LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEX5_LEIDO

TriTrypDb:

LdBPK_331880.1 , LdCL_330025500 , LDHU3_33.2780

Length:

1631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	11
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	5	1
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A0A3Q8IEX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0016567	protein ubiquitination	7	11
GO:0019538	protein metabolic process	3	11
GO:0032446	protein modification by small protein conjugation	6	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0070647	protein modification by small protein conjugation or removal	5	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1096	1100	PF00656	0.420
CLV_C14_Caspase3-7	1125	1129	PF00656	0.481
CLV_C14_Caspase3-7	1136	1140	PF00656	0.482
CLV_C14_Caspase3-7	1246	1250	PF00656	0.439
CLV_C14_Caspase3-7	1542	1546	PF00656	0.586
CLV_C14_Caspase3-7	1569	1573	PF00656	0.577
CLV_C14_Caspase3-7	312	316	PF00656	0.770
CLV_C14_Caspase3-7	353	357	PF00656	0.733
CLV_NRD_NRD_1	1027	1029	PF00675	0.619
CLV_NRD_NRD_1	1202	1204	PF00675	0.575

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAS1	Leptomonas seymouri	77%	97%
A0A1X0P3V3	Trypanosomatidae	47%	99%
A0A3R7RCV5	Trypanosoma rangeli	45%	99%
A4HLN8	Leishmania braziliensis	90%	100%
A4I973	Leishmania infantum	100%	100%
D0A6D5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9B414	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q410	Leishmania major	97%	100%
V5BPC1	Trypanosoma cruzi	45%	100%

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