD_NRD_1	378	380	PF00675	0.526
CLV_NRD_NRD_1	432	434	PF00675	0.609
CLV_NRD_NRD_1	93	95	PF00675	0.440
CLV_PCSK_KEX2_1	175	177	PF00082	0.500
CLV_PCSK_KEX2_1	378	380	PF00082	0.547
CLV_PCSK_KEX2_1	432	434	PF00082	0.609
CLV_PCSK_SKI1_1	129	133	PF00082	0.267
CLV_PCSK_SKI1_1	153	157	PF00082	0.286
CLV_PCSK_SKI1_1	228	232	PF00082	0.306
CLV_PCSK_SKI1_1	258	262	PF00082	0.563
CLV_PCSK_SKI1_1	305	309	PF00082	0.300
CLV_PCSK_SKI1_1	83	87	PF00082	0.436
CLV_Separin_Metazoa	444	448	PF03568	0.668
DEG_ODPH_VHL_1	76	88	PF01847	0.416
DOC_CYCLIN_RxL_1	489	499	PF00134	0.484
DOC_MAPK_gen_1	210	219	PF00069	0.467
DOC_MAPK_MEF2A_6	503	511	PF00069	0.433
DOC_PP1_RVXF_1	81	87	PF00149	0.376
DOC_PP4_MxPP_1	388	391	PF00568	0.615
DOC_PP4_MxPP_1	407	410	PF00568	0.674
DOC_PP4_MxPP_1	411	414	PF00568	0.676
DOC_PP4_MxPP_1	446	449	PF00568	0.689
DOC_USP7_MATH_1	131	135	PF00917	0.523
DOC_USP7_MATH_1	183	187	PF00917	0.515
DOC_USP7_MATH_1	344	348	PF00917	0.513
DOC_USP7_MATH_1	35	39	PF00917	0.457
DOC_USP7_MATH_1	495	499	PF00917	0.500
DOC_WW_Pin1_4	474	479	PF00397	0.482
LIG_14-3-3_CanoR_1	124	132	PF00244	0.489
LIG_14-3-3_CanoR_1	338	348	PF00244	0.411
LIG_14-3-3_CanoR_1	451	455	PF00244	0.660
LIG_14-3-3_CanoR_1	7	11	PF00244	0.351
LIG_Actin_WH2_2	292	307	PF00022	0.487
LIG_Clathr_ClatBox_1	231	235	PF01394	0.452
LIG_CtBP_PxDLS_1	417	421	PF00389	0.678
LIG_FHA_1	503	509	PF00498	0.433
LIG_FHA_2	198	204	PF00498	0.440
LIG_FHA_2	58	64	PF00498	0.506
LIG_LIR_Gen_1	227	234	PF02991	0.442
LIG_LIR_Gen_1	487	496	PF02991	0.434
LIG_LIR_Gen_1	514	525	PF02991	0.516
LIG_LIR_Nem_3	138	144	PF02991	0.433
LIG_LIR_Nem_3	186	190	PF02991	0.357
LIG_LIR_Nem_3	209	214	PF02991	0.460
LIG_LIR_Nem_3	227	232	PF02991	0.442
LIG_LIR_Nem_3	306	311	PF02991	0.435
LIG_LIR_Nem_3	326	330	PF02991	0.438
LIG_LIR_Nem_3	487	493	PF02991	0.434
LIG_LIR_Nem_3	50	56	PF02991	0.433
LIG_LIR_Nem_3	514	520	PF02991	0.516
LIG_LIR_Nem_3	522	527	PF02991	0.510
LIG_NRBOX	484	490	PF00104	0.500
LIG_Pex14_2	225	229	PF04695	0.500
LIG_Pex14_2	395	399	PF04695	0.618
LIG_SH2_CRK	141	145	PF00017	0.456
LIG_SH2_CRK	452	456	PF00017	0.601
LIG_SH2_CRK	490	494	PF00017	0.457
LIG_SH2_CRK	53	57	PF00017	0.433
LIG_SH2_CRK	73	77	PF00017	0.517
LIG_SH2_GRB2like	283	286	PF00017	0.554
LIG_SH2_GRB2like	55	58	PF00017	0.433
LIG_SH2_SRC	283	286	PF00017	0.531
LIG_SH2_STAP1	490	494	PF00017	0.500
LIG_SH2_STAT3	459	462	PF00017	0.767
LIG_SH2_STAT5	11	14	PF00017	0.418
LIG_SH2_STAT5	191	194	PF00017	0.433
LIG_SH2_STAT5	291	294	PF00017	0.433
LIG_SH2_STAT5	361	364	PF00017	0.402
LIG_SH2_STAT5	452	455	PF00017	0.625
LIG_SH2_STAT5	472	475	PF00017	0.363
LIG_SH2_STAT5	484	487	PF00017	0.500
LIG_SH2_STAT5	55	58	PF00017	0.433
LIG_SH2_STAT5	73	76	PF00017	0.491
LIG_SH3_3	166	172	PF00018	0.518
LIG_SH3_3	397	403	PF00018	0.575
LIG_SH3_3	407	413	PF00018	0.552
LIG_SH3_3	442	448	PF00018	0.672
LIG_Sin3_3	260	267	PF02671	0.343
LIG_TRAF2_1	233	236	PF00917	0.484
LIG_TRAF2_1	512	515	PF00917	0.500
LIG_TRAF2_2	461	466	PF00917	0.603
LIG_TYR_ITIM	488	493	PF00017	0.500
LIG_TYR_ITIM	51	56	PF00017	0.433
LIG_TYR_ITIM	71	76	PF00017	0.441
MOD_CK1_1	250	256	PF00069	0.600
MOD_CK1_1	474	480	PF00069	0.493
MOD_CK2_1	266	272	PF00069	0.582
MOD_CK2_1	360	366	PF00069	0.439
MOD_CK2_1	509	515	PF00069	0.517
MOD_GlcNHglycan	133	136	PF01048	0.295
MOD_GlcNHglycan	251	255	PF01048	0.569
MOD_GlcNHglycan	341	344	PF01048	0.298
MOD_GlcNHglycan	426	429	PF01048	0.717
MOD_GlcNHglycan	95	98	PF01048	0.543
MOD_GSK3_1	131	138	PF00069	0.523
MOD_GSK3_1	213	220	PF00069	0.463
MOD_N-GLC_1	158	163	PF02516	0.235
MOD_N-GLC_1	247	252	PF02516	0.300
MOD_N-GLC_1	323	328	PF02516	0.302
MOD_N-GLC_1	71	76	PF02516	0.252
MOD_NEK2_1	158	163	PF00069	0.484
MOD_NEK2_1	29	34	PF00069	0.441
MOD_NEK2_1	353	358	PF00069	0.601
MOD_NEK2_1	360	365	PF00069	0.362
MOD_NEK2_1	488	493	PF00069	0.515
MOD_NEK2_1	496	501	PF00069	0.532
MOD_NEK2_1	71	76	PF00069	0.487
MOD_NEK2_2	183	188	PF00069	0.460
MOD_NEK2_2	323	328	PF00069	0.457
MOD_NEK2_2	35	40	PF00069	0.457
MOD_OFUCOSY	122	128	PF10250	0.300
MOD_PIKK_1	44	50	PF00454	0.447
MOD_PIKK_1	450	456	PF00454	0.619
MOD_PKA_2	450	456	PF00069	0.728
MOD_PKA_2	6	12	PF00069	0.355
MOD_PKA_2	93	99	PF00069	0.547
MOD_Plk_2-3	297	303	PF00069	0.500
MOD_Plk_4	213	219	PF00069	0.477
MOD_Plk_4	278	284	PF00069	0.519
MOD_Plk_4	6	12	PF00069	0.374
MOD_ProDKin_1	474	480	PF00069	0.482
MOD_SUMO_rev_2	201	207	PF00179	0.520
MOD_SUMO_rev_2	271	280	PF00179	0.539
MOD_SUMO_rev_2	363	370	PF00179	0.475
TRG_DiLeu_BaEn_3	514	520	PF01217	0.452
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.574
TRG_ENDOCYTIC_2	141	144	PF00928	0.456
TRG_ENDOCYTIC_2	490	493	PF00928	0.457
TRG_ENDOCYTIC_2	53	56	PF00928	0.433
TRG_ENDOCYTIC_2	73	76	PF00928	0.491
TRG_ER_diArg_1	174	176	PF00400	0.485
TRG_ER_diArg_1	370	373	PF00400	0.498
TRG_ER_diArg_1	431	433	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.192
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	492	497	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y8	Leptomonas seymouri	39%	96%
A0A0N1I0F0	Leptomonas seymouri	77%	99%
A0A0S4IKZ4	Bodo saltans	34%	95%
A0A0S4JPT3	Bodo saltans	48%	96%
A0A1X0P4T3	Trypanosomatidae	35%	97%
A0A1X0P4V5	Trypanosomatidae	46%	95%
A0A1X0P525	Trypanosomatidae	35%	99%
A0A3Q8IGR8	Leishmania donovani	35%	100%
A0A3Q8IMW2	Leishmania donovani	36%	93%
A0A3R7NAH9	Trypanosoma rangeli	39%	100%
A0A422NK82	Trypanosoma rangeli	36%	99%
A1D4K4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	37%	72%
A2Q848	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	74%
A3LXL0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	86%
A4HDV5	Leishmania braziliensis	84%	100%
A4HN85	Leishmania braziliensis	36%	100%
A4HNG6	Leishmania braziliensis	34%	100%
A4I150	Leishmania infantum	99%	100%
A4IBV3	Leishmania infantum	36%	93%
A4IC57	Leishmania infantum	35%	100%
A5DM21	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	36%	86%
A5DW14	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	36%	82%
C9ZYE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AFP0	Leishmania major	37%	100%
E9AFX7	Leishmania major	35%	100%
E9AX84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B6U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B730	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
F1QB54	Danio rerio	42%	86%
F4HT49	Arabidopsis thaliana	37%	100%
O04319	Arabidopsis thaliana	34%	100%
O22173	Arabidopsis thaliana	38%	82%
O60176	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O64380	Arabidopsis thaliana	38%	82%
P04147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	94%
P09405	Mus musculus	23%	77%
P0CB38	Homo sapiens	39%	100%
P0CP46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	35%	81%
P0CP47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	35%	81%
P11940	Homo sapiens	37%	85%
P19338	Homo sapiens	22%	76%
P20965	Xenopus laevis	36%	86%
P21187	Drosophila melanogaster	43%	86%
P29341	Mus musculus	37%	85%
P31209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	83%
P42731	Arabidopsis thaliana	38%	86%
P60047	Gorilla gorilla gorilla	34%	100%
P60048	Hylobates lar	34%	100%
P60049	Pan troglodytes	34%	100%
P60050	Pongo pygmaeus	34%	100%
P61286	Bos taurus	37%	85%
Q05196	Arabidopsis thaliana	35%	80%
Q0CR95	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	36%	72%
Q0U1G2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	36%	73%
Q13310	Homo sapiens	40%	84%
Q1DXH0	Coccidioides immitis (strain RS)	34%	71%
Q1ZXC2	Dictyostelium discoideum	32%	67%
Q2GSX8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	37%	69%
Q4P8R9	Ustilago maydis (strain 521 / FGSC 9021)	36%	83%
Q4QA88	Leishmania major	95%	100%
Q4R4J7	Macaca fascicularis	22%	76%
Q4VXU2	Homo sapiens	35%	88%
Q4WK03	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	72%
Q54BM2	Dictyostelium discoideum	34%	96%
Q5AI15	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	86%
Q5B630	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	74%
Q5R8F7	Pongo abelii	37%	85%
Q5RF26	Pongo abelii	22%	76%
Q6BI95	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	87%
Q6CDH3	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	86%
Q6CSV3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	92%
Q6DEY7	Xenopus tropicalis	36%	86%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	94%
Q6GR16	Xenopus laevis	42%	86%
Q6IP09	Xenopus laevis	36%	86%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	93%
Q7JGR2	Macaca mulatta	34%	100%
Q7S6N6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	71%
Q8SR30	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q96DU9	Homo sapiens	34%	100%
Q98SP8	Xenopus laevis	40%	86%
Q9EPH8	Rattus norvegicus	36%	85%
Q9FXA2	Arabidopsis thaliana	41%	81%
Q9H361	Homo sapiens	36%	86%
Q9ZQA8	Arabidopsis thaliana	33%	89%
V5BYR2	Trypanosoma cruzi	36%	96%
V5DUJ1	Trypanosoma cruzi	35%	99%