RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IF00_LEIDO

TriTrypDb:

LdBPK_290400.1 , LdCL_290008800 , LDHU3_29.0550

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IF00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IF00

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.386
CLV_NRD_NRD_1	221	223	PF00675	0.423
CLV_PCSK_KEX2_1	10	12	PF00082	0.354
CLV_PCSK_KEX2_1	221	223	PF00082	0.527
CLV_PCSK_KEX2_1	5	7	PF00082	0.466
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.476
CLV_PCSK_PC7_1	217	223	PF00082	0.524
CLV_PCSK_PC7_1	6	12	PF00082	0.436
DEG_APCC_DBOX_1	5	13	PF00400	0.405
DOC_MAPK_gen_1	182	191	PF00069	0.438
DOC_MAPK_gen_1	53	61	PF00069	0.529
DOC_PP1_RVXF_1	8	15	PF00149	0.351
DOC_PP4_FxxP_1	144	147	PF00568	0.438
DOC_USP7_UBL2_3	80	84	PF12436	0.383
LIG_14-3-3_CanoR_1	10	15	PF00244	0.441
LIG_14-3-3_CanoR_1	128	134	PF00244	0.531
LIG_14-3-3_CanoR_1	187	192	PF00244	0.524
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_DLG_GKlike_1	10	17	PF00625	0.488
LIG_FHA_2	128	134	PF00498	0.438
LIG_FHA_2	13	19	PF00498	0.392
LIG_FHA_2	204	210	PF00498	0.478
LIG_LIR_Gen_1	13	19	PF02991	0.361
LIG_LIR_Gen_1	135	146	PF02991	0.452
LIG_LIR_Gen_1	190	198	PF02991	0.415
LIG_LIR_Gen_1	55	64	PF02991	0.432
LIG_LIR_Nem_3	13	17	PF02991	0.386
LIG_LIR_Nem_3	135	141	PF02991	0.427
LIG_LIR_Nem_3	165	169	PF02991	0.470
LIG_LIR_Nem_3	55	61	PF02991	0.429
LIG_NRP_CendR_1	257	260	PF00754	0.569
LIG_Pex14_2	137	141	PF04695	0.427
LIG_PTB_Apo_2	121	128	PF02174	0.525
LIG_PTB_Phospho_1	121	127	PF10480	0.525
LIG_SH2_CRK	255	259	PF00017	0.556
LIG_SH2_STAP1	27	31	PF00017	0.493
LIG_SH2_STAT5	58	61	PF00017	0.467
LIG_SH2_STAT5	69	72	PF00017	0.422
LIG_SUMO_SIM_par_1	160	165	PF11976	0.438
LIG_TRAF2_1	206	209	PF00917	0.475
LIG_WRC_WIRS_1	138	143	PF05994	0.438
LIG_WRC_WIRS_1	166	171	PF05994	0.497
LIG_WW_3	146	150	PF00397	0.438
MOD_CK1_1	165	171	PF00069	0.525
MOD_CK1_1	40	46	PF00069	0.525
MOD_CK2_1	203	209	PF00069	0.458
MOD_CK2_1	244	250	PF00069	0.592
MOD_GlcNHglycan	105	108	PF01048	0.548
MOD_GlcNHglycan	197	202	PF01048	0.461
MOD_GSK3_1	165	172	PF00069	0.549
MOD_N-GLC_1	37	42	PF02516	0.252
MOD_NEK2_1	132	137	PF00069	0.470
MOD_NEK2_1	151	156	PF00069	0.470
MOD_PIKK_1	100	106	PF00454	0.601
MOD_PK_1	187	193	PF00069	0.523
MOD_PKA_1	10	16	PF00069	0.445
MOD_PKA_2	10	16	PF00069	0.445
MOD_PKA_2	127	133	PF00069	0.520
MOD_PKA_2	151	157	PF00069	0.525
MOD_PKA_2	52	58	PF00069	0.527
MOD_PKB_1	185	193	PF00069	0.470
MOD_Plk_1	132	138	PF00069	0.431
MOD_Plk_1	244	250	PF00069	0.474
MOD_Plk_1	37	43	PF00069	0.452
MOD_SUMO_rev_2	178	184	PF00179	0.472
TRG_ENDOCYTIC_2	166	169	PF00928	0.438
TRG_ENDOCYTIC_2	193	196	PF00928	0.368
TRG_ENDOCYTIC_2	223	226	PF00928	0.574
TRG_ENDOCYTIC_2	58	61	PF00928	0.483
TRG_ER_diArg_1	221	223	PF00400	0.550
TRG_ER_diArg_1	257	260	PF00400	0.620
TRG_ER_diArg_1	75	78	PF00400	0.439
TRG_ER_diArg_1	9	11	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ3	Leptomonas seymouri	84%	100%
A0A0S4IJA0	Bodo saltans	46%	100%
A0A1X0NZI1	Trypanosomatidae	56%	99%
A0A3R7M503	Trypanosoma rangeli	59%	100%
A4HH40	Leishmania braziliensis	93%	100%
A4I493	Leishmania infantum	100%	100%
C9ZKP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9ADP0	Leishmania major	95%	100%
E9AM40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O14102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	78%
Q09442	Caenorhabditis elegans	30%	67%
Q55GD6	Dictyostelium discoideum	26%	72%
Q99181	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
V5BUK3	Trypanosoma cruzi	59%	100%