Protein prenyltransferase alpha subunit repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IF02_LEIDO

TriTrypDb:

LdBPK_241980.1 , LdCL_240025500 , LDHU3_24.2420

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF02

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018342	protein prenylation	4	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0097354	prenylation	3	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004659	prenyltransferase activity	4	3
GO:0008318	protein prenyltransferase activity	3	3
GO:0016740	transferase activity	2	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.464
CLV_C14_Caspase3-7	112	116	PF00656	0.522
CLV_C14_Caspase3-7	310	314	PF00656	0.379
CLV_C14_Caspase3-7	437	441	PF00656	0.461
CLV_NRD_NRD_1	151	153	PF00675	0.352
CLV_NRD_NRD_1	253	255	PF00675	0.354
CLV_NRD_NRD_1	384	386	PF00675	0.450
CLV_NRD_NRD_1	79	81	PF00675	0.484
CLV_PCSK_KEX2_1	150	152	PF00082	0.340
CLV_PCSK_KEX2_1	253	255	PF00082	0.364
CLV_PCSK_KEX2_1	384	386	PF00082	0.472
CLV_PCSK_KEX2_1	79	81	PF00082	0.495
CLV_PCSK_SKI1_1	122	126	PF00082	0.541
CLV_PCSK_SKI1_1	364	368	PF00082	0.450
CLV_PCSK_SKI1_1	39	43	PF00082	0.423
CLV_PCSK_SKI1_1	86	90	PF00082	0.374
DEG_APCC_DBOX_1	121	129	PF00400	0.435
DEG_Nend_UBRbox_2	1	3	PF02207	0.470
DEG_ODPH_VHL_1	367	378	PF01847	0.389
DEG_SPOP_SBC_1	64	68	PF00917	0.449
DOC_CYCLIN_RxL_1	250	259	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.503
DOC_MAPK_MEF2A_6	176	185	PF00069	0.381
DOC_PP1_RVXF_1	251	258	PF00149	0.311
DOC_PP2B_LxvP_1	33	36	PF13499	0.277
DOC_USP7_MATH_1	262	266	PF00917	0.559
DOC_USP7_MATH_1	461	465	PF00917	0.473
DOC_USP7_MATH_1	48	52	PF00917	0.559
DOC_USP7_MATH_1	99	103	PF00917	0.545
DOC_WW_Pin1_4	107	112	PF00397	0.572
DOC_WW_Pin1_4	114	119	PF00397	0.582
DOC_WW_Pin1_4	406	411	PF00397	0.431
DOC_WW_Pin1_4	441	446	PF00397	0.587
LIG_14-3-3_CanoR_1	122	132	PF00244	0.424
LIG_14-3-3_CanoR_1	256	261	PF00244	0.344
LIG_14-3-3_CanoR_1	425	431	PF00244	0.343
LIG_Actin_WH2_2	142	157	PF00022	0.353
LIG_Actin_WH2_2	410	427	PF00022	0.428
LIG_CaM_IQ_9	376	391	PF13499	0.504
LIG_eIF4E_1	430	436	PF01652	0.404
LIG_FHA_1	297	303	PF00498	0.376
LIG_FHA_2	377	383	PF00498	0.416
LIG_FXI_DFP_1	70	74	PF00024	0.453
LIG_GBD_Chelix_1	435	443	PF00786	0.433
LIG_LIR_Gen_1	144	154	PF02991	0.530
LIG_LIR_Gen_1	177	185	PF02991	0.361
LIG_LIR_Gen_1	2	12	PF02991	0.418
LIG_LIR_Gen_1	299	306	PF02991	0.330
LIG_LIR_Gen_1	459	470	PF02991	0.397
LIG_LIR_Gen_1	67	77	PF02991	0.498
LIG_LIR_Nem_3	144	149	PF02991	0.541
LIG_LIR_Nem_3	177	181	PF02991	0.322
LIG_LIR_Nem_3	182	187	PF02991	0.353
LIG_LIR_Nem_3	2	8	PF02991	0.436
LIG_LIR_Nem_3	299	304	PF02991	0.334
LIG_LIR_Nem_3	428	433	PF02991	0.398
LIG_LIR_Nem_3	459	465	PF02991	0.422
LIG_LIR_Nem_3	67	73	PF02991	0.519
LIG_NRBOX	301	307	PF00104	0.355
LIG_NRBOX	473	479	PF00104	0.370
LIG_PCNA_PIPBox_1	411	420	PF02747	0.459
LIG_PCNA_yPIPBox_3	408	418	PF02747	0.462
LIG_Pex14_1	426	430	PF04695	0.475
LIG_Pex14_2	89	93	PF04695	0.386
LIG_RPA_C_Fungi	75	87	PF08784	0.346
LIG_SH2_CRK	252	256	PF00017	0.337
LIG_SH2_CRK	5	9	PF00017	0.410
LIG_SH2_NCK_1	5	9	PF00017	0.410
LIG_SH2_PTP2	430	433	PF00017	0.470
LIG_SH2_STAP1	5	9	PF00017	0.410
LIG_SH2_STAT3	470	473	PF00017	0.371
LIG_SH2_STAT5	26	29	PF00017	0.370
LIG_SH2_STAT5	301	304	PF00017	0.324
LIG_SH2_STAT5	430	433	PF00017	0.401
LIG_SH2_STAT5	5	8	PF00017	0.408
LIG_SUMO_SIM_par_1	413	419	PF11976	0.446
LIG_SUMO_SIM_par_1	71	78	PF11976	0.347
LIG_UBA3_1	183	192	PF00899	0.445
LIG_WRC_WIRS_1	90	95	PF05994	0.399
MOD_CK1_1	110	116	PF00069	0.604
MOD_CK1_1	296	302	PF00069	0.361
MOD_CK1_1	3	9	PF00069	0.487
MOD_CK1_1	318	324	PF00069	0.580
MOD_CK1_1	416	422	PF00069	0.490
MOD_CK1_1	444	450	PF00069	0.529
MOD_CK1_1	454	460	PF00069	0.443
MOD_CK2_1	160	166	PF00069	0.521
MOD_CK2_1	190	196	PF00069	0.475
MOD_CK2_1	316	322	PF00069	0.484
MOD_CK2_1	376	382	PF00069	0.362
MOD_CK2_1	449	455	PF00069	0.400
MOD_CK2_1	88	94	PF00069	0.293
MOD_GlcNHglycan	166	169	PF01048	0.483
MOD_GlcNHglycan	2	5	PF01048	0.466
MOD_GlcNHglycan	295	299	PF01048	0.322
MOD_GlcNHglycan	339	342	PF01048	0.718
MOD_GlcNHglycan	418	421	PF01048	0.538
MOD_GlcNHglycan	446	449	PF01048	0.498
MOD_GlcNHglycan	455	459	PF01048	0.358
MOD_GSK3_1	110	117	PF00069	0.650
MOD_GSK3_1	154	161	PF00069	0.352
MOD_GSK3_1	293	300	PF00069	0.347
MOD_GSK3_1	318	325	PF00069	0.581
MOD_GSK3_1	406	413	PF00069	0.459
MOD_GSK3_1	449	456	PF00069	0.453
MOD_GSK3_1	457	464	PF00069	0.340
MOD_GSK3_1	64	71	PF00069	0.560
MOD_N-GLC_1	353	358	PF02516	0.543
MOD_N-GLC_1	465	470	PF02516	0.507
MOD_N-GLC_1	479	484	PF02516	0.372
MOD_N-GLC_2	204	206	PF02516	0.321
MOD_NEK2_1	154	159	PF00069	0.364
MOD_NEK2_1	183	188	PF00069	0.318
MOD_NEK2_1	337	342	PF00069	0.575
MOD_NEK2_1	376	381	PF00069	0.378
MOD_NEK2_1	42	47	PF00069	0.566
MOD_NEK2_1	465	470	PF00069	0.427
MOD_NEK2_1	478	483	PF00069	0.451
MOD_NEK2_1	88	93	PF00069	0.404
MOD_PIKK_1	376	382	PF00454	0.417
MOD_PIKK_1	42	48	PF00454	0.470
MOD_PKA_1	384	390	PF00069	0.443
MOD_PKA_2	154	160	PF00069	0.411
MOD_PKA_2	384	390	PF00069	0.443
MOD_PKA_2	478	484	PF00069	0.636
MOD_PKB_1	254	262	PF00069	0.356
MOD_Plk_1	218	224	PF00069	0.348
MOD_Plk_1	316	322	PF00069	0.627
MOD_Plk_1	465	471	PF00069	0.490
MOD_Plk_2-3	322	328	PF00069	0.586
MOD_Plk_4	128	134	PF00069	0.397
MOD_Plk_4	190	196	PF00069	0.355
MOD_Plk_4	297	303	PF00069	0.331
MOD_Plk_4	3	9	PF00069	0.548
MOD_Plk_4	322	328	PF00069	0.731
MOD_Plk_4	410	416	PF00069	0.641
MOD_Plk_4	426	432	PF00069	0.294
MOD_Plk_4	473	479	PF00069	0.450
MOD_ProDKin_1	107	113	PF00069	0.567
MOD_ProDKin_1	114	120	PF00069	0.566
MOD_ProDKin_1	406	412	PF00069	0.437
MOD_ProDKin_1	441	447	PF00069	0.582
MOD_SUMO_for_1	226	229	PF00179	0.287
MOD_SUMO_rev_2	156	165	PF00179	0.460
TRG_ENDOCYTIC_2	252	255	PF00928	0.506
TRG_ENDOCYTIC_2	301	304	PF00928	0.324
TRG_ENDOCYTIC_2	430	433	PF00928	0.411
TRG_ENDOCYTIC_2	5	8	PF00928	0.408
TRG_ER_diArg_1	149	152	PF00400	0.364
TRG_ER_diArg_1	252	254	PF00400	0.342
TRG_ER_diArg_1	383	385	PF00400	0.431
TRG_ER_diArg_1	79	81	PF00400	0.523
TRG_NES_CRM1_1	169	182	PF08389	0.356
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ1	Leptomonas seymouri	42%	100%
A0A0S4JLJ0	Bodo saltans	26%	100%
A0A1X0NWB3	Trypanosomatidae	26%	100%
A0A422NWV9	Trypanosoma rangeli	30%	100%
A4HDQ2	Leishmania braziliensis	73%	100%
A4I0Z8	Leishmania infantum	100%	100%
C9ZWB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AX36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAE0	Leishmania major	87%	100%