Leucine rich repeat/Leucine Rich Repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF21_LEIDO

TriTrypDb:

LdBPK_351690.1 , LdCL_350021800 , LDHU3_35.2230

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IF21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF21

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.370
CLV_C14_Caspase3-7	63	67	PF00656	0.718
CLV_NRD_NRD_1	234	236	PF00675	0.657
CLV_NRD_NRD_1	353	355	PF00675	0.580
CLV_PCSK_FUR_1	367	371	PF00082	0.510
CLV_PCSK_KEX2_1	234	236	PF00082	0.705
CLV_PCSK_KEX2_1	353	355	PF00082	0.556
CLV_PCSK_KEX2_1	369	371	PF00082	0.534
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.552
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
CLV_PCSK_SKI1_1	34	38	PF00082	0.496
CLV_PCSK_SKI1_1	353	357	PF00082	0.585
CLV_PCSK_SKI1_1	369	373	PF00082	0.480
CLV_PCSK_SKI1_1	45	49	PF00082	0.491
CLV_PCSK_SKI1_1	57	61	PF00082	0.503
DEG_APCC_DBOX_1	206	214	PF00400	0.529
DEG_SCF_FBW7_2	20	26	PF00400	0.435
DEG_SPOP_SBC_1	59	63	PF00917	0.560
DOC_CKS1_1	20	25	PF01111	0.468
DOC_CYCLIN_RxL_1	348	361	PF00134	0.559
DOC_CYCLIN_RxL_1	365	375	PF00134	0.571
DOC_CYCLIN_RxL_1	81	92	PF00134	0.350
DOC_MAPK_gen_1	365	374	PF00069	0.456
DOC_MAPK_MEF2A_6	145	152	PF00069	0.350
DOC_MAPK_MEF2A_6	18	27	PF00069	0.497
DOC_MAPK_MEF2A_6	334	342	PF00069	0.629
DOC_PP2B_LxvP_1	53	56	PF13499	0.452
DOC_USP7_MATH_1	187	191	PF00917	0.455
DOC_USP7_MATH_1	215	219	PF00917	0.533
DOC_USP7_MATH_1	290	294	PF00917	0.568
DOC_USP7_MATH_1	415	419	PF00917	0.546
DOC_USP7_UBL2_3	365	369	PF12436	0.508
DOC_USP7_UBL2_3	378	382	PF12436	0.568
DOC_WW_Pin1_4	144	149	PF00397	0.426
DOC_WW_Pin1_4	19	24	PF00397	0.585
LIG_14-3-3_CanoR_1	214	220	PF00244	0.553
LIG_14-3-3_CanoR_1	393	401	PF00244	0.371
LIG_Actin_WH2_2	387	404	PF00022	0.434
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BIR_III_4	299	303	PF00653	0.621
LIG_BIR_III_4	361	365	PF00653	0.445
LIG_BIR_III_4	69	73	PF00653	0.555
LIG_BRCT_BRCA1_1	284	288	PF00533	0.490
LIG_Clathr_ClatBox_1	36	40	PF01394	0.438
LIG_eIF4E_1	90	96	PF01652	0.386
LIG_FHA_1	145	151	PF00498	0.505
LIG_FHA_1	160	166	PF00498	0.367
LIG_FHA_1	20	26	PF00498	0.508
LIG_FHA_1	243	249	PF00498	0.519
LIG_FHA_1	378	384	PF00498	0.519
LIG_FHA_2	104	110	PF00498	0.390
LIG_FHA_2	387	393	PF00498	0.448
LIG_FHA_2	61	67	PF00498	0.575
LIG_FHA_2	95	101	PF00498	0.448
LIG_HP1_1	215	219	PF01393	0.446
LIG_LIR_Gen_1	285	296	PF02991	0.726
LIG_LIR_Gen_1	416	427	PF02991	0.539
LIG_LIR_Gen_1	89	96	PF02991	0.424
LIG_LIR_Nem_3	285	291	PF02991	0.719
LIG_LIR_Nem_3	416	422	PF02991	0.542
LIG_LIR_Nem_3	89	93	PF02991	0.417
LIG_NRBOX	351	357	PF00104	0.475
LIG_PTB_Apo_2	224	231	PF02174	0.378
LIG_PTB_Apo_2	84	91	PF02174	0.368
LIG_PTB_Phospho_1	224	230	PF10480	0.366
LIG_PTB_Phospho_1	84	90	PF10480	0.369
LIG_RPA_C_Fungi	289	301	PF08784	0.766
LIG_SH2_CRK	90	94	PF00017	0.388
LIG_SH2_STAT5	146	149	PF00017	0.436
LIG_Sin3_3	424	431	PF02671	0.341
LIG_SUMO_SIM_par_1	106	111	PF11976	0.369
LIG_TYR_ITIM	88	93	PF00017	0.367
MOD_CDK_SPK_2	144	149	PF00069	0.403
MOD_CK1_1	13	19	PF00069	0.647
MOD_CK1_1	206	212	PF00069	0.518
MOD_CK1_1	318	324	PF00069	0.617
MOD_CK1_1	400	406	PF00069	0.518
MOD_CK1_1	61	67	PF00069	0.687
MOD_CK1_1	89	95	PF00069	0.397
MOD_CK2_1	234	240	PF00069	0.708
MOD_CK2_1	386	392	PF00069	0.512
MOD_CK2_1	431	437	PF00069	0.369
MOD_CK2_1	94	100	PF00069	0.481
MOD_Cter_Amidation	232	235	PF01082	0.693
MOD_GlcNHglycan	162	165	PF01048	0.480
MOD_GlcNHglycan	288	291	PF01048	0.691
MOD_GlcNHglycan	303	306	PF01048	0.650
MOD_GlcNHglycan	313	318	PF01048	0.755
MOD_GlcNHglycan	433	436	PF01048	0.617
MOD_GlcNHglycan	45	48	PF01048	0.630
MOD_GlcNHglycan	77	80	PF01048	0.581
MOD_GSK3_1	113	120	PF00069	0.343
MOD_GSK3_1	229	236	PF00069	0.624
MOD_GSK3_1	282	289	PF00069	0.591
MOD_GSK3_1	290	297	PF00069	0.567
MOD_GSK3_1	313	320	PF00069	0.719
MOD_GSK3_1	393	400	PF00069	0.564
MOD_GSK3_1	422	429	PF00069	0.482
MOD_GSK3_1	55	62	PF00069	0.685
MOD_GSK3_1	94	101	PF00069	0.411
MOD_N-GLC_1	178	183	PF02516	0.523
MOD_N-GLC_1	258	263	PF02516	0.412
MOD_N-GLC_1	86	91	PF02516	0.379
MOD_NEK2_1	1	6	PF00069	0.457
MOD_NEK2_1	108	113	PF00069	0.342
MOD_NEK2_1	160	165	PF00069	0.389
MOD_NEK2_1	192	197	PF00069	0.476
MOD_NEK2_1	229	234	PF00069	0.640
MOD_NEK2_1	258	263	PF00069	0.461
MOD_NEK2_1	29	34	PF00069	0.385
MOD_NEK2_1	325	330	PF00069	0.677
MOD_NEK2_1	408	413	PF00069	0.596
MOD_NEK2_1	426	431	PF00069	0.503
MOD_NEK2_1	60	65	PF00069	0.738
MOD_NEK2_1	86	91	PF00069	0.320
MOD_NEK2_2	215	220	PF00069	0.476
MOD_NEK2_2	98	103	PF00069	0.481
MOD_PIKK_1	113	119	PF00454	0.411
MOD_PIKK_1	242	248	PF00454	0.573
MOD_PIKK_1	261	267	PF00454	0.494
MOD_PIKK_1	325	331	PF00454	0.600
MOD_PIKK_1	356	362	PF00454	0.568
MOD_PKA_1	234	240	PF00069	0.622
MOD_PKA_2	128	134	PF00069	0.415
MOD_PKA_2	206	212	PF00069	0.489
MOD_PKA_2	233	239	PF00069	0.614
MOD_PKA_2	253	259	PF00069	0.556
MOD_Plk_1	10	16	PF00069	0.468
MOD_Plk_1	178	184	PF00069	0.432
MOD_Plk_1	415	421	PF00069	0.444
MOD_Plk_1	49	55	PF00069	0.521
MOD_Plk_1	86	92	PF00069	0.359
MOD_Plk_2-3	178	184	PF00069	0.500
MOD_Plk_4	103	109	PF00069	0.465
MOD_Plk_4	123	129	PF00069	0.381
MOD_Plk_4	181	187	PF00069	0.364
MOD_Plk_4	320	326	PF00069	0.675
MOD_Plk_4	422	428	PF00069	0.451
MOD_ProDKin_1	144	150	PF00069	0.419
MOD_ProDKin_1	19	25	PF00069	0.578
MOD_SUMO_rev_2	11	20	PF00179	0.470
MOD_SUMO_rev_2	359	366	PF00179	0.523
TRG_DiLeu_BaEn_1	351	356	PF01217	0.449
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.405
TRG_DiLeu_LyEn_5	351	356	PF01217	0.474
TRG_ENDOCYTIC_2	90	93	PF00928	0.418
TRG_ER_diArg_1	352	354	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E0	Leptomonas seymouri	52%	100%
A0A0S4JD31	Bodo saltans	25%	86%
A0A0S4KH47	Bodo saltans	29%	100%
A0A1X0P5U4	Trypanosomatidae	34%	100%
A0A422NQ71	Trypanosoma rangeli	35%	100%
A4HMJ0	Leishmania braziliensis	83%	100%
A4IB70	Leishmania infantum	99%	100%
C9ZZH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AEZ1	Leishmania major	88%	97%
E9B647	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%