Heat_shock_70-related_protein_1_mitochondrial_pre cursor_putative/GeneDB:LmjF.30.2460/GeneDB:LmjF.30.2470/Gen eDB:LmjF.30.2480/GeneDB:LmjF.30.2490/GeneDB:LmjF.30.2550

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1, mitochondrial precursor, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IEX7_LEIDO

TriTrypDb:

LdBPK_302480.1 , LdCL_300030300 , LdCL_300030400 , LDHU3_30.3350

Length:

661

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005739	mitochondrion	5	4
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	21

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Expansion

Sequence features

A0A3Q8IEX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEX7

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	4
GO:0006458	'de novo' protein folding	3	4
GO:0006950	response to stress	2	4
GO:0006986	response to unfolded protein	4	4
GO:0009987	cellular process	1	4
GO:0010033	response to organic substance	3	4
GO:0033554	cellular response to stress	3	4
GO:0034620	cellular response to unfolded protein	5	4
GO:0035966	response to topologically incorrect protein	3	4
GO:0035967	cellular response to topologically incorrect protein	4	4

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	21
GO:0005515	protein binding	2	20
GO:0005524	ATP binding	5	21
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0016887	ATP hydrolysis activity	7	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.295
CLV_NRD_NRD_1	264	266	PF00675	0.415
CLV_NRD_NRD_1	4	6	PF00675	0.551
CLV_NRD_NRD_1	591	593	PF00675	0.311
CLV_NRD_NRD_1	99	101	PF00675	0.309
CLV_PCSK_FUR_1	547	551	PF00082	0.315
CLV_PCSK_KEX2_1	4	6	PF00082	0.551
CLV_PCSK_KEX2_1	549	551	PF00082	0.315
CLV_PCSK_KEX2_1	79	81	PF00082	0.295
CLV_PCSK_KEX2_1	94	96	PF00082	0.295

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P290	Leptomonas seymouri	53%	100%
A0A0N1I1E4	Leptomonas seymouri	49%	100%
A0A0N1I1R3	Leptomonas seymouri	47%	99%
A0A0N1I3L9	Leptomonas seymouri	40%	100%
A0A0N1PEK8	Leptomonas seymouri	29%	72%
A0A0S4IPK6	Bodo saltans	49%	100%
A0A0S4IUD0	Bodo saltans	51%	100%
A0A0S4J8H0	Bodo saltans	40%	98%
A0A0S4JK39	Bodo saltans	49%	100%
A0A0S4JND6	Bodo saltans	45%	88%

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