LeishMANIAdb
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Thymine-7-hydroxylase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thymine-7-hydroxylase, putative
Gene product:
thymine-7-hydroxylase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IEZ1_LEIDO
TriTrypDb:
LdBPK_290260.1 , LdCL_290007400 , LDHU3_29.0350
Length:
319

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, thymine-7-hydroxylase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0005488 binding 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 5
GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4 5
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0050341 thymine dioxygenase activity 5 5
GO:0051213 dioxygenase activity 3 5
GO:0005506 iron ion binding 6 1
GO:0008198 ferrous iron binding 7 1
GO:0046914 transition metal ion binding 5 1
GO:0003960 NADPH:quinone reductase activity 5 1
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 1
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 4 1
GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor 4 2
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 2
GO:0050162 oxalate oxidase activity 5 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.469
CLV_PCSK_KEX2_1 303 305 PF00082 0.470
CLV_PCSK_PC1ET2_1 303 305 PF00082 0.486
CLV_PCSK_SKI1_1 145 149 PF00082 0.518
DEG_APCC_DBOX_1 144 152 PF00400 0.504
DOC_CDC14_PxL_1 178 186 PF14671 0.496
DOC_CYCLIN_RxL_1 149 159 PF00134 0.590
DOC_MAPK_MEF2A_6 152 160 PF00069 0.472
DOC_PP2B_PxIxI_1 3 9 PF00149 0.570
DOC_PP4_FxxP_1 104 107 PF00568 0.665
DOC_PP4_FxxP_1 169 172 PF00568 0.453
DOC_PP4_FxxP_1 268 271 PF00568 0.411
DOC_PP4_FxxP_1 59 62 PF00568 0.559
DOC_USP7_MATH_1 287 291 PF00917 0.634
DOC_USP7_UBL2_3 53 57 PF12436 0.503
DOC_WW_Pin1_4 248 253 PF00397 0.476
LIG_14-3-3_CanoR_1 247 252 PF00244 0.413
LIG_14-3-3_CanoR_1 262 266 PF00244 0.398
LIG_14-3-3_CanoR_1 304 310 PF00244 0.571
LIG_BRCT_BRCA1_1 263 267 PF00533 0.427
LIG_deltaCOP1_diTrp_1 299 305 PF00928 0.474
LIG_deltaCOP1_diTrp_1 95 100 PF00928 0.665
LIG_EH1_1 198 206 PF00400 0.427
LIG_eIF4E_1 199 205 PF01652 0.427
LIG_FHA_2 125 131 PF00498 0.673
LIG_GBD_Chelix_1 146 154 PF00786 0.543
LIG_Integrin_isoDGR_2 245 247 PF01839 0.469
LIG_LIR_Apic_2 101 107 PF02991 0.665
LIG_LIR_Apic_2 167 172 PF02991 0.463
LIG_LIR_Gen_1 130 140 PF02991 0.545
LIG_LIR_Nem_3 130 135 PF02991 0.575
LIG_LIR_Nem_3 174 179 PF02991 0.442
LIG_LIR_Nem_3 197 202 PF02991 0.420
LIG_LIR_Nem_3 290 295 PF02991 0.626
LIG_LIR_Nem_3 32 38 PF02991 0.570
LIG_LYPXL_yS_3 181 184 PF13949 0.455
LIG_NRBOX 145 151 PF00104 0.559
LIG_Pex14_1 33 37 PF04695 0.569
LIG_Pex14_1 96 100 PF04695 0.665
LIG_Pex14_2 100 104 PF04695 0.665
LIG_Pex14_2 165 169 PF04695 0.454
LIG_PTB_Apo_2 53 60 PF02174 0.556
LIG_REV1ctd_RIR_1 162 171 PF16727 0.525
LIG_SH2_CRK 199 203 PF00017 0.427
LIG_SH2_STAP1 309 313 PF00017 0.685
LIG_SH2_STAT5 232 235 PF00017 0.560
LIG_SH2_STAT5 37 40 PF00017 0.584
LIG_SH3_3 179 185 PF00018 0.473
LIG_SH3_3 87 93 PF00018 0.563
LIG_TRAF2_1 62 65 PF00917 0.570
LIG_TYR_ITIM 179 184 PF00017 0.496
LIG_TYR_ITSM 195 202 PF00017 0.482
MOD_CDK_SPxK_1 248 254 PF00069 0.476
MOD_CK2_1 124 130 PF00069 0.605
MOD_GSK3_1 224 231 PF00069 0.490
MOD_GSK3_1 45 52 PF00069 0.553
MOD_NEK2_1 164 169 PF00069 0.513
MOD_NEK2_1 228 233 PF00069 0.522
MOD_NEK2_1 305 310 PF00069 0.537
MOD_NEK2_1 36 41 PF00069 0.670
MOD_PKA_2 261 267 PF00069 0.461
MOD_Plk_1 273 279 PF00069 0.604
MOD_Plk_2-3 224 230 PF00069 0.490
MOD_Plk_4 109 115 PF00069 0.665
MOD_Plk_4 124 130 PF00069 0.487
MOD_Plk_4 171 177 PF00069 0.454
MOD_Plk_4 200 206 PF00069 0.470
MOD_Plk_4 228 234 PF00069 0.411
MOD_ProDKin_1 248 254 PF00069 0.476
MOD_SUMO_rev_2 290 298 PF00179 0.619
MOD_SUMO_rev_2 314 318 PF00179 0.693
MOD_SUMO_rev_2 89 99 PF00179 0.561
TRG_ENDOCYTIC_2 140 143 PF00928 0.444
TRG_ENDOCYTIC_2 181 184 PF00928 0.454
TRG_ENDOCYTIC_2 199 202 PF00928 0.286
TRG_NES_CRM1_1 144 159 PF08389 0.592
TRG_Pf-PMV_PEXEL_1 254 258 PF00026 0.490

Homologs

Protein Taxonomy Sequence identity Coverage
A0A023GS28 Ruta graveolens 28% 86%
A0A023GS29 Ruta graveolens 27% 86%
A0A0F9ZXE3 Trichoderma harzianum 31% 100%
A0A0S4IPR8 Bodo saltans 37% 81%
A0A0S6XAW4 Fungal sp. (strain No.11243) 25% 95%
A0A0S6XGJ8 Fungal sp. (strain No.11243) 24% 99%
A0A0S6XHQ0 Fungal sp. (strain No.11243) 31% 87%
A0A159BP93 Monascus ruber 35% 97%
A0A166YZY4 Metarhizium rileyi (strain RCEF 4871) 30% 90%
A0A166YZY9 Metarhizium rileyi (strain RCEF 4871) 31% 85%
A0A1X0P0P9 Trypanosomatidae 68% 100%
A0A2R6PI27 Actinidia chinensis var. chinensis 29% 90%
A0A2U8U2L3 Sarocladium schorii 31% 94%
A0A411KUQ7 Acremonium sp. 24% 96%
A0A411L030 Aspergillus burnettii 31% 100%
A0A422MUD1 Trypanosoma rangeli 68% 100%
A0A481WNL2 Penicillium crustosum 34% 94%
A0A481WQ18 Penicillium crustosum 29% 98%
A0A4D6Q440 Crocosmia x crocosmiiflora 30% 96%
A0A4D6Q4T7 Crocosmia x crocosmiiflora 29% 86%
A0A4D6Q9B0 Crocosmia x crocosmiiflora 29% 86%
A0A4P8GG75 Phoma sp. 28% 100%
A0A5C1RDG7 Didymella fabae 34% 96%
A2A1A0 Coptis japonica 29% 91%
A2WQ39 Oryza sativa subsp. indica 31% 85%
A2Z1W9 Oryza sativa subsp. indica 30% 99%
A4HH58 Leishmania braziliensis 87% 100%
A4I478 Leishmania infantum 100% 100%
A6BM06 Dictyostelium mucoroides 30% 87%
B2GVM7 Arabidopsis thaliana 27% 100%
B6HLU0 Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) 32% 96%
B8M9K5 Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) 30% 98%
B8NI22 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 25% 88%
C8VK14 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 37% 91%
C9ZJU4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
C9ZNA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
C9ZUF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
D4N500 Papaver somniferum 28% 88%
D4N501 Papaver somniferum 28% 88%
D4N502 Papaver somniferum 27% 89%
E9ADM7 Leishmania major 95% 100%
E9AM53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AM54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
F4IY03 Arabidopsis thaliana 35% 96%
F4K7D5 Arabidopsis thaliana 25% 100%
F4KAS1 Arabidopsis thaliana 26% 100%
F4KBY0 Arabidopsis thaliana 27% 98%
G9M9M0 Ipomoea batatas 30% 89%
G9M9M1 Ipomoea batatas 30% 89%
G9M9M2 Ipomoea batatas 30% 89%
G9M9M3 Ipomoea batatas 28% 89%
G9M9M4 Ipomoea batatas 29% 89%
G9M9M5 Ipomoea batatas 29% 89%
I1R9B5 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 29% 84%
I1RV21 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 24% 96%
K0DZA0 Aspergillus rugulosus 27% 97%
K0E3U5 Aspergillus rugulosus 27% 96%
L0E2Q1 Penicillium fellutanum 24% 90%
O04274 Perilla frutescens 27% 88%
O04395 Matthiola incana 25% 100%
O04705 Triticum aestivum 31% 88%
O04706 Triticum aestivum 30% 87%
O04707 Triticum aestivum 30% 87%
O04847 Catharanthus roseus 25% 80%
O24648 Pisum sativum 28% 85%
O48882 Malus domestica 29% 97%
O49561 Arabidopsis thaliana 31% 94%
O64692 Arabidopsis thaliana 30% 95%
O65378 Arabidopsis thaliana 29% 100%
O80449 Arabidopsis thaliana 28% 90%
P05116 Solanum lycopersicum 30% 100%
P05189 Acremonium chrysogenum 33% 94%
P05326 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 96%
P07920 Solanum lycopersicum 28% 100%
P08703 Penicillium chrysogenum 32% 96%
P0C5H5 Oryza sativa subsp. indica 34% 82%
P10621 Streptomyces clavuligerus 34% 97%
P10967 Solanum lycopersicum 27% 88%
P11935 Acremonium chrysogenum 24% 96%
P12438 Streptomyces microflavus 31% 96%
P16020 Flavobacterium sp. (strain SC 12,154) 31% 98%
P18286 Streptomyces jumonjinensis 30% 97%
P19464 Persea americana 27% 100%
P24157 Solanum lycopersicum 29% 100%
P24397 Hyoscyamus niger 23% 93%
P27744 Amycolatopsis lactamdurans 32% 97%
P28038 Hordeum vulgare 29% 85%
P31237 Actinidia deliciosa 27% 100%
P31238 Doritaenopsis sp. 27% 98%
P31239 Pisum sativum 26% 100%
P31528 Dianthus caryophyllus 28% 99%
P32021 Pseudomonas savastanoi pv. phaseolicola 26% 91%
P41090 Vitis vinifera 31% 88%
P41213 Zea mays 29% 81%
P42219 Amycolatopsis lactamdurans 25% 100%
P51091 Malus domestica 30% 89%
P51092 Petunia hybrida 28% 74%
P51093 Vitis vinifera 27% 88%
P54847 Cucumis melo 27% 100%
P93771 Oryza sativa subsp. japonica 29% 86%
P93821 Arabidopsis thaliana 26% 92%
P93824 Arabidopsis thaliana 24% 89%
Q00985 Malus domestica 28% 100%
Q01IX6 Oryza sativa subsp. indica 26% 100%
Q03047 Amycolatopsis lactamdurans 24% 100%
Q04644 Cucumis melo 29% 100%
Q05963 Callistephus chinensis 30% 90%
Q05964 Dianthus caryophyllus 31% 87%
Q05965 Matthiola incana 31% 89%
Q06588 Arabidopsis thaliana 30% 99%
Q06942 Malus domestica 30% 88%
Q07353 Petunia hybrida 30% 86%
Q07512 Petunia hybrida 30% 92%
Q08506 Petunia hybrida 28% 100%
Q08507 Petunia hybrida 28% 100%
Q08508 Petunia hybrida 29% 100%
Q09052 Brassica juncea 30% 100%
Q0J1C1 Oryza sativa subsp. japonica 30% 99%
Q0JH50 Oryza sativa subsp. japonica 34% 82%
Q0WPW4 Arabidopsis thaliana 27% 100%
Q15JG7 Streptomyces hygroscopicus subsp. limoneus 27% 87%
Q1ERI0 Monascus purpureus 35% 97%
Q39103 Arabidopsis thaliana 28% 89%
Q39110 Arabidopsis thaliana 29% 85%
Q39111 Arabidopsis thaliana 27% 84%
Q39112 Arabidopsis thaliana 27% 84%
Q39224 Arabidopsis thaliana 29% 89%
Q39705 Doritaenopsis sp. 28% 98%
Q3I409 Triticum aestivum 26% 86%
Q3I410 Triticum aestivum 25% 86%
Q3I411 Triticum aestivum 26% 86%
Q40061 Hordeum vulgare 22% 94%
Q40062 Hordeum vulgare 24% 94%
Q41452 Solanum tuberosum 29% 91%
Q41931 Arabidopsis thaliana 30% 100%
Q43383 Arabidopsis thaliana 26% 80%
Q43792 Nicotiana tabacum 29% 100%
Q48739 Lysobacter lactamgenus 31% 98%
Q4PT02 Arabidopsis thaliana 29% 83%
Q4W946 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 34% 95%
Q53932 Streptomyces cattleya 25% 99%
Q54243 Streptomyces griseus 32% 97%
Q54RA4 Dictyostelium discoideum 37% 88%
Q5MNH6 Epichloe uncinata 23% 88%
Q5MNI4 Epichloe uncinata 24% 88%
Q651B6 Oryza sativa subsp. japonica 28% 84%
Q67VR7 Oryza sativa subsp. japonica 30% 86%
Q69LD8 Oryza sativa subsp. japonica 30% 87%
Q6AT12 Oryza sativa subsp. japonica 29% 83%
Q6K332 Oryza sativa subsp. japonica 36% 97%
Q6YYX9 Oryza sativa subsp. japonica 30% 83%
Q6Z244 Oryza sativa subsp. japonica 28% 95%
Q76NT9 Dictyostelium discoideum 30% 87%
Q7BS31 Pseudomonas cannabina 26% 91%
Q7BS32 Pseudomonas savastanoi pv. glycinea 26% 91%
Q7LL04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 99%
Q7XKU5 Oryza sativa subsp. japonica 26% 100%
Q7XM21 Oryza sativa subsp. japonica 30% 85%
Q7XP65 Oryza sativa subsp. japonica 27% 89%
Q7XR83 Oryza sativa subsp. japonica 24% 96%
Q7XR84 Oryza sativa subsp. japonica 26% 98%
Q7XZQ6 Petroselinum crispum 30% 95%
Q7XZQ7 Petroselinum crispum 32% 87%
Q7XZQ8 Petroselinum crispum 30% 87%
Q84MB3 Arabidopsis thaliana 25% 87%
Q84MB6 Arabidopsis thaliana 36% 96%
Q84TC2 Zea mays 24% 85%
Q8H113 Arabidopsis thaliana 37% 89%
Q8H1S4 Arabidopsis thaliana 24% 86%
Q8LEA2 Arabidopsis thaliana 25% 97%
Q8LGZ9 Oryza sativa subsp. japonica 31% 94%
Q8S0S6 Oryza sativa subsp. japonica 26% 98%
Q8S932 Diospyros kaki 28% 100%
Q8W2X5 Oryza sativa subsp. japonica 29% 93%
Q8XPV7 Ralstonia solanacearum (strain GMI1000) 27% 92%
Q93VC3 Oryza sativa subsp. japonica 31% 85%
Q94A78 Arabidopsis thaliana 27% 91%
Q94LP4 Oryza sativa subsp. japonica 27% 89%
Q96323 Arabidopsis thaliana 29% 90%
Q96330 Arabidopsis thaliana 30% 95%
Q9C5K7 Arabidopsis thaliana 24% 86%
Q9C6I4 Arabidopsis thaliana 31% 95%
Q9C7Z1 Arabidopsis thaliana 27% 99%
Q9C899 Arabidopsis thaliana 31% 88%
Q9C955 Arabidopsis thaliana 27% 85%
Q9C971 Arabidopsis thaliana 26% 90%
Q9FFF6 Arabidopsis thaliana 28% 86%
Q9FFQ4 Arabidopsis thaliana 27% 98%
Q9FFQ5 Arabidopsis thaliana 29% 100%
Q9FLV0 Arabidopsis thaliana 24% 94%
Q9FR99 Musa acuminata 29% 100%
Q9FU53 Oryza sativa subsp. japonica 28% 86%
Q9FZ21 Arabidopsis thaliana 26% 97%
Q9LE86 Arabidopsis thaliana 28% 89%
Q9LHN8 Arabidopsis thaliana 30% 88%
Q9LSW6 Arabidopsis thaliana 26% 88%
Q9LSW7 Arabidopsis thaliana 25% 87%
Q9LTH7 Arabidopsis thaliana 25% 87%
Q9LTH8 Arabidopsis thaliana 26% 88%
Q9LY48 Arabidopsis thaliana 27% 88%
Q9M2C4 Arabidopsis thaliana 26% 86%
Q9M547 Eustoma exaltatum subsp. russellianum 31% 96%
Q9MB94 Prunus mume 26% 100%
Q9S818 Arabidopsis thaliana 30% 89%
Q9SKK4 Arabidopsis thaliana 24% 89%
Q9SQ80 Pisum sativum 30% 98%
Q9SRM3 Arabidopsis thaliana 27% 80%
Q9SVS8 Arabidopsis thaliana 27% 91%
Q9XFR9 Arabidopsis thaliana 28% 94%
Q9XG83 Phaseolus coccineus 28% 96%
Q9XHG2 Malus domestica 27% 95%
Q9XHM5 Pisum sativum 24% 92%
Q9Z377 Pseudomonas amygdali pv. sesami 26% 91%
Q9Z3T0 Pseudomonas syringae pv. pisi 26% 95%
Q9ZQZ1 Dendrobium crumenatum 31% 100%
Q9ZSA7 Arabidopsis thaliana 26% 92%
Q9ZSA8 Arabidopsis thaliana 27% 91%
Q9ZT84 Arabidopsis thaliana 28% 92%
Q9ZUN4 Arabidopsis thaliana 28% 100%
Q9ZWQ9 Citrus unshiu 30% 95%
S3D784 Glarea lozoyensis (strain ATCC 20868 / MF5171) 29% 97%
S3D9F9 Glarea lozoyensis (strain ATCC 20868 / MF5171) 27% 96%
S3DB70 Glarea lozoyensis (strain ATCC 20868 / MF5171) 25% 99%
S3E7Q2 Glarea lozoyensis (strain ATCC 20868 / MF5171) 24% 97%
V5BKB3 Trypanosoma cruzi 68% 100%
W5QJZ5 Ruta graveolens 28% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS