Hypothetical_protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEX9_LEIDO

TriTrypDb:

LdCL_310026500 , LDHU3_31.3340

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IEX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.650
CLV_C14_Caspase3-7	332	336	PF00656	0.664
CLV_NRD_NRD_1	156	158	PF00675	0.456
CLV_NRD_NRD_1	159	161	PF00675	0.477
CLV_NRD_NRD_1	222	224	PF00675	0.459
CLV_NRD_NRD_1	264	266	PF00675	0.495
CLV_NRD_NRD_1	278	280	PF00675	0.503
CLV_NRD_NRD_1	297	299	PF00675	0.390
CLV_NRD_NRD_1	86	88	PF00675	0.405
CLV_PCSK_FUR_1	157	161	PF00082	0.472
CLV_PCSK_FUR_1	276	280	PF00082	0.468
CLV_PCSK_KEX2_1	156	158	PF00082	0.446
CLV_PCSK_KEX2_1	159	161	PF00082	0.453
CLV_PCSK_KEX2_1	221	223	PF00082	0.592
CLV_PCSK_KEX2_1	264	266	PF00082	0.488
CLV_PCSK_KEX2_1	278	280	PF00082	0.503
CLV_PCSK_KEX2_1	296	298	PF00082	0.394
CLV_PCSK_KEX2_1	86	88	PF00082	0.396
CLV_PCSK_PC7_1	217	223	PF00082	0.463
CLV_PCSK_PC7_1	292	298	PF00082	0.470
CLV_PCSK_SKI1_1	114	118	PF00082	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.341
DEG_SCF_FBW7_2	120	126	PF00400	0.665
DOC_ANK_TNKS_1	278	285	PF00023	0.665
DOC_CKS1_1	120	125	PF01111	0.656
DOC_CKS1_1	241	246	PF01111	0.569
DOC_MAPK_HePTP_8	2	14	PF00069	0.191
DOC_MAPK_MEF2A_6	5	14	PF00069	0.213
DOC_PP1_SILK_1	25	30	PF00149	0.308
DOC_PP2B_LxvP_1	184	187	PF13499	0.611
DOC_PP2B_LxvP_1	38	41	PF13499	0.556
DOC_USP7_MATH_1	139	143	PF00917	0.746
DOC_USP7_MATH_1	178	182	PF00917	0.677
DOC_USP7_MATH_1	187	191	PF00917	0.747
DOC_USP7_MATH_1	67	71	PF00917	0.717
DOC_USP7_MATH_2	123	129	PF00917	0.663
DOC_WW_Pin1_4	116	121	PF00397	0.649
DOC_WW_Pin1_4	240	245	PF00397	0.606
DOC_WW_Pin1_4	63	68	PF00397	0.752
LIG_14-3-3_CanoR_1	114	123	PF00244	0.804
LIG_14-3-3_CanoR_1	221	226	PF00244	0.685
LIG_14-3-3_CanoR_1	286	294	PF00244	0.668
LIG_14-3-3_CanoR_1	346	354	PF00244	0.768
LIG_APCC_ABBA_1	369	374	PF00400	0.640
LIG_Clathr_ClatBox_1	314	318	PF01394	0.595
LIG_DCNL_PONY_1	1	4	PF03556	0.335
LIG_FHA_1	22	28	PF00498	0.266
LIG_FHA_1	51	57	PF00498	0.666
LIG_FHA_2	120	126	PF00498	0.665
LIG_FHA_2	306	312	PF00498	0.625
LIG_FHA_2	371	377	PF00498	0.609
LIG_FHA_2	66	72	PF00498	0.641
LIG_LIR_Gen_1	24	33	PF02991	0.342
LIG_LIR_Nem_3	24	28	PF02991	0.228
LIG_SH2_CRK	77	81	PF00017	0.618
LIG_SH2_GRB2like	103	106	PF00017	0.644
LIG_SH2_NCK_1	77	81	PF00017	0.618
LIG_SH2_STAT3	147	150	PF00017	0.657
LIG_SH2_STAT5	320	323	PF00017	0.537
LIG_SH2_STAT5	343	346	PF00017	0.592
LIG_SH2_STAT5	8	11	PF00017	0.237
LIG_SH3_2	241	246	PF14604	0.611
LIG_SH3_3	109	115	PF00018	0.699
LIG_SH3_3	117	123	PF00018	0.767
LIG_SH3_3	198	204	PF00018	0.777
LIG_SH3_3	238	244	PF00018	0.746
LIG_SH3_3	300	306	PF00018	0.626
LIG_SH3_3	350	356	PF00018	0.644
LIG_SUMO_SIM_anti_2	311	318	PF11976	0.608
LIG_SUMO_SIM_anti_2	43	51	PF11976	0.603
LIG_SUMO_SIM_par_1	18	24	PF11976	0.204
LIG_SUMO_SIM_par_1	311	318	PF11976	0.608
LIG_TRAF2_1	123	126	PF00917	0.663
LIG_TRAF2_1	361	364	PF00917	0.642
LIG_TRAF2_1	41	44	PF00917	0.600
LIG_TYR_ITIM	186	191	PF00017	0.610
LIG_UBA3_1	27	32	PF00899	0.383
LIG_WRC_WIRS_1	22	27	PF05994	0.248
LIG_WW_3	202	206	PF00397	0.628
MOD_CDK_SPK_2	119	124	PF00069	0.667
MOD_CDK_SPxK_1	240	246	PF00069	0.569
MOD_CK1_1	106	112	PF00069	0.620
MOD_CK1_1	119	125	PF00069	0.639
MOD_CK1_1	158	164	PF00069	0.709
MOD_CK1_1	169	175	PF00069	0.672
MOD_CK1_1	179	185	PF00069	0.733
MOD_CK1_1	190	196	PF00069	0.660
MOD_CK1_1	271	277	PF00069	0.683
MOD_CK1_1	288	294	PF00069	0.597
MOD_CK1_1	358	364	PF00069	0.704
MOD_CK1_1	370	376	PF00069	0.569
MOD_CK1_1	65	71	PF00069	0.642
MOD_CK1_1	78	84	PF00069	0.637
MOD_CK2_1	119	125	PF00069	0.666
MOD_CK2_1	358	364	PF00069	0.779
MOD_CK2_1	370	376	PF00069	0.573
MOD_Cter_Amidation	219	222	PF01082	0.462
MOD_GlcNHglycan	125	130	PF01048	0.461
MOD_GlcNHglycan	133	136	PF01048	0.453
MOD_GlcNHglycan	160	163	PF01048	0.481
MOD_GlcNHglycan	196	200	PF01048	0.539
MOD_GlcNHglycan	218	221	PF01048	0.499
MOD_GlcNHglycan	252	255	PF01048	0.399
MOD_GlcNHglycan	259	262	PF01048	0.387
MOD_GlcNHglycan	287	290	PF01048	0.504
MOD_GlcNHglycan	80	83	PF01048	0.436
MOD_GlcNHglycan	96	99	PF01048	0.398
MOD_GSK3_1	151	158	PF00069	0.770
MOD_GSK3_1	207	214	PF00069	0.667
MOD_GSK3_1	268	275	PF00069	0.653
MOD_GSK3_1	61	68	PF00069	0.701
MOD_GSK3_1	90	97	PF00069	0.647
MOD_N-GLC_1	166	171	PF02516	0.462
MOD_N-GLC_1	176	181	PF02516	0.440
MOD_N-GLC_1	215	220	PF02516	0.467
MOD_N-GLC_1	250	255	PF02516	0.392
MOD_N-GLC_1	358	363	PF02516	0.445
MOD_NEK2_1	209	214	PF00069	0.775
MOD_NEK2_2	367	372	PF00069	0.646
MOD_PKA_1	221	227	PF00069	0.654
MOD_PKA_2	155	161	PF00069	0.670
MOD_PKA_2	216	222	PF00069	0.724
MOD_PKA_2	271	277	PF00069	0.677
MOD_PKA_2	285	291	PF00069	0.609
MOD_PKA_2	345	351	PF00069	0.737
MOD_PKB_1	213	221	PF00069	0.667
MOD_Plk_1	169	175	PF00069	0.668
MOD_Plk_1	358	364	PF00069	0.779
MOD_Plk_1	45	51	PF00069	0.606
MOD_Plk_4	367	373	PF00069	0.623
MOD_Plk_4	50	56	PF00069	0.631
MOD_Plk_4	75	81	PF00069	0.640
MOD_ProDKin_1	116	122	PF00069	0.650
MOD_ProDKin_1	240	246	PF00069	0.608
MOD_ProDKin_1	63	69	PF00069	0.752
TRG_ENDOCYTIC_2	188	191	PF00928	0.614
TRG_ENDOCYTIC_2	325	328	PF00928	0.564
TRG_ENDOCYTIC_2	77	80	PF00928	0.620
TRG_ER_diArg_1	156	159	PF00400	0.668
TRG_ER_diArg_1	221	223	PF00400	0.743
TRG_ER_diArg_1	263	265	PF00400	0.672
TRG_ER_diArg_1	290	293	PF00400	0.667
TRG_ER_diArg_1	296	298	PF00400	0.643
TRG_ER_diArg_1	86	88	PF00400	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D2	Leptomonas seymouri	24%	100%