DUF4520 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4520), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF35_LEIDO

TriTrypDb:

LdBPK_332890.1 , LdCL_330036000 , LDHU3_33.4040

Length:

1089

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.646
CLV_C14_Caspase3-7	33	37	PF00656	0.547
CLV_C14_Caspase3-7	632	636	PF00656	0.591
CLV_C14_Caspase3-7	702	706	PF00656	0.559
CLV_C14_Caspase3-7	800	804	PF00656	0.279
CLV_C14_Caspase3-7	83	87	PF00656	0.600
CLV_NRD_NRD_1	184	186	PF00675	0.562
CLV_NRD_NRD_1	190	192	PF00675	0.548
CLV_NRD_NRD_1	284	286	PF00675	0.500
CLV_NRD_NRD_1	63	65	PF00675	0.585
CLV_NRD_NRD_1	69	71	PF00675	0.598
CLV_NRD_NRD_1	708	710	PF00675	0.554
CLV_NRD_NRD_1	748	750	PF00675	0.511
CLV_NRD_NRD_1	774	776	PF00675	0.590
CLV_NRD_NRD_1	876	878	PF00675	0.302
CLV_PCSK_KEX2_1	184	186	PF00082	0.557
CLV_PCSK_KEX2_1	190	192	PF00082	0.553
CLV_PCSK_KEX2_1	284	286	PF00082	0.500
CLV_PCSK_KEX2_1	585	587	PF00082	0.641
CLV_PCSK_KEX2_1	62	64	PF00082	0.585
CLV_PCSK_KEX2_1	69	71	PF00082	0.594
CLV_PCSK_KEX2_1	696	698	PF00082	0.530
CLV_PCSK_KEX2_1	708	710	PF00082	0.517
CLV_PCSK_KEX2_1	748	750	PF00082	0.512
CLV_PCSK_KEX2_1	876	878	PF00082	0.302
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.641
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.501
CLV_PCSK_SKI1_1	1084	1088	PF00082	0.700
CLV_PCSK_SKI1_1	116	120	PF00082	0.470
CLV_PCSK_SKI1_1	367	371	PF00082	0.572
CLV_PCSK_SKI1_1	691	695	PF00082	0.580
CLV_PCSK_SKI1_1	823	827	PF00082	0.337
CLV_PCSK_SKI1_1	847	851	PF00082	0.302
CLV_PCSK_SKI1_1	904	908	PF00082	0.678
CLV_PCSK_SKI1_1	988	992	PF00082	0.679
DEG_APCC_DBOX_1	822	830	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.676
DEG_SCF_FBW7_1	157	162	PF00400	0.551
DEG_SCF_SKP2-CKS1_1	503	510	PF00560	0.522
DEG_SPOP_SBC_1	782	786	PF00917	0.578
DOC_ANK_TNKS_1	800	807	PF00023	0.364
DOC_CYCLIN_RxL_1	1081	1089	PF00134	0.454
DOC_MAPK_gen_1	114	121	PF00069	0.461
DOC_MAPK_gen_1	284	292	PF00069	0.478
DOC_MAPK_MEF2A_6	284	292	PF00069	0.478
DOC_MAPK_MEF2A_6	367	376	PF00069	0.566
DOC_MAPK_MEF2A_6	523	531	PF00069	0.481
DOC_MAPK_NFAT4_5	367	375	PF00069	0.568
DOC_PP1_RVXF_1	189	196	PF00149	0.487
DOC_PP1_RVXF_1	474	480	PF00149	0.543
DOC_PP1_RVXF_1	706	713	PF00149	0.516
DOC_PP1_RVXF_1	875	882	PF00149	0.484
DOC_PP1_RVXF_1	97	104	PF00149	0.516
DOC_PP2B_LxvP_1	455	458	PF13499	0.512
DOC_PP4_MxPP_1	955	958	PF00568	0.568
DOC_USP7_MATH_1	1010	1014	PF00917	0.634
DOC_USP7_MATH_1	1028	1032	PF00917	0.623
DOC_USP7_MATH_1	152	156	PF00917	0.602
DOC_USP7_MATH_1	203	207	PF00917	0.606
DOC_USP7_MATH_1	219	223	PF00917	0.566
DOC_USP7_MATH_1	395	399	PF00917	0.688
DOC_USP7_MATH_1	43	47	PF00917	0.557
DOC_USP7_MATH_1	740	744	PF00917	0.583
DOC_USP7_MATH_1	897	901	PF00917	0.613
DOC_USP7_MATH_1	938	942	PF00917	0.747
DOC_USP7_MATH_1	950	954	PF00917	0.612
DOC_USP7_MATH_1	960	964	PF00917	0.597
DOC_WW_Pin1_4	1015	1020	PF00397	0.600
DOC_WW_Pin1_4	143	148	PF00397	0.554
DOC_WW_Pin1_4	155	160	PF00397	0.513
DOC_WW_Pin1_4	2	7	PF00397	0.558
DOC_WW_Pin1_4	249	254	PF00397	0.620
DOC_WW_Pin1_4	325	330	PF00397	0.591
DOC_WW_Pin1_4	336	341	PF00397	0.675
DOC_WW_Pin1_4	393	398	PF00397	0.643
DOC_WW_Pin1_4	46	51	PF00397	0.602
DOC_WW_Pin1_4	489	494	PF00397	0.573
DOC_WW_Pin1_4	504	509	PF00397	0.492
DOC_WW_Pin1_4	589	594	PF00397	0.583
DOC_WW_Pin1_4	609	614	PF00397	0.585
DOC_WW_Pin1_4	644	649	PF00397	0.599
DOC_WW_Pin1_4	71	76	PF00397	0.561
DOC_WW_Pin1_4	758	763	PF00397	0.588
DOC_WW_Pin1_4	917	922	PF00397	0.643
LIG_14-3-3_CanoR_1	1049	1055	PF00244	0.539
LIG_14-3-3_CanoR_1	130	136	PF00244	0.565
LIG_14-3-3_CanoR_1	220	224	PF00244	0.537
LIG_14-3-3_CanoR_1	285	291	PF00244	0.474
LIG_14-3-3_CanoR_1	312	318	PF00244	0.552
LIG_14-3-3_CanoR_1	415	420	PF00244	0.620
LIG_14-3-3_CanoR_1	523	531	PF00244	0.505
LIG_14-3-3_CanoR_1	539	543	PF00244	0.596
LIG_14-3-3_CanoR_1	553	562	PF00244	0.535
LIG_14-3-3_CanoR_1	639	648	PF00244	0.570
LIG_14-3-3_CanoR_1	691	700	PF00244	0.549
LIG_14-3-3_CanoR_1	714	720	PF00244	0.487
LIG_14-3-3_CanoR_1	756	762	PF00244	0.492
LIG_14-3-3_CanoR_1	788	797	PF00244	0.505
LIG_14-3-3_CanoR_1	823	829	PF00244	0.302
LIG_14-3-3_CanoR_1	851	855	PF00244	0.300
LIG_14-3-3_CanoR_1	904	913	PF00244	0.742
LIG_14-3-3_CanoR_1	971	976	PF00244	0.672
LIG_14-3-3_CanoR_1	988	993	PF00244	0.498
LIG_Actin_WH2_2	269	286	PF00022	0.518
LIG_APCC_ABBA_1	290	295	PF00400	0.501
LIG_BRCT_BRCA1_1	1035	1039	PF00533	0.521
LIG_Clathr_ClatBox_1	371	375	PF01394	0.445
LIG_FHA_1	1081	1087	PF00498	0.516
LIG_FHA_1	177	183	PF00498	0.562
LIG_FHA_1	287	293	PF00498	0.474
LIG_FHA_1	294	300	PF00498	0.501
LIG_FHA_1	320	326	PF00498	0.598
LIG_FHA_1	354	360	PF00498	0.583
LIG_FHA_1	366	372	PF00498	0.544
LIG_FHA_1	523	529	PF00498	0.613
LIG_FHA_1	632	638	PF00498	0.612
LIG_FHA_1	657	663	PF00498	0.564
LIG_FHA_1	797	803	PF00498	0.305
LIG_FHA_1	841	847	PF00498	0.302
LIG_FHA_2	1032	1038	PF00498	0.577
LIG_FHA_2	1051	1057	PF00498	0.516
LIG_FHA_2	195	201	PF00498	0.754
LIG_FHA_2	237	243	PF00498	0.579
LIG_FHA_2	273	279	PF00498	0.509
LIG_FHA_2	304	310	PF00498	0.635
LIG_FHA_2	349	355	PF00498	0.522
LIG_FHA_2	538	544	PF00498	0.608
LIG_FHA_2	931	937	PF00498	0.678
LIG_GBD_Chelix_1	372	380	PF00786	0.572
LIG_LIR_Apic_2	1001	1007	PF02991	0.536
LIG_LIR_Apic_2	298	304	PF02991	0.515
LIG_LIR_Apic_2	625	630	PF02991	0.491
LIG_LIR_Gen_1	158	169	PF02991	0.604
LIG_LIR_Gen_1	278	288	PF02991	0.496
LIG_LIR_Gen_1	40	48	PF02991	0.534
LIG_LIR_Gen_1	807	816	PF02991	0.302
LIG_LIR_Nem_3	158	164	PF02991	0.601
LIG_LIR_Nem_3	200	204	PF02991	0.635
LIG_LIR_Nem_3	278	283	PF02991	0.503
LIG_LIR_Nem_3	40	44	PF02991	0.511
LIG_LIR_Nem_3	494	500	PF02991	0.526
LIG_LIR_Nem_3	666	672	PF02991	0.555
LIG_LIR_Nem_3	807	811	PF02991	0.302
LIG_MYND_1	143	147	PF01753	0.576
LIG_NRBOX	1068	1074	PF00104	0.538
LIG_PCNA_PIPBox_1	1048	1057	PF02747	0.535
LIG_Pex14_2	297	301	PF04695	0.492
LIG_SH2_CRK	161	165	PF00017	0.717
LIG_SH2_CRK	627	631	PF00017	0.549
LIG_SH2_CRK	871	875	PF00017	0.352
LIG_SH2_NCK_1	161	165	PF00017	0.553
LIG_SH2_NCK_1	871	875	PF00017	0.509
LIG_SH2_SRC	1004	1007	PF00017	0.539
LIG_SH2_SRC	84	87	PF00017	0.648
LIG_SH2_STAP1	1055	1059	PF00017	0.520
LIG_SH2_STAT3	569	572	PF00017	0.641
LIG_SH2_STAT5	547	550	PF00017	0.571
LIG_SH2_STAT5	627	630	PF00017	0.563
LIG_SH2_STAT5	715	718	PF00017	0.501
LIG_SH2_STAT5	752	755	PF00017	0.582
LIG_SH2_STAT5	797	800	PF00017	0.501
LIG_SH2_STAT5	84	87	PF00017	0.672
LIG_SH2_STAT5	868	871	PF00017	0.302
LIG_SH2_STAT5	878	881	PF00017	0.427
LIG_SH3_1	1004	1010	PF00018	0.597
LIG_SH3_3	1004	1010	PF00018	0.575
LIG_SH3_3	210	216	PF00018	0.620
LIG_SH3_3	262	268	PF00018	0.580
LIG_SH3_3	296	302	PF00018	0.499
LIG_SH3_3	326	332	PF00018	0.626
LIG_SH3_3	335	341	PF00018	0.778
LIG_SH3_3	356	362	PF00018	0.580
LIG_SH3_3	391	397	PF00018	0.573
LIG_SH3_3	596	602	PF00018	0.586
LIG_SH3_3	883	889	PF00018	0.458
LIG_SH3_3	994	1000	PF00018	0.581
LIG_SUMO_SIM_anti_2	824	830	PF11976	0.364
LIG_SUMO_SIM_par_1	178	183	PF11976	0.575
LIG_SUMO_SIM_par_1	370	375	PF11976	0.446
LIG_TRAF2_1	908	911	PF00917	0.612
LIG_WRC_WIRS_1	31	36	PF05994	0.467
LIG_WRC_WIRS_1	38	43	PF05994	0.518
LIG_WRC_WIRS_1	805	810	PF05994	0.302
LIG_WW_1	1006	1009	PF00397	0.588
MOD_CDK_SPK_2	46	51	PF00069	0.602
MOD_CDK_SPxK_1	504	510	PF00069	0.548
MOD_CDK_SPxK_1	589	595	PF00069	0.584
MOD_CK1_1	1013	1019	PF00069	0.595
MOD_CK1_1	1031	1037	PF00069	0.497
MOD_CK1_1	1080	1086	PF00069	0.492
MOD_CK1_1	153	159	PF00069	0.587
MOD_CK1_1	206	212	PF00069	0.597
MOD_CK1_1	308	314	PF00069	0.600
MOD_CK1_1	328	334	PF00069	0.508
MOD_CK1_1	336	342	PF00069	0.610
MOD_CK1_1	388	394	PF00069	0.643
MOD_CK1_1	398	404	PF00069	0.592
MOD_CK1_1	445	451	PF00069	0.518
MOD_CK1_1	46	52	PF00069	0.551
MOD_CK1_1	489	495	PF00069	0.545
MOD_CK1_1	589	595	PF00069	0.673
MOD_CK1_1	675	681	PF00069	0.546
MOD_CK1_1	685	691	PF00069	0.560
MOD_CK1_1	74	80	PF00069	0.585
MOD_CK1_1	763	769	PF00069	0.609
MOD_CK1_1	791	797	PF00069	0.371
MOD_CK1_1	969	975	PF00069	0.598
MOD_CK2_1	121	127	PF00069	0.614
MOD_CK2_1	194	200	PF00069	0.757
MOD_CK2_1	236	242	PF00069	0.620
MOD_CK2_1	272	278	PF00069	0.518
MOD_CK2_1	348	354	PF00069	0.529
MOD_CK2_1	537	543	PF00069	0.603
MOD_CK2_1	897	903	PF00069	0.660
MOD_CK2_1	919	925	PF00069	0.609
MOD_CK2_1	943	949	PF00069	0.620
MOD_CK2_1	950	956	PF00069	0.572
MOD_GlcNHglycan	1012	1015	PF01048	0.573
MOD_GlcNHglycan	14	17	PF01048	0.455
MOD_GlcNHglycan	152	155	PF01048	0.604
MOD_GlcNHglycan	172	175	PF01048	0.462
MOD_GlcNHglycan	205	208	PF01048	0.634
MOD_GlcNHglycan	216	219	PF01048	0.584
MOD_GlcNHglycan	342	345	PF01048	0.578
MOD_GlcNHglycan	386	390	PF01048	0.649
MOD_GlcNHglycan	415	418	PF01048	0.664
MOD_GlcNHglycan	429	432	PF01048	0.552
MOD_GlcNHglycan	493	496	PF01048	0.592
MOD_GlcNHglycan	502	505	PF01048	0.518
MOD_GlcNHglycan	558	561	PF01048	0.521
MOD_GlcNHglycan	603	606	PF01048	0.613
MOD_GlcNHglycan	652	655	PF01048	0.567
MOD_GlcNHglycan	677	680	PF01048	0.606
MOD_GlcNHglycan	731	734	PF01048	0.474
MOD_GlcNHglycan	767	770	PF01048	0.608
MOD_GlcNHglycan	779	782	PF01048	0.547
MOD_GlcNHglycan	788	791	PF01048	0.532
MOD_GlcNHglycan	899	902	PF01048	0.589
MOD_GlcNHglycan	921	924	PF01048	0.657
MOD_GlcNHglycan	936	941	PF01048	0.668
MOD_GlcNHglycan	945	948	PF01048	0.628
MOD_GlcNHglycan	961	965	PF01048	0.523
MOD_GlcNHglycan	981	984	PF01048	0.605
MOD_GSK3_1	1031	1038	PF00069	0.660
MOD_GSK3_1	131	138	PF00069	0.619
MOD_GSK3_1	155	162	PF00069	0.583
MOD_GSK3_1	202	209	PF00069	0.626
MOD_GSK3_1	328	335	PF00069	0.606
MOD_GSK3_1	336	343	PF00069	0.641
MOD_GSK3_1	384	391	PF00069	0.658
MOD_GSK3_1	393	400	PF00069	0.647
MOD_GSK3_1	411	418	PF00069	0.589
MOD_GSK3_1	46	53	PF00069	0.511
MOD_GSK3_1	500	507	PF00069	0.629
MOD_GSK3_1	533	540	PF00069	0.733
MOD_GSK3_1	777	784	PF00069	0.716
MOD_GSK3_1	971	978	PF00069	0.616
MOD_N-GLC_1	411	416	PF02516	0.548
MOD_N-GLC_1	729	734	PF02516	0.472
MOD_N-GLC_1	812	817	PF02516	0.302
MOD_N-GLC_1	847	852	PF02516	0.364
MOD_N-GLC_2	484	486	PF02516	0.544
MOD_NEK2_1	101	106	PF00069	0.524
MOD_NEK2_1	1035	1040	PF00069	0.625
MOD_NEK2_1	1044	1049	PF00069	0.525
MOD_NEK2_1	131	136	PF00069	0.506
MOD_NEK2_1	163	168	PF00069	0.576
MOD_NEK2_1	348	353	PF00069	0.570
MOD_NEK2_1	513	518	PF00069	0.600
MOD_NEK2_1	554	559	PF00069	0.664
MOD_NEK2_1	7	12	PF00069	0.532
MOD_NEK2_1	840	845	PF00069	0.326
MOD_NEK2_1	929	934	PF00069	0.669
MOD_NEK2_1	975	980	PF00069	0.728
MOD_PIKK_1	1028	1034	PF00454	0.585
MOD_PIKK_1	1044	1050	PF00454	0.446
MOD_PIKK_1	206	212	PF00454	0.570
MOD_PIKK_1	50	56	PF00454	0.569
MOD_PIKK_1	724	730	PF00454	0.514
MOD_PKA_2	12	18	PF00069	0.475
MOD_PKA_2	219	225	PF00069	0.705
MOD_PKA_2	293	299	PF00069	0.527
MOD_PKA_2	319	325	PF00069	0.618
MOD_PKA_2	427	433	PF00069	0.642
MOD_PKA_2	436	442	PF00069	0.527
MOD_PKA_2	445	451	PF00069	0.429
MOD_PKA_2	472	478	PF00069	0.494
MOD_PKA_2	50	56	PF00069	0.568
MOD_PKA_2	500	506	PF00069	0.603
MOD_PKA_2	522	528	PF00069	0.574
MOD_PKA_2	538	544	PF00069	0.498
MOD_PKA_2	740	746	PF00069	0.590
MOD_PKA_2	850	856	PF00069	0.298
MOD_Plk_1	260	266	PF00069	0.597
MOD_Plk_1	353	359	PF00069	0.518
MOD_Plk_1	821	827	PF00069	0.302
MOD_Plk_4	1050	1056	PF00069	0.547
MOD_Plk_4	131	137	PF00069	0.619
MOD_Plk_4	145	151	PF00069	0.668
MOD_Plk_4	159	165	PF00069	0.636
MOD_Plk_4	176	182	PF00069	0.544
MOD_Plk_4	27	33	PF00069	0.406
MOD_Plk_4	272	278	PF00069	0.518
MOD_Plk_4	37	43	PF00069	0.521
MOD_Plk_4	533	539	PF00069	0.538
MOD_Plk_4	622	628	PF00069	0.720
MOD_Plk_4	7	13	PF00069	0.529
MOD_Plk_4	715	721	PF00069	0.598
MOD_Plk_4	791	797	PF00069	0.356
MOD_Plk_4	824	830	PF00069	0.364
MOD_Plk_4	950	956	PF00069	0.618
MOD_Plk_4	988	994	PF00069	0.654
MOD_ProDKin_1	1015	1021	PF00069	0.600
MOD_ProDKin_1	143	149	PF00069	0.555
MOD_ProDKin_1	155	161	PF00069	0.514
MOD_ProDKin_1	2	8	PF00069	0.546
MOD_ProDKin_1	249	255	PF00069	0.618
MOD_ProDKin_1	325	331	PF00069	0.589
MOD_ProDKin_1	336	342	PF00069	0.670
MOD_ProDKin_1	393	399	PF00069	0.643
MOD_ProDKin_1	46	52	PF00069	0.599
MOD_ProDKin_1	489	495	PF00069	0.570
MOD_ProDKin_1	504	510	PF00069	0.496
MOD_ProDKin_1	589	595	PF00069	0.584
MOD_ProDKin_1	609	615	PF00069	0.585
MOD_ProDKin_1	644	650	PF00069	0.595
MOD_ProDKin_1	71	77	PF00069	0.562
MOD_ProDKin_1	758	764	PF00069	0.588
MOD_ProDKin_1	917	923	PF00069	0.646
MOD_SUMO_for_1	1002	1005	PF00179	0.613
TRG_DiLeu_BaEn_1	127	132	PF01217	0.538
TRG_DiLeu_BaEn_1	962	967	PF01217	0.645
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.586
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.639
TRG_DiLeu_LyEn_5	127	132	PF01217	0.538
TRG_ENDOCYTIC_2	161	164	PF00928	0.602
TRG_ENDOCYTIC_2	497	500	PF00928	0.548
TRG_ER_diArg_1	189	191	PF00400	0.613
TRG_ER_diArg_1	283	285	PF00400	0.510
TRG_ER_diArg_1	62	64	PF00400	0.556
TRG_ER_diArg_1	69	72	PF00400	0.583
TRG_ER_diArg_1	707	709	PF00400	0.510
TRG_ER_diArg_1	747	749	PF00400	0.508
TRG_ER_diArg_1	875	877	PF00400	0.302
TRG_Pf-PMV_PEXEL_1	1084	1089	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXR0	Leptomonas seymouri	38%	99%
A4HLY6	Leishmania braziliensis	66%	100%
A4I9B5	Leishmania infantum	99%	100%
E9B4B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q3R0	Leishmania major	80%	100%