Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEW6_LEIDO

TriTrypDb:

LdBPK_331700.1 , LdCL_330023600 , LDHU3_33.2540

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEW6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.523
CLV_C14_Caspase3-7	33	37	PF00656	0.546
CLV_C14_Caspase3-7	655	659	PF00656	0.562
CLV_C14_Caspase3-7	894	898	PF00656	0.593
CLV_MEL_PAP_1	876	882	PF00089	0.369
CLV_NRD_NRD_1	217	219	PF00675	0.479
CLV_NRD_NRD_1	277	279	PF00675	0.638
CLV_NRD_NRD_1	375	377	PF00675	0.368
CLV_NRD_NRD_1	547	549	PF00675	0.388
CLV_NRD_NRD_1	606	608	PF00675	0.457
CLV_NRD_NRD_1	724	726	PF00675	0.682
CLV_PCSK_FUR_1	275	279	PF00082	0.622
CLV_PCSK_KEX2_1	217	219	PF00082	0.479
CLV_PCSK_KEX2_1	275	277	PF00082	0.628
CLV_PCSK_KEX2_1	340	342	PF00082	0.726
CLV_PCSK_KEX2_1	375	377	PF00082	0.368
CLV_PCSK_KEX2_1	546	548	PF00082	0.430
CLV_PCSK_KEX2_1	605	607	PF00082	0.505
CLV_PCSK_KEX2_1	723	725	PF00082	0.657
CLV_PCSK_KEX2_1	831	833	PF00082	0.766
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.713
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.430
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.766
CLV_PCSK_SKI1_1	26	30	PF00082	0.744
CLV_PCSK_SKI1_1	282	286	PF00082	0.511
CLV_PCSK_SKI1_1	32	36	PF00082	0.767
CLV_PCSK_SKI1_1	421	425	PF00082	0.507
CLV_PCSK_SKI1_1	458	462	PF00082	0.523
CLV_PCSK_SKI1_1	636	640	PF00082	0.602
CLV_PCSK_SKI1_1	662	666	PF00082	0.702
CLV_PCSK_SKI1_1	754	758	PF00082	0.355
CLV_PCSK_SKI1_1	787	791	PF00082	0.623
CLV_PCSK_SKI1_1	834	838	PF00082	0.574
CLV_PCSK_SKI1_1	99	103	PF00082	0.570
CLV_Separin_Metazoa	214	218	PF03568	0.436
CLV_Separin_Metazoa	72	76	PF03568	0.612
DEG_APCC_DBOX_1	457	465	PF00400	0.493
DEG_Nend_UBRbox_1	1	4	PF02207	0.680
DEG_SCF_FBW7_1	234	241	PF00400	0.478
DEG_SCF_TRCP1_1	658	663	PF00400	0.567
DEG_SIAH_1	821	829	PF03145	0.658
DOC_CDC14_PxL_1	70	78	PF14671	0.609
DOC_CKS1_1	346	351	PF01111	0.510
DOC_CKS1_1	81	86	PF01111	0.606
DOC_CYCLIN_RxL_1	751	761	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	671	677	PF00134	0.449
DOC_MAPK_DCC_7	662	671	PF00069	0.515
DOC_MAPK_MEF2A_6	445	452	PF00069	0.349
DOC_MAPK_MEF2A_6	454	463	PF00069	0.328
DOC_PP2B_LxvP_1	671	674	PF13499	0.503
DOC_PP4_FxxP_1	346	349	PF00568	0.573
DOC_PP4_FxxP_1	774	777	PF00568	0.542
DOC_PP4_FxxP_1	783	786	PF00568	0.685
DOC_USP7_MATH_1	101	105	PF00917	0.549
DOC_USP7_MATH_1	113	117	PF00917	0.665
DOC_USP7_MATH_1	119	123	PF00917	0.642
DOC_USP7_MATH_1	142	146	PF00917	0.542
DOC_USP7_MATH_1	150	154	PF00917	0.477
DOC_USP7_MATH_1	247	251	PF00917	0.469
DOC_USP7_MATH_1	252	256	PF00917	0.367
DOC_USP7_MATH_1	320	324	PF00917	0.732
DOC_USP7_MATH_1	330	334	PF00917	0.691
DOC_USP7_MATH_1	39	43	PF00917	0.645
DOC_USP7_MATH_1	565	569	PF00917	0.639
DOC_USP7_MATH_1	656	660	PF00917	0.724
DOC_USP7_MATH_1	735	739	PF00917	0.583
DOC_USP7_MATH_1	775	779	PF00917	0.515
DOC_USP7_MATH_1	789	793	PF00917	0.533
DOC_USP7_MATH_1	816	820	PF00917	0.564
DOC_USP7_MATH_1	850	854	PF00917	0.609
DOC_USP7_MATH_1	878	882	PF00917	0.454
DOC_USP7_MATH_2	311	317	PF00917	0.494
DOC_WW_Pin1_4	234	239	PF00397	0.705
DOC_WW_Pin1_4	345	350	PF00397	0.719
DOC_WW_Pin1_4	360	365	PF00397	0.453
DOC_WW_Pin1_4	41	46	PF00397	0.620
DOC_WW_Pin1_4	453	458	PF00397	0.439
DOC_WW_Pin1_4	481	486	PF00397	0.657
DOC_WW_Pin1_4	520	525	PF00397	0.363
DOC_WW_Pin1_4	80	85	PF00397	0.762
LIG_14-3-3_CanoR_1	169	178	PF00244	0.400
LIG_14-3-3_CanoR_1	286	293	PF00244	0.384
LIG_14-3-3_CanoR_1	345	349	PF00244	0.741
LIG_14-3-3_CanoR_1	375	381	PF00244	0.393
LIG_14-3-3_CanoR_1	662	667	PF00244	0.531
LIG_14-3-3_CanoR_1	686	690	PF00244	0.474
LIG_14-3-3_CanoR_1	723	731	PF00244	0.611
LIG_14-3-3_CanoR_1	736	745	PF00244	0.656
LIG_14-3-3_CanoR_1	834	841	PF00244	0.543
LIG_14-3-3_CanoR_1	879	883	PF00244	0.404
LIG_Actin_WH2_2	163	179	PF00022	0.396
LIG_Actin_WH2_2	882	898	PF00022	0.430
LIG_BIR_III_4	469	473	PF00653	0.428
LIG_BRCT_BRCA1_1	700	704	PF00533	0.520
LIG_deltaCOP1_diTrp_1	589	596	PF00928	0.441
LIG_DLG_GKlike_1	376	384	PF00625	0.371
LIG_EVH1_1	131	135	PF00568	0.626
LIG_FHA_1	286	292	PF00498	0.469
LIG_FHA_1	364	370	PF00498	0.397
LIG_FHA_1	454	460	PF00498	0.413
LIG_FHA_1	535	541	PF00498	0.433
LIG_FHA_1	8	14	PF00498	0.630
LIG_FHA_1	835	841	PF00498	0.619
LIG_FHA_2	307	313	PF00498	0.470
LIG_FHA_2	31	37	PF00498	0.606
LIG_FHA_2	561	567	PF00498	0.486
LIG_FHA_2	799	805	PF00498	0.351
LIG_FHA_2	98	104	PF00498	0.651
LIG_GBD_Chelix_1	178	186	PF00786	0.383
LIG_HP1_1	457	461	PF01393	0.402
LIG_IRF3_LxIS_1	166	173	PF10401	0.297
LIG_LIR_Apic_2	44	50	PF02991	0.658
LIG_LIR_Apic_2	773	777	PF02991	0.541
LIG_LIR_Gen_1	614	625	PF02991	0.377
LIG_LIR_Nem_3	614	620	PF02991	0.379
LIG_LIR_Nem_3	750	756	PF02991	0.458
LIG_PDZ_Class_1	895	900	PF00595	0.543
LIG_Pex14_1	770	774	PF04695	0.517
LIG_REV1ctd_RIR_1	532	540	PF16727	0.446
LIG_RPA_C_Fungi	175	187	PF08784	0.411
LIG_RPA_C_Fungi	681	693	PF08784	0.391
LIG_SH2_CRK	490	494	PF00017	0.324
LIG_SH2_NCK_1	549	553	PF00017	0.441
LIG_SH2_NCK_1	679	683	PF00017	0.422
LIG_SH2_SRC	47	50	PF00017	0.578
LIG_SH2_SRC	549	552	PF00017	0.420
LIG_SH2_SRC	77	80	PF00017	0.516
LIG_SH2_STAP1	287	291	PF00017	0.432
LIG_SH2_STAP1	490	494	PF00017	0.324
LIG_SH2_STAP1	549	553	PF00017	0.417
LIG_SH2_STAP1	77	81	PF00017	0.577
LIG_SH2_STAT5	185	188	PF00017	0.519
LIG_SH2_STAT5	227	230	PF00017	0.537
LIG_SH2_STAT5	287	290	PF00017	0.428
LIG_SH2_STAT5	47	50	PF00017	0.691
LIG_SH2_STAT5	521	524	PF00017	0.499
LIG_SH3_1	129	135	PF00018	0.627
LIG_SH3_3	129	135	PF00018	0.627
LIG_SH3_3	237	243	PF00018	0.578
LIG_SH3_3	419	425	PF00018	0.506
LIG_SH3_3	647	653	PF00018	0.515
LIG_SH3_3	749	755	PF00018	0.449
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.368
LIG_SUMO_SIM_par_1	667	672	PF11976	0.552
LIG_SUMO_SIM_par_1	694	699	PF11976	0.452
LIG_SUMO_SIM_par_1	754	759	PF11976	0.398
LIG_TYR_ITIM	488	493	PF00017	0.455
LIG_WRC_WIRS_1	106	111	PF05994	0.595
LIG_WRC_WIRS_1	302	307	PF05994	0.413
LIG_WW_3	342	346	PF00397	0.519
MOD_CDC14_SPxK_1	484	487	PF00782	0.470
MOD_CDK_SPK_2	234	239	PF00069	0.553
MOD_CDK_SPK_2	41	46	PF00069	0.622
MOD_CDK_SPK_2	453	458	PF00069	0.439
MOD_CDK_SPxK_1	481	487	PF00069	0.509
MOD_CK1_1	105	111	PF00069	0.603
MOD_CK1_1	355	361	PF00069	0.514
MOD_CK1_1	362	368	PF00069	0.526
MOD_CK1_1	379	385	PF00069	0.367
MOD_CK1_1	738	744	PF00069	0.680
MOD_CK1_1	792	798	PF00069	0.517
MOD_CK2_1	140	146	PF00069	0.585
MOD_CK2_1	306	312	PF00069	0.610
MOD_CK2_1	32	38	PF00069	0.685
MOD_CK2_1	348	354	PF00069	0.617
MOD_CK2_1	560	566	PF00069	0.473
MOD_CK2_1	66	72	PF00069	0.745
MOD_CK2_1	699	705	PF00069	0.563
MOD_CK2_1	770	776	PF00069	0.474
MOD_CK2_1	97	103	PF00069	0.619
MOD_CMANNOS	592	595	PF00535	0.475
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.537
MOD_GlcNHglycan	117	120	PF01048	0.728
MOD_GlcNHglycan	121	124	PF01048	0.749
MOD_GlcNHglycan	188	191	PF01048	0.579
MOD_GlcNHglycan	230	233	PF01048	0.642
MOD_GlcNHglycan	249	252	PF01048	0.262
MOD_GlcNHglycan	254	257	PF01048	0.454
MOD_GlcNHglycan	264	267	PF01048	0.571
MOD_GlcNHglycan	331	335	PF01048	0.724
MOD_GlcNHglycan	395	398	PF01048	0.467
MOD_GlcNHglycan	658	661	PF01048	0.688
MOD_GlcNHglycan	662	665	PF01048	0.704
MOD_GlcNHglycan	671	674	PF01048	0.540
MOD_GlcNHglycan	848	851	PF01048	0.585
MOD_GlcNHglycan	859	862	PF01048	0.629
MOD_GSK3_1	115	122	PF00069	0.735
MOD_GSK3_1	136	143	PF00069	0.615
MOD_GSK3_1	150	157	PF00069	0.413
MOD_GSK3_1	234	241	PF00069	0.564
MOD_GSK3_1	344	351	PF00069	0.665
MOD_GSK3_1	355	362	PF00069	0.494
MOD_GSK3_1	534	541	PF00069	0.361
MOD_GSK3_1	656	663	PF00069	0.748
MOD_GSK3_1	669	676	PF00069	0.519
MOD_GSK3_1	725	732	PF00069	0.703
MOD_GSK3_1	846	853	PF00069	0.487
MOD_GSK3_1	97	104	PF00069	0.602
MOD_N-GLC_1	124	129	PF02516	0.774
MOD_N-GLC_1	30	35	PF02516	0.551
MOD_N-GLC_1	398	403	PF02516	0.468
MOD_N-GLC_1	748	753	PF02516	0.515
MOD_N-GLC_1	792	797	PF02516	0.621
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	102	107	PF00069	0.541
MOD_NEK2_1	186	191	PF00069	0.517
MOD_NEK2_1	262	267	PF00069	0.564
MOD_NEK2_1	534	539	PF00069	0.330
MOD_NEK2_1	669	674	PF00069	0.464
MOD_NEK2_1	895	900	PF00069	0.552
MOD_NEK2_2	685	690	PF00069	0.439
MOD_PIKK_1	113	119	PF00454	0.615
MOD_PIKK_1	425	431	PF00454	0.497
MOD_PIKK_1	475	481	PF00454	0.601
MOD_PIKK_1	677	683	PF00454	0.446
MOD_PIKK_1	729	735	PF00454	0.718
MOD_PKA_1	724	730	PF00069	0.514
MOD_PKA_2	238	244	PF00069	0.618
MOD_PKA_2	252	258	PF00069	0.414
MOD_PKA_2	285	291	PF00069	0.493
MOD_PKA_2	344	350	PF00069	0.686
MOD_PKA_2	352	358	PF00069	0.505
MOD_PKA_2	656	662	PF00069	0.618
MOD_PKA_2	685	691	PF00069	0.475
MOD_PKA_2	724	730	PF00069	0.606
MOD_PKA_2	735	741	PF00069	0.616
MOD_PKA_2	764	770	PF00069	0.489
MOD_PKA_2	878	884	PF00069	0.491
MOD_PKB_1	723	731	PF00069	0.572
MOD_PKB_1	832	840	PF00069	0.641
MOD_Plk_1	102	108	PF00069	0.618
MOD_Plk_1	398	404	PF00069	0.412
MOD_Plk_1	748	754	PF00069	0.503
MOD_Plk_1	792	798	PF00069	0.614
MOD_Plk_2-3	560	566	PF00069	0.408
MOD_Plk_2-3	699	705	PF00069	0.514
MOD_Plk_4	241	247	PF00069	0.520
MOD_Plk_4	725	731	PF00069	0.723
MOD_Plk_4	748	754	PF00069	0.466
MOD_Plk_4	792	798	PF00069	0.552
MOD_Plk_4	851	857	PF00069	0.602
MOD_ProDKin_1	234	240	PF00069	0.697
MOD_ProDKin_1	345	351	PF00069	0.696
MOD_ProDKin_1	360	366	PF00069	0.498
MOD_ProDKin_1	41	47	PF00069	0.613
MOD_ProDKin_1	453	459	PF00069	0.425
MOD_ProDKin_1	481	487	PF00069	0.642
MOD_ProDKin_1	520	526	PF00069	0.369
MOD_ProDKin_1	80	86	PF00069	0.762
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.493
TRG_ENDOCYTIC_2	490	493	PF00928	0.325
TRG_ER_diArg_1	216	218	PF00400	0.476
TRG_ER_diArg_1	275	278	PF00400	0.622
TRG_ER_diArg_1	374	376	PF00400	0.356
TRG_ER_diArg_1	547	549	PF00400	0.388
TRG_ER_diArg_1	605	607	PF00400	0.503
TRG_ER_diArg_1	723	725	PF00400	0.648
TRG_NES_CRM1_1	614	627	PF08389	0.315
TRG_NLS_MonoExtC_3	545	551	PF00514	0.389
TRG_NLS_MonoExtN_4	828	835	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	754	759	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E0	Leptomonas seymouri	47%	99%
A0A1X0P134	Trypanosomatidae	26%	100%
A0A3R7KAP3	Trypanosoma rangeli	28%	100%
A4HLM1	Leishmania braziliensis	78%	100%
A4I932	Leishmania infantum	100%	100%
D0A535	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B3Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q427	Leishmania major	93%	100%
V5BLS1	Trypanosoma cruzi	28%	100%