SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IEW5_LEIDO

TriTrypDb:

LdBPK_302330.1 , LdCL_300028800 , LDHU3_30.3150

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.457
CLV_NRD_NRD_1	294	296	PF00675	0.300
CLV_NRD_NRD_1	303	305	PF00675	0.303
CLV_PCSK_FUR_1	300	304	PF00082	0.302
CLV_PCSK_KEX2_1	19	21	PF00082	0.449
CLV_PCSK_KEX2_1	294	296	PF00082	0.281
CLV_PCSK_KEX2_1	302	304	PF00082	0.276
CLV_PCSK_PC7_1	16	22	PF00082	0.491
CLV_PCSK_SKI1_1	26	30	PF00082	0.334
DOC_CDC14_PxL_1	228	236	PF14671	0.530
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.558
DOC_MAPK_gen_1	247	255	PF00069	0.513
DOC_MAPK_gen_1	302	313	PF00069	0.571
DOC_MAPK_MEF2A_6	36	45	PF00069	0.497
DOC_MAPK_NFAT4_5	36	44	PF00069	0.558
DOC_MAPK_RevD_3	288	303	PF00069	0.433
DOC_PP2B_LxvP_1	251	254	PF13499	0.562
DOC_PP2B_LxvP_1	41	44	PF13499	0.560
DOC_PP2B_LxvP_1	53	56	PF13499	0.567
DOC_USP7_MATH_1	122	126	PF00917	0.456
DOC_USP7_MATH_1	263	267	PF00917	0.542
DOC_USP7_MATH_1	288	292	PF00917	0.507
DOC_WW_Pin1_4	129	134	PF00397	0.471
DOC_WW_Pin1_4	259	264	PF00397	0.433
DOC_WW_Pin1_4	280	285	PF00397	0.562
DOC_WW_Pin1_4	61	66	PF00397	0.533
LIG_14-3-3_CanoR_1	104	108	PF00244	0.471
LIG_14-3-3_CanoR_1	174	180	PF00244	0.467
LIG_14-3-3_CanoR_1	294	298	PF00244	0.557
LIG_14-3-3_CanoR_1	337	341	PF00244	0.603
LIG_14-3-3_CanoR_1	61	65	PF00244	0.547
LIG_14-3-3_CanoR_1	95	101	PF00244	0.516
LIG_APCC_ABBA_1	83	88	PF00400	0.586
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	171	175	PF00533	0.586
LIG_BRCT_BRCA1_1	177	181	PF00533	0.515
LIG_deltaCOP1_diTrp_1	88	96	PF00928	0.562
LIG_FHA_1	174	180	PF00498	0.530
LIG_FHA_1	235	241	PF00498	0.561
LIG_FHA_2	49	55	PF00498	0.561
LIG_Integrin_RGD_1	36	38	PF01839	0.281
LIG_LIR_Gen_1	233	243	PF02991	0.553
LIG_LIR_Gen_1	88	96	PF02991	0.562
LIG_LIR_Nem_3	178	184	PF02991	0.487
LIG_LIR_Nem_3	224	228	PF02991	0.482
LIG_LIR_Nem_3	233	238	PF02991	0.488
LIG_LIR_Nem_3	88	93	PF02991	0.562
LIG_Pex14_1	347	351	PF04695	0.491
LIG_Pex14_1	92	96	PF04695	0.562
LIG_Pex14_2	86	90	PF04695	0.586
LIG_SH2_CRK	47	51	PF00017	0.562
LIG_SH2_NCK_1	193	197	PF00017	0.530
LIG_SH2_SRC	148	151	PF00017	0.586
LIG_SH2_STAP1	148	152	PF00017	0.586
LIG_SH2_STAT5	146	149	PF00017	0.478
LIG_SH2_STAT5	184	187	PF00017	0.509
LIG_SH2_STAT5	244	247	PF00017	0.495
LIG_SH2_STAT5	351	354	PF00017	0.522
LIG_SH2_STAT5	47	50	PF00017	0.484
LIG_SH3_3	266	272	PF00018	0.496
LIG_SH3_5	180	184	PF00018	0.558
LIG_SUMO_SIM_par_1	236	242	PF11976	0.530
LIG_TYR_ITIM	45	50	PF00017	0.562
MOD_CK1_1	106	112	PF00069	0.482
MOD_CK1_1	155	161	PF00069	0.534
MOD_CK1_1	191	197	PF00069	0.586
MOD_CK1_1	257	263	PF00069	0.586
MOD_CK1_1	265	271	PF00069	0.581
MOD_CK2_1	129	135	PF00069	0.482
MOD_CK2_1	194	200	PF00069	0.507
MOD_CK2_1	218	224	PF00069	0.517
MOD_CK2_1	303	309	PF00069	0.544
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.502
MOD_GlcNHglycan	108	111	PF01048	0.333
MOD_GlcNHglycan	154	157	PF01048	0.346
MOD_GlcNHglycan	197	200	PF01048	0.362
MOD_GlcNHglycan	290	293	PF01048	0.309
MOD_GSK3_1	105	112	PF00069	0.464
MOD_GSK3_1	169	176	PF00069	0.549
MOD_GSK3_1	191	198	PF00069	0.591
MOD_GSK3_1	230	237	PF00069	0.539
MOD_GSK3_1	255	262	PF00069	0.505
MOD_GSK3_1	327	334	PF00069	0.692
MOD_N-GLC_1	152	157	PF02516	0.233
MOD_N-GLC_1	331	336	PF02516	0.684
MOD_N-GLC_2	278	280	PF02516	0.386
MOD_NEK2_1	127	132	PF00069	0.521
MOD_NEK2_1	152	157	PF00069	0.525
MOD_NEK2_1	175	180	PF00069	0.552
MOD_NEK2_1	234	239	PF00069	0.515
MOD_NEK2_1	245	250	PF00069	0.524
MOD_NEK2_1	255	260	PF00069	0.536
MOD_NEK2_1	336	341	PF00069	0.527
MOD_NEK2_1	39	44	PF00069	0.518
MOD_NEK2_2	188	193	PF00069	0.562
MOD_PIKK_1	48	54	PF00454	0.586
MOD_PKA_1	303	309	PF00069	0.542
MOD_PKA_2	103	109	PF00069	0.460
MOD_PKA_2	173	179	PF00069	0.530
MOD_PKA_2	293	299	PF00069	0.557
MOD_PKA_2	303	309	PF00069	0.532
MOD_PKA_2	336	342	PF00069	0.520
MOD_PKA_2	60	66	PF00069	0.577
MOD_PKA_2	94	100	PF00069	0.508
MOD_Plk_1	309	315	PF00069	0.496
MOD_Plk_2-3	230	236	PF00069	0.543
MOD_Plk_2-3	309	315	PF00069	0.513
MOD_Plk_4	122	128	PF00069	0.542
MOD_Plk_4	188	194	PF00069	0.562
MOD_Plk_4	230	236	PF00069	0.514
MOD_Plk_4	239	245	PF00069	0.478
MOD_Plk_4	265	271	PF00069	0.546
MOD_Plk_4	331	337	PF00069	0.764
MOD_ProDKin_1	129	135	PF00069	0.471
MOD_ProDKin_1	259	265	PF00069	0.433
MOD_ProDKin_1	280	286	PF00069	0.562
MOD_ProDKin_1	61	67	PF00069	0.533
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.501
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.502
TRG_ENDOCYTIC_2	47	50	PF00928	0.515
TRG_ER_diArg_1	19	21	PF00400	0.482
TRG_ER_diArg_1	246	249	PF00400	0.482
TRG_ER_diArg_1	293	295	PF00400	0.487
TRG_ER_diArg_1	299	302	PF00400	0.508
TRG_ER_diArg_1	303	305	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ4	Leptomonas seymouri	51%	97%
A0A1X0P1P8	Trypanosomatidae	39%	100%
A0A3R7MQP1	Trypanosoma rangeli	39%	100%
A4HIG4	Leishmania braziliensis	78%	100%
A4I5R0	Leishmania infantum	100%	100%
C9ZR29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B105	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q761	Leishmania major	90%	100%
V5BLC5	Trypanosoma cruzi	40%	72%