Zinc finger, C3HC4 type (RING finger) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger) containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEX4_LEIDO

TriTrypDb:

LdCL_240019200 , LDHU3_24.1700

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEX4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	85	87	PF00675	0.568
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SPOP_SBC_1	43	47	PF00917	0.619
DOC_PP4_FxxP_1	59	62	PF00568	0.634
DOC_USP7_MATH_1	138	142	PF00917	0.657
DOC_USP7_MATH_1	69	73	PF00917	0.617
LIG_14-3-3_CanoR_1	86	91	PF00244	0.511
LIG_BIR_III_2	137	141	PF00653	0.693
LIG_deltaCOP1_diTrp_1	111	117	PF00928	0.613
LIG_FHA_1	23	29	PF00498	0.347
LIG_LIR_Apic_2	22	27	PF02991	0.311
LIG_LIR_Apic_2	57	62	PF02991	0.510
LIG_LIR_Gen_1	111	119	PF02991	0.611
LIG_LIR_Nem_3	111	117	PF02991	0.497
LIG_PDZ_Class_2	150	155	PF00595	0.677
LIG_SH2_STAT5	103	106	PF00017	0.632
LIG_SH3_3	101	107	PF00018	0.659
LIG_SH3_3	6	12	PF00018	0.576
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.606
MOD_CK1_1	102	108	PF00069	0.633
MOD_CK1_1	4	10	PF00069	0.616
MOD_GlcNHglycan	56	59	PF01048	0.587
MOD_GSK3_1	139	146	PF00069	0.654
MOD_GSK3_1	60	67	PF00069	0.599
MOD_GSK3_1	71	78	PF00069	0.577
MOD_GSK3_1	94	101	PF00069	0.661
MOD_N-GLC_1	1	6	PF02516	0.651
MOD_N-GLC_2	110	112	PF02516	0.491
MOD_NEK2_1	1	6	PF00069	0.651
MOD_NEK2_1	51	56	PF00069	0.486
MOD_NEK2_1	71	76	PF00069	0.551
MOD_NEK2_1	98	103	PF00069	0.674
MOD_PKA_1	86	92	PF00069	0.594
MOD_Plk_1	67	73	PF00069	0.547
MOD_Plk_4	71	77	PF00069	0.602
MOD_Plk_4	99	105	PF00069	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ9	Leptomonas seymouri	61%	100%
A0A1X0NVM4	Trypanosomatidae	33%	100%
A0A3R7KGI2	Trypanosoma rangeli	34%	100%