Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ5_LEIDO

TriTrypDb:

LdBPK_332310.1 , LdCL_330030100 , LDHU3_33.3350

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.654
CLV_C14_Caspase3-7	541	545	PF00656	0.652
CLV_NRD_NRD_1	293	295	PF00675	0.622
CLV_NRD_NRD_1	344	346	PF00675	0.693
CLV_NRD_NRD_1	38	40	PF00675	0.622
CLV_NRD_NRD_1	4	6	PF00675	0.692
CLV_NRD_NRD_1	602	604	PF00675	0.637
CLV_NRD_NRD_1	618	620	PF00675	0.491
CLV_NRD_NRD_1	727	729	PF00675	0.631
CLV_NRD_NRD_1	87	89	PF00675	0.764
CLV_PCSK_FUR_1	2	6	PF00082	0.659
CLV_PCSK_FUR_1	342	346	PF00082	0.695
CLV_PCSK_KEX2_1	293	295	PF00082	0.622
CLV_PCSK_KEX2_1	342	344	PF00082	0.694
CLV_PCSK_KEX2_1	37	39	PF00082	0.675
CLV_PCSK_KEX2_1	4	6	PF00082	0.692
CLV_PCSK_KEX2_1	510	512	PF00082	0.521
CLV_PCSK_KEX2_1	602	604	PF00082	0.637
CLV_PCSK_KEX2_1	618	620	PF00082	0.491
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.650
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.521
CLV_PCSK_SKI1_1	22	26	PF00082	0.615
CLV_PCSK_SKI1_1	284	288	PF00082	0.534
CLV_PCSK_SKI1_1	352	356	PF00082	0.690
CLV_PCSK_SKI1_1	486	490	PF00082	0.580
CLV_PCSK_SKI1_1	528	532	PF00082	0.654
CLV_PCSK_SKI1_1	718	722	PF00082	0.670
CLV_PCSK_SKI1_1	72	76	PF00082	0.599
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SPOP_SBC_1	689	693	PF00917	0.671
DOC_CKS1_1	103	108	PF01111	0.682
DOC_CKS1_1	127	132	PF01111	0.630
DOC_MAPK_gen_1	49	58	PF00069	0.548
DOC_PP1_RVXF_1	508	515	PF00149	0.538
DOC_PP4_FxxP_1	43	46	PF00568	0.697
DOC_PP4_FxxP_1	683	686	PF00568	0.679
DOC_USP7_MATH_1	146	150	PF00917	0.605
DOC_USP7_MATH_1	174	178	PF00917	0.769
DOC_USP7_MATH_1	199	203	PF00917	0.667
DOC_USP7_MATH_1	206	210	PF00917	0.589
DOC_USP7_MATH_1	296	300	PF00917	0.647
DOC_USP7_MATH_1	347	351	PF00917	0.734
DOC_USP7_MATH_1	517	521	PF00917	0.594
DOC_USP7_MATH_1	563	567	PF00917	0.664
DOC_USP7_MATH_1	573	577	PF00917	0.594
DOC_USP7_MATH_1	606	610	PF00917	0.598
DOC_USP7_MATH_1	648	652	PF00917	0.677
DOC_USP7_MATH_1	673	677	PF00917	0.679
DOC_USP7_MATH_1	689	693	PF00917	0.567
DOC_USP7_MATH_1	741	745	PF00917	0.578
DOC_WW_Pin1_4	102	107	PF00397	0.574
DOC_WW_Pin1_4	126	131	PF00397	0.724
DOC_WW_Pin1_4	178	183	PF00397	0.667
DOC_WW_Pin1_4	187	192	PF00397	0.515
DOC_WW_Pin1_4	197	202	PF00397	0.638
DOC_WW_Pin1_4	204	209	PF00397	0.540
DOC_WW_Pin1_4	319	324	PF00397	0.660
DOC_WW_Pin1_4	333	338	PF00397	0.575
DOC_WW_Pin1_4	393	398	PF00397	0.618
DOC_WW_Pin1_4	450	455	PF00397	0.732
DOC_WW_Pin1_4	459	464	PF00397	0.613
DOC_WW_Pin1_4	529	534	PF00397	0.652
DOC_WW_Pin1_4	542	547	PF00397	0.557
DOC_WW_Pin1_4	579	584	PF00397	0.652
DOC_WW_Pin1_4	644	649	PF00397	0.708
DOC_WW_Pin1_4	87	92	PF00397	0.663
LIG_14-3-3_CanoR_1	173	179	PF00244	0.595
LIG_14-3-3_CanoR_1	212	218	PF00244	0.631
LIG_14-3-3_CanoR_1	315	323	PF00244	0.658
LIG_14-3-3_CanoR_1	357	362	PF00244	0.635
LIG_14-3-3_CanoR_1	376	381	PF00244	0.563
LIG_14-3-3_CanoR_1	511	519	PF00244	0.541
LIG_14-3-3_CanoR_1	612	621	PF00244	0.621
LIG_14-3-3_CanoR_1	707	716	PF00244	0.595
LIG_14-3-3_CanoR_1	76	81	PF00244	0.694
LIG_BIR_III_2	28	32	PF00653	0.655
LIG_BIR_III_4	307	311	PF00653	0.619
LIG_BRCT_BRCA1_1	229	233	PF00533	0.533
LIG_BRCT_BRCA1_1	32	36	PF00533	0.649
LIG_deltaCOP1_diTrp_1	747	756	PF00928	0.507
LIG_DLG_GKlike_1	376	384	PF00625	0.655
LIG_EVH1_2	495	499	PF00568	0.534
LIG_FHA_1	187	193	PF00498	0.685
LIG_FHA_2	127	133	PF00498	0.748
LIG_FHA_2	23	29	PF00498	0.800
LIG_FHA_2	697	703	PF00498	0.673
LIG_LIR_Apic_2	40	46	PF02991	0.799
LIG_LIR_Apic_2	681	686	PF02991	0.672
LIG_LIR_Apic_2	735	741	PF02991	0.667
LIG_LIR_Apic_2	90	95	PF02991	0.595
LIG_LIR_Gen_1	262	270	PF02991	0.514
LIG_LIR_Gen_1	59	68	PF02991	0.652
LIG_LIR_Gen_1	607	616	PF02991	0.590
LIG_LIR_Gen_1	747	757	PF02991	0.504
LIG_LIR_Nem_3	223	229	PF02991	0.588
LIG_LIR_Nem_3	262	266	PF02991	0.582
LIG_LIR_Nem_3	59	64	PF02991	0.650
LIG_LIR_Nem_3	607	613	PF02991	0.598
LIG_LIR_Nem_3	630	636	PF02991	0.635
LIG_LIR_Nem_3	747	752	PF02991	0.520
LIG_PCNA_yPIPBox_3	746	757	PF02747	0.549
LIG_Pex14_1	502	506	PF04695	0.517
LIG_RPA_C_Fungi	607	619	PF08784	0.589
LIG_SH2_CRK	738	742	PF00017	0.552
LIG_SH2_CRK	92	96	PF00017	0.593
LIG_SH2_GRB2like	633	636	PF00017	0.646
LIG_SH2_NCK_1	217	221	PF00017	0.560
LIG_SH2_NCK_1	301	305	PF00017	0.593
LIG_SH2_NCK_1	92	96	PF00017	0.593
LIG_SH2_SRC	636	639	PF00017	0.579
LIG_SH2_STAT5	506	509	PF00017	0.538
LIG_SH3_3	100	106	PF00018	0.717
LIG_SH3_3	124	130	PF00018	0.661
LIG_SH3_3	176	182	PF00018	0.671
LIG_SH3_3	195	201	PF00018	0.705
LIG_SH3_3	457	463	PF00018	0.717
LIG_SH3_3	713	719	PF00018	0.620
LIG_TRAF2_1	114	117	PF00917	0.719
LIG_TRAF2_1	405	408	PF00917	0.664
LIG_TRAF2_1	430	433	PF00917	0.673
LIG_TRAF2_1	434	437	PF00917	0.642
LIG_TRAF2_1	596	599	PF00917	0.642
LIG_WRC_WIRS_1	375	380	PF05994	0.666
LIG_WW_1	550	553	PF00397	0.539
LIG_WW_3	453	457	PF00397	0.754
MOD_CDC14_SPxK_1	453	456	PF00782	0.682
MOD_CDK_SPK_2	105	110	PF00069	0.630
MOD_CDK_SPxK_1	450	456	PF00069	0.683
MOD_CDK_SPxxK_3	197	204	PF00069	0.698
MOD_CK1_1	108	114	PF00069	0.664
MOD_CK1_1	138	144	PF00069	0.664
MOD_CK1_1	17	23	PF00069	0.767
MOD_CK1_1	177	183	PF00069	0.691
MOD_CK1_1	187	193	PF00069	0.500
MOD_CK1_1	200	206	PF00069	0.593
MOD_CK1_1	299	305	PF00069	0.628
MOD_CK1_1	348	354	PF00069	0.749
MOD_CK1_1	379	385	PF00069	0.727
MOD_CK1_1	461	467	PF00069	0.635
MOD_CK1_1	641	647	PF00069	0.657
MOD_CK1_1	691	697	PF00069	0.645
MOD_CK1_1	79	85	PF00069	0.707
MOD_CK1_1	9	15	PF00069	0.733
MOD_CK2_1	402	408	PF00069	0.703
MOD_CK2_1	459	465	PF00069	0.582
MOD_CK2_1	696	702	PF00069	0.674
MOD_CK2_1	741	747	PF00069	0.582
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.634
MOD_DYRK1A_RPxSP_1	542	546	PF00069	0.686
MOD_GlcNHglycan	110	113	PF01048	0.710
MOD_GlcNHglycan	116	120	PF01048	0.681
MOD_GlcNHglycan	148	151	PF01048	0.608
MOD_GlcNHglycan	208	211	PF01048	0.659
MOD_GlcNHglycan	218	221	PF01048	0.548
MOD_GlcNHglycan	297	301	PF01048	0.643
MOD_GlcNHglycan	317	320	PF01048	0.665
MOD_GlcNHglycan	338	341	PF01048	0.717
MOD_GlcNHglycan	347	350	PF01048	0.701
MOD_GlcNHglycan	363	366	PF01048	0.580
MOD_GlcNHglycan	419	422	PF01048	0.648
MOD_GlcNHglycan	514	517	PF01048	0.588
MOD_GlcNHglycan	519	522	PF01048	0.589
MOD_GlcNHglycan	524	527	PF01048	0.589
MOD_GlcNHglycan	563	566	PF01048	0.651
MOD_GlcNHglycan	585	588	PF01048	0.592
MOD_GlcNHglycan	606	609	PF01048	0.594
MOD_GlcNHglycan	64	67	PF01048	0.660
MOD_GlcNHglycan	640	643	PF01048	0.709
MOD_GlcNHglycan	660	663	PF01048	0.487
MOD_GlcNHglycan	675	678	PF01048	0.535
MOD_GlcNHglycan	680	683	PF01048	0.500
MOD_GlcNHglycan	693	696	PF01048	0.538
MOD_GlcNHglycan	72	75	PF01048	0.612
MOD_GlcNHglycan	738	741	PF01048	0.550
MOD_GSK3_1	135	142	PF00069	0.721
MOD_GSK3_1	174	181	PF00069	0.697
MOD_GSK3_1	200	207	PF00069	0.646
MOD_GSK3_1	315	322	PF00069	0.688
MOD_GSK3_1	357	364	PF00069	0.686
MOD_GSK3_1	374	381	PF00069	0.583
MOD_GSK3_1	4	11	PF00069	0.640
MOD_GSK3_1	41	48	PF00069	0.590
MOD_GSK3_1	438	445	PF00069	0.840
MOD_GSK3_1	517	524	PF00069	0.615
MOD_GSK3_1	529	536	PF00069	0.563
MOD_GSK3_1	538	545	PF00069	0.642
MOD_GSK3_1	573	580	PF00069	0.661
MOD_GSK3_1	644	651	PF00069	0.707
MOD_GSK3_1	684	691	PF00069	0.656
MOD_GSK3_1	718	725	PF00069	0.672
MOD_GSK3_1	76	83	PF00069	0.792
MOD_N-GLC_1	658	663	PF02516	0.662
MOD_NEK2_1	186	191	PF00069	0.804
MOD_NEK2_1	266	271	PF00069	0.523
MOD_NEK2_1	285	290	PF00069	0.643
MOD_NEK2_1	378	383	PF00069	0.713
MOD_NEK2_1	64	69	PF00069	0.609
MOD_NEK2_1	658	663	PF00069	0.623
MOD_NEK2_2	438	443	PF00069	0.687
MOD_PIKK_1	180	186	PF00454	0.632
MOD_PIKK_1	285	291	PF00454	0.567
MOD_PIKK_1	4	10	PF00454	0.679
MOD_PIKK_1	80	86	PF00454	0.658
MOD_PK_1	357	363	PF00069	0.600
MOD_PK_1	76	82	PF00069	0.711
MOD_PKA_1	4	10	PF00069	0.690
MOD_PKA_2	213	219	PF00069	0.606
MOD_PKA_2	227	233	PF00069	0.568
MOD_PKA_2	356	362	PF00069	0.611
MOD_PKA_2	4	10	PF00069	0.727
MOD_PKA_2	442	448	PF00069	0.672
MOD_PKA_2	62	68	PF00069	0.605
MOD_PKA_2	696	702	PF00069	0.597
MOD_PKB_1	2	10	PF00069	0.660
MOD_PKB_1	343	351	PF00069	0.656
MOD_Plk_1	17	23	PF00069	0.725
MOD_Plk_1	266	272	PF00069	0.525
MOD_Plk_1	296	302	PF00069	0.625
MOD_Plk_1	629	635	PF00069	0.550
MOD_Plk_1	722	728	PF00069	0.679
MOD_Plk_1	734	740	PF00069	0.565
MOD_Plk_4	174	180	PF00069	0.671
MOD_Plk_4	722	728	PF00069	0.693
MOD_ProDKin_1	102	108	PF00069	0.574
MOD_ProDKin_1	126	132	PF00069	0.726
MOD_ProDKin_1	178	184	PF00069	0.666
MOD_ProDKin_1	187	193	PF00069	0.517
MOD_ProDKin_1	197	203	PF00069	0.636
MOD_ProDKin_1	204	210	PF00069	0.538
MOD_ProDKin_1	319	325	PF00069	0.660
MOD_ProDKin_1	333	339	PF00069	0.574
MOD_ProDKin_1	393	399	PF00069	0.618
MOD_ProDKin_1	450	456	PF00069	0.735
MOD_ProDKin_1	459	465	PF00069	0.692
MOD_ProDKin_1	529	535	PF00069	0.650
MOD_ProDKin_1	542	548	PF00069	0.557
MOD_ProDKin_1	579	585	PF00069	0.655
MOD_ProDKin_1	644	650	PF00069	0.706
MOD_ProDKin_1	87	93	PF00069	0.665
MOD_SUMO_rev_2	504	512	PF00179	0.452
MOD_SUMO_rev_2	586	596	PF00179	0.644
TRG_DiLeu_BaEn_3	482	488	PF01217	0.545
TRG_DiLeu_BaEn_4	328	334	PF01217	0.661
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.696
TRG_ER_diArg_1	1	4	PF00400	0.656
TRG_ER_diArg_1	211	214	PF00400	0.656
TRG_ER_diArg_1	293	295	PF00400	0.622
TRG_ER_diArg_1	342	345	PF00400	0.694
TRG_ER_diArg_1	601	603	PF00400	0.654
TRG_ER_diArg_1	85	88	PF00400	0.847
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLT1	Leishmania braziliensis	56%	100%
A4I990	Leishmania infantum	100%	100%
E9B457	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3W8	Leishmania major	83%	99%