p21-C-terminal region-binding protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p21-C-terminal region-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEX8_LEIDO

TriTrypDb:

LdBPK_282030.1 , LdCL_280025400 , LDHU3_28.2680

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.745
CLV_C14_Caspase3-7	238	242	PF00656	0.754
CLV_C14_Caspase3-7	329	333	PF00656	0.764
CLV_C14_Caspase3-7	347	351	PF00656	0.513
CLV_C14_Caspase3-7	449	453	PF00656	0.619
CLV_C14_Caspase3-7	488	492	PF00656	0.619
CLV_C14_Caspase3-7	559	563	PF00656	0.563
CLV_C14_Caspase3-7	58	62	PF00656	0.690
CLV_NRD_NRD_1	103	105	PF00675	0.664
CLV_NRD_NRD_1	130	132	PF00675	0.721
CLV_NRD_NRD_1	212	214	PF00675	0.642
CLV_NRD_NRD_1	225	227	PF00675	0.695
CLV_NRD_NRD_1	311	313	PF00675	0.824
CLV_NRD_NRD_1	568	570	PF00675	0.369
CLV_NRD_NRD_1	666	668	PF00675	0.486
CLV_NRD_NRD_1	75	77	PF00675	0.667
CLV_NRD_NRD_1	93	95	PF00675	0.680
CLV_PCSK_FUR_1	621	625	PF00082	0.487
CLV_PCSK_FUR_1	91	95	PF00082	0.604
CLV_PCSK_KEX2_1	101	103	PF00082	0.642
CLV_PCSK_KEX2_1	130	132	PF00082	0.773
CLV_PCSK_KEX2_1	225	227	PF00082	0.797
CLV_PCSK_KEX2_1	28	30	PF00082	0.694
CLV_PCSK_KEX2_1	3	5	PF00082	0.741
CLV_PCSK_KEX2_1	310	312	PF00082	0.823
CLV_PCSK_KEX2_1	623	625	PF00082	0.502
CLV_PCSK_KEX2_1	665	667	PF00082	0.545
CLV_PCSK_KEX2_1	77	79	PF00082	0.670
CLV_PCSK_KEX2_1	93	95	PF00082	0.704
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.618
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.694
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.741
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.502
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.679
CLV_PCSK_PC7_1	126	132	PF00082	0.601
CLV_PCSK_SKI1_1	131	135	PF00082	0.767
CLV_PCSK_SKI1_1	28	32	PF00082	0.596
CLV_PCSK_SKI1_1	462	466	PF00082	0.346
CLV_PCSK_SKI1_1	624	628	PF00082	0.489
CLV_PCSK_SKI1_1	77	81	PF00082	0.782
CLV_PCSK_SKI1_1	94	98	PF00082	0.446
DEG_APCC_DBOX_1	130	138	PF00400	0.596
DOC_ANK_TNKS_1	434	441	PF00023	0.536
DOC_CKS1_1	83	88	PF01111	0.644
DOC_CYCLIN_RxL_1	459	469	PF00134	0.546
DOC_MAPK_DCC_7	130	139	PF00069	0.597
DOC_MAPK_DCC_7	3	13	PF00069	0.729
DOC_MAPK_gen_1	101	107	PF00069	0.677
DOC_MAPK_gen_1	130	137	PF00069	0.595
DOC_MAPK_gen_1	3	13	PF00069	0.729
DOC_MAPK_gen_1	460	467	PF00069	0.546
DOC_MAPK_JIP1_4	131	137	PF00069	0.593
DOC_MAPK_MEF2A_6	130	139	PF00069	0.597
DOC_MAPK_MEF2A_6	369	376	PF00069	0.546
DOC_MAPK_MEF2A_6	472	480	PF00069	0.546
DOC_MAPK_NFAT4_5	369	377	PF00069	0.546
DOC_PP1_RVXF_1	101	108	PF00149	0.676
DOC_PP1_RVXF_1	136	142	PF00149	0.735
DOC_USP7_MATH_1	253	257	PF00917	0.807
DOC_USP7_MATH_1	258	262	PF00917	0.844
DOC_USP7_MATH_1	317	321	PF00917	0.721
DOC_USP7_MATH_1	380	384	PF00917	0.546
DOC_USP7_MATH_1	455	459	PF00917	0.563
DOC_USP7_MATH_1	547	551	PF00917	0.616
DOC_USP7_MATH_1	586	590	PF00917	0.563
DOC_USP7_UBL2_3	97	101	PF12436	0.417
DOC_WW_Pin1_4	254	259	PF00397	0.833
DOC_WW_Pin1_4	376	381	PF00397	0.546
DOC_WW_Pin1_4	597	602	PF00397	0.619
DOC_WW_Pin1_4	62	67	PF00397	0.665
DOC_WW_Pin1_4	82	87	PF00397	0.449
LIG_14-3-3_CanoR_1	102	108	PF00244	0.654
LIG_14-3-3_CanoR_1	147	156	PF00244	0.751
LIG_14-3-3_CanoR_1	213	217	PF00244	0.729
LIG_14-3-3_CanoR_1	29	37	PF00244	0.797
LIG_14-3-3_CanoR_1	533	541	PF00244	0.546
LIG_14-3-3_CanoR_1	624	629	PF00244	0.539
LIG_14-3-3_CanoR_1	665	671	PF00244	0.539
LIG_Actin_RPEL_3	428	447	PF02755	0.546
LIG_BIR_III_4	491	495	PF00653	0.546
LIG_BRCT_BRCA1_1	646	650	PF00533	0.455
LIG_Clathr_ClatBox_1	334	338	PF01394	0.411
LIG_CtBP_PxDLS_1	475	479	PF00389	0.546
LIG_CtBP_PxDLS_1	601	605	PF00389	0.619
LIG_CtBP_PxDLS_1	86	90	PF00389	0.679
LIG_FHA_1	380	386	PF00498	0.546
LIG_FHA_1	442	448	PF00498	0.546
LIG_FHA_1	477	483	PF00498	0.536
LIG_FHA_1	603	609	PF00498	0.530
LIG_FHA_2	392	398	PF00498	0.544
LIG_FHA_2	503	509	PF00498	0.619
LIG_LIR_Gen_1	378	387	PF02991	0.546
LIG_LIR_Nem_3	140	144	PF02991	0.763
LIG_LIR_Nem_3	336	342	PF02991	0.546
LIG_LIR_Nem_3	378	384	PF02991	0.546
LIG_LIR_Nem_3	399	405	PF02991	0.550
LIG_MYND_1	132	136	PF01753	0.687
LIG_SH2_NCK_1	377	381	PF00017	0.530
LIG_SH2_STAP1	26	30	PF00017	0.593
LIG_SH2_STAT3	636	639	PF00017	0.562
LIG_SH2_STAT5	178	181	PF00017	0.727
LIG_SH2_STAT5	470	473	PF00017	0.546
LIG_SH2_STAT5	607	610	PF00017	0.546
LIG_SH3_1	80	86	PF00018	0.706
LIG_SH3_2	142	147	PF14604	0.810
LIG_SH3_3	130	136	PF00018	0.748
LIG_SH3_3	139	145	PF00018	0.696
LIG_SH3_3	436	442	PF00018	0.536
LIG_SH3_3	536	542	PF00018	0.546
LIG_SH3_3	595	601	PF00018	0.619
LIG_SH3_3	60	66	PF00018	0.766
LIG_SH3_3	80	86	PF00018	0.453
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.466
LIG_SUMO_SIM_par_1	332	338	PF11976	0.411
LIG_SUMO_SIM_par_1	463	469	PF11976	0.546
LIG_SUMO_SIM_par_1	474	479	PF11976	0.546
LIG_SUMO_SIM_par_1	600	605	PF11976	0.557
LIG_SUMO_SIM_par_1	9	16	PF11976	0.724
LIG_TRAF2_1	202	205	PF00917	0.675
LIG_TRAF2_1	246	249	PF00917	0.629
LIG_TRAF2_1	295	298	PF00917	0.822
LIG_TRAF2_1	395	398	PF00917	0.546
LIG_UBA3_1	524	530	PF00899	0.546
MOD_CK1_1	140	146	PF00069	0.733
MOD_CK1_1	150	156	PF00069	0.695
MOD_CK1_1	188	194	PF00069	0.826
MOD_CK1_1	237	243	PF00069	0.736
MOD_CK1_1	33	39	PF00069	0.707
MOD_CK1_1	379	385	PF00069	0.546
MOD_CK1_1	576	582	PF00069	0.591
MOD_CK1_1	62	68	PF00069	0.727
MOD_CK2_1	157	163	PF00069	0.755
MOD_CK2_1	18	24	PF00069	0.805
MOD_CK2_1	198	204	PF00069	0.752
MOD_CK2_1	233	239	PF00069	0.774
MOD_CK2_1	243	249	PF00069	0.699
MOD_CK2_1	292	298	PF00069	0.823
MOD_CK2_1	317	323	PF00069	0.721
MOD_CK2_1	391	397	PF00069	0.544
MOD_CK2_1	502	508	PF00069	0.619
MOD_CK2_1	62	68	PF00069	0.635
MOD_GlcNHglycan	119	122	PF01048	0.746
MOD_GlcNHglycan	149	152	PF01048	0.747
MOD_GlcNHglycan	189	193	PF01048	0.783
MOD_GlcNHglycan	200	203	PF01048	0.660
MOD_GlcNHglycan	268	272	PF01048	0.739
MOD_GlcNHglycan	298	304	PF01048	0.820
MOD_GlcNHglycan	46	49	PF01048	0.728
MOD_GlcNHglycan	549	552	PF01048	0.349
MOD_GlcNHglycan	558	561	PF01048	0.342
MOD_GlcNHglycan	586	589	PF01048	0.361
MOD_GlcNHglycan	590	593	PF01048	0.349
MOD_GSK3_1	146	153	PF00069	0.719
MOD_GSK3_1	184	191	PF00069	0.812
MOD_GSK3_1	194	201	PF00069	0.729
MOD_GSK3_1	233	240	PF00069	0.723
MOD_GSK3_1	254	261	PF00069	0.836
MOD_GSK3_1	276	283	PF00069	0.676
MOD_GSK3_1	29	36	PF00069	0.668
MOD_GSK3_1	376	383	PF00069	0.522
MOD_GSK3_1	44	51	PF00069	0.786
MOD_GSK3_1	441	448	PF00069	0.516
MOD_GSK3_1	547	554	PF00069	0.544
MOD_GSK3_1	576	583	PF00069	0.619
MOD_GSK3_1	584	591	PF00069	0.524
MOD_N-GLC_1	117	122	PF02516	0.751
MOD_N-GLC_1	243	248	PF02516	0.634
MOD_NEK2_1	212	217	PF00069	0.733
MOD_NEK2_1	266	271	PF00069	0.572
MOD_NEK2_1	344	349	PF00069	0.530
MOD_NEK2_1	43	48	PF00069	0.761
MOD_NEK2_1	476	481	PF00069	0.546
MOD_NEK2_1	602	607	PF00069	0.530
MOD_PK_1	59	65	PF00069	0.668
MOD_PKA_1	103	109	PF00069	0.642
MOD_PKA_1	580	586	PF00069	0.619
MOD_PKA_1	666	672	PF00069	0.540
MOD_PKA_2	103	109	PF00069	0.642
MOD_PKA_2	146	152	PF00069	0.820
MOD_PKA_2	212	218	PF00069	0.733
MOD_PKA_2	43	49	PF00069	0.680
MOD_PKA_2	532	538	PF00069	0.543
MOD_PKA_2	576	582	PF00069	0.521
MOD_PKA_2	666	672	PF00069	0.540
MOD_Plk_1	13	19	PF00069	0.605
MOD_Plk_1	188	194	PF00069	0.669
MOD_Plk_1	33	39	PF00069	0.518
MOD_Plk_1	476	482	PF00069	0.546
MOD_Plk_1	602	608	PF00069	0.539
MOD_Plk_2-3	234	240	PF00069	0.796
MOD_Plk_2-3	292	298	PF00069	0.832
MOD_Plk_4	380	386	PF00069	0.546
MOD_Plk_4	404	410	PF00069	0.546
MOD_Plk_4	413	419	PF00069	0.546
MOD_Plk_4	446	452	PF00069	0.546
MOD_Plk_4	520	526	PF00069	0.516
MOD_Plk_4	59	65	PF00069	0.707
MOD_Plk_4	624	630	PF00069	0.514
MOD_Plk_4	644	650	PF00069	0.343
MOD_Plk_4	85	91	PF00069	0.675
MOD_ProDKin_1	254	260	PF00069	0.835
MOD_ProDKin_1	376	382	PF00069	0.546
MOD_ProDKin_1	597	603	PF00069	0.619
MOD_ProDKin_1	62	68	PF00069	0.663
MOD_ProDKin_1	82	88	PF00069	0.442
MOD_SUMO_rev_2	246	253	PF00179	0.620
MOD_SUMO_rev_2	491	501	PF00179	0.605
TRG_DiLeu_BaEn_4	204	210	PF01217	0.682
TRG_DiLeu_BaEn_4	612	618	PF01217	0.546
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.594
TRG_ER_diArg_1	102	104	PF00400	0.657
TRG_ER_diArg_1	130	132	PF00400	0.769
TRG_ER_diArg_1	17	20	PF00400	0.640
TRG_ER_diArg_1	310	312	PF00400	0.767
TRG_ER_diArg_1	630	633	PF00400	0.524
TRG_ER_diArg_1	664	667	PF00400	0.632
TRG_ER_diArg_1	90	93	PF00400	0.629
TRG_NLS_MonoCore_2	100	105	PF00514	0.670
TRG_NLS_MonoExtC_3	75	80	PF00514	0.715
TRG_NLS_MonoExtN_4	2	7	PF00514	0.737
TRG_NLS_MonoExtN_4	74	80	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7I5	Leptomonas seymouri	55%	100%
A4HGP4	Leishmania braziliensis	74%	99%
A4I3R7	Leishmania infantum	99%	100%
E9B010	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4Q875	Leishmania major	90%	100%