Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF08_LEIDO

TriTrypDb:

LdBPK_290600.1 , LdCL_290010800 , LDHU3_29.0830

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IF08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.454
CLV_NRD_NRD_1	114	116	PF00675	0.619
CLV_NRD_NRD_1	127	129	PF00675	0.451
CLV_NRD_NRD_1	131	133	PF00675	0.457
CLV_NRD_NRD_1	146	148	PF00675	0.460
CLV_NRD_NRD_1	184	186	PF00675	0.609
CLV_NRD_NRD_1	187	189	PF00675	0.578
CLV_NRD_NRD_1	206	208	PF00675	0.646
CLV_NRD_NRD_1	368	370	PF00675	0.615
CLV_NRD_NRD_1	400	402	PF00675	0.667
CLV_NRD_NRD_1	433	435	PF00675	0.545
CLV_NRD_NRD_1	450	452	PF00675	0.648
CLV_PCSK_FUR_1	125	129	PF00082	0.469
CLV_PCSK_FUR_1	185	189	PF00082	0.461
CLV_PCSK_FUR_1	204	208	PF00082	0.601
CLV_PCSK_FUR_1	448	452	PF00082	0.474
CLV_PCSK_KEX2_1	116	118	PF00082	0.542
CLV_PCSK_KEX2_1	125	127	PF00082	0.473
CLV_PCSK_KEX2_1	130	132	PF00082	0.447
CLV_PCSK_KEX2_1	145	147	PF00082	0.406
CLV_PCSK_KEX2_1	184	186	PF00082	0.609
CLV_PCSK_KEX2_1	187	189	PF00082	0.578
CLV_PCSK_KEX2_1	206	208	PF00082	0.646
CLV_PCSK_KEX2_1	368	370	PF00082	0.707
CLV_PCSK_KEX2_1	400	402	PF00082	0.665
CLV_PCSK_KEX2_1	433	435	PF00082	0.545
CLV_PCSK_KEX2_1	450	452	PF00082	0.648
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.608
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.584
CLV_PCSK_PC7_1	126	132	PF00082	0.588
CLV_PCSK_PC7_1	446	452	PF00082	0.467
CLV_PCSK_SKI1_1	142	146	PF00082	0.429
CLV_PCSK_SKI1_1	226	230	PF00082	0.805
CLV_PCSK_SKI1_1	328	332	PF00082	0.568
DEG_SPOP_SBC_1	279	283	PF00917	0.598
DEG_SPOP_SBC_1	294	298	PF00917	0.510
DEG_SPOP_SBC_1	392	396	PF00917	0.667
DEG_SPOP_SBC_1	455	459	PF00917	0.612
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.570
DOC_MAPK_DCC_7	185	195	PF00069	0.576
DOC_MAPK_gen_1	113	121	PF00069	0.464
DOC_MAPK_gen_1	184	195	PF00069	0.564
DOC_MAPK_gen_1	446	455	PF00069	0.559
DOC_MAPK_GRA24_9	181	195	PF00069	0.567
DOC_MAPK_RevD_3	420	434	PF00069	0.505
DOC_USP7_MATH_1	2	6	PF00917	0.566
DOC_USP7_MATH_1	271	275	PF00917	0.665
DOC_USP7_MATH_1	279	283	PF00917	0.576
DOC_USP7_MATH_1	35	39	PF00917	0.646
DOC_USP7_MATH_1	370	374	PF00917	0.638
DOC_USP7_MATH_1	392	396	PF00917	0.697
DOC_USP7_MATH_1	454	458	PF00917	0.651
DOC_USP7_MATH_1	80	84	PF00917	0.628
DOC_USP7_UBL2_3	253	257	PF12436	0.481
DOC_WW_Pin1_4	205	210	PF00397	0.644
DOC_WW_Pin1_4	263	268	PF00397	0.690
DOC_WW_Pin1_4	5	10	PF00397	0.627
LIG_14-3-3_CanoR_1	328	333	PF00244	0.581
LIG_14-3-3_CanoR_1	369	375	PF00244	0.670
LIG_14-3-3_CanoR_1	390	398	PF00244	0.622
LIG_BIR_III_4	249	253	PF00653	0.531
LIG_DLG_GKlike_1	90	98	PF00625	0.444
LIG_eIF4E_1	171	177	PF01652	0.556
LIG_FHA_1	167	173	PF00498	0.574
LIG_FHA_1	457	463	PF00498	0.728
LIG_FHA_2	233	239	PF00498	0.616
LIG_FHA_2	244	250	PF00498	0.444
LIG_FHA_2	279	285	PF00498	0.708
LIG_FHA_2	309	315	PF00498	0.567
LIG_FHA_2	329	335	PF00498	0.575
LIG_FHA_2	439	445	PF00498	0.573
LIG_Integrin_RGD_1	469	471	PF01839	0.597
LIG_LIR_Apic_2	323	329	PF02991	0.633
LIG_LIR_Gen_1	342	350	PF02991	0.530
LIG_LIR_Gen_1	418	426	PF02991	0.544
LIG_LIR_Gen_1	51	61	PF02991	0.566
LIG_LIR_Gen_1	62	71	PF02991	0.511
LIG_LIR_Nem_3	342	348	PF02991	0.557
LIG_LIR_Nem_3	418	422	PF02991	0.549
LIG_LIR_Nem_3	51	57	PF02991	0.580
LIG_LIR_Nem_3	62	67	PF02991	0.519
LIG_MYND_1	12	16	PF01753	0.604
LIG_SH2_CRK	345	349	PF00017	0.451
LIG_SH2_SRC	171	174	PF00017	0.552
LIG_SH2_STAP1	50	54	PF00017	0.592
LIG_SH2_STAP1	94	98	PF00017	0.493
LIG_SH2_STAT5	171	174	PF00017	0.568
LIG_SH2_STAT5	63	66	PF00017	0.558
LIG_SH3_1	206	212	PF00018	0.592
LIG_SH3_3	191	197	PF00018	0.622
LIG_SH3_3	206	212	PF00018	0.633
LIG_SH3_3	6	12	PF00018	0.584
LIG_TRAF2_1	236	239	PF00917	0.499
LIG_TRAF2_1	39	42	PF00917	0.586
LIG_TRAF2_1	70	73	PF00917	0.416
LIG_UBA3_1	67	74	PF00899	0.470
MOD_CK1_1	232	238	PF00069	0.606
MOD_CK1_1	272	278	PF00069	0.754
MOD_CK1_1	36	42	PF00069	0.576
MOD_CK1_1	394	400	PF00069	0.694
MOD_CK1_1	457	463	PF00069	0.658
MOD_CK1_1	477	483	PF00069	0.751
MOD_CK1_1	5	11	PF00069	0.697
MOD_CK1_1	59	65	PF00069	0.511
MOD_CK1_1	79	85	PF00069	0.644
MOD_CK2_1	196	202	PF00069	0.639
MOD_CK2_1	232	238	PF00069	0.586
MOD_CK2_1	278	284	PF00069	0.669
MOD_CK2_1	328	334	PF00069	0.543
MOD_CK2_1	35	41	PF00069	0.583
MOD_CK2_1	438	444	PF00069	0.574
MOD_CK2_1	67	73	PF00069	0.536
MOD_Cter_Amidation	185	188	PF01082	0.458
MOD_GlcNHglycan	17	20	PF01048	0.692
MOD_GlcNHglycan	198	201	PF01048	0.644
MOD_GlcNHglycan	220	223	PF01048	0.633
MOD_GlcNHglycan	232	235	PF01048	0.538
MOD_GlcNHglycan	297	300	PF01048	0.779
MOD_GlcNHglycan	35	38	PF01048	0.583
MOD_GlcNHglycan	4	7	PF01048	0.724
MOD_GlcNHglycan	476	479	PF01048	0.562
MOD_GlcNHglycan	78	81	PF01048	0.658
MOD_GlcNHglycan	82	85	PF01048	0.634
MOD_GSK3_1	1	8	PF00069	0.642
MOD_GSK3_1	229	236	PF00069	0.674
MOD_GSK3_1	261	268	PF00069	0.671
MOD_GSK3_1	36	43	PF00069	0.668
MOD_GSK3_1	388	395	PF00069	0.676
MOD_GSK3_1	454	461	PF00069	0.670
MOD_GSK3_1	76	83	PF00069	0.598
MOD_GSK3_1	86	93	PF00069	0.532
MOD_N-GLC_1	229	234	PF02516	0.530
MOD_PIKK_1	166	172	PF00454	0.675
MOD_PIKK_1	243	249	PF00454	0.539
MOD_PIKK_1	265	271	PF00454	0.630
MOD_PK_1	410	416	PF00069	0.564
MOD_PKA_1	126	132	PF00069	0.458
MOD_PKA_2	126	132	PF00069	0.487
MOD_PKA_2	294	300	PF00069	0.730
MOD_PKA_2	474	480	PF00069	0.602
MOD_Plk_1	40	46	PF00069	0.647
MOD_Plk_1	438	444	PF00069	0.580
MOD_Plk_1	59	65	PF00069	0.531
MOD_Plk_2-3	438	444	PF00069	0.580
MOD_Plk_4	220	226	PF00069	0.586
MOD_ProDKin_1	205	211	PF00069	0.643
MOD_ProDKin_1	263	269	PF00069	0.691
MOD_ProDKin_1	5	11	PF00069	0.629
TRG_DiLeu_BaEn_4	72	78	PF01217	0.447
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.586
TRG_ENDOCYTIC_2	345	348	PF00928	0.446
TRG_ER_diArg_1	112	115	PF00400	0.599
TRG_ER_diArg_1	125	128	PF00400	0.448
TRG_ER_diArg_1	130	132	PF00400	0.467
TRG_ER_diArg_1	146	148	PF00400	0.409
TRG_ER_diArg_1	184	187	PF00400	0.643
TRG_ER_diArg_1	204	207	PF00400	0.640
TRG_ER_diArg_1	367	369	PF00400	0.635
TRG_ER_diArg_1	433	435	PF00400	0.546
TRG_ER_diArg_1	448	451	PF00400	0.613
TRG_ER_diArg_1	463	466	PF00400	0.663
TRG_NLS_Bipartite_1	127	149	PF00514	0.475
TRG_NLS_MonoExtN_4	113	119	PF00514	0.360
TRG_NLS_MonoExtN_4	142	149	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW8	Leptomonas seymouri	39%	97%
A0A1X0NZK9	Trypanosomatidae	24%	95%
A4HH66	Leishmania braziliensis	65%	99%
A4I4B0	Leishmania infantum	99%	100%
E9ADR0	Leishmania major	91%	100%
E9AM20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%