Crossover junction endonuclease MUS81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ERCC4 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEY2_LEIDO

TriTrypDb:

LdBPK_241580.1 , LdCL_240021000 , LDHU3_24.1930

Length:

1151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0048476	Holliday junction resolvase complex	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905347	endodeoxyribonuclease complex	4	1
GO:1905348	endonuclease complex	3	1

Expansion

Sequence features

A0A3Q8IEY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEY2

Function

Biological processes
Term	Name	Level	Count
GO:0000737	obsolete DNA catabolic process, endonucleolytic	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	7
GO:0006308	DNA catabolic process	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0019439	aromatic compound catabolic process	4	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034655	nucleobase-containing compound catabolic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0044270	cellular nitrogen compound catabolic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046700	heterocycle catabolic process	4	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901361	organic cyclic compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006310	DNA recombination	5	2
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	1
GO:0035556	intracellular signal transduction	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051726	regulation of cell cycle	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903046	meiotic cell cycle process	2	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0005488	binding	1	7
GO:0008821	crossover junction DNA endonuclease activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	6	7
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0048256	flap endonuclease activity	6	1
GO:0048257	3'-flap endonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1039	1043	PF00656	0.465
CLV_C14_Caspase3-7	221	225	PF00656	0.550
CLV_C14_Caspase3-7	283	287	PF00656	0.761
CLV_C14_Caspase3-7	301	305	PF00656	0.421
CLV_C14_Caspase3-7	537	541	PF00656	0.545
CLV_C14_Caspase3-7	827	831	PF00656	0.311
CLV_NRD_NRD_1	1115	1117	PF00675	0.497
CLV_NRD_NRD_1	320	322	PF00675	0.601
CLV_NRD_NRD_1	378	380	PF00675	0.533
CLV_NRD_NRD_1	777	779	PF00675	0.585
CLV_NRD_NRD_1	787	789	PF00675	0.239
CLV_NRD_NRD_1	856	858	PF00675	0.273
CLV_NRD_NRD_1	876	878	PF00675	0.183
CLV_NRD_NRD_1	991	993	PF00675	0.430
CLV_PCSK_FUR_1	988	992	PF00082	0.406
CLV_PCSK_KEX2_1	1114	1116	PF00082	0.509
CLV_PCSK_KEX2_1	322	324	PF00082	0.608
CLV_PCSK_KEX2_1	378	380	PF00082	0.533
CLV_PCSK_KEX2_1	467	469	PF00082	0.555
CLV_PCSK_KEX2_1	777	779	PF00082	0.529
CLV_PCSK_KEX2_1	876	878	PF00082	0.297
CLV_PCSK_KEX2_1	990	992	PF00082	0.415
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.608
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.555
CLV_PCSK_PC7_1	1111	1117	PF00082	0.413
CLV_PCSK_SKI1_1	1078	1082	PF00082	0.384
CLV_PCSK_SKI1_1	35	39	PF00082	0.555
CLV_PCSK_SKI1_1	633	637	PF00082	0.586
CLV_PCSK_SKI1_1	876	880	PF00082	0.297
DEG_APCC_DBOX_1	59	67	PF00400	0.512
DEG_SCF_FBW7_1	395	401	PF00400	0.592
DEG_SPOP_SBC_1	48	52	PF00917	0.503
DEG_SPOP_SBC_1	525	529	PF00917	0.527
DEG_SPOP_SBC_1	686	690	PF00917	0.602
DOC_ANK_TNKS_1	1037	1044	PF00023	0.467
DOC_ANK_TNKS_1	260	267	PF00023	0.599
DOC_ANK_TNKS_1	488	495	PF00023	0.546
DOC_ANK_TNKS_1	991	998	PF00023	0.485
DOC_CKS1_1	185	190	PF01111	0.576
DOC_CKS1_1	395	400	PF01111	0.588
DOC_CYCLIN_RxL_1	32	42	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.567
DOC_MAPK_gen_1	1135	1141	PF00069	0.353
DOC_MAPK_gen_1	753	762	PF00069	0.384
DOC_MAPK_MEF2A_6	241	248	PF00069	0.522
DOC_PP1_RVXF_1	751	757	PF00149	0.408
DOC_PP1_RVXF_1	883	890	PF00149	0.297
DOC_PP2B_LxvP_1	249	252	PF13499	0.577
DOC_PP2B_LxvP_1	296	299	PF13499	0.548
DOC_PP2B_LxvP_1	402	405	PF13499	0.521
DOC_PP2B_LxvP_1	607	610	PF13499	0.643
DOC_PP4_FxxP_1	292	295	PF00568	0.562
DOC_USP7_MATH_1	1094	1098	PF00917	0.343
DOC_USP7_MATH_1	179	183	PF00917	0.613
DOC_USP7_MATH_1	204	208	PF00917	0.601
DOC_USP7_MATH_1	280	284	PF00917	0.556
DOC_USP7_MATH_1	472	476	PF00917	0.549
DOC_USP7_MATH_1	48	52	PF00917	0.515
DOC_USP7_MATH_1	587	591	PF00917	0.514
DOC_USP7_MATH_1	64	68	PF00917	0.511
DOC_USP7_MATH_1	641	645	PF00917	0.538
DOC_USP7_MATH_1	665	669	PF00917	0.569
DOC_USP7_MATH_1	685	689	PF00917	0.621
DOC_USP7_MATH_1	693	697	PF00917	0.718
DOC_USP7_MATH_1	793	797	PF00917	0.269
DOC_USP7_MATH_1	834	838	PF00917	0.256
DOC_USP7_MATH_1	897	901	PF00917	0.286
DOC_USP7_MATH_1	936	940	PF00917	0.262
DOC_USP7_MATH_1	947	951	PF00917	0.253
DOC_WW_Pin1_4	106	111	PF00397	0.502
DOC_WW_Pin1_4	116	121	PF00397	0.569
DOC_WW_Pin1_4	147	152	PF00397	0.550
DOC_WW_Pin1_4	155	160	PF00397	0.557
DOC_WW_Pin1_4	184	189	PF00397	0.627
DOC_WW_Pin1_4	195	200	PF00397	0.492
DOC_WW_Pin1_4	234	239	PF00397	0.573
DOC_WW_Pin1_4	267	272	PF00397	0.799
DOC_WW_Pin1_4	330	335	PF00397	0.698
DOC_WW_Pin1_4	360	365	PF00397	0.715
DOC_WW_Pin1_4	379	384	PF00397	0.500
DOC_WW_Pin1_4	394	399	PF00397	0.594
DOC_WW_Pin1_4	517	522	PF00397	0.542
DOC_WW_Pin1_4	627	632	PF00397	0.590
DOC_WW_Pin1_4	637	642	PF00397	0.582
DOC_WW_Pin1_4	687	692	PF00397	0.568
DOC_WW_Pin1_4	702	707	PF00397	0.528
DOC_WW_Pin1_4	717	722	PF00397	0.539
DOC_WW_Pin1_4	730	735	PF00397	0.451
DOC_WW_Pin1_4	808	813	PF00397	0.248
DOC_WW_Pin1_4	87	92	PF00397	0.596
DOC_WW_Pin1_4	879	884	PF00397	0.269
DOC_WW_Pin1_4	925	930	PF00397	0.294
DOC_WW_Pin1_4	931	936	PF00397	0.353
LIG_14-3-3_CanoR_1	1076	1085	PF00244	0.363
LIG_14-3-3_CanoR_1	1089	1098	PF00244	0.358
LIG_14-3-3_CanoR_1	112	120	PF00244	0.613
LIG_14-3-3_CanoR_1	1129	1138	PF00244	0.373
LIG_14-3-3_CanoR_1	125	129	PF00244	0.541
LIG_14-3-3_CanoR_1	325	334	PF00244	0.600
LIG_14-3-3_CanoR_1	462	466	PF00244	0.622
LIG_14-3-3_CanoR_1	482	490	PF00244	0.550
LIG_14-3-3_CanoR_1	556	564	PF00244	0.454
LIG_14-3-3_CanoR_1	662	672	PF00244	0.598
LIG_14-3-3_CanoR_1	719	728	PF00244	0.550
LIG_14-3-3_CanoR_1	835	845	PF00244	0.223
LIG_14-3-3_CanoR_1	857	863	PF00244	0.269
LIG_14-3-3_CanoR_1	871	879	PF00244	0.269
LIG_14-3-3_CanoR_1	962	972	PF00244	0.486
LIG_14-3-3_CanoR_1	982	988	PF00244	0.262
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BIR_III_1	1	5	PF00653	0.582
LIG_BIR_III_2	1122	1126	PF00653	0.418
LIG_BIR_III_3	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	288	292	PF00533	0.596
LIG_BRCT_BRCA1_1	50	54	PF00533	0.518
LIG_BRCT_BRCA1_1	91	95	PF00533	0.529
LIG_BRCT_BRCA1_1	968	972	PF00533	0.269
LIG_BRCT_BRCA1_2	968	974	PF00533	0.265
LIG_Clathr_ClatBox_1	419	423	PF01394	0.539
LIG_deltaCOP1_diTrp_1	304	310	PF00928	0.513
LIG_FHA_1	1050	1056	PF00498	0.400
LIG_FHA_1	1140	1146	PF00498	0.353
LIG_FHA_1	138	144	PF00498	0.608
LIG_FHA_1	15	21	PF00498	0.541
LIG_FHA_1	172	178	PF00498	0.713
LIG_FHA_1	251	257	PF00498	0.509
LIG_FHA_1	399	405	PF00498	0.590
LIG_FHA_1	48	54	PF00498	0.533
LIG_FHA_1	495	501	PF00498	0.560
LIG_FHA_1	504	510	PF00498	0.625
LIG_FHA_1	664	670	PF00498	0.581
LIG_FHA_1	687	693	PF00498	0.528
LIG_FHA_1	705	711	PF00498	0.640
LIG_FHA_1	749	755	PF00498	0.394
LIG_FHA_1	965	971	PF00498	0.297
LIG_FHA_2	160	166	PF00498	0.620
LIG_FHA_2	299	305	PF00498	0.536
LIG_FHA_2	311	317	PF00498	0.525
LIG_FHA_2	333	339	PF00498	0.582
LIG_FHA_2	395	401	PF00498	0.592
LIG_FHA_2	448	454	PF00498	0.712
LIG_FHA_2	549	555	PF00498	0.416
LIG_FHA_2	68	74	PF00498	0.530
LIG_FHA_2	725	731	PF00498	0.620
LIG_FHA_2	825	831	PF00498	0.257
LIG_FHA_2	857	863	PF00498	0.269
LIG_FHA_2	916	922	PF00498	0.270
LIG_GBD_Chelix_1	886	894	PF00786	0.223
LIG_Integrin_RGD_1	219	221	PF01839	0.546
LIG_LIR_Apic_2	289	295	PF02991	0.563
LIG_LIR_Gen_1	340	347	PF02991	0.562
LIG_LIR_Gen_1	384	393	PF02991	0.518
LIG_LIR_Gen_1	92	103	PF02991	0.536
LIG_LIR_Gen_1	969	980	PF02991	0.297
LIG_LIR_LC3C_4	852	855	PF02991	0.269
LIG_LIR_LC3C_4	892	896	PF02991	0.223
LIG_LIR_Nem_3	1100	1106	PF02991	0.335
LIG_LIR_Nem_3	340	345	PF02991	0.565
LIG_LIR_Nem_3	384	389	PF02991	0.515
LIG_LIR_Nem_3	882	887	PF02991	0.269
LIG_LIR_Nem_3	92	98	PF02991	0.543
LIG_LIR_Nem_3	969	975	PF02991	0.297
LIG_NRBOX	1094	1100	PF00104	0.333
LIG_NRBOX	414	420	PF00104	0.562
LIG_PDZ_Class_3	1146	1151	PF00595	0.427
LIG_Pex14_1	306	310	PF04695	0.523
LIG_Pex14_1	758	762	PF04695	0.341
LIG_REV1ctd_RIR_1	532	540	PF16727	0.486
LIG_SH2_CRK	1103	1107	PF00017	0.356
LIG_SH2_CRK	638	642	PF00017	0.579
LIG_SH2_NCK_1	581	585	PF00017	0.516
LIG_SH2_PTP2	1138	1141	PF00017	0.372
LIG_SH2_STAT3	872	875	PF00017	0.269
LIG_SH2_STAT5	1138	1141	PF00017	0.372
LIG_SH2_STAT5	872	875	PF00017	0.253
LIG_SH3_2	107	112	PF14604	0.510
LIG_SH3_2	236	241	PF14604	0.559
LIG_SH3_3	104	110	PF00018	0.509
LIG_SH3_3	153	159	PF00018	0.580
LIG_SH3_3	185	191	PF00018	0.595
LIG_SH3_3	230	236	PF00018	0.604
LIG_SH3_3	518	524	PF00018	0.553
LIG_SH3_3	607	613	PF00018	0.753
LIG_SH3_3	655	661	PF00018	0.560
LIG_SH3_3	666	672	PF00018	0.796
LIG_SH3_3	700	706	PF00018	0.651
LIG_SH3_3	88	94	PF00018	0.591
LIG_SH3_3	930	936	PF00018	0.236
LIG_SH3_3	96	102	PF00018	0.569
LIG_SUMO_SIM_anti_2	1052	1057	PF11976	0.364
LIG_SUMO_SIM_anti_2	411	420	PF11976	0.597
LIG_SUMO_SIM_par_1	803	809	PF11976	0.269
LIG_TRAF2_1	163	166	PF00917	0.592
LIG_TRAF2_1	742	745	PF00917	0.478
LIG_UBA3_1	783	789	PF00899	0.223
LIG_Vh1_VBS_1	495	513	PF01044	0.505
LIG_WW_3	630	634	PF00397	0.569
MOD_CDC14_SPxK_1	109	112	PF00782	0.563
MOD_CDC14_SPxK_1	198	201	PF00782	0.522
MOD_CDC14_SPxK_1	630	633	PF00782	0.568
MOD_CDC14_SPxK_1	882	885	PF00782	0.297
MOD_CDK_SPK_2	116	121	PF00069	0.532
MOD_CDK_SPK_2	517	522	PF00069	0.523
MOD_CDK_SPxK_1	106	112	PF00069	0.557
MOD_CDK_SPxK_1	195	201	PF00069	0.520
MOD_CDK_SPxK_1	267	273	PF00069	0.554
MOD_CDK_SPxK_1	627	633	PF00069	0.571
MOD_CDK_SPxK_1	879	885	PF00069	0.297
MOD_CDK_SPxxK_3	234	241	PF00069	0.566
MOD_CK1_1	1097	1103	PF00069	0.341
MOD_CK1_1	116	122	PF00069	0.571
MOD_CK1_1	137	143	PF00069	0.590
MOD_CK1_1	150	156	PF00069	0.509
MOD_CK1_1	181	187	PF00069	0.540
MOD_CK1_1	237	243	PF00069	0.690
MOD_CK1_1	272	278	PF00069	0.614
MOD_CK1_1	333	339	PF00069	0.664
MOD_CK1_1	360	366	PF00069	0.627
MOD_CK1_1	373	379	PF00069	0.548
MOD_CK1_1	382	388	PF00069	0.560
MOD_CK1_1	391	397	PF00069	0.520
MOD_CK1_1	41	47	PF00069	0.539
MOD_CK1_1	476	482	PF00069	0.562
MOD_CK1_1	527	533	PF00069	0.567
MOD_CK1_1	566	572	PF00069	0.596
MOD_CK1_1	625	631	PF00069	0.580
MOD_CK1_1	642	648	PF00069	0.720
MOD_CK1_1	67	73	PF00069	0.552
MOD_CK1_1	715	721	PF00069	0.573
MOD_CK1_1	733	739	PF00069	0.505
MOD_CK1_1	87	93	PF00069	0.490
MOD_CK2_1	159	165	PF00069	0.611
MOD_CK2_1	310	316	PF00069	0.519
MOD_CK2_1	332	338	PF00069	0.592
MOD_CK2_1	394	400	PF00069	0.588
MOD_CK2_1	447	453	PF00069	0.622
MOD_CK2_1	808	814	PF00069	0.269
MOD_Cter_Amidation	775	778	PF01082	0.501
MOD_DYRK1A_RPxSP_1	927	931	PF00069	0.297
MOD_GlcNHglycan	1008	1011	PF01048	0.538
MOD_GlcNHglycan	1038	1041	PF01048	0.499
MOD_GlcNHglycan	1068	1071	PF01048	0.353
MOD_GlcNHglycan	1091	1094	PF01048	0.389
MOD_GlcNHglycan	128	131	PF01048	0.670
MOD_GlcNHglycan	152	155	PF01048	0.544
MOD_GlcNHglycan	181	184	PF01048	0.578
MOD_GlcNHglycan	23	26	PF01048	0.504
MOD_GlcNHglycan	274	277	PF01048	0.608
MOD_GlcNHglycan	282	285	PF01048	0.558
MOD_GlcNHglycan	327	330	PF01048	0.756
MOD_GlcNHglycan	335	338	PF01048	0.584
MOD_GlcNHglycan	354	357	PF01048	0.497
MOD_GlcNHglycan	469	473	PF01048	0.732
MOD_GlcNHglycan	485	488	PF01048	0.589
MOD_GlcNHglycan	529	532	PF01048	0.578
MOD_GlcNHglycan	582	585	PF01048	0.524
MOD_GlcNHglycan	589	592	PF01048	0.541
MOD_GlcNHglycan	604	607	PF01048	0.496
MOD_GlcNHglycan	612	616	PF01048	0.574
MOD_GlcNHglycan	644	647	PF01048	0.573
MOD_GlcNHglycan	651	654	PF01048	0.604
MOD_GlcNHglycan	66	69	PF01048	0.526
MOD_GlcNHglycan	695	698	PF01048	0.694
MOD_GlcNHglycan	766	769	PF01048	0.502
MOD_GlcNHglycan	774	777	PF01048	0.466
MOD_GlcNHglycan	836	839	PF01048	0.292
MOD_GlcNHglycan	86	89	PF01048	0.482
MOD_GlcNHglycan	899	902	PF01048	0.266
MOD_GlcNHglycan	938	941	PF01048	0.352
MOD_GlcNHglycan	945	948	PF01048	0.257
MOD_GlcNHglycan	998	1001	PF01048	0.516
MOD_GSK3_1	1060	1067	PF00069	0.559
MOD_GSK3_1	1094	1101	PF00069	0.368
MOD_GSK3_1	155	162	PF00069	0.665
MOD_GSK3_1	21	28	PF00069	0.534
MOD_GSK3_1	278	285	PF00069	0.556
MOD_GSK3_1	323	330	PF00069	0.637
MOD_GSK3_1	333	340	PF00069	0.747
MOD_GSK3_1	360	367	PF00069	0.595
MOD_GSK3_1	394	401	PF00069	0.717
MOD_GSK3_1	468	475	PF00069	0.743
MOD_GSK3_1	478	485	PF00069	0.628
MOD_GSK3_1	505	512	PF00069	0.551
MOD_GSK3_1	513	520	PF00069	0.573
MOD_GSK3_1	564	571	PF00069	0.402
MOD_GSK3_1	627	634	PF00069	0.603
MOD_GSK3_1	637	644	PF00069	0.717
MOD_GSK3_1	663	670	PF00069	0.723
MOD_GSK3_1	720	727	PF00069	0.549
MOD_GSK3_1	804	811	PF00069	0.303
MOD_GSK3_1	845	852	PF00069	0.424
MOD_GSK3_1	89	96	PF00069	0.598
MOD_GSK3_1	899	906	PF00069	0.222
MOD_GSK3_1	915	922	PF00069	0.474
MOD_GSK3_1	923	930	PF00069	0.265
MOD_GSK3_1	943	950	PF00069	0.412
MOD_GSK3_1	960	967	PF00069	0.269
MOD_GSK3_1	97	104	PF00069	0.585
MOD_LATS_1	1074	1080	PF00433	0.380
MOD_N-GLC_1	424	429	PF02516	0.640
MOD_N-GLC_1	601	606	PF02516	0.547
MOD_N-GLC_1	964	969	PF02516	0.270
MOD_N-GLC_2	1062	1064	PF02516	0.357
MOD_N-GLC_2	542	544	PF02516	0.524
MOD_NEK2_1	1049	1054	PF00069	0.408
MOD_NEK2_1	1098	1103	PF00069	0.363
MOD_NEK2_1	126	131	PF00069	0.572
MOD_NEK2_1	310	315	PF00069	0.574
MOD_NEK2_1	38	43	PF00069	0.553
MOD_NEK2_1	444	449	PF00069	0.615
MOD_NEK2_1	478	483	PF00069	0.593
MOD_NEK2_1	49	54	PF00069	0.513
MOD_NEK2_1	495	500	PF00069	0.600
MOD_NEK2_1	509	514	PF00069	0.683
MOD_NEK2_1	526	531	PF00069	0.517
MOD_NEK2_1	534	539	PF00069	0.527
MOD_NEK2_1	555	560	PF00069	0.422
MOD_NEK2_1	564	569	PF00069	0.515
MOD_NEK2_1	863	868	PF00069	0.269
MOD_NEK2_1	975	980	PF00069	0.366
MOD_NEK2_2	548	553	PF00069	0.418
MOD_PIKK_1	165	171	PF00454	0.549
MOD_PIKK_1	181	187	PF00454	0.566
MOD_PIKK_1	41	47	PF00454	0.555
MOD_PIKK_1	639	645	PF00454	0.649
MOD_PIKK_1	704	710	PF00454	0.496
MOD_PIKK_1	89	95	PF00454	0.570
MOD_PIKK_1	919	925	PF00454	0.270
MOD_PKA_2	1128	1134	PF00069	0.384
MOD_PKA_2	113	119	PF00069	0.598
MOD_PKA_2	124	130	PF00069	0.562
MOD_PKA_2	272	278	PF00069	0.569
MOD_PKA_2	461	467	PF00069	0.623
MOD_PKA_2	535	541	PF00069	0.485
MOD_PKA_2	555	561	PF00069	0.429
MOD_PKA_2	715	721	PF00069	0.712
MOD_PKA_2	764	770	PF00069	0.481
MOD_PKA_2	834	840	PF00069	0.223
MOD_PKA_2	856	862	PF00069	0.269
MOD_PKA_2	870	876	PF00069	0.269
MOD_PKA_2	963	969	PF00069	0.269
MOD_PKB_1	112	120	PF00069	0.573
MOD_PKB_1	217	225	PF00069	0.584
MOD_PKB_1	321	329	PF00069	0.609
MOD_PKB_1	637	645	PF00069	0.546
MOD_PKB_1	941	949	PF00069	0.297
MOD_PKB_1	962	970	PF00069	0.297
MOD_Plk_1	278	284	PF00069	0.518
MOD_Plk_1	460	466	PF00069	0.544
MOD_Plk_1	863	869	PF00069	0.269
MOD_Plk_2-3	453	459	PF00069	0.597
MOD_Plk_4	1094	1100	PF00069	0.370
MOD_Plk_4	1102	1108	PF00069	0.328
MOD_Plk_4	244	250	PF00069	0.518
MOD_Plk_4	337	343	PF00069	0.515
MOD_Plk_4	385	391	PF00069	0.630
MOD_Plk_4	49	55	PF00069	0.527
MOD_Plk_4	505	511	PF00069	0.474
MOD_Plk_4	644	650	PF00069	0.548
MOD_Plk_4	793	799	PF00069	0.269
MOD_Plk_4	849	855	PF00069	0.269
MOD_ProDKin_1	106	112	PF00069	0.505
MOD_ProDKin_1	116	122	PF00069	0.568
MOD_ProDKin_1	147	153	PF00069	0.551
MOD_ProDKin_1	155	161	PF00069	0.562
MOD_ProDKin_1	184	190	PF00069	0.625
MOD_ProDKin_1	195	201	PF00069	0.489
MOD_ProDKin_1	234	240	PF00069	0.572
MOD_ProDKin_1	267	273	PF00069	0.801
MOD_ProDKin_1	330	336	PF00069	0.695
MOD_ProDKin_1	360	366	PF00069	0.709
MOD_ProDKin_1	379	385	PF00069	0.499
MOD_ProDKin_1	394	400	PF00069	0.597
MOD_ProDKin_1	517	523	PF00069	0.541
MOD_ProDKin_1	627	633	PF00069	0.592
MOD_ProDKin_1	637	643	PF00069	0.580
MOD_ProDKin_1	687	693	PF00069	0.569
MOD_ProDKin_1	702	708	PF00069	0.528
MOD_ProDKin_1	717	723	PF00069	0.543
MOD_ProDKin_1	730	736	PF00069	0.442
MOD_ProDKin_1	808	814	PF00069	0.248
MOD_ProDKin_1	87	93	PF00069	0.598
MOD_ProDKin_1	879	885	PF00069	0.269
MOD_ProDKin_1	925	931	PF00069	0.294
MOD_SUMO_rev_2	852	860	PF00179	0.269
TRG_DiLeu_BaEn_1	411	416	PF01217	0.559
TRG_DiLeu_BaEn_1	874	879	PF01217	0.269
TRG_DiLeu_BaEn_2	967	973	PF01217	0.269
TRG_DiLeu_BaEn_4	411	417	PF01217	0.513
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.577
TRG_DiLeu_LyEn_5	874	879	PF01217	0.269
TRG_ENDOCYTIC_2	1103	1106	PF00928	0.352
TRG_ENDOCYTIC_2	1138	1141	PF00928	0.372
TRG_ER_diArg_1	111	114	PF00400	0.773
TRG_ER_diArg_1	1113	1116	PF00400	0.488
TRG_ER_diArg_1	216	219	PF00400	0.670
TRG_ER_diArg_1	228	231	PF00400	0.782
TRG_ER_diArg_1	377	379	PF00400	0.541
TRG_ER_diArg_1	576	579	PF00400	0.417
TRG_ER_diArg_1	699	702	PF00400	0.541
TRG_ER_diArg_1	753	756	PF00400	0.408
TRG_ER_diArg_1	876	878	PF00400	0.297
TRG_ER_diArg_1	941	944	PF00400	0.297
TRG_ER_diArg_1	961	964	PF00400	0.183
TRG_ER_diArg_1	987	990	PF00400	0.363
TRG_NLS_MonoExtC_3	320	325	PF00514	0.608
TRG_NLS_MonoExtN_4	319	326	PF00514	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ9	Leptomonas seymouri	36%	100%
A4HDI9	Leishmania braziliensis	65%	99%
A4I0Z0	Leishmania infantum	99%	100%
E9AWZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QAH9	Leishmania major	87%	100%