PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEY3_LEIDO

TriTrypDb:

LdBPK_301890.1 , LdCL_300024200

Length:

1022

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1005	1009	PF00656	0.604
CLV_C14_Caspase3-7	564	568	PF00656	0.636
CLV_C14_Caspase3-7	989	993	PF00656	0.563
CLV_NRD_NRD_1	150	152	PF00675	0.592
CLV_NRD_NRD_1	291	293	PF00675	0.574
CLV_NRD_NRD_1	434	436	PF00675	0.576
CLV_NRD_NRD_1	605	607	PF00675	0.555
CLV_NRD_NRD_1	919	921	PF00675	0.523
CLV_NRD_NRD_1	956	958	PF00675	0.593
CLV_PCSK_KEX2_1	150	152	PF00082	0.592
CLV_PCSK_KEX2_1	291	293	PF00082	0.574
CLV_PCSK_KEX2_1	41	43	PF00082	0.762
CLV_PCSK_KEX2_1	434	436	PF00082	0.576
CLV_PCSK_KEX2_1	605	607	PF00082	0.555
CLV_PCSK_KEX2_1	955	957	PF00082	0.583
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.762
CLV_PCSK_PC7_1	952	958	PF00082	0.595
CLV_PCSK_SKI1_1	1013	1017	PF00082	0.697
CLV_PCSK_SKI1_1	306	310	PF00082	0.659
CLV_PCSK_SKI1_1	508	512	PF00082	0.543
CLV_PCSK_SKI1_1	605	609	PF00082	0.670
CLV_PCSK_SKI1_1	616	620	PF00082	0.527
CLV_PCSK_SKI1_1	695	699	PF00082	0.558
CLV_PCSK_SKI1_1	715	719	PF00082	0.327
CLV_PCSK_SKI1_1	854	858	PF00082	0.497
DEG_APCC_DBOX_1	604	612	PF00400	0.663
DOC_CKS1_1	61	66	PF01111	0.606
DOC_CYCLIN_RxL_1	303	313	PF00134	0.541
DOC_CYCLIN_yClb3_PxF_3	188	194	PF00134	0.723
DOC_CYCLIN_yClb5_NLxxxL_5	578	587	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	248	254	PF00134	0.708
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	861	867	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	941	947	PF00134	0.501
DOC_MAPK_gen_1	291	298	PF00069	0.545
DOC_MAPK_gen_1	712	722	PF00069	0.658
DOC_MAPK_HePTP_8	288	300	PF00069	0.538
DOC_MAPK_HePTP_8	804	816	PF00069	0.513
DOC_MAPK_MEF2A_6	291	300	PF00069	0.536
DOC_MAPK_MEF2A_6	460	467	PF00069	0.611
DOC_MAPK_MEF2A_6	807	816	PF00069	0.514
DOC_MAPK_RevD_3	279	292	PF00069	0.652
DOC_PP1_RVXF_1	1011	1017	PF00149	0.697
DOC_PP1_RVXF_1	116	122	PF00149	0.605
DOC_PP1_RVXF_1	852	858	PF00149	0.504
DOC_PP2B_LxvP_1	411	414	PF13499	0.574
DOC_PP2B_LxvP_1	583	586	PF13499	0.555
DOC_PP2B_LxvP_1	861	864	PF13499	0.534
DOC_PP2B_LxvP_1	936	939	PF13499	0.606
DOC_PP2B_LxvP_1	941	944	PF13499	0.609
DOC_PP4_FxxP_1	159	162	PF00568	0.567
DOC_PP4_FxxP_1	538	541	PF00568	0.649
DOC_PP4_FxxP_1	91	94	PF00568	0.702
DOC_USP7_MATH_1	1002	1006	PF00917	0.675
DOC_USP7_MATH_1	204	208	PF00917	0.713
DOC_USP7_MATH_1	255	259	PF00917	0.536
DOC_USP7_MATH_1	321	325	PF00917	0.589
DOC_USP7_MATH_1	353	357	PF00917	0.630
DOC_USP7_MATH_1	376	380	PF00917	0.711
DOC_USP7_MATH_1	480	484	PF00917	0.584
DOC_USP7_MATH_1	498	502	PF00917	0.598
DOC_USP7_MATH_1	531	535	PF00917	0.725
DOC_USP7_MATH_1	541	545	PF00917	0.683
DOC_USP7_MATH_1	558	562	PF00917	0.691
DOC_USP7_MATH_1	618	622	PF00917	0.598
DOC_USP7_MATH_1	739	743	PF00917	0.613
DOC_USP7_MATH_1	996	1000	PF00917	0.627
DOC_USP7_UBL2_3	114	118	PF12436	0.618
DOC_USP7_UBL2_3	328	332	PF12436	0.619
DOC_WW_Pin1_4	1006	1011	PF00397	0.763
DOC_WW_Pin1_4	136	141	PF00397	0.622
DOC_WW_Pin1_4	196	201	PF00397	0.746
DOC_WW_Pin1_4	537	542	PF00397	0.673
DOC_WW_Pin1_4	60	65	PF00397	0.583
DOC_WW_Pin1_4	726	731	PF00397	0.706
DOC_WW_Pin1_4	865	870	PF00397	0.684
LIG_14-3-3_CanoR_1	291	297	PF00244	0.663
LIG_14-3-3_CanoR_1	310	318	PF00244	0.372
LIG_14-3-3_CanoR_1	521	530	PF00244	0.536
LIG_14-3-3_CanoR_1	580	586	PF00244	0.592
LIG_14-3-3_CanoR_1	605	611	PF00244	0.670
LIG_14-3-3_CanoR_1	700	706	PF00244	0.494
LIG_14-3-3_CanoR_1	81	86	PF00244	0.608
LIG_14-3-3_CanoR_1	975	984	PF00244	0.637
LIG_Actin_WH2_2	139	155	PF00022	0.553
LIG_Actin_WH2_2	603	618	PF00022	0.676
LIG_Actin_WH2_2	801	817	PF00022	0.627
LIG_BIR_III_4	302	306	PF00653	0.581
LIG_BRCT_BRCA1_1	1011	1015	PF00533	0.749
LIG_BRCT_BRCA1_1	275	279	PF00533	0.653
LIG_EVH1_1	202	206	PF00568	0.674
LIG_EVH1_2	190	194	PF00568	0.746
LIG_FHA_1	197	203	PF00498	0.732
LIG_FHA_1	247	253	PF00498	0.774
LIG_FHA_1	293	299	PF00498	0.628
LIG_FHA_1	382	388	PF00498	0.600
LIG_FHA_1	408	414	PF00498	0.648
LIG_FHA_1	483	489	PF00498	0.624
LIG_FHA_1	513	519	PF00498	0.664
LIG_FHA_1	610	616	PF00498	0.606
LIG_FHA_1	706	712	PF00498	0.584
LIG_FHA_1	714	720	PF00498	0.559
LIG_FHA_1	889	895	PF00498	0.511
LIG_FHA_1	986	992	PF00498	0.527
LIG_FHA_2	245	251	PF00498	0.718
LIG_FHA_2	410	416	PF00498	0.712
LIG_FHA_2	700	706	PF00498	0.525
LIG_FHA_2	746	752	PF00498	0.709
LIG_FHA_2	967	973	PF00498	0.589
LIG_GBD_Chelix_1	570	578	PF00786	0.556
LIG_GBD_Chelix_1	983	991	PF00786	0.508
LIG_LIR_Apic_2	537	541	PF02991	0.562
LIG_LIR_Apic_2	89	94	PF02991	0.618
LIG_LIR_Gen_1	839	849	PF02991	0.517
LIG_LIR_Gen_1	99	108	PF02991	0.610
LIG_LIR_Nem_3	1012	1018	PF02991	0.700
LIG_LIR_Nem_3	155	161	PF02991	0.584
LIG_LIR_Nem_3	839	844	PF02991	0.546
LIG_LIR_Nem_3	99	103	PF02991	0.628
LIG_MYND_1	200	204	PF01753	0.797
LIG_MYND_1	237	241	PF01753	0.785
LIG_MYND_1	316	320	PF01753	0.614
LIG_MYND_3	228	232	PF01753	0.675
LIG_MYND_3	315	319	PF01753	0.690
LIG_PROFILIN_1	180	186	PF00235	0.685
LIG_PROFILIN_1	187	193	PF00235	0.623
LIG_REV1ctd_RIR_1	1013	1021	PF16727	0.686
LIG_REV1ctd_RIR_1	695	704	PF16727	0.507
LIG_SH2_CRK	100	104	PF00017	0.657
LIG_SH2_CRK	116	120	PF00017	0.485
LIG_SH2_NCK_1	100	104	PF00017	0.670
LIG_SH2_NCK_1	743	747	PF00017	0.684
LIG_SH2_STAT3	658	661	PF00017	0.625
LIG_SH2_STAT5	116	119	PF00017	0.629
LIG_SH2_STAT5	144	147	PF00017	0.557
LIG_SH2_STAT5	653	656	PF00017	0.464
LIG_SH2_STAT5	658	661	PF00017	0.485
LIG_SH2_STAT5	743	746	PF00017	0.695
LIG_SH3_1	402	408	PF00018	0.700
LIG_SH3_3	177	183	PF00018	0.795
LIG_SH3_3	184	190	PF00018	0.675
LIG_SH3_3	197	203	PF00018	0.780
LIG_SH3_3	235	241	PF00018	0.658
LIG_SH3_3	368	374	PF00018	0.566
LIG_SH3_3	401	407	PF00018	0.742
LIG_SH3_3	474	480	PF00018	0.510
LIG_SH3_3	548	554	PF00018	0.667
LIG_SH3_3	58	64	PF00018	0.591
LIG_SH3_3	730	736	PF00018	0.758
LIG_SUMO_SIM_anti_2	124	131	PF11976	0.608
LIG_SUMO_SIM_anti_2	716	721	PF11976	0.543
LIG_SUMO_SIM_anti_2	982	989	PF11976	0.526
LIG_SUMO_SIM_par_1	409	415	PF11976	0.638
LIG_SUMO_SIM_par_1	606	613	PF11976	0.666
LIG_SUMO_SIM_par_1	982	989	PF11976	0.605
LIG_TRAF2_1	641	644	PF00917	0.680
LIG_TYR_ITIM	790	795	PF00017	0.665
LIG_WRC_WIRS_1	256	261	PF05994	0.533
LIG_WRC_WIRS_1	906	911	PF05994	0.539
LIG_WW_2	200	203	PF00397	0.712
MOD_CDK_SPK_2	60	65	PF00069	0.606
MOD_CDK_SPxxK_3	1006	1013	PF00069	0.798
MOD_CK1_1	1009	1015	PF00069	0.695
MOD_CK1_1	343	349	PF00069	0.677
MOD_CK1_1	381	387	PF00069	0.630
MOD_CK1_1	506	512	PF00069	0.566
MOD_CK1_1	516	522	PF00069	0.520
MOD_CK1_1	534	540	PF00069	0.752
MOD_CK1_1	594	600	PF00069	0.699
MOD_CK1_1	609	615	PF00069	0.421
MOD_CK2_1	244	250	PF00069	0.702
MOD_CK2_1	409	415	PF00069	0.747
MOD_CK2_1	558	564	PF00069	0.710
MOD_CK2_1	745	751	PF00069	0.741
MOD_CK2_1	966	972	PF00069	0.592
MOD_CK2_1	979	985	PF00069	0.404
MOD_Cter_Amidation	148	151	PF01082	0.614
MOD_Cter_Amidation	603	606	PF01082	0.569
MOD_GlcNHglycan	1004	1007	PF01048	0.732
MOD_GlcNHglycan	108	111	PF01048	0.397
MOD_GlcNHglycan	206	209	PF01048	0.716
MOD_GlcNHglycan	252	255	PF01048	0.601
MOD_GlcNHglycan	276	279	PF01048	0.542
MOD_GlcNHglycan	337	340	PF01048	0.648
MOD_GlcNHglycan	354	358	PF01048	0.452
MOD_GlcNHglycan	36	39	PF01048	0.655
MOD_GlcNHglycan	390	393	PF01048	0.614
MOD_GlcNHglycan	505	508	PF01048	0.594
MOD_GlcNHglycan	51	54	PF01048	0.656
MOD_GlcNHglycan	523	526	PF01048	0.629
MOD_GlcNHglycan	533	536	PF01048	0.664
MOD_GlcNHglycan	543	546	PF01048	0.633
MOD_GlcNHglycan	560	563	PF01048	0.733
MOD_GlcNHglycan	583	586	PF01048	0.673
MOD_GlcNHglycan	600	603	PF01048	0.448
MOD_GlcNHglycan	616	619	PF01048	0.598
MOD_GlcNHglycan	620	623	PF01048	0.425
MOD_GlcNHglycan	784	787	PF01048	0.781
MOD_GlcNHglycan	88	91	PF01048	0.638
MOD_GlcNHglycan	910	914	PF01048	0.591
MOD_GlcNHglycan	998	1001	PF01048	0.683
MOD_GSK3_1	1002	1009	PF00069	0.790
MOD_GSK3_1	102	109	PF00069	0.646
MOD_GSK3_1	117	124	PF00069	0.568
MOD_GSK3_1	192	199	PF00069	0.774
MOD_GSK3_1	211	218	PF00069	0.753
MOD_GSK3_1	246	253	PF00069	0.726
MOD_GSK3_1	255	262	PF00069	0.516
MOD_GSK3_1	264	271	PF00069	0.473
MOD_GSK3_1	310	317	PF00069	0.604
MOD_GSK3_1	394	401	PF00069	0.754
MOD_GSK3_1	463	470	PF00069	0.580
MOD_GSK3_1	506	513	PF00069	0.602
MOD_GSK3_1	537	544	PF00069	0.684
MOD_GSK3_1	565	572	PF00069	0.591
MOD_GSK3_1	594	601	PF00069	0.595
MOD_GSK3_1	606	613	PF00069	0.557
MOD_GSK3_1	614	621	PF00069	0.420
MOD_GSK3_1	741	748	PF00069	0.782
MOD_GSK3_1	905	912	PF00069	0.625
MOD_LATS_1	290	296	PF00433	0.653
MOD_N-GLC_1	121	126	PF02516	0.686
MOD_N-GLC_1	273	278	PF02516	0.583
MOD_N-GLC_1	581	586	PF02516	0.593
MOD_N-GLC_1	844	849	PF02516	0.482
MOD_NEK2_1	1016	1021	PF00069	0.682
MOD_NEK2_1	102	107	PF00069	0.495
MOD_NEK2_1	194	199	PF00069	0.731
MOD_NEK2_1	215	220	PF00069	0.832
MOD_NEK2_1	259	264	PF00069	0.509
MOD_NEK2_1	335	340	PF00069	0.527
MOD_NEK2_1	425	430	PF00069	0.638
MOD_NEK2_1	467	472	PF00069	0.578
MOD_NEK2_1	49	54	PF00069	0.601
MOD_NEK2_1	512	517	PF00069	0.532
MOD_NEK2_1	610	615	PF00069	0.546
MOD_NEK2_1	793	798	PF00069	0.546
MOD_NEK2_1	898	903	PF00069	0.608
MOD_NEK2_1	909	914	PF00069	0.495
MOD_NEK2_1	986	991	PF00069	0.478
MOD_NEK2_2	922	927	PF00069	0.639
MOD_NEK2_2	932	937	PF00069	0.541
MOD_PIKK_1	629	635	PF00454	0.705
MOD_PIKK_1	657	663	PF00454	0.486
MOD_PKA_2	1002	1008	PF00069	0.772
MOD_PKA_2	1016	1022	PF00069	0.618
MOD_PKA_2	152	158	PF00069	0.555
MOD_PKA_2	49	55	PF00069	0.601
MOD_PKA_2	699	705	PF00069	0.483
MOD_PKA_2	976	982	PF00069	0.648
MOD_Plk_1	211	217	PF00069	0.748
MOD_Plk_1	713	719	PF00069	0.553
MOD_Plk_1	793	799	PF00069	0.551
MOD_Plk_1	844	850	PF00069	0.481
MOD_Plk_1	898	904	PF00069	0.563
MOD_Plk_1	932	938	PF00069	0.586
MOD_Plk_1	948	954	PF00069	0.548
MOD_Plk_4	255	261	PF00069	0.545
MOD_Plk_4	446	452	PF00069	0.573
MOD_Plk_4	606	612	PF00069	0.661
MOD_Plk_4	715	721	PF00069	0.573
MOD_Plk_4	979	985	PF00069	0.556
MOD_Plk_4	986	992	PF00069	0.448
MOD_ProDKin_1	1006	1012	PF00069	0.766
MOD_ProDKin_1	136	142	PF00069	0.613
MOD_ProDKin_1	196	202	PF00069	0.745
MOD_ProDKin_1	537	543	PF00069	0.674
MOD_ProDKin_1	60	66	PF00069	0.583
MOD_ProDKin_1	726	732	PF00069	0.707
MOD_ProDKin_1	865	871	PF00069	0.680
MOD_SUMO_for_1	711	714	PF00179	0.559
MOD_SUMO_for_1	967	970	PF00179	0.425
MOD_SUMO_rev_2	54	64	PF00179	0.610
MOD_SUMO_rev_2	691	697	PF00179	0.569
TRG_DiLeu_BaEn_1	432	437	PF01217	0.699
TRG_DiLeu_BaEn_1	885	890	PF01217	0.632
TRG_DiLeu_BaEn_3	948	954	PF01217	0.649
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.754
TRG_ENDOCYTIC_2	100	103	PF00928	0.658
TRG_ENDOCYTIC_2	116	119	PF00928	0.491
TRG_ENDOCYTIC_2	664	667	PF00928	0.609
TRG_ENDOCYTIC_2	792	795	PF00928	0.548
TRG_ER_diArg_1	130	133	PF00400	0.608
TRG_ER_diArg_1	150	153	PF00400	0.344
TRG_ER_diArg_1	309	312	PF00400	0.659
TRG_ER_diArg_1	434	436	PF00400	0.576
TRG_ER_diArg_1	605	607	PF00400	0.555
TRG_ER_diArg_1	681	684	PF00400	0.574
TRG_ER_diArg_1	954	957	PF00400	0.574
TRG_ER_diArg_1	974	977	PF00400	0.297
TRG_Pf-PMV_PEXEL_1	306	311	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM5	Leptomonas seymouri	57%	91%
A4HIC4	Leishmania braziliensis	74%	98%
A4I5L6	Leishmania infantum	99%	100%
E9B0W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4Q7A5	Leishmania major	94%	100%