Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF25_LEIDO

TriTrypDb:

LdBPK_332720.1 , LdCL_330034300 , LDHU3_33.3860

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.605
CLV_NRD_NRD_1	293	295	PF00675	0.540
CLV_NRD_NRD_1	425	427	PF00675	0.606
CLV_NRD_NRD_1	49	51	PF00675	0.756
CLV_NRD_NRD_1	505	507	PF00675	0.565
CLV_NRD_NRD_1	61	63	PF00675	0.613
CLV_PCSK_KEX2_1	293	295	PF00082	0.518
CLV_PCSK_KEX2_1	424	426	PF00082	0.618
CLV_PCSK_KEX2_1	49	51	PF00082	0.756
CLV_PCSK_KEX2_1	61	63	PF00082	0.591
CLV_PCSK_PC7_1	57	63	PF00082	0.589
CLV_PCSK_SKI1_1	101	105	PF00082	0.655
CLV_PCSK_SKI1_1	215	219	PF00082	0.519
CLV_PCSK_SKI1_1	355	359	PF00082	0.470
CLV_PCSK_SKI1_1	366	370	PF00082	0.366
CLV_PCSK_SKI1_1	434	438	PF00082	0.475
CLV_PCSK_SKI1_1	507	511	PF00082	0.565
CLV_PCSK_SKI1_1	540	544	PF00082	0.380
CLV_PCSK_SKI1_1	71	75	PF00082	0.385
CLV_PCSK_SKI1_1	80	84	PF00082	0.365
DEG_APCC_DBOX_1	452	460	PF00400	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.572
DEG_SPOP_SBC_1	115	119	PF00917	0.584
DEG_SPOP_SBC_1	185	189	PF00917	0.507
DEG_SPOP_SBC_1	32	36	PF00917	0.550
DEG_SPOP_SBC_1	485	489	PF00917	0.582
DOC_CDC14_PxL_1	535	543	PF14671	0.369
DOC_MAPK_MEF2A_6	536	543	PF00069	0.395
DOC_PP1_RVXF_1	306	313	PF00149	0.569
DOC_PP2B_LxvP_1	28	31	PF13499	0.625
DOC_PP4_MxPP_1	51	54	PF00568	0.560
DOC_USP7_MATH_1	115	119	PF00917	0.593
DOC_USP7_MATH_1	185	189	PF00917	0.562
DOC_USP7_MATH_1	267	271	PF00917	0.715
DOC_USP7_MATH_1	276	280	PF00917	0.665
DOC_USP7_MATH_1	319	323	PF00917	0.471
DOC_USP7_MATH_1	360	364	PF00917	0.450
DOC_USP7_MATH_1	373	377	PF00917	0.371
DOC_USP7_MATH_1	419	423	PF00917	0.664
DOC_USP7_MATH_1	42	46	PF00917	0.557
DOC_USP7_MATH_1	485	489	PF00917	0.584
DOC_USP7_MATH_1	490	494	PF00917	0.559
DOC_WW_Pin1_4	188	193	PF00397	0.508
DOC_WW_Pin1_4	220	225	PF00397	0.532
DOC_WW_Pin1_4	284	289	PF00397	0.596
DOC_WW_Pin1_4	477	482	PF00397	0.527
LIG_14-3-3_CanoR_1	2	8	PF00244	0.576
LIG_14-3-3_CanoR_1	277	281	PF00244	0.584
LIG_14-3-3_CanoR_1	283	290	PF00244	0.562
LIG_14-3-3_CanoR_1	366	371	PF00244	0.471
LIG_14-3-3_CanoR_1	377	381	PF00244	0.485
LIG_14-3-3_CanoR_1	424	429	PF00244	0.593
LIG_14-3-3_CanoR_1	506	514	PF00244	0.633
LIG_14-3-3_CanoR_1	61	66	PF00244	0.647
LIG_14-3-3_CanoR_1	71	78	PF00244	0.353
LIG_BIR_III_4	204	208	PF00653	0.402
LIG_BIR_III_4	263	267	PF00653	0.534
LIG_BIR_III_4	395	399	PF00653	0.623
LIG_BRCT_BRCA1_1	255	259	PF00533	0.620
LIG_BRCT_BRCA1_1	3	7	PF00533	0.632
LIG_BRCT_BRCA1_1	343	347	PF00533	0.405
LIG_FHA_1	107	113	PF00498	0.620
LIG_FHA_1	148	154	PF00498	0.443
LIG_FHA_1	204	210	PF00498	0.349
LIG_FHA_1	33	39	PF00498	0.668
LIG_FHA_2	412	418	PF00498	0.724
LIG_FHA_2	42	48	PF00498	0.683
LIG_FHA_2	468	474	PF00498	0.401
LIG_FHA_2	478	484	PF00498	0.510
LIG_Integrin_RGD_1	131	133	PF01839	0.550
LIG_LIR_Gen_1	256	267	PF02991	0.580
LIG_LIR_Gen_1	344	352	PF02991	0.436
LIG_LIR_Gen_1	378	388	PF02991	0.541
LIG_LIR_Nem_3	256	262	PF02991	0.637
LIG_LIR_Nem_3	344	350	PF02991	0.428
LIG_LIR_Nem_3	378	383	PF02991	0.729
LIG_LIR_Nem_3	547	553	PF02991	0.442
LIG_LYPXL_yS_3	538	541	PF13949	0.373
LIG_RPA_C_Fungi	155	167	PF08784	0.417
LIG_SH2_STAP1	197	201	PF00017	0.388
LIG_SH2_STAP1	327	331	PF00017	0.482
LIG_SH2_STAP1	361	365	PF00017	0.466
LIG_SH2_STAT5	338	341	PF00017	0.390
LIG_SH2_STAT5	389	392	PF00017	0.540
LIG_SH2_STAT5	468	471	PF00017	0.397
LIG_SH3_1	222	228	PF00018	0.545
LIG_SH3_1	426	432	PF00018	0.587
LIG_SH3_2	429	434	PF14604	0.566
LIG_SH3_3	222	228	PF00018	0.664
LIG_SH3_3	426	432	PF00018	0.614
LIG_SH3_3	435	441	PF00018	0.573
LIG_SH3_3	52	58	PF00018	0.651
LIG_SH3_3	566	572	PF00018	0.459
LIG_SH3_3	573	579	PF00018	0.539
LIG_SH3_CIN85_PxpxPR_1	429	434	PF14604	0.566
LIG_SUMO_SIM_par_1	443	450	PF11976	0.484
LIG_TRAF2_1	103	106	PF00917	0.653
LIG_TRAF2_1	413	416	PF00917	0.587
LIG_TRFH_1	437	441	PF08558	0.423
LIG_TYR_ITIM	195	200	PF00017	0.379
LIG_UBA3_1	532	536	PF00899	0.355
LIG_WRC_WIRS_1	491	496	PF05994	0.549
LIG_WW_3	431	435	PF00397	0.552
MOD_CK1_1	113	119	PF00069	0.653
MOD_CK1_1	16	22	PF00069	0.595
MOD_CK1_1	175	181	PF00069	0.612
MOD_CK1_1	188	194	PF00069	0.545
MOD_CK1_1	203	209	PF00069	0.326
MOD_CK1_1	270	276	PF00069	0.586
MOD_CK1_1	311	317	PF00069	0.540
MOD_CK1_1	375	381	PF00069	0.687
MOD_CK1_1	461	467	PF00069	0.451
MOD_CK1_1	489	495	PF00069	0.632
MOD_CK1_1	60	66	PF00069	0.585
MOD_CK2_1	411	417	PF00069	0.655
MOD_CK2_1	467	473	PF00069	0.412
MOD_CK2_1	492	498	PF00069	0.640
MOD_Cter_Amidation	504	507	PF01082	0.604
MOD_GlcNHglycan	113	116	PF01048	0.640
MOD_GlcNHglycan	118	121	PF01048	0.622
MOD_GlcNHglycan	141	144	PF01048	0.524
MOD_GlcNHglycan	15	18	PF01048	0.595
MOD_GlcNHglycan	20	23	PF01048	0.619
MOD_GlcNHglycan	238	241	PF01048	0.715
MOD_GlcNHglycan	269	272	PF01048	0.527
MOD_GlcNHglycan	3	6	PF01048	0.573
MOD_GlcNHglycan	300	303	PF01048	0.590
MOD_GlcNHglycan	395	399	PF01048	0.652
MOD_GlcNHglycan	404	407	PF01048	0.639
MOD_GlcNHglycan	426	429	PF01048	0.557
MOD_GlcNHglycan	464	467	PF01048	0.495
MOD_GlcNHglycan	488	491	PF01048	0.571
MOD_GlcNHglycan	494	497	PF01048	0.623
MOD_GlcNHglycan	510	513	PF01048	0.788
MOD_GlcNHglycan	9	12	PF01048	0.574
MOD_GSK3_1	106	113	PF00069	0.593
MOD_GSK3_1	114	121	PF00069	0.576
MOD_GSK3_1	184	191	PF00069	0.545
MOD_GSK3_1	220	227	PF00069	0.576
MOD_GSK3_1	294	301	PF00069	0.728
MOD_GSK3_1	3	10	PF00069	0.602
MOD_GSK3_1	369	376	PF00069	0.507
MOD_GSK3_1	390	397	PF00069	0.571
MOD_GSK3_1	458	465	PF00069	0.510
MOD_GSK3_1	485	492	PF00069	0.662
MOD_GSK3_1	56	63	PF00069	0.690
MOD_GSK3_1	97	104	PF00069	0.727
MOD_N-GLC_1	175	180	PF02516	0.537
MOD_N-GLC_2	284	286	PF02516	0.554
MOD_N-GLC_2	546	548	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	137	142	PF00069	0.460
MOD_NEK2_1	146	151	PF00069	0.401
MOD_NEK2_1	33	38	PF00069	0.575
MOD_NEK2_1	458	463	PF00069	0.488
MOD_NEK2_1	508	513	PF00069	0.704
MOD_NEK2_1	7	12	PF00069	0.576
MOD_NEK2_2	419	424	PF00069	0.602
MOD_PIKK_1	101	107	PF00454	0.591
MOD_PIKK_1	451	457	PF00454	0.381
MOD_PKA_1	424	430	PF00069	0.586
MOD_PKA_1	61	67	PF00069	0.576
MOD_PKA_2	1	7	PF00069	0.572
MOD_PKA_2	137	143	PF00069	0.458
MOD_PKA_2	276	282	PF00069	0.584
MOD_PKA_2	376	382	PF00069	0.518
MOD_PKA_2	402	408	PF00069	0.540
MOD_PKA_2	424	430	PF00069	0.586
MOD_PKA_2	56	62	PF00069	0.597
MOD_Plk_1	147	153	PF00069	0.364
MOD_Plk_2-3	411	417	PF00069	0.725
MOD_Plk_4	190	196	PF00069	0.598
MOD_Plk_4	3	9	PF00069	0.601
MOD_ProDKin_1	188	194	PF00069	0.502
MOD_ProDKin_1	220	226	PF00069	0.534
MOD_ProDKin_1	284	290	PF00069	0.594
MOD_ProDKin_1	477	483	PF00069	0.537
TRG_ENDOCYTIC_2	197	200	PF00928	0.342
TRG_ENDOCYTIC_2	538	541	PF00928	0.453
TRG_ER_diArg_1	212	215	PF00400	0.345
TRG_ER_diArg_1	423	426	PF00400	0.614
TRG_ER_diArg_1	48	50	PF00400	0.765
TRG_ER_diArg_1	560	563	PF00400	0.513
TRG_ER_diArg_1	65	68	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA9	Leptomonas seymouri	29%	98%
A4HLW9	Leishmania braziliensis	63%	100%
A4I998	Leishmania infantum	100%	100%
E9B498	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3S8	Leishmania major	86%	100%