Pentatricopeptide repeat domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF22_LEIDO

TriTrypDb:

LdBPK_242290.1 , LdCL_240028500 , LDHU3_24.2810

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.583
CLV_PCSK_KEX2_1	209	211	PF00082	0.480
CLV_PCSK_KEX2_1	239	241	PF00082	0.506
CLV_PCSK_KEX2_1	86	88	PF00082	0.337
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.463
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.419
CLV_PCSK_SKI1_1	122	126	PF00082	0.617
CLV_PCSK_SKI1_1	219	223	PF00082	0.559
CLV_PCSK_SKI1_1	239	243	PF00082	0.488
CLV_PCSK_SKI1_1	83	87	PF00082	0.418
DOC_AGCK_PIF_1	161	166	PF00069	0.604
DOC_CYCLIN_RxL_1	213	226	PF00134	0.538
DOC_CYCLIN_RxL_1	236	245	PF00134	0.486
DOC_PP1_SILK_1	63	68	PF00149	0.271
DOC_PP2B_LxvP_1	241	244	PF13499	0.691
DOC_PP4_FxxP_1	217	220	PF00568	0.530
DOC_PP4_MxPP_1	1	4	PF00568	0.526
DOC_USP7_MATH_1	231	235	PF00917	0.670
LIG_ActinCP_TwfCPI_2	217	227	PF01115	0.502
LIG_eIF4E_1	164	170	PF01652	0.371
LIG_FHA_1	121	127	PF00498	0.604
LIG_FHA_1	165	171	PF00498	0.304
LIG_FHA_1	61	67	PF00498	0.306
LIG_LIR_Gen_1	114	125	PF02991	0.572
LIG_LIR_Gen_1	165	172	PF02991	0.312
LIG_LIR_Gen_1	60	70	PF02991	0.340
LIG_LIR_Nem_3	114	120	PF02991	0.531
LIG_LIR_Nem_3	165	169	PF02991	0.312
LIG_LIR_Nem_3	60	65	PF02991	0.340
LIG_Pex14_1	18	22	PF04695	0.532
LIG_Pex14_2	242	246	PF04695	0.446
LIG_SH2_NCK_1	110	114	PF00017	0.459
LIG_SH2_SRC	110	113	PF00017	0.453
LIG_SH2_STAP1	166	170	PF00017	0.317
LIG_SH2_STAP1	181	185	PF00017	0.329
LIG_SH2_STAT3	26	29	PF00017	0.553
LIG_SH2_STAT5	164	167	PF00017	0.308
LIG_SH3_3	157	163	PF00018	0.552
LIG_SUMO_SIM_par_1	200	206	PF11976	0.606
LIG_TRAF2_1	137	140	PF00917	0.636
LIG_TRAF2_1	50	53	PF00917	0.419
LIG_WRC_WIRS_1	117	122	PF05994	0.613
MOD_CK1_1	60	66	PF00069	0.419
MOD_Cter_Amidation	207	210	PF01082	0.472
MOD_GlcNHglycan	140	143	PF01048	0.657
MOD_GlcNHglycan	222	225	PF01048	0.607
MOD_GlcNHglycan	34	38	PF01048	0.601
MOD_GlcNHglycan	5	8	PF01048	0.591
MOD_GSK3_1	116	123	PF00069	0.601
MOD_GSK3_1	231	238	PF00069	0.597
MOD_GSK3_1	57	64	PF00069	0.401
MOD_N-GLC_1	57	62	PF02516	0.371
MOD_NEK2_1	120	125	PF00069	0.613
MOD_NEK2_1	235	240	PF00069	0.715
MOD_NEK2_1	46	51	PF00069	0.321
MOD_NEK2_1	57	62	PF00069	0.281
MOD_PIKK_1	194	200	PF00454	0.431
MOD_PKB_1	136	144	PF00069	0.521
MOD_Plk_1	57	63	PF00069	0.354
MOD_Plk_4	120	126	PF00069	0.641
MOD_Plk_4	61	67	PF00069	0.313
MOD_SUMO_for_1	85	88	PF00179	0.419
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.561
TRG_ENDOCYTIC_2	110	113	PF00928	0.616
TRG_ENDOCYTIC_2	166	169	PF00928	0.337
TRG_ER_diArg_1	135	138	PF00400	0.622
TRG_NES_CRM1_1	114	127	PF08389	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ2	Leptomonas seymouri	77%	99%
A0A0N1I1J7	Leptomonas seymouri	25%	88%
A0A0S4IYI9	Bodo saltans	24%	91%
A0A0S4KKY6	Bodo saltans	55%	100%
A0A1X0NXK5	Trypanosomatidae	61%	100%
A0A1X0P0D8	Trypanosomatidae	24%	78%
A0A3Q8IJ22	Leishmania donovani	24%	88%
A0A3R7KPI7	Trypanosoma rangeli	26%	88%
A4HDT1	Leishmania braziliensis	89%	100%
A4I129	Leishmania infantum	100%	100%
A4IDQ9	Leishmania infantum	25%	100%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AX66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAB0	Leishmania major	96%	100%
V5DLI8	Trypanosoma cruzi	25%	81%