Cell division cycle 45 (CDC45), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cell division cycle 45

Species:

Leishmania donovani

UniProt:

A0A3Q8IF06_LEIDO

TriTrypDb:

LdBPK_332450.1 , LdCL_330031500 , LDHU3_33.3500

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IF06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF06

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006270	DNA replication initiation	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0007049	cell cycle	2	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0051301	cell division	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0033554	cellular response to stress	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071163	DNA replication preinitiation complex assembly	3	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902977	mitotic DNA replication preinitiation complex assembly	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.499
CLV_NRD_NRD_1	128	130	PF00675	0.280
CLV_NRD_NRD_1	151	153	PF00675	0.260
CLV_NRD_NRD_1	163	165	PF00675	0.192
CLV_NRD_NRD_1	167	169	PF00675	0.167
CLV_NRD_NRD_1	179	181	PF00675	0.183
CLV_NRD_NRD_1	21	23	PF00675	0.335
CLV_NRD_NRD_1	296	298	PF00675	0.220
CLV_NRD_NRD_1	322	324	PF00675	0.247
CLV_NRD_NRD_1	448	450	PF00675	0.315
CLV_NRD_NRD_1	500	502	PF00675	0.247
CLV_NRD_NRD_1	582	584	PF00675	0.290
CLV_NRD_NRD_1	600	602	PF00675	0.350
CLV_NRD_NRD_1	603	605	PF00675	0.303
CLV_NRD_NRD_1	760	762	PF00675	0.673
CLV_NRD_NRD_1	763	765	PF00675	0.673
CLV_PCSK_FUR_1	161	165	PF00082	0.220
CLV_PCSK_FUR_1	601	605	PF00082	0.266
CLV_PCSK_FUR_1	761	765	PF00082	0.621
CLV_PCSK_KEX2_1	128	130	PF00082	0.280
CLV_PCSK_KEX2_1	161	163	PF00082	0.229
CLV_PCSK_KEX2_1	166	168	PF00082	0.232
CLV_PCSK_KEX2_1	172	174	PF00082	0.242
CLV_PCSK_KEX2_1	179	181	PF00082	0.199
CLV_PCSK_KEX2_1	296	298	PF00082	0.221
CLV_PCSK_KEX2_1	322	324	PF00082	0.247
CLV_PCSK_KEX2_1	582	584	PF00082	0.291
CLV_PCSK_KEX2_1	599	601	PF00082	0.341
CLV_PCSK_KEX2_1	603	605	PF00082	0.303
CLV_PCSK_KEX2_1	762	764	PF00082	0.684
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.362
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.584
CLV_PCSK_PC7_1	162	168	PF00082	0.230
CLV_PCSK_PC7_1	599	605	PF00082	0.266
CLV_PCSK_SKI1_1	323	327	PF00082	0.288
CLV_PCSK_SKI1_1	464	468	PF00082	0.303
CLV_PCSK_SKI1_1	47	51	PF00082	0.303
CLV_PCSK_SKI1_1	590	594	PF00082	0.303
CLV_PCSK_SKI1_1	603	607	PF00082	0.194
CLV_PCSK_SKI1_1	643	647	PF00082	0.180
CLV_PCSK_SKI1_1	722	726	PF00082	0.508
CLV_PCSK_SKI1_1	745	749	PF00082	0.496
DEG_APCC_DBOX_1	385	393	PF00400	0.466
DEG_APCC_DBOX_1	602	610	PF00400	0.478
DEG_APCC_DBOX_1	744	752	PF00400	0.585
DEG_SPOP_SBC_1	554	558	PF00917	0.503
DOC_CKS1_1	717	722	PF01111	0.623
DOC_CYCLIN_RxL_1	604	615	PF00134	0.512
DOC_CYCLIN_RxL_1	716	727	PF00134	0.515
DOC_CYCLIN_RxL_1	742	753	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.462
DOC_MAPK_DCC_7	604	614	PF00069	0.440
DOC_MAPK_FxFP_2	49	52	PF00069	0.503
DOC_MAPK_gen_1	22	29	PF00069	0.284
DOC_MAPK_MEF2A_6	22	29	PF00069	0.284
DOC_MAPK_MEF2A_6	396	403	PF00069	0.466
DOC_MAPK_MEF2A_6	86	94	PF00069	0.452
DOC_MAPK_RevD_3	488	502	PF00069	0.419
DOC_PP1_RVXF_1	132	139	PF00149	0.420
DOC_PP1_RVXF_1	234	240	PF00149	0.445
DOC_PP1_RVXF_1	500	507	PF00149	0.466
DOC_PP1_RVXF_1	588	594	PF00149	0.503
DOC_PP2B_LxvP_1	28	31	PF13499	0.503
DOC_PP2B_LxvP_1	96	99	PF13499	0.462
DOC_PP4_FxxP_1	49	52	PF00568	0.503
DOC_PP4_FxxP_1	717	720	PF00568	0.507
DOC_USP7_MATH_1	2	6	PF00917	0.543
DOC_USP7_MATH_1	228	232	PF00917	0.424
DOC_USP7_MATH_1	260	264	PF00917	0.462
DOC_USP7_MATH_1	333	337	PF00917	0.520
DOC_USP7_MATH_1	36	40	PF00917	0.420
DOC_USP7_MATH_1	544	548	PF00917	0.505
DOC_USP7_MATH_1	563	567	PF00917	0.442
DOC_USP7_MATH_1	57	61	PF00917	0.503
DOC_USP7_MATH_1	627	631	PF00917	0.523
DOC_USP7_MATH_1	658	662	PF00917	0.530
DOC_USP7_MATH_1	74	78	PF00917	0.503
DOC_USP7_MATH_2	10	16	PF00917	0.436
DOC_WW_Pin1_4	226	231	PF00397	0.413
DOC_WW_Pin1_4	488	493	PF00397	0.447
DOC_WW_Pin1_4	569	574	PF00397	0.527
DOC_WW_Pin1_4	697	702	PF00397	0.382
DOC_WW_Pin1_4	716	721	PF00397	0.507
LIG_14-3-3_CanoR_1	13	18	PF00244	0.364
LIG_14-3-3_CanoR_1	262	269	PF00244	0.467
LIG_14-3-3_CanoR_1	339	347	PF00244	0.464
LIG_14-3-3_CanoR_1	359	364	PF00244	0.420
LIG_14-3-3_CanoR_1	513	520	PF00244	0.466
LIG_14-3-3_CanoR_1	582	587	PF00244	0.455
LIG_14-3-3_CanoR_1	590	596	PF00244	0.425
LIG_14-3-3_CanoR_1	603	613	PF00244	0.445
LIG_Actin_WH2_2	739	754	PF00022	0.405
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BIR_III_2	227	231	PF00653	0.503
LIG_BIR_III_3	1	5	PF00653	0.550
LIG_BIR_III_4	543	547	PF00653	0.435
LIG_CaM_IQ_9	314	329	PF13499	0.503
LIG_deltaCOP1_diTrp_1	62	73	PF00928	0.435
LIG_FHA_1	107	113	PF00498	0.435
LIG_FHA_1	301	307	PF00498	0.456
LIG_FHA_1	457	463	PF00498	0.426
LIG_FHA_1	698	704	PF00498	0.483
LIG_FHA_1	737	743	PF00498	0.478
LIG_FHA_2	200	206	PF00498	0.521
LIG_FHA_2	360	366	PF00498	0.522
LIG_GBD_Chelix_1	587	595	PF00786	0.262
LIG_LIR_Apic_2	714	720	PF02991	0.510
LIG_LIR_Gen_1	361	369	PF02991	0.464
LIG_LIR_Gen_1	576	586	PF02991	0.531
LIG_LIR_Gen_1	58	68	PF02991	0.443
LIG_LIR_Gen_1	682	689	PF02991	0.421
LIG_LIR_Gen_1	775	784	PF02991	0.470
LIG_LIR_Gen_1	88	99	PF02991	0.420
LIG_LIR_Gen_1	9	19	PF02991	0.340
LIG_LIR_Nem_3	103	108	PF02991	0.420
LIG_LIR_Nem_3	117	122	PF02991	0.413
LIG_LIR_Nem_3	300	304	PF02991	0.420
LIG_LIR_Nem_3	361	367	PF02991	0.503
LIG_LIR_Nem_3	58	64	PF02991	0.443
LIG_LIR_Nem_3	589	595	PF02991	0.509
LIG_LIR_Nem_3	682	688	PF02991	0.421
LIG_LIR_Nem_3	775	781	PF02991	0.470
LIG_LIR_Nem_3	88	94	PF02991	0.420
LIG_LIR_Nem_3	9	14	PF02991	0.338
LIG_LRP6_Inhibitor_1	439	445	PF00058	0.219
LIG_NBox_RRM_1	527	537	PF00076	0.420
LIG_NRBOX	388	394	PF00104	0.420
LIG_PCNA_PIPBox_1	144	153	PF02747	0.488
LIG_PCNA_yPIPBox_3	142	151	PF02747	0.487
LIG_PCNA_yPIPBox_3	422	431	PF02747	0.464
LIG_Pex14_2	49	53	PF04695	0.503
LIG_REV1ctd_RIR_1	148	157	PF16727	0.437
LIG_SH2_CRK	562	566	PF00017	0.437
LIG_SH2_NCK_1	562	566	PF00017	0.437
LIG_SH2_PTP2	685	688	PF00017	0.466
LIG_SH2_STAP1	269	273	PF00017	0.420
LIG_SH2_STAP1	301	305	PF00017	0.466
LIG_SH2_STAP1	369	373	PF00017	0.435
LIG_SH2_STAP1	453	457	PF00017	0.420
LIG_SH2_STAT3	369	372	PF00017	0.503
LIG_SH2_STAT5	105	108	PF00017	0.503
LIG_SH2_STAT5	294	297	PF00017	0.448
LIG_SH2_STAT5	304	307	PF00017	0.391
LIG_SH2_STAT5	356	359	PF00017	0.488
LIG_SH2_STAT5	44	47	PF00017	0.503
LIG_SH2_STAT5	479	482	PF00017	0.503
LIG_SH2_STAT5	685	688	PF00017	0.466
LIG_SH2_STAT5	741	744	PF00017	0.639
LIG_SH3_1	562	568	PF00018	0.437
LIG_SH3_2	565	570	PF14604	0.466
LIG_SH3_2	638	643	PF14604	0.380
LIG_SH3_3	562	568	PF00018	0.437
LIG_SH3_3	635	641	PF00018	0.466
LIG_SH3_3	698	704	PF00018	0.470
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.420
LIG_SUMO_SIM_anti_2	684	690	PF11976	0.444
LIG_SUMO_SIM_anti_2	779	785	PF11976	0.665
LIG_SUMO_SIM_par_1	111	117	PF11976	0.387
LIG_SUMO_SIM_par_1	515	521	PF11976	0.506
LIG_SUMO_SIM_par_1	610	615	PF11976	0.456
LIG_SUMO_SIM_par_1	684	690	PF11976	0.459
LIG_SUMO_SIM_par_1	744	750	PF11976	0.546
LIG_SUMO_SIM_par_1	98	104	PF11976	0.443
LIG_TRAF2_1	203	206	PF00917	0.532
LIG_TRAF2_1	491	494	PF00917	0.435
LIG_TRAF2_2	230	235	PF00917	0.503
LIG_TRFH_1	53	57	PF08558	0.420
LIG_UBA3_1	746	752	PF00899	0.583
LIG_WRC_WIRS_1	457	462	PF05994	0.421
LIG_WRC_WIRS_1	575	580	PF05994	0.420
LIG_WRPW_2	119	122	PF00400	0.420
LIG_WW_3	719	723	PF00397	0.627
MOD_CDK_SPxK_1	716	722	PF00069	0.624
MOD_CK1_1	195	201	PF00069	0.452
MOD_CK1_1	341	347	PF00069	0.421
MOD_CK1_1	577	583	PF00069	0.475
MOD_CK1_1	630	636	PF00069	0.419
MOD_CK1_1	653	659	PF00069	0.514
MOD_CK1_1	663	669	PF00069	0.563
MOD_CK1_1	750	756	PF00069	0.666
MOD_CK2_1	199	205	PF00069	0.521
MOD_CK2_1	261	267	PF00069	0.462
MOD_CK2_1	488	494	PF00069	0.486
MOD_CK2_1	57	63	PF00069	0.503
MOD_CK2_1	74	80	PF00069	0.503
MOD_GlcNHglycan	240	243	PF01048	0.266
MOD_GlcNHglycan	245	249	PF01048	0.355
MOD_GlcNHglycan	263	266	PF01048	0.238
MOD_GlcNHglycan	374	377	PF01048	0.296
MOD_GlcNHglycan	4	7	PF01048	0.571
MOD_GlcNHglycan	514	517	PF01048	0.266
MOD_GlcNHglycan	630	633	PF01048	0.303
MOD_GlcNHglycan	634	637	PF01048	0.303
MOD_GlcNHglycan	638	641	PF01048	0.303
MOD_GlcNHglycan	655	658	PF01048	0.339
MOD_GlcNHglycan	660	663	PF01048	0.354
MOD_GSK3_1	13	20	PF00069	0.456
MOD_GSK3_1	192	199	PF00069	0.451
MOD_GSK3_1	226	233	PF00069	0.420
MOD_GSK3_1	313	320	PF00069	0.503
MOD_GSK3_1	36	43	PF00069	0.420
MOD_GSK3_1	368	375	PF00069	0.550
MOD_GSK3_1	410	417	PF00069	0.466
MOD_GSK3_1	430	437	PF00069	0.333
MOD_GSK3_1	451	458	PF00069	0.443
MOD_GSK3_1	591	598	PF00069	0.503
MOD_GSK3_1	628	635	PF00069	0.561
MOD_GSK3_1	747	754	PF00069	0.528
MOD_N-GLC_1	737	742	PF02516	0.527
MOD_NEK2_1	106	111	PF00069	0.462
MOD_NEK2_1	278	283	PF00069	0.435
MOD_NEK2_1	317	322	PF00069	0.503
MOD_NEK2_1	358	363	PF00069	0.492
MOD_NEK2_1	392	397	PF00069	0.503
MOD_NEK2_1	40	45	PF00069	0.462
MOD_NEK2_1	591	596	PF00069	0.477
MOD_NEK2_1	612	617	PF00069	0.503
MOD_NEK2_1	747	752	PF00069	0.592
MOD_PIKK_1	228	234	PF00454	0.421
MOD_PIKK_1	368	374	PF00454	0.576
MOD_PIKK_1	387	393	PF00454	0.425
MOD_PIKK_1	430	436	PF00454	0.380
MOD_PK_1	582	588	PF00069	0.488
MOD_PKA_1	582	588	PF00069	0.488
MOD_PKA_2	12	18	PF00069	0.455
MOD_PKA_2	261	267	PF00069	0.503
MOD_PKA_2	338	344	PF00069	0.464
MOD_PKA_2	358	364	PF00069	0.503
MOD_PKA_2	387	393	PF00069	0.503
MOD_PKA_2	512	518	PF00069	0.466
MOD_PKA_2	582	588	PF00069	0.462
MOD_PKA_2	653	659	PF00069	0.435
MOD_PKB_1	443	451	PF00069	0.500
MOD_PKB_1	734	742	PF00069	0.537
MOD_Plk_1	195	201	PF00069	0.466
MOD_Plk_1	269	275	PF00069	0.503
MOD_Plk_1	455	461	PF00069	0.420
MOD_Plk_1	736	742	PF00069	0.586
MOD_Plk_1	80	86	PF00069	0.430
MOD_Plk_2-3	192	198	PF00069	0.512
MOD_Plk_2-3	456	462	PF00069	0.437
MOD_Plk_4	13	19	PF00069	0.452
MOD_Plk_4	269	275	PF00069	0.503
MOD_Plk_4	278	284	PF00069	0.503
MOD_Plk_4	300	306	PF00069	0.420
MOD_Plk_4	359	365	PF00069	0.420
MOD_Plk_4	40	46	PF00069	0.439
MOD_Plk_4	474	480	PF00069	0.460
MOD_Plk_4	544	550	PF00069	0.466
MOD_Plk_4	582	588	PF00069	0.462
MOD_Plk_4	737	743	PF00069	0.517
MOD_ProDKin_1	226	232	PF00069	0.413
MOD_ProDKin_1	488	494	PF00069	0.447
MOD_ProDKin_1	569	575	PF00069	0.527
MOD_ProDKin_1	697	703	PF00069	0.387
MOD_ProDKin_1	716	722	PF00069	0.506
MOD_SUMO_rev_2	59	67	PF00179	0.448
TRG_AP2beta_CARGO_1	589	599	PF09066	0.503
TRG_DiLeu_BaEn_1	353	358	PF01217	0.503
TRG_DiLeu_BaEn_1	744	749	PF01217	0.579
TRG_DiLeu_BaEn_2	62	68	PF01217	0.503
TRG_DiLeu_BaEn_4	493	499	PF01217	0.435
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.478
TRG_DiLeu_BaLyEn_6	698	703	PF01217	0.561
TRG_ENDOCYTIC_2	105	108	PF00928	0.465
TRG_ENDOCYTIC_2	119	122	PF00928	0.374
TRG_ENDOCYTIC_2	61	64	PF00928	0.437
TRG_ENDOCYTIC_2	685	688	PF00928	0.503
TRG_ER_diArg_1	127	129	PF00400	0.480
TRG_ER_diArg_1	161	164	PF00400	0.424
TRG_ER_diArg_1	166	168	PF00400	0.426
TRG_ER_diArg_1	179	182	PF00400	0.428
TRG_ER_diArg_1	295	297	PF00400	0.422
TRG_ER_diArg_1	321	323	PF00400	0.447
TRG_ER_diArg_1	386	389	PF00400	0.578
TRG_ER_diArg_1	440	443	PF00400	0.508
TRG_ER_diArg_1	581	583	PF00400	0.490
TRG_ER_diArg_1	599	601	PF00400	0.550
TRG_ER_diArg_1	733	736	PF00400	0.506
TRG_ER_diArg_1	760	763	PF00400	0.665
TRG_NES_CRM1_1	307	319	PF08389	0.503
TRG_NLS_MonoCore_2	760	765	PF00514	0.577
TRG_NLS_MonoExtC_3	151	157	PF00514	0.435
TRG_NLS_MonoExtC_3	761	766	PF00514	0.576
TRG_NLS_MonoExtN_4	761	766	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.220
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	722	727	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R4	Leptomonas seymouri	66%	95%
A0A422P0B5	Trypanosoma rangeli	43%	100%
A4HLU5	Leishmania braziliensis	81%	100%
D0A683	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHQ0	Leishmania infantum	100%	100%
E9B471	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O74113	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q4Q3V5	Leishmania major	94%	100%
V5BP84	Trypanosoma cruzi	42%	100%