Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ3_LEIDO

TriTrypDb:

LdBPK_302020.1 , LdCL_300025500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.793
CLV_NRD_NRD_1	302	304	PF00675	0.716
CLV_NRD_NRD_1	335	337	PF00675	0.664
CLV_PCSK_FUR_1	333	337	PF00082	0.660
CLV_PCSK_KEX2_1	304	306	PF00082	0.727
CLV_PCSK_KEX2_1	333	335	PF00082	0.666
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.813
CLV_PCSK_PC7_1	329	335	PF00082	0.666
DEG_SCF_FBW7_1	24	30	PF00400	0.645
DEG_SPOP_SBC_1	64	68	PF00917	0.687
DOC_CKS1_1	24	29	PF01111	0.645
DOC_PP2B_LxvP_1	113	116	PF13499	0.512
DOC_PP2B_LxvP_1	96	99	PF13499	0.824
DOC_PP2B_PxIxI_1	77	83	PF00149	0.706
DOC_PP4_FxxP_1	187	190	PF00568	0.674
DOC_USP7_MATH_1	135	139	PF00917	0.786
DOC_USP7_MATH_1	142	146	PF00917	0.776
DOC_USP7_MATH_1	181	185	PF00917	0.707
DOC_USP7_MATH_1	65	69	PF00917	0.686
DOC_WW_Pin1_4	145	150	PF00397	0.810
DOC_WW_Pin1_4	177	182	PF00397	0.665
DOC_WW_Pin1_4	186	191	PF00397	0.644
DOC_WW_Pin1_4	196	201	PF00397	0.740
DOC_WW_Pin1_4	23	28	PF00397	0.644
DOC_WW_Pin1_4	233	238	PF00397	0.791
DOC_WW_Pin1_4	242	247	PF00397	0.659
LIG_14-3-3_CanoR_1	164	169	PF00244	0.816
LIG_14-3-3_CanoR_1	241	246	PF00244	0.678
LIG_14-3-3_CanoR_1	63	71	PF00244	0.687
LIG_BRCT_BRCA1_1	183	187	PF00533	0.665
LIG_eIF4E_1	225	231	PF01652	0.644
LIG_FHA_1	225	231	PF00498	0.762
LIG_FHA_1	253	259	PF00498	0.809
LIG_FHA_1	313	319	PF00498	0.633
LIG_FHA_2	191	197	PF00498	0.827
LIG_FHA_2	259	265	PF00498	0.834
LIG_FHA_2	65	71	PF00498	0.653
LIG_LIR_Apic_2	184	190	PF02991	0.667
LIG_LIR_Nem_3	221	225	PF02991	0.660
LIG_SH2_CRK	86	90	PF00017	0.784
LIG_SH2_SRC	288	291	PF00017	0.826
LIG_SH2_STAT3	108	111	PF00017	0.667
LIG_SH2_STAT3	225	228	PF00017	0.596
LIG_SH3_3	231	237	PF00018	0.794
LIG_SH3_3	320	326	PF00018	0.651
LIG_SH3_3	54	60	PF00018	0.673
LIG_SH3_CIN85_PxpxPR_1	58	63	PF14604	0.673
LIG_SUMO_SIM_anti_2	315	321	PF11976	0.639
LIG_SUMO_SIM_par_1	20	26	PF11976	0.651
LIG_TRAF2_1	261	264	PF00917	0.837
MOD_CK1_1	138	144	PF00069	0.784
MOD_CK1_1	145	151	PF00069	0.768
MOD_CK1_1	159	165	PF00069	0.602
MOD_CK1_1	251	257	PF00069	0.800
MOD_CK2_1	190	196	PF00069	0.827
MOD_CK2_1	258	264	PF00069	0.831
MOD_CK2_1	41	47	PF00069	0.671
MOD_CK2_1	64	70	PF00069	0.687
MOD_CK2_1	97	103	PF00069	0.671
MOD_GlcNHglycan	103	106	PF01048	0.669
MOD_GlcNHglycan	118	121	PF01048	0.565
MOD_GlcNHglycan	140	143	PF01048	0.834
MOD_GlcNHglycan	151	154	PF01048	0.670
MOD_GlcNHglycan	158	161	PF01048	0.537
MOD_GlcNHglycan	43	46	PF01048	0.673
MOD_GlcNHglycan	67	70	PF01048	0.687
MOD_GSK3_1	134	141	PF00069	0.838
MOD_GSK3_1	145	152	PF00069	0.652
MOD_GSK3_1	155	162	PF00069	0.642
MOD_GSK3_1	177	184	PF00069	0.635
MOD_GSK3_1	186	193	PF00069	0.748
MOD_GSK3_1	23	30	PF00069	0.644
MOD_GSK3_1	247	254	PF00069	0.712
MOD_GSK3_1	97	104	PF00069	0.758
MOD_NEK2_1	155	160	PF00069	0.809
MOD_NEK2_1	248	253	PF00069	0.649
MOD_PIKK_1	15	21	PF00454	0.638
MOD_PIKK_1	224	230	PF00454	0.803
MOD_PKA_2	76	82	PF00069	0.665
MOD_Plk_1	162	168	PF00069	0.818
MOD_Plk_1	276	282	PF00069	0.765
MOD_Plk_1	284	290	PF00069	0.765
MOD_Plk_2-3	259	265	PF00069	0.679
MOD_Plk_2-3	284	290	PF00069	0.733
MOD_Plk_4	164	170	PF00069	0.714
MOD_Plk_4	248	254	PF00069	0.639
MOD_Plk_4	97	103	PF00069	0.671
MOD_ProDKin_1	145	151	PF00069	0.814
MOD_ProDKin_1	177	183	PF00069	0.666
MOD_ProDKin_1	186	192	PF00069	0.643
MOD_ProDKin_1	196	202	PF00069	0.740
MOD_ProDKin_1	23	29	PF00069	0.644
MOD_ProDKin_1	233	239	PF00069	0.791
MOD_ProDKin_1	242	248	PF00069	0.660
MOD_SUMO_rev_2	259	269	PF00179	0.835
TRG_DiLeu_BaEn_1	8	13	PF01217	0.647
TRG_ENDOCYTIC_2	86	89	PF00928	0.784
TRG_ER_diArg_1	302	305	PF00400	0.819
TRG_ER_diArg_1	332	335	PF00400	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I5M9	Leishmania infantum	100%	100%
Q4Q792	Leishmania major	79%	78%