Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEY7_LEIDO

TriTrypDb:

LdBPK_332110.1 , LdCL_330028000 , LDHU3_33.3030

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.619
CLV_C14_Caspase3-7	253	257	PF00656	0.691
CLV_NRD_NRD_1	161	163	PF00675	0.636
CLV_NRD_NRD_1	262	264	PF00675	0.664
CLV_NRD_NRD_1	343	345	PF00675	0.589
CLV_NRD_NRD_1	41	43	PF00675	0.609
CLV_NRD_NRD_1	86	88	PF00675	0.571
CLV_PCSK_KEX2_1	161	163	PF00082	0.636
CLV_PCSK_KEX2_1	262	264	PF00082	0.664
CLV_PCSK_KEX2_1	497	499	PF00082	0.757
CLV_PCSK_KEX2_1	504	506	PF00082	0.593
CLV_PCSK_KEX2_1	563	565	PF00082	0.597
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.757
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.593
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.610
CLV_PCSK_SKI1_1	555	559	PF00082	0.620
CLV_PCSK_SKI1_1	560	564	PF00082	0.583
DEG_Nend_UBRbox_4	1	3	PF02207	0.587
DEG_SPOP_SBC_1	175	179	PF00917	0.564
DEG_SPOP_SBC_1	220	224	PF00917	0.692
DEG_SPOP_SBC_1	228	232	PF00917	0.596
DOC_CDC14_PxL_1	448	456	PF14671	0.562
DOC_CYCLIN_RxL_1	371	381	PF00134	0.481
DOC_MAPK_gen_1	560	570	PF00069	0.714
DOC_PP2B_LxvP_1	192	195	PF13499	0.680
DOC_USP7_MATH_1	176	180	PF00917	0.582
DOC_USP7_MATH_1	198	202	PF00917	0.674
DOC_USP7_MATH_1	204	208	PF00917	0.733
DOC_USP7_MATH_1	22	26	PF00917	0.500
DOC_USP7_MATH_1	220	224	PF00917	0.646
DOC_USP7_MATH_1	244	248	PF00917	0.687
DOC_USP7_MATH_1	340	344	PF00917	0.766
DOC_USP7_MATH_1	351	355	PF00917	0.608
DOC_USP7_MATH_1	357	361	PF00917	0.501
DOC_USP7_MATH_1	419	423	PF00917	0.676
DOC_USP7_MATH_1	428	432	PF00917	0.581
DOC_USP7_MATH_1	460	464	PF00917	0.677
DOC_USP7_MATH_1	470	474	PF00917	0.579
DOC_USP7_MATH_1	67	71	PF00917	0.710
DOC_USP7_UBL2_3	504	508	PF12436	0.786
DOC_WW_Pin1_4	162	167	PF00397	0.791
DOC_WW_Pin1_4	169	174	PF00397	0.531
DOC_WW_Pin1_4	211	216	PF00397	0.669
DOC_WW_Pin1_4	568	573	PF00397	0.589
LIG_14-3-3_CanoR_1	122	127	PF00244	0.551
LIG_14-3-3_CanoR_1	132	140	PF00244	0.605
LIG_14-3-3_CanoR_1	262	268	PF00244	0.734
LIG_14-3-3_CanoR_1	311	320	PF00244	0.739
LIG_14-3-3_CanoR_1	532	541	PF00244	0.697
LIG_BRCT_BRCA1_1	94	98	PF00533	0.641
LIG_Clathr_ClatBox_1	286	290	PF01394	0.670
LIG_eIF4E_1	398	404	PF01652	0.473
LIG_FHA_1	185	191	PF00498	0.718
LIG_FHA_1	232	238	PF00498	0.779
LIG_FHA_1	250	256	PF00498	0.524
LIG_FHA_1	386	392	PF00498	0.460
LIG_FHA_1	477	483	PF00498	0.669
LIG_FHA_2	134	140	PF00498	0.704
LIG_FHA_2	145	151	PF00498	0.576
LIG_FHA_2	198	204	PF00498	0.648
LIG_FHA_2	405	411	PF00498	0.606
LIG_Integrin_RGD_1	82	84	PF01839	0.768
LIG_LIR_Apic_2	447	452	PF02991	0.625
LIG_LIR_Apic_2	95	99	PF02991	0.592
LIG_LIR_Gen_1	276	283	PF02991	0.698
LIG_LIR_Gen_1	444	453	PF02991	0.545
LIG_LIR_Nem_3	271	277	PF02991	0.752
LIG_LIR_Nem_3	31	35	PF02991	0.567
LIG_LIR_Nem_3	444	448	PF02991	0.541
LIG_PCNA_yPIPBox_3	371	380	PF02747	0.582
LIG_Pex14_2	445	449	PF04695	0.579
LIG_SH2_NCK_1	245	249	PF00017	0.653
LIG_SH2_STAP1	124	128	PF00017	0.558
LIG_SH2_STAP1	245	249	PF00017	0.653
LIG_SH2_STAT3	113	116	PF00017	0.637
LIG_SH2_STAT5	124	127	PF00017	0.556
LIG_SH2_STAT5	267	270	PF00017	0.745
LIG_SH2_STAT5	32	35	PF00017	0.483
LIG_SH2_STAT5	398	401	PF00017	0.476
LIG_SH2_STAT5	7	10	PF00017	0.602
LIG_SH3_3	188	194	PF00018	0.701
LIG_SH3_3	479	485	PF00018	0.764
LIG_SH3_3	61	67	PF00018	0.713
LIG_SH3_3	69	75	PF00018	0.682
LIG_SUMO_SIM_par_1	363	369	PF11976	0.669
LIG_SUMO_SIM_par_1	375	381	PF11976	0.468
LIG_TRAF2_1	407	410	PF00917	0.623
LIG_TYR_ITIM	36	41	PF00017	0.591
LIG_UBA3_1	558	563	PF00899	0.719
LIG_WRC_WIRS_1	140	145	PF05994	0.690
LIG_WRC_WIRS_1	412	417	PF05994	0.536
MOD_CK1_1	17	23	PF00069	0.662
MOD_CK1_1	214	220	PF00069	0.705
MOD_CK1_1	222	228	PF00069	0.630
MOD_CK1_1	229	235	PF00069	0.622
MOD_CK1_1	236	242	PF00069	0.628
MOD_CK1_1	314	320	PF00069	0.705
MOD_CK1_1	330	336	PF00069	0.664
MOD_CK1_1	343	349	PF00069	0.656
MOD_CK1_1	414	420	PF00069	0.616
MOD_CK1_1	432	438	PF00069	0.503
MOD_CK2_1	133	139	PF00069	0.705
MOD_CK2_1	144	150	PF00069	0.568
MOD_CK2_1	335	341	PF00069	0.714
MOD_CK2_1	387	393	PF00069	0.458
MOD_CK2_1	404	410	PF00069	0.499
MOD_CK2_1	441	447	PF00069	0.649
MOD_Cter_Amidation	159	162	PF01082	0.709
MOD_GlcNHglycan	178	181	PF01048	0.658
MOD_GlcNHglycan	200	203	PF01048	0.743
MOD_GlcNHglycan	206	209	PF01048	0.755
MOD_GlcNHglycan	226	229	PF01048	0.486
MOD_GlcNHglycan	24	27	PF01048	0.387
MOD_GlcNHglycan	246	249	PF01048	0.633
MOD_GlcNHglycan	252	255	PF01048	0.669
MOD_GlcNHglycan	337	340	PF01048	0.704
MOD_GlcNHglycan	353	356	PF01048	0.520
MOD_GlcNHglycan	422	425	PF01048	0.661
MOD_GlcNHglycan	431	434	PF01048	0.556
MOD_GlcNHglycan	462	465	PF01048	0.667
MOD_GlcNHglycan	472	475	PF01048	0.617
MOD_GlcNHglycan	479	482	PF01048	0.600
MOD_GlcNHglycan	537	540	PF01048	0.713
MOD_GlcNHglycan	9	12	PF01048	0.618
MOD_GSK3_1	174	181	PF00069	0.661
MOD_GSK3_1	194	201	PF00069	0.536
MOD_GSK3_1	214	221	PF00069	0.625
MOD_GSK3_1	222	229	PF00069	0.648
MOD_GSK3_1	231	238	PF00069	0.671
MOD_GSK3_1	296	303	PF00069	0.732
MOD_GSK3_1	314	321	PF00069	0.529
MOD_GSK3_1	326	333	PF00069	0.727
MOD_GSK3_1	343	350	PF00069	0.506
MOD_GSK3_1	411	418	PF00069	0.641
MOD_GSK3_1	428	435	PF00069	0.510
MOD_GSK3_1	437	444	PF00069	0.620
MOD_GSK3_1	460	467	PF00069	0.667
MOD_GSK3_1	470	477	PF00069	0.593
MOD_GSK3_1	513	520	PF00069	0.752
MOD_GSK3_1	564	571	PF00069	0.713
MOD_N-GLC_1	404	409	PF02516	0.552
MOD_N-GLC_1	564	569	PF02516	0.535
MOD_NEK2_1	154	159	PF00069	0.747
MOD_NEK2_1	218	223	PF00069	0.638
MOD_NEK2_1	233	238	PF00069	0.666
MOD_NEK2_1	385	390	PF00069	0.464
MOD_NEK2_1	394	399	PF00069	0.469
MOD_NEK2_1	415	420	PF00069	0.570
MOD_NEK2_1	437	442	PF00069	0.592
MOD_NEK2_2	2	7	PF00069	0.502
MOD_PIKK_1	296	302	PF00454	0.676
MOD_PIKK_1	327	333	PF00454	0.770
MOD_PIKK_1	385	391	PF00454	0.457
MOD_PK_1	564	570	PF00069	0.709
MOD_PKA_2	249	255	PF00069	0.772
MOD_PKA_2	343	349	PF00069	0.587
MOD_PKA_2	50	56	PF00069	0.523
MOD_Plk_1	564	570	PF00069	0.716
MOD_Plk_2-3	378	384	PF00069	0.558
MOD_Plk_4	178	184	PF00069	0.643
MOD_Plk_4	2	8	PF00069	0.508
MOD_Plk_4	214	220	PF00069	0.610
MOD_Plk_4	387	393	PF00069	0.458
MOD_Plk_4	394	400	PF00069	0.471
MOD_Plk_4	411	417	PF00069	0.375
MOD_Plk_4	564	570	PF00069	0.703
MOD_Plk_4	67	73	PF00069	0.583
MOD_Plk_4	92	98	PF00069	0.709
MOD_ProDKin_1	162	168	PF00069	0.792
MOD_ProDKin_1	169	175	PF00069	0.525
MOD_ProDKin_1	211	217	PF00069	0.668
TRG_DiLeu_BaEn_2	283	289	PF01217	0.562
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.460
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.664
TRG_ENDOCYTIC_2	274	277	PF00928	0.742
TRG_ENDOCYTIC_2	38	41	PF00928	0.487
TRG_ER_diArg_1	161	164	PF00400	0.635
TRG_ER_diArg_1	262	265	PF00400	0.662
TRG_NES_CRM1_1	284	297	PF08389	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A9	Leptomonas seymouri	35%	96%
A4HLR1	Leishmania braziliensis	68%	99%
A4I961	Leishmania infantum	98%	100%
E9B437	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3Y8	Leishmania major	88%	99%