Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ8_LEIDO

TriTrypDb:

LdBPK_312180.1 , LdCL_310029800 , LDHU3_31.3890

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.742
CLV_C14_Caspase3-7	227	231	PF00656	0.571
CLV_C14_Caspase3-7	66	70	PF00656	0.717
CLV_NRD_NRD_1	127	129	PF00675	0.675
CLV_NRD_NRD_1	316	318	PF00675	0.619
CLV_NRD_NRD_1	347	349	PF00675	0.709
CLV_NRD_NRD_1	40	42	PF00675	0.673
CLV_NRD_NRD_1	580	582	PF00675	0.657
CLV_PCSK_FUR_1	40	44	PF00082	0.739
CLV_PCSK_KEX2_1	316	318	PF00082	0.628
CLV_PCSK_KEX2_1	40	42	PF00082	0.728
CLV_PCSK_KEX2_1	580	582	PF00082	0.633
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.742
CLV_PCSK_SKI1_1	200	204	PF00082	0.708
CLV_PCSK_SKI1_1	349	353	PF00082	0.750
CLV_PCSK_SKI1_1	685	689	PF00082	0.698
CLV_PCSK_SKI1_1	734	738	PF00082	0.562
DEG_APCC_DBOX_1	57	65	PF00400	0.714
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DEG_SCF_FBW7_1	148	154	PF00400	0.764
DOC_CDC14_PxL_1	134	142	PF14671	0.719
DOC_CKS1_1	148	153	PF01111	0.764
DOC_CKS1_1	265	270	PF01111	0.607
DOC_CKS1_1	400	405	PF01111	0.581
DOC_CKS1_1	522	527	PF01111	0.725
DOC_CYCLIN_RxL_1	197	204	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	702	708	PF00134	0.678
DOC_MAPK_gen_1	15	22	PF00069	0.551
DOC_MAPK_gen_1	570	578	PF00069	0.594
DOC_MAPK_gen_1	701	709	PF00069	0.678
DOC_MAPK_gen_1	86	95	PF00069	0.738
DOC_MAPK_MEF2A_6	701	709	PF00069	0.678
DOC_PP1_SILK_1	124	129	PF00149	0.733
DOC_PP2B_LxvP_1	119	122	PF13499	0.664
DOC_PP2B_LxvP_1	506	509	PF13499	0.646
DOC_PP4_FxxP_1	203	206	PF00568	0.602
DOC_PP4_FxxP_1	531	534	PF00568	0.607
DOC_USP7_MATH_1	122	126	PF00917	0.703
DOC_USP7_MATH_1	163	167	PF00917	0.753
DOC_USP7_MATH_1	189	193	PF00917	0.661
DOC_USP7_MATH_1	232	236	PF00917	0.665
DOC_USP7_MATH_1	263	267	PF00917	0.651
DOC_USP7_MATH_1	273	277	PF00917	0.654
DOC_USP7_MATH_1	557	561	PF00917	0.700
DOC_USP7_MATH_1	563	567	PF00917	0.695
DOC_USP7_MATH_1	596	600	PF00917	0.705
DOC_USP7_MATH_1	60	64	PF00917	0.650
DOC_USP7_MATH_1	613	617	PF00917	0.701
DOC_USP7_MATH_1	624	628	PF00917	0.525
DOC_USP7_MATH_1	681	685	PF00917	0.716
DOC_USP7_MATH_1	708	712	PF00917	0.680
DOC_USP7_MATH_1	736	740	PF00917	0.682
DOC_USP7_MATH_1	742	746	PF00917	0.640
DOC_USP7_UBL2_3	728	732	PF12436	0.626
DOC_USP7_UBL2_3	759	763	PF12436	0.592
DOC_WW_Pin1_4	144	149	PF00397	0.746
DOC_WW_Pin1_4	151	156	PF00397	0.687
DOC_WW_Pin1_4	201	206	PF00397	0.679
DOC_WW_Pin1_4	264	269	PF00397	0.730
DOC_WW_Pin1_4	338	343	PF00397	0.728
DOC_WW_Pin1_4	399	404	PF00397	0.685
DOC_WW_Pin1_4	458	463	PF00397	0.734
DOC_WW_Pin1_4	485	490	PF00397	0.779
DOC_WW_Pin1_4	498	503	PF00397	0.600
DOC_WW_Pin1_4	521	526	PF00397	0.697
DOC_WW_Pin1_4	532	537	PF00397	0.590
DOC_WW_Pin1_4	670	675	PF00397	0.772
DOC_WW_Pin1_4	676	681	PF00397	0.723
LIG_14-3-3_CanoR_1	128	134	PF00244	0.661
LIG_14-3-3_CanoR_1	190	197	PF00244	0.667
LIG_14-3-3_CanoR_1	285	291	PF00244	0.672
LIG_14-3-3_CanoR_1	297	303	PF00244	0.567
LIG_14-3-3_CanoR_1	364	373	PF00244	0.600
LIG_14-3-3_CanoR_1	544	548	PF00244	0.664
LIG_14-3-3_CanoR_1	580	590	PF00244	0.636
LIG_14-3-3_CanoR_1	645	650	PF00244	0.688
LIG_14-3-3_CanoR_1	694	702	PF00244	0.712
LIG_14-3-3_CanoR_1	71	81	PF00244	0.702
LIG_14-3-3_CanoR_1	741	749	PF00244	0.670
LIG_14-3-3_CanoR_1	86	95	PF00244	0.525
LIG_Actin_WH2_2	114	130	PF00022	0.727
LIG_APCC_ABBA_1	222	227	PF00400	0.666
LIG_APCC_ABBAyCdc20_2	221	227	PF00400	0.670
LIG_APCC_ABBAyCdc20_2	425	431	PF00400	0.699
LIG_BRCT_BRCA1_1	601	605	PF00533	0.730
LIG_BRCT_BRCA1_1	91	95	PF00533	0.742
LIG_Clathr_ClatBox_1	140	144	PF01394	0.721
LIG_EH1_1	572	580	PF00400	0.611
LIG_eIF4E_1	573	579	PF01652	0.607
LIG_FHA_1	360	366	PF00498	0.681
LIG_FHA_1	5	11	PF00498	0.485
LIG_FHA_1	525	531	PF00498	0.740
LIG_FHA_1	583	589	PF00498	0.597
LIG_FHA_1	620	626	PF00498	0.721
LIG_FHA_2	402	408	PF00498	0.695
LIG_FXI_DFP_1	140	144	PF00024	0.660
LIG_Integrin_isoDGR_2	335	337	PF01839	0.709
LIG_LIR_Apic_2	142	148	PF02991	0.737
LIG_LIR_Apic_2	391	396	PF02991	0.565
LIG_LIR_Apic_2	516	522	PF02991	0.728
LIG_LIR_Apic_2	529	534	PF02991	0.579
LIG_LIR_Gen_1	516	525	PF02991	0.723
LIG_LIR_Nem_3	314	318	PF02991	0.735
LIG_LIR_Nem_3	389	393	PF02991	0.672
LIG_LIR_Nem_3	511	517	PF02991	0.731
LIG_LIR_Nem_3	6	12	PF02991	0.482
LIG_MYND_1	32	36	PF01753	0.603
LIG_PAM2_1	109	121	PF00658	0.673
LIG_PTAP_UEV_1	341	346	PF05743	0.693
LIG_Rb_pABgroove_1	135	143	PF01858	0.718
LIG_SH2_CRK	145	149	PF00017	0.686
LIG_SH2_CRK	18	22	PF00017	0.572
LIG_SH2_CRK	315	319	PF00017	0.743
LIG_SH2_CRK	393	397	PF00017	0.675
LIG_SH2_CRK	573	577	PF00017	0.639
LIG_SH2_CRK	755	759	PF00017	0.603
LIG_SH2_GRB2like	519	522	PF00017	0.696
LIG_SH2_PTP2	519	522	PF00017	0.726
LIG_SH2_SRC	18	21	PF00017	0.574
LIG_SH2_SRC	466	469	PF00017	0.626
LIG_SH2_SRC	517	520	PF00017	0.740
LIG_SH2_STAT3	446	449	PF00017	0.744
LIG_SH2_STAT3	548	551	PF00017	0.602
LIG_SH2_STAT5	393	396	PF00017	0.696
LIG_SH2_STAT5	444	447	PF00017	0.744
LIG_SH2_STAT5	519	522	PF00017	0.726
LIG_SH2_STAT5	753	756	PF00017	0.674
LIG_SH3_1	145	151	PF00018	0.750
LIG_SH3_1	262	268	PF00018	0.716
LIG_SH3_1	519	525	PF00018	0.723
LIG_SH3_3	145	151	PF00018	0.750
LIG_SH3_3	26	32	PF00018	0.580
LIG_SH3_3	262	268	PF00018	0.722
LIG_SH3_3	281	287	PF00018	0.571
LIG_SH3_3	304	310	PF00018	0.662
LIG_SH3_3	339	345	PF00018	0.695
LIG_SH3_3	475	481	PF00018	0.700
LIG_SH3_3	519	525	PF00018	0.698
LIG_SH3_3	675	681	PF00018	0.749
LIG_SH3_3	702	708	PF00018	0.739
LIG_SH3_3	713	719	PF00018	0.569
LIG_SUMO_SIM_par_1	523	529	PF11976	0.671
LIG_SUMO_SIM_par_1	535	540	PF11976	0.556
LIG_TRAF2_1	179	182	PF00917	0.679
LIG_TRAF2_1	595	598	PF00917	0.628
LIG_UBA3_1	8	15	PF00899	0.484
LIG_WW_3	353	357	PF00397	0.743
MOD_CDC14_SPxK_1	673	676	PF00782	0.728
MOD_CDK_SPK_2	147	152	PF00069	0.758
MOD_CDK_SPK_2	264	269	PF00069	0.606
MOD_CDK_SPxK_1	670	676	PF00069	0.741
MOD_CDK_SPxxK_3	399	406	PF00069	0.689
MOD_CK1_1	147	153	PF00069	0.761
MOD_CK1_1	166	172	PF00069	0.528
MOD_CK1_1	213	219	PF00069	0.747
MOD_CK1_1	244	250	PF00069	0.655
MOD_CK1_1	257	263	PF00069	0.658
MOD_CK1_1	276	282	PF00069	0.549
MOD_CK1_1	298	304	PF00069	0.638
MOD_CK1_1	383	389	PF00069	0.720
MOD_CK1_1	491	497	PF00069	0.750
MOD_CK1_1	535	541	PF00069	0.692
MOD_CK1_1	54	60	PF00069	0.726
MOD_CK1_1	543	549	PF00069	0.668
MOD_CK1_1	599	605	PF00069	0.772
MOD_CK1_1	62	68	PF00069	0.699
MOD_CK1_1	627	633	PF00069	0.623
MOD_CK1_1	643	649	PF00069	0.592
MOD_CK1_1	665	671	PF00069	0.721
MOD_CK1_1	70	76	PF00069	0.621
MOD_CK1_1	743	749	PF00069	0.658
MOD_CK1_1	84	90	PF00069	0.564
MOD_CK2_1	151	157	PF00069	0.780
MOD_CK2_1	401	407	PF00069	0.693
MOD_CK2_1	432	438	PF00069	0.678
MOD_CK2_1	563	569	PF00069	0.661
MOD_CK2_1	60	66	PF00069	0.698
MOD_CK2_1	617	623	PF00069	0.696
MOD_CK2_1	634	640	PF00069	0.747
MOD_CK2_1	647	653	PF00069	0.599
MOD_CK2_1	669	675	PF00069	0.724
MOD_CK2_1	694	700	PF00069	0.713
MOD_CK2_1	71	77	PF00069	0.631
MOD_DYRK1A_RPxSP_1	458	462	PF00069	0.702
MOD_GlcNHglycan	130	133	PF01048	0.674
MOD_GlcNHglycan	177	180	PF01048	0.660
MOD_GlcNHglycan	192	195	PF01048	0.508
MOD_GlcNHglycan	281	284	PF01048	0.659
MOD_GlcNHglycan	451	454	PF01048	0.686
MOD_GlcNHglycan	471	475	PF01048	0.755
MOD_GlcNHglycan	601	604	PF01048	0.684
MOD_GlcNHglycan	738	741	PF01048	0.693
MOD_GlcNHglycan	744	748	PF01048	0.718
MOD_GSK3_1	147	154	PF00069	0.762
MOD_GSK3_1	162	169	PF00069	0.584
MOD_GSK3_1	275	282	PF00069	0.663
MOD_GSK3_1	376	383	PF00069	0.720
MOD_GSK3_1	407	414	PF00069	0.771
MOD_GSK3_1	47	54	PF00069	0.694
MOD_GSK3_1	488	495	PF00069	0.770
MOD_GSK3_1	520	527	PF00069	0.682
MOD_GSK3_1	60	67	PF00069	0.650
MOD_GSK3_1	613	620	PF00069	0.730
MOD_GSK3_1	623	630	PF00069	0.547
MOD_GSK3_1	636	643	PF00069	0.594
MOD_GSK3_1	665	672	PF00069	0.717
MOD_GSK3_1	676	683	PF00069	0.615
MOD_GSK3_1	71	78	PF00069	0.658
MOD_GSK3_1	736	743	PF00069	0.685
MOD_GSK3_1	82	89	PF00069	0.617
MOD_N-GLC_1	213	218	PF02516	0.720
MOD_N-GLC_1	640	645	PF02516	0.705
MOD_N-GLC_2	409	411	PF02516	0.680
MOD_NEK2_1	127	132	PF00069	0.660
MOD_NEK2_1	275	280	PF00069	0.624
MOD_NEK2_1	470	475	PF00069	0.753
MOD_NEK2_1	542	547	PF00069	0.670
MOD_NEK2_1	582	587	PF00069	0.628
MOD_NEK2_1	644	649	PF00069	0.778
MOD_NEK2_1	81	86	PF00069	0.703
MOD_NEK2_2	388	393	PF00069	0.565
MOD_NEK2_2	563	568	PF00069	0.663
MOD_NEK2_2	758	763	PF00069	0.668
MOD_PIKK_1	166	172	PF00454	0.774
MOD_PIKK_1	329	335	PF00454	0.761
MOD_PIKK_1	365	371	PF00454	0.612
MOD_PIKK_1	383	389	PF00454	0.620
MOD_PIKK_1	488	494	PF00454	0.724
MOD_PIKK_1	665	671	PF00454	0.715
MOD_PK_1	645	651	PF00069	0.625
MOD_PK_1	694	700	PF00069	0.713
MOD_PKA_1	128	134	PF00069	0.676
MOD_PKA_2	127	133	PF00069	0.659
MOD_PKA_2	189	195	PF00069	0.659
MOD_PKA_2	543	549	PF00069	0.717
MOD_PKA_2	644	650	PF00069	0.653
MOD_PKA_2	693	699	PF00069	0.748
MOD_PKA_2	70	76	PF00069	0.666
MOD_PKA_2	740	746	PF00069	0.691
MOD_PKA_2	82	88	PF00069	0.626
MOD_Plk_1	244	250	PF00069	0.689
MOD_Plk_1	411	417	PF00069	0.711
MOD_Plk_1	470	476	PF00069	0.756
MOD_Plk_1	596	602	PF00069	0.764
MOD_Plk_1	640	646	PF00069	0.704
MOD_Plk_1	76	82	PF00069	0.702
MOD_Plk_1	89	95	PF00069	0.569
MOD_Plk_4	122	128	PF00069	0.730
MOD_Plk_4	286	292	PF00069	0.632
MOD_Plk_4	388	394	PF00069	0.565
MOD_Plk_4	4	10	PF00069	0.493
MOD_Plk_4	411	417	PF00069	0.680
MOD_Plk_4	492	498	PF00069	0.713
MOD_Plk_4	526	532	PF00069	0.742
MOD_Plk_4	543	549	PF00069	0.527
MOD_Plk_4	574	580	PF00069	0.633
MOD_ProDKin_1	144	150	PF00069	0.746
MOD_ProDKin_1	151	157	PF00069	0.690
MOD_ProDKin_1	201	207	PF00069	0.681
MOD_ProDKin_1	264	270	PF00069	0.733
MOD_ProDKin_1	338	344	PF00069	0.728
MOD_ProDKin_1	399	405	PF00069	0.686
MOD_ProDKin_1	458	464	PF00069	0.732
MOD_ProDKin_1	485	491	PF00069	0.780
MOD_ProDKin_1	498	504	PF00069	0.600
MOD_ProDKin_1	521	527	PF00069	0.700
MOD_ProDKin_1	532	538	PF00069	0.588
MOD_ProDKin_1	670	676	PF00069	0.773
MOD_SUMO_for_1	179	182	PF00179	0.679
MOD_SUMO_for_1	357	360	PF00179	0.686
MOD_SUMO_rev_2	142	148	PF00179	0.676
MOD_SUMO_rev_2	374	379	PF00179	0.805
MOD_SUMO_rev_2	711	716	PF00179	0.577
TRG_DiLeu_BaEn_1	436	441	PF01217	0.594
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.692
TRG_ENDOCYTIC_2	315	318	PF00928	0.738
TRG_ENDOCYTIC_2	517	520	PF00928	0.740
TRG_ENDOCYTIC_2	573	576	PF00928	0.641
TRG_ER_diArg_1	315	317	PF00400	0.606
TRG_ER_diArg_1	40	43	PF00400	0.677
TRG_ER_diArg_1	570	573	PF00400	0.630
TRG_ER_diArg_1	579	581	PF00400	0.554
TRG_ER_diLys_1	759	763	PF00400	0.652
TRG_NLS_MonoExtN_4	38	45	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJJ4	Leishmania braziliensis	53%	100%
A4I6Z1	Leishmania infantum	99%	100%
E9B212	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q649	Leishmania major	86%	100%