LeishMANIAdb
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Phosphatidylethanolamine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidylethanolamine N-methyltransferase
Gene product:
phosphatidylethanolaminen-methyltransferase-lik e protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IF09_LEIDO
TriTrypDb:
LdBPK_312360.1 * , LdCL_310031600 , LDHU3_31.4210
Length:
219

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 8
GO:0016020 membrane 2 8
GO:0031090 organelle membrane 3 8
GO:0031966 mitochondrial membrane 4 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A0A3Q8IF09
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF09

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 8
GO:0006644 phospholipid metabolic process 4 8
GO:0006650 glycerophospholipid metabolic process 5 8
GO:0006656 phosphatidylcholine biosynthetic process 5 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0008610 lipid biosynthetic process 4 8
GO:0008654 phospholipid biosynthetic process 5 8
GO:0009058 biosynthetic process 2 8
GO:0009987 cellular process 1 8
GO:0019637 organophosphate metabolic process 3 8
GO:0032259 methylation 2 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044255 cellular lipid metabolic process 3 8
GO:0045017 glycerolipid biosynthetic process 4 8
GO:0046470 phosphatidylcholine metabolic process 4 8
GO:0046474 glycerophospholipid biosynthetic process 5 8
GO:0046486 glycerolipid metabolic process 4 8
GO:0071704 organic substance metabolic process 2 8
GO:0090407 organophosphate biosynthetic process 4 8
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
Molecular functions
Term Name Level Count
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity 6 8
GO:0003824 catalytic activity 1 8
GO:0004608 phosphatidylethanolamine N-methyltransferase activity 6 8
GO:0008168 methyltransferase activity 4 8
GO:0008170 N-methyltransferase activity 5 8
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 8
GO:0016740 transferase activity 2 8
GO:0016741 transferase activity, transferring one-carbon groups 3 8
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity 6 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 200 202 PF00675 0.322
CLV_NRD_NRD_1 216 218 PF00675 0.326
CLV_NRD_NRD_1 35 37 PF00675 0.371
CLV_PCSK_KEX2_1 202 204 PF00082 0.327
CLV_PCSK_KEX2_1 35 37 PF00082 0.408
CLV_PCSK_KEX2_1 46 48 PF00082 0.394
CLV_PCSK_PC1ET2_1 202 204 PF00082 0.327
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.335
CLV_PCSK_PC7_1 31 37 PF00082 0.389
DOC_PP4_FxxP_1 149 152 PF00568 0.488
DOC_PP4_FxxP_1 191 194 PF00568 0.527
DOC_USP7_MATH_1 2 6 PF00917 0.464
DOC_USP7_MATH_1 210 214 PF00917 0.695
LIG_14-3-3_CanoR_1 140 146 PF00244 0.488
LIG_EH_1 192 196 PF12763 0.485
LIG_FHA_1 110 116 PF00498 0.395
LIG_FHA_1 12 18 PF00498 0.331
LIG_FHA_1 175 181 PF00498 0.401
LIG_FHA_1 194 200 PF00498 0.488
LIG_FHA_1 83 89 PF00498 0.452
LIG_LIR_Apic_2 147 152 PF02991 0.488
LIG_LIR_Gen_1 117 124 PF02991 0.401
LIG_LIR_Gen_1 192 200 PF02991 0.508
LIG_LIR_Gen_1 24 34 PF02991 0.401
LIG_LIR_LC3C_4 112 116 PF02991 0.433
LIG_LIR_Nem_3 117 122 PF02991 0.347
LIG_LIR_Nem_3 131 136 PF02991 0.488
LIG_LIR_Nem_3 24 29 PF02991 0.401
LIG_Pex14_2 191 195 PF04695 0.527
LIG_PTB_Apo_2 148 155 PF02174 0.527
LIG_PTB_Phospho_1 148 154 PF10480 0.527
LIG_SH2_CRK 9 13 PF00017 0.327
LIG_SH2_NCK_1 51 55 PF00017 0.317
LIG_SH2_STAP1 51 55 PF00017 0.317
LIG_SH2_STAT5 128 131 PF00017 0.488
LIG_SH2_STAT5 132 135 PF00017 0.488
LIG_SH2_STAT5 154 157 PF00017 0.333
LIG_SH2_STAT5 190 193 PF00017 0.488
LIG_SH3_3 70 76 PF00018 0.306
LIG_SUMO_SIM_par_1 112 118 PF11976 0.472
LIG_TYR_ITIM 7 12 PF00017 0.380
LIG_WRC_WIRS_1 116 121 PF05994 0.472
MOD_CK1_1 11 17 PF00069 0.258
MOD_Cter_Amidation 44 47 PF01082 0.380
MOD_GlcNHglycan 186 189 PF01048 0.258
MOD_GlcNHglycan 212 215 PF01048 0.478
MOD_GlcNHglycan 60 63 PF01048 0.421
MOD_GSK3_1 110 117 PF00069 0.347
MOD_NEK2_1 107 112 PF00069 0.325
MOD_NEK2_1 114 119 PF00069 0.270
MOD_NEK2_1 122 127 PF00069 0.267
MOD_NEK2_1 155 160 PF00069 0.338
MOD_NEK2_1 162 167 PF00069 0.359
MOD_PIKK_1 82 88 PF00454 0.415
MOD_PKA_1 35 41 PF00069 0.560
MOD_PKA_2 139 145 PF00069 0.488
MOD_PKA_2 35 41 PF00069 0.598
MOD_Plk_4 110 116 PF00069 0.347
MOD_Plk_4 124 130 PF00069 0.347
MOD_Plk_4 171 177 PF00069 0.425
MOD_Plk_4 21 27 PF00069 0.401
TRG_AP2beta_CARGO_1 131 140 PF09066 0.488
TRG_DiLeu_BaLyEn_6 75 80 PF01217 0.293
TRG_ENDOCYTIC_2 132 135 PF00928 0.513
TRG_ENDOCYTIC_2 9 12 PF00928 0.381
TRG_ER_diArg_1 200 203 PF00400 0.522
TRG_ER_diArg_1 34 36 PF00400 0.604

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H5 Leptomonas seymouri 68% 99%
A0A0S4IUX3 Bodo saltans 51% 100%
A4HJL2 Leishmania braziliensis 79% 100%
A4I735 Leishmania infantum 98% 100%
C8VRV0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 42% 100%
E9B230 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
O74827 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 99%
P05375 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 44% 100%
Q08388 Rattus norvegicus 40% 100%
Q4Q632 Leishmania major 90% 100%
Q54H80 Dictyostelium discoideum 29% 100%
Q54SD5 Dictyostelium discoideum 39% 100%
Q61907 Mus musculus 39% 100%
Q7S5W9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 44% 100%
Q7YRH6 Bos taurus 43% 100%
Q9UBM1 Homo sapiens 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS