Suppressor of G2 allele of SKP1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Suppressor of G2 allele of SKP1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEZ0_LEIDO

TriTrypDb:

LdBPK_201610.1 , LdCL_200020900 , LDHU3_20.1980

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051087	protein-folding chaperone binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.354
CLV_NRD_NRD_1	98	100	PF00675	0.841
CLV_PCSK_KEX2_1	171	173	PF00082	0.365
CLV_PCSK_SKI1_1	124	128	PF00082	0.738
CLV_PCSK_SKI1_1	176	180	PF00082	0.379
CLV_PCSK_SKI1_1	39	43	PF00082	0.428
CLV_PCSK_SKI1_1	78	82	PF00082	0.400
DOC_MAPK_gen_1	132	141	PF00069	0.433
DOC_MAPK_gen_1	28	37	PF00069	0.565
DOC_MAPK_gen_1	78	86	PF00069	0.565
DOC_MAPK_HePTP_8	36	48	PF00069	0.592
DOC_MAPK_MEF2A_6	134	143	PF00069	0.638
DOC_MAPK_MEF2A_6	39	48	PF00069	0.586
DOC_MAPK_MEF2A_6	78	86	PF00069	0.571
LIG_14-3-3_CanoR_1	99	108	PF00244	0.722
LIG_BIR_III_2	146	150	PF00653	0.638
LIG_FHA_1	22	28	PF00498	0.501
LIG_FHA_1	5	11	PF00498	0.753
LIG_FHA_2	120	126	PF00498	0.713
LIG_FHA_2	186	192	PF00498	0.563
LIG_FHA_2	29	35	PF00498	0.635
LIG_FHA_2	40	46	PF00498	0.592
LIG_Integrin_isoDGR_2	53	55	PF01839	0.415
LIG_LIR_Gen_1	13	23	PF02991	0.650
LIG_LIR_Gen_1	135	143	PF02991	0.597
LIG_LIR_Gen_1	187	198	PF02991	0.554
LIG_LIR_Gen_1	62	73	PF02991	0.619
LIG_LIR_Nem_3	13	18	PF02991	0.591
LIG_LIR_Nem_3	135	139	PF02991	0.579
LIG_LIR_Nem_3	187	193	PF02991	0.554
LIG_LIR_Nem_3	58	64	PF02991	0.565
LIG_SH2_CRK	61	65	PF00017	0.576
LIG_SH2_STAP1	57	61	PF00017	0.631
LIG_SH2_STAT5	26	29	PF00017	0.554
LIG_SH3_3	104	110	PF00018	0.777
LIG_WRC_WIRS_1	175	180	PF05994	0.554
MOD_CK1_1	181	187	PF00069	0.563
MOD_CK2_1	174	180	PF00069	0.554
MOD_CK2_1	207	213	PF00069	0.578
MOD_CK2_1	39	45	PF00069	0.601
MOD_GlcNHglycan	101	104	PF01048	0.741
MOD_GlcNHglycan	135	139	PF01048	0.401
MOD_GlcNHglycan	180	183	PF01048	0.450
MOD_GSK3_1	174	181	PF00069	0.554
MOD_GSK3_1	35	42	PF00069	0.576
MOD_NEK2_1	174	179	PF00069	0.554
MOD_NEK2_2	73	78	PF00069	0.580
MOD_PKA_1	99	105	PF00069	0.799
MOD_Plk_1	134	140	PF00069	0.594
MOD_Plk_1	28	34	PF00069	0.603
MOD_Plk_1	82	88	PF00069	0.579
MOD_Plk_2-3	207	213	PF00069	0.650
MOD_Plk_4	181	187	PF00069	0.570
MOD_SUMO_for_1	139	142	PF00179	0.601
MOD_SUMO_for_1	147	150	PF00179	0.554
MOD_SUMO_for_1	80	83	PF00179	0.579
MOD_SUMO_rev_2	142	149	PF00179	0.565
TRG_ENDOCYTIC_2	15	18	PF00928	0.650
TRG_ENDOCYTIC_2	61	64	PF00928	0.576
TRG_NLS_MonoCore_2	193	198	PF00514	0.638
TRG_NLS_MonoExtC_3	193	199	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR6	Leptomonas seymouri	71%	98%
A0A0S4JRF8	Bodo saltans	56%	73%
A0A1X0NW51	Trypanosomatidae	57%	96%
A0A3R7M4C8	Trypanosoma rangeli	55%	99%
A4HYZ4	Leishmania infantum	99%	100%
C9ZIN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
E9AIL2	Leishmania braziliensis	89%	100%
E9AUU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCN8	Leishmania major	95%	100%
V5BCX0	Trypanosoma cruzi	55%	99%