DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEW9_LEIDO

TriTrypDb:

LdBPK_201290.1 , LdCL_200017400 , LDHU3_20.1600

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	152	154	PF00082	0.376
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.376
CLV_PCSK_SKI1_1	89	93	PF00082	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DOC_CKS1_1	76	81	PF01111	0.718
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.582
DOC_PP2B_LxvP_1	20	23	PF13499	0.582
DOC_SPAK_OSR1_1	111	115	PF12202	0.656
DOC_USP7_MATH_1	15	19	PF00917	0.800
DOC_USP7_MATH_1	175	179	PF00917	0.376
DOC_USP7_MATH_1	181	185	PF00917	0.376
DOC_USP7_MATH_2	204	210	PF00917	0.326
DOC_WW_Pin1_4	10	15	PF00397	0.734
DOC_WW_Pin1_4	115	120	PF00397	0.636
DOC_WW_Pin1_4	222	227	PF00397	0.490
DOC_WW_Pin1_4	38	43	PF00397	0.596
DOC_WW_Pin1_4	64	69	PF00397	0.637
DOC_WW_Pin1_4	75	80	PF00397	0.727
LIG_14-3-3_CanoR_1	168	174	PF00244	0.430
LIG_14-3-3_CanoR_1	186	191	PF00244	0.430
LIG_BIR_III_2	223	227	PF00653	0.485
LIG_BRCT_BRCA1_1	169	173	PF00533	0.501
LIG_FHA_1	164	170	PF00498	0.402
LIG_FHA_1	183	189	PF00498	0.412
LIG_FHA_1	99	105	PF00498	0.638
LIG_FHA_2	218	224	PF00498	0.390
LIG_FHA_2	229	235	PF00498	0.613
LIG_FHA_2	90	96	PF00498	0.653
LIG_HCF-1_HBM_1	132	135	PF13415	0.326
LIG_LIR_Apic_2	117	123	PF02991	0.601
LIG_LIR_Nem_3	132	138	PF02991	0.404
LIG_LIR_Nem_3	214	218	PF02991	0.430
LIG_PCNA_yPIPBox_3	136	149	PF02747	0.376
LIG_PDZ_Class_2	230	235	PF00595	0.633
LIG_SH2_PTP2	120	123	PF00017	0.557
LIG_SH2_STAP1	165	169	PF00017	0.287
LIG_SH2_STAT3	34	37	PF00017	0.636
LIG_SH2_STAT5	120	123	PF00017	0.557
LIG_SH2_STAT5	165	168	PF00017	0.365
LIG_SH2_STAT5	219	222	PF00017	0.450
LIG_SH3_3	124	130	PF00018	0.611
LIG_SH3_3	22	28	PF00018	0.614
LIG_SH3_3	5	11	PF00018	0.750
LIG_SH3_3	73	79	PF00018	0.767
LIG_SUMO_SIM_par_1	89	95	PF11976	0.560
LIG_UBA3_1	144	152	PF00899	0.376
MOD_CDK_SPK_2	38	43	PF00069	0.596
MOD_CDK_SPxK_1	75	81	PF00069	0.703
MOD_CK1_1	163	169	PF00069	0.287
MOD_CK1_1	18	24	PF00069	0.733
MOD_CK1_1	41	47	PF00069	0.734
MOD_CK1_1	74	80	PF00069	0.646
MOD_CK2_1	186	192	PF00069	0.326
MOD_CK2_1	56	62	PF00069	0.823
MOD_CK2_1	89	95	PF00069	0.690
MOD_GlcNHglycan	20	23	PF01048	0.800
MOD_GlcNHglycan	43	46	PF01048	0.736
MOD_GlcNHglycan	47	50	PF01048	0.771
MOD_GlcNHglycan	62	65	PF01048	0.633
MOD_GlcNHglycan	73	76	PF01048	0.677
MOD_GSK3_1	159	166	PF00069	0.355
MOD_GSK3_1	182	189	PF00069	0.371
MOD_GSK3_1	2	9	PF00069	0.665
MOD_GSK3_1	41	48	PF00069	0.786
MOD_GSK3_1	56	63	PF00069	0.739
MOD_GSK3_1	71	78	PF00069	0.608
MOD_N-GLC_1	159	164	PF02516	0.376
MOD_N-GLC_1	71	76	PF02516	0.743
MOD_NEK2_1	167	172	PF00069	0.482
MOD_NEK2_1	182	187	PF00069	0.316
MOD_NEK2_1	190	195	PF00069	0.404
MOD_NEK2_1	2	7	PF00069	0.611
MOD_NEK2_2	175	180	PF00069	0.501
MOD_NEK2_2	217	222	PF00069	0.430
MOD_PIKK_1	105	111	PF00454	0.653
MOD_PIKK_1	204	210	PF00454	0.501
MOD_PKA_2	167	173	PF00069	0.436
MOD_Plk_1	163	169	PF00069	0.350
MOD_Plk_1	175	181	PF00069	0.430
MOD_Plk_1	71	77	PF00069	0.825
MOD_Plk_4	206	212	PF00069	0.359
MOD_ProDKin_1	10	16	PF00069	0.735
MOD_ProDKin_1	115	121	PF00069	0.631
MOD_ProDKin_1	222	228	PF00069	0.502
MOD_ProDKin_1	38	44	PF00069	0.596
MOD_ProDKin_1	64	70	PF00069	0.634
MOD_ProDKin_1	75	81	PF00069	0.726
TRG_DiLeu_BaEn_2	205	211	PF01217	0.430
TRG_ENDOCYTIC_2	135	138	PF00928	0.385
TRG_ENDOCYTIC_2	215	218	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I766	Leptomonas seymouri	44%	69%
A0A3R7K2X3	Trypanosoma rangeli	30%	100%
A4HYW8	Leishmania infantum	99%	100%
E9AII0	Leishmania braziliensis	48%	100%
E9AUR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCS1	Leishmania major	78%	100%