Phosphatidylethanolamine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolaminen-methyltransferase-lik e protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IF09_LEIDO

TriTrypDb:

LdBPK_312360.1 , LdCL_310031600 , LDHU3_31.4210

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	8
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IF09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF09

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006656	phosphatidylcholine biosynthetic process	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0032259	methylation	2	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0045017	glycerolipid biosynthetic process	4	8
GO:0046470	phosphatidylcholine metabolic process	4	8
GO:0046474	glycerophospholipid biosynthetic process	5	8
GO:0046486	glycerolipid metabolic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity	6	8
GO:0003824	catalytic activity	1	8
GO:0004608	phosphatidylethanolamine N-methyltransferase activity	6	8
GO:0008168	methyltransferase activity	4	8
GO:0008170	N-methyltransferase activity	5	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity	6	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.322
CLV_NRD_NRD_1	216	218	PF00675	0.326
CLV_NRD_NRD_1	35	37	PF00675	0.371
CLV_PCSK_KEX2_1	202	204	PF00082	0.327
CLV_PCSK_KEX2_1	35	37	PF00082	0.408
CLV_PCSK_KEX2_1	46	48	PF00082	0.394
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.327
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.335
CLV_PCSK_PC7_1	31	37	PF00082	0.389
DOC_PP4_FxxP_1	149	152	PF00568	0.488
DOC_PP4_FxxP_1	191	194	PF00568	0.527
DOC_USP7_MATH_1	2	6	PF00917	0.464
DOC_USP7_MATH_1	210	214	PF00917	0.695
LIG_14-3-3_CanoR_1	140	146	PF00244	0.488
LIG_EH_1	192	196	PF12763	0.485
LIG_FHA_1	110	116	PF00498	0.395
LIG_FHA_1	12	18	PF00498	0.331
LIG_FHA_1	175	181	PF00498	0.401
LIG_FHA_1	194	200	PF00498	0.488
LIG_FHA_1	83	89	PF00498	0.452
LIG_LIR_Apic_2	147	152	PF02991	0.488
LIG_LIR_Gen_1	117	124	PF02991	0.401
LIG_LIR_Gen_1	192	200	PF02991	0.508
LIG_LIR_Gen_1	24	34	PF02991	0.401
LIG_LIR_LC3C_4	112	116	PF02991	0.433
LIG_LIR_Nem_3	117	122	PF02991	0.347
LIG_LIR_Nem_3	131	136	PF02991	0.488
LIG_LIR_Nem_3	24	29	PF02991	0.401
LIG_Pex14_2	191	195	PF04695	0.527
LIG_PTB_Apo_2	148	155	PF02174	0.527
LIG_PTB_Phospho_1	148	154	PF10480	0.527
LIG_SH2_CRK	9	13	PF00017	0.327
LIG_SH2_NCK_1	51	55	PF00017	0.317
LIG_SH2_STAP1	51	55	PF00017	0.317
LIG_SH2_STAT5	128	131	PF00017	0.488
LIG_SH2_STAT5	132	135	PF00017	0.488
LIG_SH2_STAT5	154	157	PF00017	0.333
LIG_SH2_STAT5	190	193	PF00017	0.488
LIG_SH3_3	70	76	PF00018	0.306
LIG_SUMO_SIM_par_1	112	118	PF11976	0.472
LIG_TYR_ITIM	7	12	PF00017	0.380
LIG_WRC_WIRS_1	116	121	PF05994	0.472
MOD_CK1_1	11	17	PF00069	0.258
MOD_Cter_Amidation	44	47	PF01082	0.380
MOD_GlcNHglycan	186	189	PF01048	0.258
MOD_GlcNHglycan	212	215	PF01048	0.478
MOD_GlcNHglycan	60	63	PF01048	0.421
MOD_GSK3_1	110	117	PF00069	0.347
MOD_NEK2_1	107	112	PF00069	0.325
MOD_NEK2_1	114	119	PF00069	0.270
MOD_NEK2_1	122	127	PF00069	0.267
MOD_NEK2_1	155	160	PF00069	0.338
MOD_NEK2_1	162	167	PF00069	0.359
MOD_PIKK_1	82	88	PF00454	0.415
MOD_PKA_1	35	41	PF00069	0.560
MOD_PKA_2	139	145	PF00069	0.488
MOD_PKA_2	35	41	PF00069	0.598
MOD_Plk_4	110	116	PF00069	0.347
MOD_Plk_4	124	130	PF00069	0.347
MOD_Plk_4	171	177	PF00069	0.425
MOD_Plk_4	21	27	PF00069	0.401
TRG_AP2beta_CARGO_1	131	140	PF09066	0.488
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.293
TRG_ENDOCYTIC_2	132	135	PF00928	0.513
TRG_ENDOCYTIC_2	9	12	PF00928	0.381
TRG_ER_diArg_1	200	203	PF00400	0.522
TRG_ER_diArg_1	34	36	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H5	Leptomonas seymouri	68%	99%
A0A0S4IUX3	Bodo saltans	51%	100%
A4HJL2	Leishmania braziliensis	79%	100%
A4I735	Leishmania infantum	98%	100%
C8VRV0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	100%
E9B230	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O74827	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	99%
P05375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
Q08388	Rattus norvegicus	40%	100%
Q4Q632	Leishmania major	90%	100%
Q54H80	Dictyostelium discoideum	29%	100%
Q54SD5	Dictyostelium discoideum	39%	100%
Q61907	Mus musculus	39%	100%
Q7S5W9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	100%
Q7YRH6	Bos taurus	43%	100%
Q9UBM1	Homo sapiens	39%	100%