EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEY6_LEIDO

TriTrypDb:

LdBPK_302610.1 , LdCL_300031700

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.603
CLV_NRD_NRD_1	284	286	PF00675	0.597
CLV_NRD_NRD_1	389	391	PF00675	0.425
CLV_NRD_NRD_1	638	640	PF00675	0.656
CLV_NRD_NRD_1	644	646	PF00675	0.603
CLV_NRD_NRD_1	665	667	PF00675	0.630
CLV_NRD_NRD_1	701	703	PF00675	0.561
CLV_PCSK_FUR_1	663	667	PF00082	0.633
CLV_PCSK_KEX2_1	130	132	PF00082	0.612
CLV_PCSK_KEX2_1	389	391	PF00082	0.425
CLV_PCSK_KEX2_1	601	603	PF00082	0.616
CLV_PCSK_KEX2_1	644	646	PF00082	0.637
CLV_PCSK_KEX2_1	665	667	PF00082	0.630
CLV_PCSK_KEX2_1	701	703	PF00082	0.561
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.612
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.616
CLV_PCSK_SKI1_1	360	364	PF00082	0.449
CLV_PCSK_SKI1_1	389	393	PF00082	0.449
CLV_PCSK_SKI1_1	441	445	PF00082	0.432
DEG_APCC_DBOX_1	488	496	PF00400	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DEG_SPOP_SBC_1	149	153	PF00917	0.624
DEG_SPOP_SBC_1	221	225	PF00917	0.650
DOC_CDC14_PxL_1	559	567	PF14671	0.665
DOC_CKS1_1	413	418	PF01111	0.441
DOC_CYCLIN_RxL_1	506	516	PF00134	0.446
DOC_MAPK_DCC_7	557	567	PF00069	0.644
DOC_MAPK_gen_1	198	207	PF00069	0.619
DOC_MAPK_gen_1	397	404	PF00069	0.516
DOC_MAPK_gen_1	509	519	PF00069	0.444
DOC_PP1_RVXF_1	363	369	PF00149	0.421
DOC_PP2B_LxvP_1	565	568	PF13499	0.662
DOC_PP4_MxPP_1	264	267	PF00568	0.566
DOC_SPAK_OSR1_1	673	677	PF12202	0.628
DOC_USP7_MATH_1	149	153	PF00917	0.680
DOC_USP7_MATH_1	154	158	PF00917	0.664
DOC_USP7_MATH_1	161	165	PF00917	0.652
DOC_USP7_MATH_1	221	225	PF00917	0.748
DOC_USP7_MATH_1	305	309	PF00917	0.745
DOC_USP7_MATH_1	34	38	PF00917	0.607
DOC_USP7_MATH_1	649	653	PF00917	0.674
DOC_USP7_MATH_1	90	94	PF00917	0.639
DOC_USP7_MATH_1	95	99	PF00917	0.614
DOC_USP7_MATH_2	23	29	PF00917	0.645
DOC_USP7_UBL2_3	626	630	PF12436	0.687
DOC_WW_Pin1_4	227	232	PF00397	0.691
DOC_WW_Pin1_4	237	242	PF00397	0.654
DOC_WW_Pin1_4	412	417	PF00397	0.468
DOC_WW_Pin1_4	66	71	PF00397	0.662
LIG_14-3-3_CanoR_1	285	291	PF00244	0.660
LIG_14-3-3_CanoR_1	333	343	PF00244	0.549
LIG_14-3-3_CanoR_1	352	356	PF00244	0.476
LIG_14-3-3_CanoR_1	506	512	PF00244	0.359
LIG_14-3-3_CanoR_1	577	583	PF00244	0.601
LIG_Actin_WH2_2	406	424	PF00022	0.423
LIG_APCC_ABBA_1	511	516	PF00400	0.437
LIG_BRCT_BRCA1_1	353	357	PF00533	0.501
LIG_BRCT_BRCA1_1	436	440	PF00533	0.462
LIG_BRCT_BRCA1_1	670	674	PF00533	0.626
LIG_Clathr_ClatBox_1	517	521	PF01394	0.414
LIG_eIF4E_1	514	520	PF01652	0.446
LIG_FHA_1	485	491	PF00498	0.443
LIG_FHA_1	506	512	PF00498	0.483
LIG_FHA_1	577	583	PF00498	0.589
LIG_FHA_1	86	92	PF00498	0.639
LIG_FHA_2	437	443	PF00498	0.427
LIG_FHA_2	55	61	PF00498	0.652
LIG_FHA_2	583	589	PF00498	0.610
LIG_FHA_2	657	663	PF00498	0.684
LIG_LIR_Gen_1	367	375	PF02991	0.433
LIG_LIR_Gen_1	400	407	PF02991	0.308
LIG_LIR_Gen_1	456	463	PF02991	0.450
LIG_LIR_Nem_3	331	335	PF02991	0.506
LIG_LIR_Nem_3	367	371	PF02991	0.424
LIG_LIR_Nem_3	400	404	PF02991	0.329
LIG_LIR_Nem_3	437	443	PF02991	0.449
LIG_LIR_Nem_3	456	460	PF02991	0.269
LIG_LIR_Nem_3	609	615	PF02991	0.626
LIG_LYPXL_yS_3	612	615	PF13949	0.618
LIG_MYND_1	560	564	PF01753	0.541
LIG_NRBOX	406	412	PF00104	0.424
LIG_PCNA_yPIPBox_3	680	694	PF02747	0.635
LIG_SH2_CRK	332	336	PF00017	0.504
LIG_SH2_NCK_1	109	113	PF00017	0.698
LIG_SH2_SRC	109	112	PF00017	0.697
LIG_SH2_STAP1	216	220	PF00017	0.582
LIG_SH2_STAP1	514	518	PF00017	0.443
LIG_SH2_STAP1	546	550	PF00017	0.671
LIG_SH2_STAT3	716	719	PF00017	0.578
LIG_SH2_STAT5	212	215	PF00017	0.623
LIG_SH3_1	475	481	PF00018	0.454
LIG_SH3_1	557	563	PF00018	0.642
LIG_SH3_3	164	170	PF00018	0.658
LIG_SH3_3	17	23	PF00018	0.658
LIG_SH3_3	475	481	PF00018	0.454
LIG_SH3_3	557	563	PF00018	0.642
LIG_SH3_3	679	685	PF00018	0.663
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.417
LIG_SUMO_SIM_par_1	266	272	PF11976	0.650
LIG_SUMO_SIM_par_1	409	415	PF11976	0.371
LIG_UBA3_1	264	273	PF00899	0.572
LIG_UBA3_1	391	399	PF00899	0.441
LIG_UBA3_1	459	468	PF00899	0.412
LIG_UBA3_1	708	717	PF00899	0.533
MOD_CDK_SPxK_1	237	243	PF00069	0.659
MOD_CDK_SPxxK_3	241	248	PF00069	0.665
MOD_CK1_1	150	156	PF00069	0.637
MOD_CK1_1	174	180	PF00069	0.805
MOD_CK1_1	219	225	PF00069	0.589
MOD_CK1_1	244	250	PF00069	0.774
MOD_CK1_1	252	258	PF00069	0.719
MOD_CK1_1	269	275	PF00069	0.559
MOD_CK1_1	280	286	PF00069	0.786
MOD_CK1_1	308	314	PF00069	0.648
MOD_CK1_1	331	337	PF00069	0.656
MOD_CK1_1	41	47	PF00069	0.696
MOD_CK1_1	584	590	PF00069	0.650
MOD_CK1_1	661	667	PF00069	0.673
MOD_CK2_1	154	160	PF00069	0.672
MOD_CK2_1	32	38	PF00069	0.689
MOD_CK2_1	417	423	PF00069	0.465
MOD_CK2_1	54	60	PF00069	0.701
MOD_CK2_1	95	101	PF00069	0.642
MOD_GlcNHglycan	152	155	PF01048	0.731
MOD_GlcNHglycan	163	166	PF01048	0.733
MOD_GlcNHglycan	173	176	PF01048	0.660
MOD_GlcNHglycan	318	321	PF01048	0.618
MOD_GlcNHglycan	381	384	PF01048	0.456
MOD_GlcNHglycan	64	67	PF01048	0.682
MOD_GSK3_1	14	21	PF00069	0.609
MOD_GSK3_1	144	151	PF00069	0.711
MOD_GSK3_1	170	177	PF00069	0.674
MOD_GSK3_1	216	223	PF00069	0.589
MOD_GSK3_1	237	244	PF00069	0.778
MOD_GSK3_1	249	256	PF00069	0.704
MOD_GSK3_1	277	284	PF00069	0.728
MOD_GSK3_1	30	37	PF00069	0.650
MOD_GSK3_1	308	315	PF00069	0.631
MOD_GSK3_1	331	338	PF00069	0.576
MOD_GSK3_1	38	45	PF00069	0.634
MOD_GSK3_1	607	614	PF00069	0.607
MOD_GSK3_1	62	69	PF00069	0.701
MOD_GSK3_1	664	671	PF00069	0.600
MOD_GSK3_1	707	714	PF00069	0.555
MOD_GSK3_1	71	78	PF00069	0.618
MOD_GSK3_1	81	88	PF00069	0.593
MOD_N-GLC_1	249	254	PF02516	0.745
MOD_N-GLC_1	281	286	PF02516	0.685
MOD_N-GLC_1	607	612	PF02516	0.616
MOD_NEK2_1	220	225	PF00069	0.589
MOD_NEK2_1	335	340	PF00069	0.515
MOD_NEK2_1	40	45	PF00069	0.675
MOD_NEK2_1	436	441	PF00069	0.402
MOD_NEK2_1	615	620	PF00069	0.627
MOD_NEK2_2	417	422	PF00069	0.473
MOD_PIKK_1	14	20	PF00454	0.592
MOD_PIKK_1	174	180	PF00454	0.669
MOD_PIKK_1	707	713	PF00454	0.553
MOD_PIKK_1	75	81	PF00454	0.632
MOD_PKA_1	130	136	PF00069	0.615
MOD_PKA_2	130	136	PF00069	0.676
MOD_PKA_2	144	150	PF00069	0.621
MOD_PKA_2	252	258	PF00069	0.723
MOD_PKA_2	278	284	PF00069	0.688
MOD_PKA_2	351	357	PF00069	0.518
MOD_PKA_2	505	511	PF00069	0.418
MOD_PKA_2	576	582	PF00069	0.624
MOD_PKA_2	664	670	PF00069	0.617
MOD_Plk_1	249	255	PF00069	0.742
MOD_Plk_1	70	76	PF00069	0.642
MOD_Plk_2-3	400	406	PF00069	0.437
MOD_Plk_4	711	717	PF00069	0.575
MOD_ProDKin_1	227	233	PF00069	0.694
MOD_ProDKin_1	237	243	PF00069	0.653
MOD_ProDKin_1	412	418	PF00069	0.465
MOD_ProDKin_1	66	72	PF00069	0.660
MOD_SUMO_rev_2	269	274	PF00179	0.530
MOD_SUMO_rev_2	47	57	PF00179	0.697
TRG_DiLeu_BaEn_1	515	520	PF01217	0.448
TRG_DiLeu_BaEn_2	422	428	PF01217	0.430
TRG_ENDOCYTIC_2	332	335	PF00928	0.510
TRG_ENDOCYTIC_2	457	460	PF00928	0.440
TRG_ENDOCYTIC_2	514	517	PF00928	0.449
TRG_ENDOCYTIC_2	612	615	PF00928	0.618
TRG_ER_diArg_1	276	279	PF00400	0.602
TRG_ER_diArg_1	389	391	PF00400	0.422
TRG_ER_diArg_1	450	453	PF00400	0.425
TRG_ER_diArg_1	644	646	PF00400	0.644
TRG_ER_diArg_1	663	666	PF00400	0.506
TRG_ER_diArg_1	701	703	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HIJ3	Leishmania braziliensis	58%	100%
A4I5T8	Leishmania infantum	99%	100%
E9B132	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q733	Leishmania major	89%	100%