Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF12_LEIDO

TriTrypDb:

LdBPK_351550.1 , LdCL_350020400 , LDHU3_35.2070

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.651
CLV_C14_Caspase3-7	381	385	PF00656	0.550
CLV_C14_Caspase3-7	554	558	PF00656	0.706
CLV_NRD_NRD_1	132	134	PF00675	0.666
CLV_NRD_NRD_1	324	326	PF00675	0.453
CLV_NRD_NRD_1	345	347	PF00675	0.587
CLV_NRD_NRD_1	355	357	PF00675	0.503
CLV_NRD_NRD_1	412	414	PF00675	0.475
CLV_NRD_NRD_1	468	470	PF00675	0.444
CLV_NRD_NRD_1	505	507	PF00675	0.615
CLV_PCSK_KEX2_1	132	134	PF00082	0.666
CLV_PCSK_KEX2_1	324	326	PF00082	0.453
CLV_PCSK_KEX2_1	345	347	PF00082	0.587
CLV_PCSK_KEX2_1	354	356	PF00082	0.512
CLV_PCSK_KEX2_1	411	413	PF00082	0.458
CLV_PCSK_KEX2_1	468	470	PF00082	0.444
CLV_PCSK_KEX2_1	504	506	PF00082	0.630
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.517
CLV_PCSK_PC7_1	464	470	PF00082	0.432
CLV_PCSK_SKI1_1	225	229	PF00082	0.548
CLV_PCSK_SKI1_1	231	235	PF00082	0.578
CLV_PCSK_SKI1_1	266	270	PF00082	0.644
CLV_PCSK_SKI1_1	360	364	PF00082	0.567
CLV_PCSK_SKI1_1	468	472	PF00082	0.434
CLV_PCSK_SKI1_1	96	100	PF00082	0.504
DEG_APCC_DBOX_1	467	475	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DEG_SPOP_SBC_1	121	125	PF00917	0.513
DEG_SPOP_SBC_1	601	605	PF00917	0.563
DOC_CKS1_1	363	368	PF01111	0.598
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.542
DOC_MAPK_gen_1	231	239	PF00069	0.554
DOC_MAPK_gen_1	324	332	PF00069	0.466
DOC_MAPK_gen_1	354	363	PF00069	0.510
DOC_MAPK_gen_1	411	420	PF00069	0.480
DOC_MAPK_gen_1	646	653	PF00069	0.451
DOC_MAPK_MEF2A_6	646	653	PF00069	0.614
DOC_MAPK_RevD_3	309	325	PF00069	0.660
DOC_PP1_RVXF_1	264	271	PF00149	0.419
DOC_PP2B_LxvP_1	119	122	PF13499	0.558
DOC_PP2B_LxvP_1	216	219	PF13499	0.520
DOC_PP2B_LxvP_1	330	333	PF13499	0.471
DOC_PP2B_LxvP_1	373	376	PF13499	0.566
DOC_PP4_MxPP_1	671	674	PF00568	0.503
DOC_USP7_MATH_1	138	142	PF00917	0.617
DOC_USP7_MATH_1	335	339	PF00917	0.496
DOC_USP7_MATH_1	454	458	PF00917	0.474
DOC_USP7_MATH_1	459	463	PF00917	0.521
DOC_USP7_MATH_1	86	90	PF00917	0.585
DOC_WW_Pin1_4	134	139	PF00397	0.587
DOC_WW_Pin1_4	280	285	PF00397	0.639
DOC_WW_Pin1_4	295	300	PF00397	0.410
DOC_WW_Pin1_4	362	367	PF00397	0.600
DOC_WW_Pin1_4	398	403	PF00397	0.536
DOC_WW_Pin1_4	621	626	PF00397	0.667
DOC_WW_Pin1_4	70	75	PF00397	0.683
LIG_14-3-3_CanoR_1	162	167	PF00244	0.548
LIG_14-3-3_CanoR_1	225	233	PF00244	0.653
LIG_14-3-3_CanoR_1	243	250	PF00244	0.556
LIG_14-3-3_CanoR_1	354	363	PF00244	0.773
LIG_14-3-3_CanoR_1	42	50	PF00244	0.472
LIG_14-3-3_CanoR_1	67	74	PF00244	0.643
LIG_14-3-3_CanoR_1	80	90	PF00244	0.472
LIG_AP2alpha_1	9	13	PF02296	0.451
LIG_APCC_ABBAyCdc20_2	411	417	PF00400	0.464
LIG_BRCT_BRCA1_1	223	227	PF00533	0.542
LIG_BRCT_BRCA1_1	306	310	PF00533	0.485
LIG_BRCT_BRCA1_1	461	465	PF00533	0.420
LIG_Clathr_ClatBox_1	403	407	PF01394	0.482
LIG_deltaCOP1_diTrp_1	546	553	PF00928	0.536
LIG_FHA_1	195	201	PF00498	0.511
LIG_FHA_1	232	238	PF00498	0.565
LIG_FHA_1	272	278	PF00498	0.556
LIG_FHA_1	327	333	PF00498	0.471
LIG_FHA_1	363	369	PF00498	0.516
LIG_FHA_1	385	391	PF00498	0.560
LIG_FHA_1	443	449	PF00498	0.479
LIG_FHA_1	477	483	PF00498	0.620
LIG_FHA_1	632	638	PF00498	0.621
LIG_FHA_1	664	670	PF00498	0.627
LIG_FHA_2	154	160	PF00498	0.594
LIG_FHA_2	281	287	PF00498	0.513
LIG_FHA_2	289	295	PF00498	0.483
LIG_FHA_2	552	558	PF00498	0.537
LIG_FHA_2	653	659	PF00498	0.470
LIG_LIR_Gen_1	224	233	PF02991	0.682
LIG_LIR_Gen_1	267	277	PF02991	0.546
LIG_LIR_Gen_1	48	58	PF02991	0.478
LIG_LIR_Gen_1	512	519	PF02991	0.482
LIG_LIR_Nem_3	11	16	PF02991	0.462
LIG_LIR_Nem_3	224	230	PF02991	0.686
LIG_LIR_Nem_3	267	273	PF02991	0.557
LIG_LIR_Nem_3	298	303	PF02991	0.494
LIG_LIR_Nem_3	342	347	PF02991	0.588
LIG_LIR_Nem_3	48	53	PF02991	0.426
LIG_LIR_Nem_3	512	517	PF02991	0.477
LIG_PCNA_yPIPBox_3	104	114	PF02747	0.567
LIG_Pex14_2	9	13	PF04695	0.451
LIG_PTAP_UEV_1	258	263	PF05743	0.539
LIG_RPA_C_Fungi	179	191	PF08784	0.547
LIG_RPA_C_Fungi	350	362	PF08784	0.556
LIG_SH2_CRK	344	348	PF00017	0.595
LIG_SH2_STAP1	10	14	PF00017	0.466
LIG_SH2_STAT3	425	428	PF00017	0.402
LIG_SH2_STAT5	16	19	PF00017	0.452
LIG_SH2_STAT5	408	411	PF00017	0.582
LIG_SH2_STAT5	534	537	PF00017	0.495
LIG_SH3_3	256	262	PF00018	0.572
LIG_SH3_3	415	421	PF00018	0.462
LIG_SH3_3	622	628	PF00018	0.786
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.564
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.458
LIG_SUMO_SIM_anti_2	572	577	PF11976	0.438
LIG_SUMO_SIM_par_1	649	656	PF11976	0.469
MOD_CDC14_SPxK_1	298	301	PF00782	0.508
MOD_CDK_SPK_2	621	626	PF00069	0.598
MOD_CDK_SPxK_1	295	301	PF00069	0.513
MOD_CDK_SPxxK_3	398	405	PF00069	0.530
MOD_CK1_1	123	129	PF00069	0.705
MOD_CK1_1	147	153	PF00069	0.585
MOD_CK1_1	155	161	PF00069	0.640
MOD_CK1_1	457	463	PF00069	0.521
MOD_CK1_1	512	518	PF00069	0.551
MOD_CK1_1	536	542	PF00069	0.546
MOD_CK1_1	555	561	PF00069	0.665
MOD_CK1_1	630	636	PF00069	0.654
MOD_CK1_1	69	75	PF00069	0.612
MOD_CK1_1	84	90	PF00069	0.447
MOD_CK2_1	155	161	PF00069	0.601
MOD_CK2_1	175	181	PF00069	0.420
MOD_CK2_1	288	294	PF00069	0.543
MOD_CK2_1	652	658	PF00069	0.429
MOD_Cter_Amidation	130	133	PF01082	0.549
MOD_GlcNHglycan	149	152	PF01048	0.582
MOD_GlcNHglycan	177	180	PF01048	0.532
MOD_GlcNHglycan	259	262	PF01048	0.531
MOD_GlcNHglycan	357	360	PF01048	0.587
MOD_GlcNHglycan	384	387	PF01048	0.579
MOD_GlcNHglycan	486	489	PF01048	0.651
MOD_GlcNHglycan	500	503	PF01048	0.544
MOD_GlcNHglycan	511	514	PF01048	0.560
MOD_GlcNHglycan	539	542	PF01048	0.556
MOD_GlcNHglycan	557	560	PF01048	0.418
MOD_GSK3_1	134	141	PF00069	0.573
MOD_GSK3_1	14	21	PF00069	0.495
MOD_GSK3_1	147	154	PF00069	0.547
MOD_GSK3_1	162	169	PF00069	0.600
MOD_GSK3_1	217	224	PF00069	0.530
MOD_GSK3_1	378	385	PF00069	0.618
MOD_GSK3_1	476	483	PF00069	0.524
MOD_GSK3_1	533	540	PF00069	0.527
MOD_GSK3_1	551	558	PF00069	0.418
MOD_GSK3_1	596	603	PF00069	0.595
MOD_GSK3_1	61	68	PF00069	0.569
MOD_GSK3_1	626	633	PF00069	0.620
MOD_GSK3_1	652	659	PF00069	0.464
MOD_GSK3_1	69	76	PF00069	0.569
MOD_GSK3_1	80	87	PF00069	0.469
MOD_N-GLC_1	144	149	PF02516	0.604
MOD_N-GLC_1	596	601	PF02516	0.541
MOD_N-GLC_1	639	644	PF02516	0.606
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	14	19	PF00069	0.630
MOD_NEK2_1	144	149	PF00069	0.651
MOD_NEK2_1	194	199	PF00069	0.506
MOD_NEK2_1	303	308	PF00069	0.432
MOD_NEK2_1	347	352	PF00069	0.555
MOD_NEK2_1	475	480	PF00069	0.461
MOD_NEK2_1	61	66	PF00069	0.611
MOD_NEK2_2	335	340	PF00069	0.496
MOD_PIKK_1	14	20	PF00454	0.638
MOD_PIKK_1	169	175	PF00454	0.612
MOD_PIKK_1	194	200	PF00454	0.559
MOD_PIKK_1	61	67	PF00454	0.472
MOD_PIKK_1	81	87	PF00454	0.561
MOD_PK_1	162	168	PF00069	0.590
MOD_PKA_1	231	237	PF00069	0.556
MOD_PKA_1	354	360	PF00069	0.777
MOD_PKA_2	24	30	PF00069	0.419
MOD_PKA_2	288	294	PF00069	0.648
MOD_PKA_2	347	353	PF00069	0.614
MOD_PKA_2	354	360	PF00069	0.766
MOD_PKA_2	41	47	PF00069	0.435
MOD_PKA_2	66	72	PF00069	0.645
MOD_Plk_1	166	172	PF00069	0.656
MOD_Plk_1	596	602	PF00069	0.478
MOD_Plk_4	1	7	PF00069	0.515
MOD_Plk_4	106	112	PF00069	0.500
MOD_Plk_4	166	172	PF00069	0.626
MOD_Plk_4	304	310	PF00069	0.520
MOD_Plk_4	326	332	PF00069	0.509
MOD_Plk_4	335	341	PF00069	0.510
MOD_Plk_4	569	575	PF00069	0.426
MOD_Plk_4	608	614	PF00069	0.503
MOD_ProDKin_1	134	140	PF00069	0.585
MOD_ProDKin_1	280	286	PF00069	0.636
MOD_ProDKin_1	295	301	PF00069	0.406
MOD_ProDKin_1	362	368	PF00069	0.600
MOD_ProDKin_1	398	404	PF00069	0.534
MOD_ProDKin_1	621	627	PF00069	0.670
MOD_ProDKin_1	70	76	PF00069	0.681
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.525
TRG_ENDOCYTIC_2	10	13	PF00928	0.457
TRG_ENDOCYTIC_2	300	303	PF00928	0.500
TRG_ENDOCYTIC_2	344	347	PF00928	0.595
TRG_ENDOCYTIC_2	50	53	PF00928	0.456
TRG_ER_diArg_1	184	187	PF00400	0.549
TRG_ER_diArg_1	323	325	PF00400	0.466
TRG_ER_diArg_1	344	346	PF00400	0.605
TRG_ER_diArg_1	354	356	PF00400	0.479
TRG_ER_diArg_1	412	414	PF00400	0.480
TRG_ER_diArg_1	468	470	PF00400	0.444
TRG_ER_diArg_1	504	506	PF00400	0.630
TRG_ER_diArg_1	645	648	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXS6	Leptomonas seymouri	47%	91%
A4HMH6	Leishmania braziliensis	80%	100%
A4IB56	Leishmania infantum	100%	100%
C9ZZG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AEX7	Leishmania major	91%	100%
E9B633	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%