LeishMANIAdb
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AAA domain (Cdc48 subfamily)/AAA domain (Dynein-related subfamily), putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AAA domain (Cdc48 subfamily)/AAA domain (Dynein-related subfamily), putative
Gene product:
AAA domain (Cdc48 subfamily), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IEX3_LEIDO
TriTrypDb:
LdBPK_301700.1 * , LdCL_300022300 , LDHU3_30.2380
Length:
860

Annotations

LeishMANIAdb annotations

These proteins are apparently divergent members of the greater ClpB family found in both Eukaryota and Prokaryota. The TM segments are unusual additions.. Anchored into the membrane using the very last 3 helical segment (similar to tail-anchored proteins)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3Q8IEX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEX3

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034605 cellular response to heat 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 517 519 PF00675 0.358
CLV_NRD_NRD_1 586 588 PF00675 0.483
CLV_NRD_NRD_1 694 696 PF00675 0.613
CLV_NRD_NRD_1 71 73 PF00675 0.709
CLV_PCSK_FUR_1 86 90 PF00082 0.774
CLV_PCSK_KEX2_1 274 276 PF00082 0.434
CLV_PCSK_KEX2_1 344 346 PF00082 0.296
CLV_PCSK_KEX2_1 517 519 PF00082 0.349
CLV_PCSK_KEX2_1 586 588 PF00082 0.483
CLV_PCSK_KEX2_1 694 696 PF00082 0.615
CLV_PCSK_KEX2_1 71 73 PF00082 0.711
CLV_PCSK_KEX2_1 88 90 PF00082 0.773
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.459
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.362
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.762
CLV_PCSK_SKI1_1 163 167 PF00082 0.496
CLV_PCSK_SKI1_1 286 290 PF00082 0.479
CLV_PCSK_SKI1_1 434 438 PF00082 0.282
CLV_PCSK_SKI1_1 480 484 PF00082 0.353
CLV_PCSK_SKI1_1 527 531 PF00082 0.364
CLV_PCSK_SKI1_1 641 645 PF00082 0.543
CLV_PCSK_SKI1_1 753 757 PF00082 0.413
CLV_PCSK_SKI1_1 769 773 PF00082 0.300
CLV_PCSK_SKI1_1 77 81 PF00082 0.743
CLV_PCSK_SKI1_1 827 831 PF00082 0.386
DEG_APCC_DBOX_1 162 170 PF00400 0.362
DEG_APCC_DBOX_1 264 272 PF00400 0.681
DEG_SCF_FBW7_1 708 715 PF00400 0.670
DEG_SPOP_SBC_1 222 226 PF00917 0.783
DEG_SPOP_SBC_1 615 619 PF00917 0.802
DEG_SPOP_SBC_1 703 707 PF00917 0.745
DOC_CKS1_1 540 545 PF01111 0.535
DOC_CKS1_1 709 714 PF01111 0.739
DOC_CYCLIN_RxL_1 738 748 PF00134 0.606
DOC_CYCLIN_RxL_1 750 760 PF00134 0.562
DOC_CYCLIN_RxL_1 769 783 PF00134 0.477
DOC_CYCLIN_yCln2_LP_2 815 821 PF00134 0.447
DOC_CYCLIN_yCln2_LP_2 832 838 PF00134 0.447
DOC_MAPK_gen_1 161 168 PF00069 0.315
DOC_MAPK_gen_1 514 523 PF00069 0.546
DOC_MAPK_HePTP_8 772 784 PF00069 0.562
DOC_MAPK_JIP1_4 325 331 PF00069 0.562
DOC_MAPK_MEF2A_6 161 170 PF00069 0.335
DOC_MAPK_MEF2A_6 325 332 PF00069 0.482
DOC_MAPK_MEF2A_6 517 525 PF00069 0.531
DOC_MAPK_MEF2A_6 775 784 PF00069 0.493
DOC_MAPK_MEF2A_6 837 845 PF00069 0.447
DOC_PP2B_LxvP_1 681 684 PF13499 0.748
DOC_PP2B_LxvP_1 815 818 PF13499 0.447
DOC_PP4_FxxP_1 331 334 PF00568 0.534
DOC_USP7_MATH_1 188 192 PF00917 0.676
DOC_USP7_MATH_1 222 226 PF00917 0.795
DOC_USP7_MATH_1 254 258 PF00917 0.699
DOC_USP7_MATH_1 288 292 PF00917 0.640
DOC_USP7_MATH_1 296 300 PF00917 0.600
DOC_USP7_MATH_1 310 314 PF00917 0.586
DOC_USP7_MATH_1 439 443 PF00917 0.482
DOC_USP7_MATH_1 48 52 PF00917 0.451
DOC_USP7_MATH_1 599 603 PF00917 0.680
DOC_USP7_MATH_1 610 614 PF00917 0.782
DOC_USP7_MATH_1 647 651 PF00917 0.643
DOC_USP7_MATH_1 702 706 PF00917 0.781
DOC_USP7_MATH_1 712 716 PF00917 0.691
DOC_USP7_MATH_1 720 724 PF00917 0.721
DOC_USP7_MATH_1 850 854 PF00917 0.461
DOC_WW_Pin1_4 223 228 PF00397 0.706
DOC_WW_Pin1_4 286 291 PF00397 0.679
DOC_WW_Pin1_4 469 474 PF00397 0.586
DOC_WW_Pin1_4 539 544 PF00397 0.538
DOC_WW_Pin1_4 606 611 PF00397 0.693
DOC_WW_Pin1_4 64 69 PF00397 0.580
DOC_WW_Pin1_4 679 684 PF00397 0.814
DOC_WW_Pin1_4 708 713 PF00397 0.769
DOC_WW_Pin1_4 89 94 PF00397 0.567
LIG_14-3-3_CanoR_1 221 227 PF00244 0.708
LIG_14-3-3_CanoR_1 265 269 PF00244 0.653
LIG_14-3-3_CanoR_1 275 279 PF00244 0.698
LIG_14-3-3_CanoR_1 345 350 PF00244 0.562
LIG_14-3-3_CanoR_1 441 447 PF00244 0.482
LIG_14-3-3_CanoR_1 552 557 PF00244 0.617
LIG_14-3-3_CanoR_1 9 17 PF00244 0.506
LIG_Actin_WH2_2 784 800 PF00022 0.447
LIG_AP2alpha_2 497 499 PF02296 0.465
LIG_APCC_ABBA_1 147 152 PF00400 0.557
LIG_BIR_III_2 287 291 PF00653 0.554
LIG_EH1_1 788 796 PF00400 0.402
LIG_eIF4E_1 836 842 PF01652 0.480
LIG_FHA_1 116 122 PF00498 0.472
LIG_FHA_1 144 150 PF00498 0.518
LIG_FHA_1 214 220 PF00498 0.803
LIG_FHA_1 235 241 PF00498 0.670
LIG_FHA_1 325 331 PF00498 0.505
LIG_FHA_1 447 453 PF00498 0.490
LIG_FHA_1 558 564 PF00498 0.666
LIG_FHA_1 565 571 PF00498 0.621
LIG_FHA_1 576 582 PF00498 0.511
LIG_FHA_1 590 596 PF00498 0.636
LIG_FHA_1 704 710 PF00498 0.764
LIG_FHA_1 735 741 PF00498 0.645
LIG_FHA_2 108 114 PF00498 0.495
LIG_FHA_2 287 293 PF00498 0.649
LIG_FHA_2 492 498 PF00498 0.495
LIG_FHA_2 511 517 PF00498 0.445
LIG_FHA_2 598 604 PF00498 0.689
LIG_FHA_2 672 678 PF00498 0.794
LIG_FHA_2 749 755 PF00498 0.633
LIG_FHA_2 763 769 PF00498 0.529
LIG_FHA_2 97 103 PF00498 0.599
LIG_GBD_Chelix_1 777 785 PF00786 0.338
LIG_GBD_Chelix_1 807 815 PF00786 0.393
LIG_LIR_Apic_2 538 543 PF02991 0.603
LIG_LIR_Gen_1 109 117 PF02991 0.523
LIG_LIR_Gen_1 376 387 PF02991 0.482
LIG_LIR_Gen_1 542 553 PF02991 0.573
LIG_LIR_Gen_1 646 655 PF02991 0.609
LIG_LIR_Gen_1 730 740 PF02991 0.692
LIG_LIR_Gen_1 800 811 PF02991 0.314
LIG_LIR_Nem_3 146 150 PF02991 0.537
LIG_LIR_Nem_3 376 382 PF02991 0.482
LIG_LIR_Nem_3 504 509 PF02991 0.524
LIG_LIR_Nem_3 542 548 PF02991 0.567
LIG_LIR_Nem_3 646 651 PF02991 0.628
LIG_LIR_Nem_3 730 736 PF02991 0.701
LIG_LIR_Nem_3 800 806 PF02991 0.314
LIG_MYND_3 355 359 PF01753 0.546
LIG_NRBOX 524 530 PF00104 0.601
LIG_NRBOX 780 786 PF00104 0.408
LIG_NRBOX 828 834 PF00104 0.402
LIG_NRBOX 840 846 PF00104 0.250
LIG_PAM2_1 225 237 PF00658 0.609
LIG_PCNA_PIPBox_1 476 485 PF02747 0.562
LIG_PCNA_yPIPBox_3 161 169 PF02747 0.369
LIG_PCNA_yPIPBox_3 476 488 PF02747 0.574
LIG_Pex14_1 423 427 PF04695 0.482
LIG_SH2_CRK 540 544 PF00017 0.627
LIG_SH2_GRB2like 468 471 PF00017 0.516
LIG_SH2_NCK_1 379 383 PF00017 0.482
LIG_SH2_NCK_1 512 516 PF00017 0.588
LIG_SH2_NCK_1 540 544 PF00017 0.627
LIG_SH2_SRC 468 471 PF00017 0.516
LIG_SH2_STAP1 150 154 PF00017 0.527
LIG_SH2_STAP1 177 181 PF00017 0.603
LIG_SH2_STAT3 301 304 PF00017 0.525
LIG_SH2_STAT5 301 304 PF00017 0.525
LIG_SH2_STAT5 366 369 PF00017 0.513
LIG_SH2_STAT5 468 471 PF00017 0.482
LIG_SH2_STAT5 512 515 PF00017 0.561
LIG_SH3_3 179 185 PF00018 0.684
LIG_SH3_3 214 220 PF00018 0.813
LIG_SH3_3 28 34 PF00018 0.534
LIG_SH3_3 379 385 PF00018 0.482
LIG_SH3_3 505 511 PF00018 0.519
LIG_SH3_3 592 598 PF00018 0.569
LIG_SH3_3 649 655 PF00018 0.698
LIG_SH3_3 719 725 PF00018 0.721
LIG_SUMO_SIM_anti_2 241 246 PF11976 0.658
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.484
LIG_SUMO_SIM_anti_2 592 597 PF11976 0.618
LIG_SUMO_SIM_anti_2 768 774 PF11976 0.622
LIG_SUMO_SIM_par_1 403 410 PF11976 0.484
LIG_SUMO_SIM_par_1 578 585 PF11976 0.548
LIG_SUMO_SIM_par_1 778 783 PF11976 0.398
LIG_SUMO_SIM_par_1 840 846 PF11976 0.393
LIG_TRAF2_1 474 477 PF00917 0.528
LIG_TRFH_1 507 511 PF08558 0.463
LIG_UBA3_1 394 400 PF00899 0.480
LIG_UBA3_1 482 488 PF00899 0.460
LIG_UBA3_1 742 747 PF00899 0.641
LIG_UBA3_1 790 798 PF00899 0.297
LIG_UBA3_1 829 837 PF00899 0.424
LIG_WRC_WIRS_1 108 113 PF05994 0.528
LIG_WRC_WIRS_1 144 149 PF05994 0.511
LIG_WRC_WIRS_1 369 374 PF05994 0.482
LIG_WRC_WIRS_1 553 558 PF05994 0.567
MOD_CDC14_SPxK_1 682 685 PF00782 0.723
MOD_CDK_SPxK_1 679 685 PF00069 0.726
MOD_CDK_SPxxK_3 286 293 PF00069 0.672
MOD_CDK_SPxxK_3 64 71 PF00069 0.573
MOD_CK1_1 107 113 PF00069 0.397
MOD_CK1_1 225 231 PF00069 0.749
MOD_CK1_1 371 377 PF00069 0.482
MOD_CK1_1 442 448 PF00069 0.482
MOD_CK1_1 51 57 PF00069 0.591
MOD_CK1_1 64 70 PF00069 0.447
MOD_CK1_1 698 704 PF00069 0.755
MOD_CK1_1 91 97 PF00069 0.560
MOD_CK2_1 254 260 PF00069 0.655
MOD_CK2_1 286 292 PF00069 0.608
MOD_CK2_1 411 417 PF00069 0.562
MOD_CK2_1 432 438 PF00069 0.513
MOD_CK2_1 510 516 PF00069 0.514
MOD_CK2_1 528 534 PF00069 0.537
MOD_CK2_1 597 603 PF00069 0.678
MOD_CK2_1 671 677 PF00069 0.788
MOD_CK2_1 748 754 PF00069 0.605
MOD_GlcNHglycan 12 15 PF01048 0.694
MOD_GlcNHglycan 139 142 PF01048 0.769
MOD_GlcNHglycan 211 214 PF01048 0.543
MOD_GlcNHglycan 281 285 PF01048 0.498
MOD_GlcNHglycan 316 319 PF01048 0.439
MOD_GlcNHglycan 334 337 PF01048 0.225
MOD_GlcNHglycan 359 363 PF01048 0.296
MOD_GlcNHglycan 390 393 PF01048 0.308
MOD_GlcNHglycan 395 398 PF01048 0.282
MOD_GlcNHglycan 424 427 PF01048 0.289
MOD_GlcNHglycan 45 48 PF01048 0.813
MOD_GlcNHglycan 50 53 PF01048 0.807
MOD_GlcNHglycan 578 581 PF01048 0.389
MOD_GlcNHglycan 700 703 PF01048 0.599
MOD_GlcNHglycan 722 725 PF01048 0.504
MOD_GlcNHglycan 845 848 PF01048 0.407
MOD_GlcNHglycan 854 857 PF01048 0.702
MOD_GlcNHglycan 93 96 PF01048 0.809
MOD_GSK3_1 126 133 PF00069 0.538
MOD_GSK3_1 209 216 PF00069 0.775
MOD_GSK3_1 221 228 PF00069 0.769
MOD_GSK3_1 310 317 PF00069 0.551
MOD_GSK3_1 38 45 PF00069 0.544
MOD_GSK3_1 437 444 PF00069 0.482
MOD_GSK3_1 446 453 PF00069 0.483
MOD_GSK3_1 535 542 PF00069 0.629
MOD_GSK3_1 576 583 PF00069 0.623
MOD_GSK3_1 605 612 PF00069 0.729
MOD_GSK3_1 616 623 PF00069 0.798
MOD_GSK3_1 625 632 PF00069 0.775
MOD_GSK3_1 684 691 PF00069 0.757
MOD_GSK3_1 694 701 PF00069 0.751
MOD_GSK3_1 704 711 PF00069 0.726
MOD_GSK3_1 84 91 PF00069 0.569
MOD_LATS_1 272 278 PF00433 0.545
MOD_N-GLC_1 209 214 PF02516 0.542
MOD_N-GLC_1 469 474 PF02516 0.385
MOD_N-GLC_2 489 491 PF02516 0.302
MOD_NEK2_1 264 269 PF00069 0.634
MOD_NEK2_1 358 363 PF00069 0.534
MOD_NEK2_1 411 416 PF00069 0.517
MOD_NEK2_1 422 427 PF00069 0.441
MOD_NEK2_1 450 455 PF00069 0.482
MOD_NEK2_1 528 533 PF00069 0.589
MOD_NEK2_1 605 610 PF00069 0.640
MOD_NEK2_1 789 794 PF00069 0.360
MOD_NEK2_1 797 802 PF00069 0.337
MOD_NEK2_1 843 848 PF00069 0.320
MOD_PIKK_1 115 121 PF00454 0.536
MOD_PIKK_1 296 302 PF00454 0.622
MOD_PIKK_1 528 534 PF00454 0.617
MOD_PIKK_1 564 570 PF00454 0.634
MOD_PK_1 345 351 PF00069 0.562
MOD_PKA_1 274 280 PF00069 0.583
MOD_PKA_1 694 700 PF00069 0.796
MOD_PKA_1 88 94 PF00069 0.592
MOD_PKA_2 220 226 PF00069 0.736
MOD_PKA_2 254 260 PF00069 0.680
MOD_PKA_2 264 270 PF00069 0.651
MOD_PKA_2 274 280 PF00069 0.618
MOD_PKA_2 446 452 PF00069 0.531
MOD_PKA_2 48 54 PF00069 0.545
MOD_PKA_2 625 631 PF00069 0.725
MOD_PKA_2 669 675 PF00069 0.703
MOD_PKA_2 694 700 PF00069 0.750
MOD_PKA_2 850 856 PF00069 0.479
MOD_PKA_2 88 94 PF00069 0.592
MOD_Plk_1 104 110 PF00069 0.561
MOD_Plk_1 677 683 PF00069 0.775
MOD_Plk_1 695 701 PF00069 0.751
MOD_Plk_2-3 104 110 PF00069 0.561
MOD_Plk_2-3 748 754 PF00069 0.553
MOD_Plk_2-3 762 768 PF00069 0.568
MOD_Plk_4 324 330 PF00069 0.530
MOD_Plk_4 345 351 PF00069 0.562
MOD_Plk_4 374 380 PF00069 0.482
MOD_Plk_4 446 452 PF00069 0.490
MOD_Plk_4 704 710 PF00069 0.796
MOD_Plk_4 780 786 PF00069 0.374
MOD_Plk_4 789 795 PF00069 0.307
MOD_Plk_4 797 803 PF00069 0.211
MOD_Plk_4 817 823 PF00069 0.150
MOD_ProDKin_1 223 229 PF00069 0.706
MOD_ProDKin_1 286 292 PF00069 0.677
MOD_ProDKin_1 469 475 PF00069 0.586
MOD_ProDKin_1 539 545 PF00069 0.536
MOD_ProDKin_1 606 612 PF00069 0.694
MOD_ProDKin_1 64 70 PF00069 0.575
MOD_ProDKin_1 679 685 PF00069 0.818
MOD_ProDKin_1 708 714 PF00069 0.767
MOD_ProDKin_1 89 95 PF00069 0.570
MOD_SUMO_rev_2 148 154 PF00179 0.534
TRG_DiLeu_BaEn_2 515 521 PF01217 0.577
TRG_DiLeu_BaEn_4 103 109 PF01217 0.566
TRG_DiLeu_BaLyEn_6 524 529 PF01217 0.601
TRG_ENDOCYTIC_2 366 369 PF00928 0.501
TRG_ENDOCYTIC_2 379 382 PF00928 0.448
TRG_ENDOCYTIC_2 733 736 PF00928 0.692
TRG_ER_diArg_1 586 588 PF00400 0.683
TRG_ER_diArg_1 71 74 PF00400 0.519
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.282
TRG_Pf-PMV_PEXEL_1 480 484 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 527 532 PF00026 0.329
TRG_Pf-PMV_PEXEL_1 641 646 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 741 746 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 753 758 PF00026 0.387
TRG_Pf-PMV_PEXEL_1 759 764 PF00026 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHZ4 Leptomonas seymouri 56% 87%
A0A1X0P2X6 Trypanosomatidae 42% 98%
A0A422P3I3 Trypanosoma rangeli 39% 100%
A4HIB3 Leishmania braziliensis 81% 100%
A4I5J7 Leishmania infantum 99% 100%
C9ZQX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9B0U2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q7C4 Leishmania major 92% 100%
V5BPI4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS