Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF37_LEIDO

TriTrypDb:

LdBPK_210780.1 , LdCL_210012700 , LDHU3_21.0860

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.517
CLV_NRD_NRD_1	243	245	PF00675	0.503
CLV_NRD_NRD_1	280	282	PF00675	0.598
CLV_PCSK_FUR_1	234	238	PF00082	0.510
CLV_PCSK_KEX2_1	236	238	PF00082	0.517
CLV_PCSK_KEX2_1	280	282	PF00082	0.457
CLV_PCSK_SKI1_1	170	174	PF00082	0.451
CLV_PCSK_SKI1_1	197	201	PF00082	0.463
DEG_APCC_DBOX_1	22	30	PF00400	0.433
DEG_Nend_UBRbox_3	1	3	PF02207	0.531
DEG_SCF_FBW7_2	323	330	PF00400	0.713
DEG_SPOP_SBC_1	352	356	PF00917	0.716
DOC_CKS1_1	314	319	PF01111	0.685
DOC_CKS1_1	324	329	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.442
DOC_MAPK_gen_1	150	158	PF00069	0.556
DOC_MAPK_MEF2A_6	178	187	PF00069	0.510
DOC_MAPK_MEF2A_6	221	229	PF00069	0.519
DOC_MAPK_MEF2A_6	23	32	PF00069	0.437
DOC_MAPK_MEF2A_6	40	47	PF00069	0.446
DOC_MAPK_NFAT4_5	23	31	PF00069	0.432
DOC_PP1_RVXF_1	150	156	PF00149	0.573
DOC_PP1_RVXF_1	168	174	PF00149	0.556
DOC_PP1_RVXF_1	195	202	PF00149	0.406
DOC_PP2B_LxvP_1	183	186	PF13499	0.539
DOC_PP2B_LxvP_1	28	31	PF13499	0.427
DOC_USP7_MATH_1	130	134	PF00917	0.615
DOC_USP7_MATH_1	21	25	PF00917	0.455
DOC_USP7_MATH_1	336	340	PF00917	0.584
DOC_USP7_MATH_1	352	356	PF00917	0.617
DOC_USP7_MATH_1	8	12	PF00917	0.540
DOC_USP7_UBL2_3	96	100	PF12436	0.508
DOC_WW_Pin1_4	1	6	PF00397	0.575
DOC_WW_Pin1_4	313	318	PF00397	0.713
DOC_WW_Pin1_4	323	328	PF00397	0.667
DOC_WW_Pin1_4	353	358	PF00397	0.677
DOC_WW_Pin1_4	59	64	PF00397	0.634
LIG_14-3-3_CanoR_1	23	27	PF00244	0.470
LIG_14-3-3_CanoR_1	55	59	PF00244	0.566
LIG_14-3-3_CanoR_1	70	80	PF00244	0.656
LIG_Actin_WH2_2	40	57	PF00022	0.516
LIG_AP2alpha_1	226	230	PF02296	0.415
LIG_BRCT_BRCA1_1	354	358	PF00533	0.598
LIG_BRCT_BRCA1_1	61	65	PF00533	0.532
LIG_Clathr_ClatBox_1	29	33	PF01394	0.503
LIG_deltaCOP1_diTrp_1	154	157	PF00928	0.392
LIG_deltaCOP1_diTrp_1	16	20	PF00928	0.565
LIG_EH_1	223	227	PF12763	0.477
LIG_EH1_1	249	257	PF00400	0.504
LIG_eIF4E_1	250	256	PF01652	0.464
LIG_FHA_1	117	123	PF00498	0.643
LIG_FHA_1	175	181	PF00498	0.559
LIG_FHA_1	187	193	PF00498	0.369
LIG_FHA_1	73	79	PF00498	0.630
LIG_FHA_2	108	114	PF00498	0.630
LIG_GBD_Chelix_1	270	278	PF00786	0.534
LIG_LIR_Apic_2	16	21	PF02991	0.560
LIG_LIR_Gen_1	154	159	PF02991	0.432
LIG_LIR_Gen_1	216	225	PF02991	0.471
LIG_LIR_Gen_1	228	238	PF02991	0.243
LIG_LIR_Nem_3	113	117	PF02991	0.628
LIG_LIR_Nem_3	154	158	PF02991	0.427
LIG_LIR_Nem_3	216	220	PF02991	0.471
LIG_LIR_Nem_3	223	229	PF02991	0.380
LIG_LIR_Nem_3	326	331	PF02991	0.724
LIG_LIR_Nem_3	33	37	PF02991	0.488
LIG_Pex14_2	201	205	PF04695	0.371
LIG_Pex14_2	226	230	PF04695	0.402
LIG_SH2_STAT5	166	169	PF00017	0.455
LIG_SH2_STAT5	250	253	PF00017	0.466
LIG_SH2_STAT5	301	304	PF00017	0.614
LIG_SH2_STAT5	315	318	PF00017	0.677
LIG_SH2_STAT5	325	328	PF00017	0.714
LIG_SH3_3	311	317	PF00018	0.658
LIG_SUMO_SIM_anti_2	24	31	PF11976	0.500
LIG_TRAF2_1	208	211	PF00917	0.426
LIG_TRAF2_1	83	86	PF00917	0.602
LIG_TRAF2_1	88	91	PF00917	0.580
LIG_UBA3_1	341	348	PF00899	0.614
MOD_CDK_SPxK_1	323	329	PF00069	0.670
MOD_CK1_1	262	268	PF00069	0.462
MOD_CK1_1	3	9	PF00069	0.556
MOD_CK2_1	107	113	PF00069	0.608
MOD_CK2_1	205	211	PF00069	0.416
MOD_CK2_1	80	86	PF00069	0.606
MOD_Cter_Amidation	242	245	PF01082	0.496
MOD_GlcNHglycan	124	127	PF01048	0.581
MOD_GlcNHglycan	132	135	PF01048	0.575
MOD_GlcNHglycan	167	170	PF01048	0.476
MOD_GlcNHglycan	297	300	PF01048	0.574
MOD_GlcNHglycan	311	314	PF01048	0.616
MOD_GlcNHglycan	8	11	PF01048	0.610
MOD_GlcNHglycan	81	85	PF01048	0.672
MOD_GSK3_1	262	269	PF00069	0.509
MOD_GSK3_1	270	277	PF00069	0.543
MOD_GSK3_1	309	316	PF00069	0.756
MOD_GSK3_1	352	359	PF00069	0.651
MOD_N-GLC_1	122	127	PF02516	0.573
MOD_N-GLC_1	49	54	PF02516	0.467
MOD_N-GLC_2	332	334	PF02516	0.502
MOD_NEK2_1	157	162	PF00069	0.430
MOD_NEK2_1	22	27	PF00069	0.496
MOD_NEK2_1	270	275	PF00069	0.594
MOD_NEK2_1	54	59	PF00069	0.673
MOD_NEK2_1	71	76	PF00069	0.582
MOD_PIKK_1	262	268	PF00454	0.533
MOD_PKA_2	22	28	PF00069	0.472
MOD_PKA_2	220	226	PF00069	0.501
MOD_PKA_2	259	265	PF00069	0.423
MOD_PKA_2	54	60	PF00069	0.620
MOD_Plk_1	49	55	PF00069	0.468
MOD_Plk_4	160	166	PF00069	0.596
MOD_Plk_4	22	28	PF00069	0.438
MOD_Plk_4	251	257	PF00069	0.410
MOD_ProDKin_1	1	7	PF00069	0.575
MOD_ProDKin_1	313	319	PF00069	0.712
MOD_ProDKin_1	323	329	PF00069	0.670
MOD_ProDKin_1	353	359	PF00069	0.680
MOD_ProDKin_1	59	65	PF00069	0.636
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.664
TRG_ENDOCYTIC_2	101	104	PF00928	0.517
TRG_ENDOCYTIC_2	114	117	PF00928	0.547
TRG_ENDOCYTIC_2	139	142	PF00928	0.678
TRG_ENDOCYTIC_2	325	328	PF00928	0.731
TRG_ER_diArg_1	150	153	PF00400	0.528
TRG_ER_diArg_1	233	236	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD8	Leptomonas seymouri	63%	100%
A0A1X0NXM4	Trypanosomatidae	38%	100%
A0A3R7NME4	Trypanosoma rangeli	36%	100%
A4HZ71	Leishmania infantum	98%	100%
E9AIQ2	Leishmania braziliensis	77%	100%
E9AV38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCE3	Leishmania major	89%	100%