Rhodanese-like domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ4_LEIDO

TriTrypDb:

LdBPK_351180.1 , LdCL_350016600 , LDHU3_35.1550

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004792	thiosulfate sulfurtransferase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.639
CLV_C14_Caspase3-7	193	197	PF00656	0.670
CLV_C14_Caspase3-7	293	297	PF00656	0.671
CLV_C14_Caspase3-7	580	584	PF00656	0.576
CLV_NRD_NRD_1	240	242	PF00675	0.459
CLV_NRD_NRD_1	435	437	PF00675	0.516
CLV_NRD_NRD_1	449	451	PF00675	0.505
CLV_NRD_NRD_1	542	544	PF00675	0.686
CLV_NRD_NRD_1	607	609	PF00675	0.772
CLV_NRD_NRD_1	76	78	PF00675	0.759
CLV_PCSK_FUR_1	540	544	PF00082	0.631
CLV_PCSK_KEX2_1	240	242	PF00082	0.484
CLV_PCSK_KEX2_1	435	437	PF00082	0.516
CLV_PCSK_KEX2_1	449	451	PF00082	0.505
CLV_PCSK_KEX2_1	542	544	PF00082	0.686
CLV_PCSK_KEX2_1	607	609	PF00082	0.772
CLV_PCSK_KEX2_1	76	78	PF00082	0.748
CLV_PCSK_SKI1_1	323	327	PF00082	0.437
CLV_PCSK_SKI1_1	450	454	PF00082	0.559
CLV_PCSK_SKI1_1	76	80	PF00082	0.640
DEG_Nend_Nbox_1	1	3	PF02207	0.710
DEG_SCF_TRCP1_1	296	302	PF00400	0.523
DEG_SPOP_SBC_1	145	149	PF00917	0.708
DEG_SPOP_SBC_1	168	172	PF00917	0.679
DEG_SPOP_SBC_1	180	184	PF00917	0.512
DEG_SPOP_SBC_1	300	304	PF00917	0.656
DOC_MAPK_gen_1	384	392	PF00069	0.496
DOC_MAPK_MEF2A_6	563	572	PF00069	0.633
DOC_PP2B_LxvP_1	511	514	PF13499	0.590
DOC_PP4_FxxP_1	382	385	PF00568	0.473
DOC_USP7_MATH_1	12	16	PF00917	0.674
DOC_USP7_MATH_1	145	149	PF00917	0.742
DOC_USP7_MATH_1	168	172	PF00917	0.743
DOC_USP7_MATH_1	179	183	PF00917	0.542
DOC_USP7_MATH_1	533	537	PF00917	0.762
DOC_USP7_MATH_1	7	11	PF00917	0.696
DOC_USP7_MATH_1	84	88	PF00917	0.769
DOC_USP7_UBL2_3	248	252	PF12436	0.452
DOC_USP7_UBL2_3	37	41	PF12436	0.672
DOC_USP7_UBL2_3	502	506	PF12436	0.589
DOC_WW_Pin1_4	170	175	PF00397	0.788
DOC_WW_Pin1_4	24	29	PF00397	0.685
DOC_WW_Pin1_4	260	265	PF00397	0.490
DOC_WW_Pin1_4	369	374	PF00397	0.463
DOC_WW_Pin1_4	483	488	PF00397	0.600
DOC_WW_Pin1_4	591	596	PF00397	0.703
DOC_WW_Pin1_4	597	602	PF00397	0.734
LIG_14-3-3_CanoR_1	111	116	PF00244	0.658
LIG_14-3-3_CanoR_1	449	455	PF00244	0.585
LIG_14-3-3_CanoR_1	567	573	PF00244	0.672
LIG_14-3-3_CanoR_1	70	78	PF00244	0.683
LIG_14-3-3_CanoR_1	91	97	PF00244	0.699
LIG_Actin_WH2_2	271	289	PF00022	0.528
LIG_BRCT_BRCA1_1	147	151	PF00533	0.722
LIG_eIF4E_1	397	403	PF01652	0.471
LIG_FHA_1	183	189	PF00498	0.639
LIG_FHA_1	261	267	PF00498	0.590
LIG_FHA_1	38	44	PF00498	0.727
LIG_FHA_1	506	512	PF00498	0.500
LIG_FHA_1	539	545	PF00498	0.662
LIG_FHA_1	548	554	PF00498	0.610
LIG_FHA_1	597	603	PF00498	0.696
LIG_FHA_1	80	86	PF00498	0.741
LIG_FHA_2	182	188	PF00498	0.779
LIG_FHA_2	191	197	PF00498	0.670
LIG_FHA_2	212	218	PF00498	0.639
LIG_FHA_2	244	250	PF00498	0.545
LIG_FHA_2	263	269	PF00498	0.330
LIG_FHA_2	300	306	PF00498	0.549
LIG_FHA_2	327	333	PF00498	0.477
LIG_FHA_2	342	348	PF00498	0.413
LIG_FHA_2	370	376	PF00498	0.463
LIG_FHA_2	555	561	PF00498	0.611
LIG_FHA_2	578	584	PF00498	0.632
LIG_LIR_Apic_2	202	208	PF02991	0.653
LIG_LIR_Apic_2	209	213	PF02991	0.607
LIG_LIR_Apic_2	379	385	PF02991	0.472
LIG_LIR_Gen_1	265	275	PF02991	0.430
LIG_LIR_Gen_1	334	345	PF02991	0.316
LIG_LIR_Gen_1	364	373	PF02991	0.471
LIG_LIR_Gen_1	467	476	PF02991	0.488
LIG_LIR_Nem_3	265	270	PF02991	0.531
LIG_LIR_Nem_3	334	340	PF02991	0.316
LIG_LIR_Nem_3	349	354	PF02991	0.467
LIG_LIR_Nem_3	364	369	PF02991	0.471
LIG_LIR_Nem_3	409	413	PF02991	0.471
LIG_LIR_Nem_3	467	471	PF02991	0.496
LIG_LIR_Nem_3	499	504	PF02991	0.508
LIG_PCNA_yPIPBox_3	428	438	PF02747	0.472
LIG_Pex14_1	426	430	PF04695	0.538
LIG_Rb_LxCxE_1	87	108	PF01857	0.623
LIG_SH2_CRK	430	434	PF00017	0.488
LIG_SH2_CRK	501	505	PF00017	0.507
LIG_SH2_NCK_1	205	209	PF00017	0.544
LIG_SH2_SRC	333	336	PF00017	0.459
LIG_SH2_STAT5	394	397	PF00017	0.471
LIG_SH2_STAT5	413	416	PF00017	0.471
LIG_SH2_STAT5	479	482	PF00017	0.642
LIG_SH3_1	205	211	PF00018	0.536
LIG_SH3_1	598	604	PF00018	0.732
LIG_SH3_3	205	211	PF00018	0.648
LIG_SH3_3	267	273	PF00018	0.497
LIG_SH3_3	511	517	PF00018	0.583
LIG_SH3_3	598	604	PF00018	0.751
LIG_TRAF2_1	130	133	PF00917	0.654
LIG_TRAF2_1	319	322	PF00917	0.528
LIG_TRAF2_1	372	375	PF00917	0.536
LIG_TRAF2_1	472	475	PF00917	0.488
LIG_TYR_ITSM	263	270	PF00017	0.414
LIG_UBA3_1	407	415	PF00899	0.536
LIG_WRC_WIRS_1	451	456	PF05994	0.575
LIG_WW_3	604	608	PF00397	0.765
MOD_CDC14_SPxK_1	486	489	PF00782	0.613
MOD_CDK_SPK_2	24	29	PF00069	0.685
MOD_CDK_SPxK_1	483	489	PF00069	0.617
MOD_CDK_SPxxK_3	170	177	PF00069	0.679
MOD_CDK_SPxxK_3	591	598	PF00069	0.734
MOD_CDK_SPxxK_3	600	607	PF00069	0.705
MOD_CK1_1	114	120	PF00069	0.693
MOD_CK1_1	147	153	PF00069	0.588
MOD_CK1_1	182	188	PF00069	0.622
MOD_CK1_1	527	533	PF00069	0.672
MOD_CK1_1	536	542	PF00069	0.658
MOD_CK1_1	600	606	PF00069	0.815
MOD_CK1_1	98	104	PF00069	0.699
MOD_CK2_1	243	249	PF00069	0.616
MOD_CK2_1	262	268	PF00069	0.354
MOD_CK2_1	299	305	PF00069	0.610
MOD_CK2_1	316	322	PF00069	0.331
MOD_CK2_1	326	332	PF00069	0.431
MOD_CK2_1	341	347	PF00069	0.432
MOD_CK2_1	369	375	PF00069	0.488
MOD_CK2_1	441	447	PF00069	0.544
MOD_CK2_1	570	576	PF00069	0.525
MOD_CK2_1	98	104	PF00069	0.685
MOD_Cter_Amidation	35	38	PF01082	0.596
MOD_GlcNHglycan	10	13	PF01048	0.718
MOD_GlcNHglycan	158	161	PF01048	0.720
MOD_GlcNHglycan	164	167	PF01048	0.693
MOD_GlcNHglycan	199	204	PF01048	0.690
MOD_GlcNHglycan	296	299	PF01048	0.736
MOD_GlcNHglycan	310	313	PF01048	0.457
MOD_GlcNHglycan	318	321	PF01048	0.583
MOD_GlcNHglycan	443	446	PF01048	0.512
MOD_GlcNHglycan	82	85	PF01048	0.666
MOD_GlcNHglycan	86	89	PF01048	0.605
MOD_GlcNHglycan	97	100	PF01048	0.573
MOD_GSK3_1	1	8	PF00069	0.715
MOD_GSK3_1	20	27	PF00069	0.476
MOD_GSK3_1	229	236	PF00069	0.517
MOD_GSK3_1	256	263	PF00069	0.567
MOD_GSK3_1	577	584	PF00069	0.559
MOD_GSK3_1	596	603	PF00069	0.812
MOD_GSK3_1	80	87	PF00069	0.787
MOD_N-GLC_1	111	116	PF02516	0.660
MOD_N-GLC_1	190	195	PF02516	0.768
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	144	149	PF00069	0.707
MOD_NEK2_1	229	234	PF00069	0.491
MOD_NEK2_1	299	304	PF00069	0.664
MOD_NEK2_1	325	330	PF00069	0.434
MOD_NEK2_1	480	485	PF00069	0.594
MOD_NEK2_1	570	575	PF00069	0.518
MOD_NEK2_1	78	83	PF00069	0.799
MOD_PIKK_1	533	539	PF00454	0.702
MOD_PK_1	111	117	PF00069	0.566
MOD_PKA_1	37	43	PF00069	0.584
MOD_PKA_2	480	486	PF00069	0.605
MOD_PKA_2	69	75	PF00069	0.681
MOD_PKA_2	90	96	PF00069	0.609
MOD_Plk_1	111	117	PF00069	0.633
MOD_Plk_1	190	196	PF00069	0.769
MOD_Plk_1	218	224	PF00069	0.496
MOD_Plk_1	346	352	PF00069	0.471
MOD_Plk_2-3	341	347	PF00069	0.471
MOD_Plk_4	229	235	PF00069	0.458
MOD_Plk_4	262	268	PF00069	0.429
MOD_Plk_4	406	412	PF00069	0.495
MOD_Plk_4	577	583	PF00069	0.597
MOD_ProDKin_1	170	176	PF00069	0.783
MOD_ProDKin_1	24	30	PF00069	0.686
MOD_ProDKin_1	260	266	PF00069	0.493
MOD_ProDKin_1	369	375	PF00069	0.463
MOD_ProDKin_1	483	489	PF00069	0.598
MOD_ProDKin_1	591	597	PF00069	0.705
MOD_ProDKin_1	600	606	PF00069	0.738
MOD_SUMO_for_1	561	564	PF00179	0.577
MOD_SUMO_rev_2	148	158	PF00179	0.714
MOD_SUMO_rev_2	316	325	PF00179	0.527
MOD_SUMO_rev_2	590	600	PF00179	0.736
TRG_DiLeu_BaEn_1	321	326	PF01217	0.469
TRG_DiLeu_BaEn_4	132	138	PF01217	0.596
TRG_DiLeu_BaEn_4	321	327	PF01217	0.555
TRG_ENDOCYTIC_2	267	270	PF00928	0.503
TRG_ENDOCYTIC_2	413	416	PF00928	0.471
TRG_ENDOCYTIC_2	430	433	PF00928	0.462
TRG_ENDOCYTIC_2	501	504	PF00928	0.509
TRG_ER_diArg_1	234	237	PF00400	0.416
TRG_ER_diArg_1	239	241	PF00400	0.447
TRG_ER_diArg_1	434	436	PF00400	0.500
TRG_ER_diArg_1	448	450	PF00400	0.504
TRG_ER_diArg_1	540	543	PF00400	0.694
TRG_ER_diArg_1	606	608	PF00400	0.763
TRG_ER_diArg_1	76	78	PF00400	0.821
TRG_NES_CRM1_1	463	475	PF08389	0.485
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U9	Leptomonas seymouri	73%	100%
A0A0S4IZW5	Bodo saltans	46%	100%
A4HMD8	Leishmania braziliensis	77%	99%
A4IB11	Leishmania infantum	100%	100%
C9ZNL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AEU0	Leishmania major	91%	100%
E9B5Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%