Mediator of RNA polymerase II transcription subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ9_LEIDO

TriTrypDb:

LdBPK_201780.1 , LdCL_200022700 , LDHU3_20.2170

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.549
CLV_NRD_NRD_1	27	29	PF00675	0.449
DEG_APCC_DBOX_1	160	168	PF00400	0.425
DOC_CYCLIN_yClb5_NLxxxL_5	144	152	PF00134	0.458
DOC_MAPK_gen_1	142	151	PF00069	0.485
DOC_MAPK_gen_1	51	59	PF00069	0.404
DOC_MAPK_HePTP_8	141	153	PF00069	0.391
DOC_MAPK_MEF2A_6	144	153	PF00069	0.414
DOC_USP7_MATH_1	140	144	PF00917	0.469
DOC_USP7_MATH_1	168	172	PF00917	0.547
DOC_USP7_UBL2_3	29	33	PF12436	0.405
DOC_WW_Pin1_4	59	64	PF00397	0.451
DOC_WW_Pin1_4	81	86	PF00397	0.532
LIG_14-3-3_CanoR_1	125	131	PF00244	0.529
LIG_Actin_WH2_2	152	167	PF00022	0.414
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_FHA_1	105	111	PF00498	0.537
LIG_FHA_1	121	127	PF00498	0.346
LIG_FHA_1	92	98	PF00498	0.463
LIG_LIR_Gen_1	21	30	PF02991	0.372
LIG_PDZ_Class_1	182	187	PF00595	0.482
LIG_PTB_Apo_2	72	79	PF02174	0.482
LIG_PTB_Phospho_1	72	78	PF10480	0.488
LIG_SH2_CRK	35	39	PF00017	0.428
LIG_SH2_NCK_1	66	70	PF00017	0.455
LIG_SH2_STAT5	30	33	PF00017	0.409
LIG_SH2_STAT5	78	81	PF00017	0.454
LIG_SH2_STAT5	8	11	PF00017	0.428
LIG_SH3_2	137	142	PF14604	0.385
LIG_SH3_3	134	140	PF00018	0.425
LIG_UBA3_1	111	119	PF00899	0.472
LIG_UBA3_1	138	144	PF00899	0.467
LIG_UBA3_1	152	157	PF00899	0.362
MOD_CDK_SPxxK_3	81	88	PF00069	0.520
MOD_CK1_1	10	16	PF00069	0.391
MOD_CK1_1	23	29	PF00069	0.421
MOD_CK1_1	67	73	PF00069	0.596
MOD_CK2_1	126	132	PF00069	0.450
MOD_CK2_1	140	146	PF00069	0.420
MOD_Cter_Amidation	26	29	PF01082	0.454
MOD_GlcNHglycan	169	173	PF01048	0.439
MOD_GlcNHglycan	25	28	PF01048	0.496
MOD_GlcNHglycan	68	72	PF01048	0.574
MOD_GlcNHglycan	9	12	PF01048	0.380
MOD_GSK3_1	77	84	PF00069	0.404
MOD_GSK3_1	87	94	PF00069	0.421
MOD_NEK2_1	112	117	PF00069	0.339
MOD_NEK2_1	126	131	PF00069	0.399
MOD_PIKK_1	104	110	PF00454	0.489
MOD_PIKK_1	12	18	PF00454	0.472
MOD_PIKK_1	91	97	PF00454	0.449
MOD_PKA_2	50	56	PF00069	0.464
MOD_Plk_1	20	26	PF00069	0.376
MOD_Plk_4	126	132	PF00069	0.371
MOD_ProDKin_1	59	65	PF00069	0.462
MOD_ProDKin_1	81	87	PF00069	0.534
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.370
TRG_ENDOCYTIC_2	35	38	PF00928	0.421
TRG_ENDOCYTIC_2	78	81	PF00928	0.464
TRG_ER_diArg_1	161	164	PF00400	0.429
TRG_NES_CRM1_1	109	121	PF08389	0.360
TRG_NLS_MonoExtN_4	181	187	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT0	Leptomonas seymouri	38%	83%
A4HZ15	Leishmania infantum	97%	100%
E9AUW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	73%
Q4QCM0	Leishmania major	81%	74%