AMP-binding enzyme/AMP-binding enzyme C-terminal domain/Ankyrin repeat/Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme/Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEY8_LEIDO

TriTrypDb:

LdBPK_282190.1 , LdCL_280027000 , LDHU3_28.2970

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEY8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019748	secondary metabolic process	2	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043038	amino acid activation	4	1
GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0044550	secondary metabolite biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0019842	vitamin binding	3	1
GO:0031177	phosphopantetheine binding	3	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0072341	modified amino acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.479
CLV_C14_Caspase3-7	613	617	PF00656	0.533
CLV_C14_Caspase3-7	621	625	PF00656	0.529
CLV_NRD_NRD_1	159	161	PF00675	0.321
CLV_NRD_NRD_1	492	494	PF00675	0.300
CLV_NRD_NRD_1	579	581	PF00675	0.430
CLV_NRD_NRD_1	785	787	PF00675	0.549
CLV_NRD_NRD_1	82	84	PF00675	0.418
CLV_NRD_NRD_1	847	849	PF00675	0.449
CLV_NRD_NRD_1	91	93	PF00675	0.472
CLV_NRD_NRD_1	946	948	PF00675	0.607
CLV_NRD_NRD_1	960	962	PF00675	0.571
CLV_NRD_NRD_1	976	978	PF00675	0.503
CLV_PCSK_FUR_1	490	494	PF00082	0.376
CLV_PCSK_FUR_1	984	988	PF00082	0.551
CLV_PCSK_KEX2_1	158	160	PF00082	0.318
CLV_PCSK_KEX2_1	492	494	PF00082	0.300
CLV_PCSK_KEX2_1	579	581	PF00082	0.430
CLV_PCSK_KEX2_1	70	72	PF00082	0.504
CLV_PCSK_KEX2_1	785	787	PF00082	0.549
CLV_PCSK_KEX2_1	81	83	PF00082	0.373
CLV_PCSK_KEX2_1	847	849	PF00082	0.449
CLV_PCSK_KEX2_1	91	93	PF00082	0.534
CLV_PCSK_KEX2_1	944	946	PF00082	0.643
CLV_PCSK_KEX2_1	976	978	PF00082	0.663
CLV_PCSK_KEX2_1	986	988	PF00082	0.524
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.504
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.373
CLV_PCSK_PC1ET2_1	944	946	PF00082	0.708
CLV_PCSK_PC1ET2_1	986	988	PF00082	0.603
CLV_PCSK_PC7_1	154	160	PF00082	0.472
CLV_PCSK_SKI1_1	242	246	PF00082	0.376
CLV_PCSK_SKI1_1	338	342	PF00082	0.333
CLV_PCSK_SKI1_1	503	507	PF00082	0.455
CLV_PCSK_SKI1_1	580	584	PF00082	0.436
CLV_PCSK_SKI1_1	83	87	PF00082	0.441
CLV_PCSK_SKI1_1	847	851	PF00082	0.359
DEG_APCC_DBOX_1	356	364	PF00400	0.336
DEG_APCC_DBOX_1	502	510	PF00400	0.451
DEG_APCC_DBOX_1	773	781	PF00400	0.406
DOC_CKS1_1	278	283	PF01111	0.360
DOC_CKS1_1	311	316	PF01111	0.300
DOC_CKS1_1	591	596	PF01111	0.570
DOC_CKS1_1	897	902	PF01111	0.479
DOC_CYCLIN_RxL_1	577	585	PF00134	0.362
DOC_CYCLIN_RxL_1	841	853	PF00134	0.361
DOC_CYCLIN_yClb5_NLxxxL_5	233	240	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.469
DOC_MAPK_gen_1	490	499	PF00069	0.319
DOC_MAPK_gen_1	597	605	PF00069	0.498
DOC_MAPK_gen_1	667	676	PF00069	0.366
DOC_MAPK_gen_1	785	796	PF00069	0.525
DOC_MAPK_gen_1	860	870	PF00069	0.324
DOC_MAPK_gen_1	881	890	PF00069	0.267
DOC_MAPK_MEF2A_6	144	152	PF00069	0.437
DOC_MAPK_MEF2A_6	667	676	PF00069	0.387
DOC_MAPK_MEF2A_6	789	798	PF00069	0.470
DOC_PP1_RVXF_1	578	585	PF00149	0.440
DOC_PP2B_LxvP_1	570	573	PF13499	0.376
DOC_PP2B_LxvP_1	645	648	PF13499	0.461
DOC_PP2B_LxvP_1	690	693	PF13499	0.500
DOC_PP2B_LxvP_1	740	743	PF13499	0.516
DOC_PP4_FxxP_1	266	269	PF00568	0.360
DOC_PP4_FxxP_1	575	578	PF00568	0.411
DOC_USP7_MATH_1	449	453	PF00917	0.328
DOC_USP7_MATH_1	752	756	PF00917	0.575
DOC_USP7_MATH_1	797	801	PF00917	0.369
DOC_USP7_MATH_1	839	843	PF00917	0.336
DOC_USP7_MATH_1	871	875	PF00917	0.360
DOC_WW_Pin1_4	100	105	PF00397	0.719
DOC_WW_Pin1_4	196	201	PF00397	0.339
DOC_WW_Pin1_4	261	266	PF00397	0.353
DOC_WW_Pin1_4	277	282	PF00397	0.171
DOC_WW_Pin1_4	310	315	PF00397	0.340
DOC_WW_Pin1_4	452	457	PF00397	0.419
DOC_WW_Pin1_4	532	537	PF00397	0.492
DOC_WW_Pin1_4	590	595	PF00397	0.545
DOC_WW_Pin1_4	744	749	PF00397	0.472
DOC_WW_Pin1_4	789	794	PF00397	0.459
DOC_WW_Pin1_4	896	901	PF00397	0.480
LIG_14-3-3_CanoR_1	345	351	PF00244	0.336
LIG_14-3-3_CanoR_1	475	484	PF00244	0.328
LIG_14-3-3_CanoR_1	635	641	PF00244	0.505
LIG_14-3-3_CanoR_1	789	793	PF00244	0.507
LIG_14-3-3_CanoR_1	823	829	PF00244	0.436
LIG_14-3-3_CanoR_1	863	868	PF00244	0.302
LIG_14-3-3_CanoR_1	91	95	PF00244	0.529
LIG_14-3-3_CanoR_1	961	966	PF00244	0.566
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	262	266	PF00533	0.302
LIG_BRCT_BRCA1_1	412	416	PF00533	0.359
LIG_BRCT_BRCA1_1	453	457	PF00533	0.407
LIG_deltaCOP1_diTrp_1	894	903	PF00928	0.419
LIG_FHA_1	124	130	PF00498	0.281
LIG_FHA_1	137	143	PF00498	0.393
LIG_FHA_1	306	312	PF00498	0.300
LIG_FHA_1	468	474	PF00498	0.300
LIG_FHA_1	533	539	PF00498	0.538
LIG_FHA_1	543	549	PF00498	0.613
LIG_FHA_1	593	599	PF00498	0.555
LIG_FHA_1	651	657	PF00498	0.467
LIG_FHA_1	789	795	PF00498	0.447
LIG_FHA_1	808	814	PF00498	0.545
LIG_FHA_1	877	883	PF00498	0.328
LIG_FHA_1	908	914	PF00498	0.508
LIG_FHA_2	101	107	PF00498	0.658
LIG_FHA_2	287	293	PF00498	0.395
LIG_FHA_2	351	357	PF00498	0.376
LIG_FHA_2	380	386	PF00498	0.376
LIG_FHA_2	968	974	PF00498	0.536
LIG_GBD_Chelix_1	560	568	PF00786	0.440
LIG_Integrin_RGD_1	26	28	PF01839	0.425
LIG_LIR_Apic_2	263	269	PF02991	0.360
LIG_LIR_Apic_2	574	578	PF02991	0.443
LIG_LIR_Gen_1	122	132	PF02991	0.369
LIG_LIR_Gen_1	139	148	PF02991	0.485
LIG_LIR_Gen_1	370	380	PF02991	0.300
LIG_LIR_Gen_1	639	649	PF02991	0.430
LIG_LIR_Gen_1	953	960	PF02991	0.611
LIG_LIR_Nem_3	122	128	PF02991	0.374
LIG_LIR_Nem_3	139	143	PF02991	0.453
LIG_LIR_Nem_3	30	36	PF02991	0.413
LIG_LIR_Nem_3	359	364	PF02991	0.327
LIG_LIR_Nem_3	370	375	PF02991	0.264
LIG_LIR_Nem_3	432	437	PF02991	0.396
LIG_LIR_Nem_3	631	637	PF02991	0.407
LIG_LIR_Nem_3	754	760	PF02991	0.465
LIG_LIR_Nem_3	953	959	PF02991	0.613
LIG_LIR_Nem_3	964	968	PF02991	0.560
LIG_MLH1_MIPbox_1	263	267	PF16413	0.360
LIG_NRBOX	563	569	PF00104	0.476
LIG_NRBOX	845	851	PF00104	0.360
LIG_PCNA_PIPBox_1	514	523	PF02747	0.436
LIG_Pex3_1	564	575	PF04882	0.468
LIG_REV1ctd_RIR_1	465	473	PF16727	0.336
LIG_RPA_C_Fungi	552	564	PF08784	0.476
LIG_RPA_C_Fungi	836	848	PF08784	0.267
LIG_SH2_CRK	125	129	PF00017	0.359
LIG_SH2_CRK	634	638	PF00017	0.438
LIG_SH2_NCK_1	43	47	PF00017	0.453
LIG_SH2_SRC	655	658	PF00017	0.471
LIG_SH2_SRC	685	688	PF00017	0.384
LIG_SH2_STAP1	125	129	PF00017	0.359
LIG_SH2_STAP1	43	47	PF00017	0.453
LIG_SH2_STAT5	125	128	PF00017	0.384
LIG_SH2_STAT5	216	219	PF00017	0.353
LIG_SH2_STAT5	239	242	PF00017	0.328
LIG_SH2_STAT5	286	289	PF00017	0.337
LIG_SH2_STAT5	655	658	PF00017	0.462
LIG_SH2_STAT5	673	676	PF00017	0.298
LIG_SH2_STAT5	708	711	PF00017	0.376
LIG_SH2_STAT5	919	922	PF00017	0.497
LIG_SH2_STAT5	965	968	PF00017	0.602
LIG_SH3_3	142	148	PF00018	0.462
LIG_SH3_3	308	314	PF00018	0.300
LIG_SH3_3	588	594	PF00018	0.601
LIG_SH3_3	690	696	PF00018	0.426
LIG_SH3_3	742	748	PF00018	0.588
LIG_TRAF2_1	179	182	PF00917	0.328
LIG_TRAF2_1	22	25	PF00917	0.381
LIG_TRAF2_1	417	420	PF00917	0.304
LIG_TRAF2_1	505	508	PF00917	0.477
LIG_TRAF2_1	563	566	PF00917	0.464
LIG_TRAF2_1	607	610	PF00917	0.454
LIG_TYR_ITIM	966	971	PF00017	0.488
LIG_TYR_ITSM	368	375	PF00017	0.360
LIG_WRC_WIRS_1	572	577	PF05994	0.443
MOD_CDK_SPxK_1	196	202	PF00069	0.267
MOD_CDK_SPxxK_3	590	597	PF00069	0.552
MOD_CK1_1	120	126	PF00069	0.468
MOD_CK1_1	220	226	PF00069	0.300
MOD_CK1_1	318	324	PF00069	0.461
MOD_CK1_1	452	458	PF00069	0.374
MOD_CK1_1	59	65	PF00069	0.387
MOD_CK1_1	800	806	PF00069	0.487
MOD_CK1_1	922	928	PF00069	0.616
MOD_CK2_1	176	182	PF00069	0.459
MOD_CK2_1	379	385	PF00069	0.374
MOD_CK2_1	475	481	PF00069	0.388
MOD_CK2_1	722	728	PF00069	0.604
MOD_CK2_1	744	750	PF00069	0.532
MOD_CK2_1	967	973	PF00069	0.692
MOD_CK2_1	992	998	PF00069	0.608
MOD_Cter_Amidation	490	493	PF01082	0.300
MOD_GlcNHglycan	15	18	PF01048	0.425
MOD_GlcNHglycan	178	181	PF01048	0.290
MOD_GlcNHglycan	182	186	PF01048	0.298
MOD_GlcNHglycan	219	222	PF01048	0.300
MOD_GlcNHglycan	428	431	PF01048	0.341
MOD_GlcNHglycan	52	55	PF01048	0.569
MOD_GlcNHglycan	530	533	PF01048	0.584
MOD_GlcNHglycan	841	844	PF01048	0.376
MOD_GlcNHglycan	873	876	PF01048	0.304
MOD_GlcNHglycan	922	925	PF01048	0.573
MOD_GlcNHglycan	927	930	PF01048	0.586
MOD_GlcNHglycan	998	1002	PF01048	0.588
MOD_GSK3_1	164	171	PF00069	0.328
MOD_GSK3_1	194	201	PF00069	0.387
MOD_GSK3_1	216	223	PF00069	0.302
MOD_GSK3_1	280	287	PF00069	0.329
MOD_GSK3_1	305	312	PF00069	0.360
MOD_GSK3_1	315	322	PF00069	0.362
MOD_GSK3_1	325	332	PF00069	0.219
MOD_GSK3_1	367	374	PF00069	0.376
MOD_GSK3_1	528	535	PF00069	0.523
MOD_GSK3_1	582	589	PF00069	0.509
MOD_GSK3_1	592	599	PF00069	0.537
MOD_GSK3_1	918	925	PF00069	0.551
MOD_GSK3_1	950	957	PF00069	0.604
MOD_N-GLC_1	950	955	PF02516	0.614
MOD_NEK2_1	128	133	PF00069	0.322
MOD_NEK2_1	136	141	PF00069	0.366
MOD_NEK2_1	260	265	PF00069	0.307
MOD_NEK2_1	350	355	PF00069	0.379
MOD_NEK2_1	426	431	PF00069	0.328
MOD_NEK2_1	49	54	PF00069	0.598
MOD_NEK2_1	582	587	PF00069	0.369
MOD_NEK2_1	666	671	PF00069	0.387
MOD_NEK2_1	837	842	PF00069	0.376
MOD_NEK2_1	918	923	PF00069	0.545
MOD_NEK2_2	752	757	PF00069	0.430
MOD_NEK2_2	967	972	PF00069	0.476
MOD_PIKK_1	117	123	PF00454	0.327
MOD_PIKK_1	286	292	PF00454	0.360
MOD_PIKK_1	344	350	PF00454	0.351
MOD_PIKK_1	519	525	PF00454	0.443
MOD_PIKK_1	598	604	PF00454	0.570
MOD_PKA_1	961	967	PF00069	0.573
MOD_PKA_2	344	350	PF00069	0.336
MOD_PKA_2	66	72	PF00069	0.423
MOD_PKA_2	788	794	PF00069	0.514
MOD_PKA_2	822	828	PF00069	0.388
MOD_PKA_2	90	96	PF00069	0.549
MOD_PKA_2	954	960	PF00069	0.640
MOD_Plk_1	168	174	PF00069	0.502
MOD_Plk_1	208	214	PF00069	0.451
MOD_Plk_1	367	373	PF00069	0.300
MOD_Plk_1	59	65	PF00069	0.387
MOD_Plk_4	120	126	PF00069	0.429
MOD_Plk_4	169	175	PF00069	0.376
MOD_Plk_4	280	286	PF00069	0.475
MOD_Plk_4	325	331	PF00069	0.397
MOD_Plk_4	367	373	PF00069	0.314
MOD_Plk_4	571	577	PF00069	0.445
MOD_Plk_4	636	642	PF00069	0.511
MOD_Plk_4	752	758	PF00069	0.420
MOD_Plk_4	863	869	PF00069	0.350
MOD_Plk_4	961	967	PF00069	0.598
MOD_ProDKin_1	100	106	PF00069	0.719
MOD_ProDKin_1	196	202	PF00069	0.339
MOD_ProDKin_1	261	267	PF00069	0.353
MOD_ProDKin_1	277	283	PF00069	0.171
MOD_ProDKin_1	310	316	PF00069	0.340
MOD_ProDKin_1	452	458	PF00069	0.419
MOD_ProDKin_1	532	538	PF00069	0.483
MOD_ProDKin_1	590	596	PF00069	0.553
MOD_ProDKin_1	744	750	PF00069	0.467
MOD_ProDKin_1	789	795	PF00069	0.450
MOD_ProDKin_1	896	902	PF00069	0.484
MOD_SUMO_rev_2	220	229	PF00179	0.300
MOD_SUMO_rev_2	494	499	PF00179	0.376
TRG_DiLeu_BaEn_1	878	883	PF01217	0.360
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.470
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.571
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.466
TRG_DiLeu_BaLyEn_6	845	850	PF01217	0.407
TRG_DiLeu_LyEn_5	878	883	PF01217	0.376
TRG_ENDOCYTIC_2	125	128	PF00928	0.360
TRG_ENDOCYTIC_2	372	375	PF00928	0.300
TRG_ENDOCYTIC_2	434	437	PF00928	0.483
TRG_ENDOCYTIC_2	634	637	PF00928	0.440
TRG_ENDOCYTIC_2	673	676	PF00928	0.394
TRG_ENDOCYTIC_2	968	971	PF00928	0.517
TRG_ER_diArg_1	158	160	PF00400	0.321
TRG_ER_diArg_1	36	39	PF00400	0.444
TRG_ER_diArg_1	396	399	PF00400	0.376
TRG_ER_diArg_1	489	492	PF00400	0.376
TRG_ER_diArg_1	578	580	PF00400	0.423
TRG_ER_diArg_1	82	84	PF00400	0.418
TRG_ER_diArg_1	846	848	PF00400	0.337
TRG_ER_diArg_1	945	947	PF00400	0.687
TRG_ER_diArg_1	976	978	PF00400	0.561
TRG_NES_CRM1_1	807	819	PF08389	0.360
TRG_NLS_Bipartite_1	70	85	PF00514	0.344
TRG_NLS_Bipartite_1	944	965	PF00514	0.642
TRG_NLS_MonoCore_2	943	948	PF00514	0.651
TRG_NLS_MonoExtN_4	958	965	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	847	851	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E5	Leptomonas seymouri	52%	98%
A0A0S4JM65	Bodo saltans	29%	84%
A4HGQ9	Leishmania braziliensis	80%	100%
A4I3T3	Leishmania infantum	99%	100%
E9B025	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q861	Leishmania major	94%	100%