Aminomethyltransferase folate-binding domain/Glycine cleavage T-protein C-terminal barrel domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate-binding protein YgfZ, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ2_LEIDO

TriTrypDb:

LdBPK_241810.1 , LdCL_240023700 , LDHU3_24.2220

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A0A3Q8IEZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	2
GO:0006790	sulfur compound metabolic process	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0005488	binding	1	1
GO:0005542	folic acid binding	3	1
GO:0019842	vitamin binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0072341	modified amino acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0004047	aminomethyltransferase activity	5	1
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.650
CLV_C14_Caspase3-7	177	181	PF00656	0.560
CLV_NRD_NRD_1	14	16	PF00675	0.452
CLV_NRD_NRD_1	210	212	PF00675	0.482
CLV_NRD_NRD_1	284	286	PF00675	0.418
CLV_NRD_NRD_1	379	381	PF00675	0.532
CLV_NRD_NRD_1	96	98	PF00675	0.454
CLV_PCSK_KEX2_1	14	16	PF00082	0.452
CLV_PCSK_KEX2_1	210	212	PF00082	0.418
CLV_PCSK_KEX2_1	286	288	PF00082	0.375
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.375
CLV_PCSK_PC7_1	10	16	PF00082	0.469
CLV_PCSK_SKI1_1	14	18	PF00082	0.420
CLV_PCSK_SKI1_1	381	385	PF00082	0.489
DEG_SPOP_SBC_1	169	173	PF00917	0.646
DEG_SPOP_SBC_1	193	197	PF00917	0.622
DOC_ANK_TNKS_1	234	241	PF00023	0.493
DOC_CYCLIN_RxL_1	245	253	PF00134	0.420
DOC_MAPK_DCC_7	354	364	PF00069	0.531
DOC_MAPK_gen_1	285	293	PF00069	0.386
DOC_MAPK_gen_1	354	364	PF00069	0.392
DOC_MAPK_gen_1	95	102	PF00069	0.426
DOC_MAPK_MEF2A_6	285	293	PF00069	0.381
DOC_MAPK_MEF2A_6	357	364	PF00069	0.343
DOC_PP1_RVXF_1	258	265	PF00149	0.391
DOC_PP4_FxxP_1	155	158	PF00568	0.417
DOC_PP4_FxxP_1	164	167	PF00568	0.510
DOC_PP4_FxxP_1	222	225	PF00568	0.398
DOC_USP7_MATH_1	122	126	PF00917	0.694
DOC_USP7_MATH_1	134	138	PF00917	0.607
DOC_USP7_MATH_1	170	174	PF00917	0.763
DOC_USP7_MATH_1	178	182	PF00917	0.740
DOC_USP7_MATH_1	185	189	PF00917	0.688
DOC_USP7_MATH_1	369	373	PF00917	0.466
DOC_USP7_MATH_1	41	45	PF00917	0.366
DOC_USP7_UBL2_3	381	385	PF12436	0.457
DOC_USP7_UBL2_3	95	99	PF12436	0.517
DOC_WW_Pin1_4	137	142	PF00397	0.708
DOC_WW_Pin1_4	194	199	PF00397	0.695
DOC_WW_Pin1_4	200	205	PF00397	0.637
DOC_WW_Pin1_4	221	226	PF00397	0.524
DOC_WW_Pin1_4	365	370	PF00397	0.584
LIG_14-3-3_CanoR_1	135	140	PF00244	0.706
LIG_14-3-3_CanoR_1	150	158	PF00244	0.590
LIG_14-3-3_CanoR_1	285	290	PF00244	0.383
LIG_Actin_WH2_2	335	352	PF00022	0.406
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.523
LIG_BRCT_BRCA1_1	248	252	PF00533	0.424
LIG_EVH1_2	204	208	PF00568	0.425
LIG_FHA_1	227	233	PF00498	0.493
LIG_FHA_1	286	292	PF00498	0.375
LIG_FHA_1	31	37	PF00498	0.382
LIG_FHA_1	313	319	PF00498	0.606
LIG_FHA_1	354	360	PF00498	0.572
LIG_FHA_1	51	57	PF00498	0.357
LIG_FHA_2	112	118	PF00498	0.449
LIG_FHA_2	144	150	PF00498	0.643
LIG_LIR_Apic_2	152	158	PF02991	0.453
LIG_LIR_Apic_2	161	167	PF02991	0.498
LIG_LIR_Apic_2	217	221	PF02991	0.552
LIG_LIR_Gen_1	226	233	PF02991	0.469
LIG_LIR_LC3C_4	108	111	PF02991	0.454
LIG_LIR_Nem_3	226	231	PF02991	0.421
LIG_LIR_Nem_3	44	49	PF02991	0.309
LIG_Pex14_1	218	222	PF04695	0.369
LIG_SH2_CRK	228	232	PF00017	0.535
LIG_SH2_STAP1	228	232	PF00017	0.433
LIG_SH2_STAT3	269	272	PF00017	0.369
LIG_SH2_STAT5	228	231	PF00017	0.451
LIG_SH2_STAT5	269	272	PF00017	0.388
LIG_SH2_STAT5	351	354	PF00017	0.411
LIG_SH2_STAT5	51	54	PF00017	0.454
LIG_SH3_3	138	144	PF00018	0.735
LIG_SH3_3	164	170	PF00018	0.646
LIG_SH3_3	199	205	PF00018	0.670
LIG_SH3_3	295	301	PF00018	0.636
LIG_SH3_3	317	323	PF00018	0.531
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.396
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.428
LIG_SUMO_SIM_par_1	108	114	PF11976	0.339
LIG_SUMO_SIM_par_1	315	322	PF11976	0.567
LIG_SUMO_SIM_par_1	74	81	PF11976	0.437
LIG_TRAF2_1	114	117	PF00917	0.509
LIG_TRAF2_1	146	149	PF00917	0.709
LIG_UBA3_1	346	354	PF00899	0.489
LIG_UBA3_1	87	95	PF00899	0.429
MOD_CK1_1	125	131	PF00069	0.734
MOD_CK1_1	137	143	PF00069	0.694
MOD_CK1_1	171	177	PF00069	0.742
MOD_CK1_1	181	187	PF00069	0.689
MOD_CK2_1	111	117	PF00069	0.480
MOD_CK2_1	143	149	PF00069	0.660
MOD_GlcNHglycan	127	130	PF01048	0.732
MOD_GlcNHglycan	176	179	PF01048	0.734
MOD_GlcNHglycan	187	190	PF01048	0.663
MOD_GlcNHglycan	325	328	PF01048	0.529
MOD_GlcNHglycan	81	85	PF01048	0.455
MOD_GSK3_1	111	118	PF00069	0.389
MOD_GSK3_1	123	130	PF00069	0.689
MOD_GSK3_1	168	175	PF00069	0.621
MOD_GSK3_1	181	188	PF00069	0.561
MOD_GSK3_1	227	234	PF00069	0.501
MOD_GSK3_1	281	288	PF00069	0.416
MOD_GSK3_1	304	311	PF00069	0.633
MOD_GSK3_1	365	372	PF00069	0.551
MOD_N-GLC_1	246	251	PF02516	0.551
MOD_NEK2_1	115	120	PF00069	0.548
MOD_NEK2_1	231	236	PF00069	0.431
MOD_NEK2_1	281	286	PF00069	0.450
MOD_NEK2_1	50	55	PF00069	0.355
MOD_NEK2_2	41	46	PF00069	0.431
MOD_PK_1	135	141	PF00069	0.751
MOD_PKA_1	285	291	PF00069	0.381
MOD_PKA_2	123	129	PF00069	0.730
MOD_PKA_2	134	140	PF00069	0.684
MOD_PKA_2	149	155	PF00069	0.597
MOD_PKA_2	19	25	PF00069	0.455
MOD_Plk_1	115	121	PF00069	0.412
MOD_Plk_1	246	252	PF00069	0.513
MOD_Plk_4	203	209	PF00069	0.526
MOD_Plk_4	227	233	PF00069	0.454
MOD_Plk_4	41	47	PF00069	0.352
MOD_Plk_4	71	77	PF00069	0.429
MOD_ProDKin_1	137	143	PF00069	0.705
MOD_ProDKin_1	194	200	PF00069	0.692
MOD_ProDKin_1	221	227	PF00069	0.518
MOD_ProDKin_1	365	371	PF00069	0.584
MOD_SUMO_rev_2	376	386	PF00179	0.426
MOD_SUMO_rev_2	89	96	PF00179	0.511
TRG_DiLeu_BaEn_1	382	387	PF01217	0.511
TRG_ENDOCYTIC_2	228	231	PF00928	0.394
TRG_ENDOCYTIC_2	46	49	PF00928	0.390
TRG_ER_diArg_1	14	16	PF00400	0.452
TRG_ER_diArg_1	17	20	PF00400	0.456
TRG_ER_diArg_1	209	211	PF00400	0.415
TRG_ER_diArg_1	347	350	PF00400	0.393
TRG_NLS_MonoExtN_4	95	101	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	62%	89%
A0A0S4JL83	Bodo saltans	39%	100%
A0A3R7K245	Trypanosoma rangeli	47%	100%
A2R472	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	88%
A4HDN4	Leishmania braziliensis	77%	100%
A4R8F9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AH81	Leishmania infantum	98%	100%
E9AX19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4P7A4	Ustilago maydis (strain 521 / FGSC 9021)	27%	97%
Q4QAF7	Leishmania major	86%	94%
Q54NS1	Dictyostelium discoideum	26%	96%
Q6C8Y7	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	82%
Q7RYZ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	89%
Q8CAK1	Mus musculus	30%	100%
V5AJ90	Trypanosoma cruzi	47%	100%