GPI-anchored surface protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IEV9_LEIDO

TriTrypDb:

LdBPK_350620.1 , LdCL_350011100 , LDHU3_35.0760

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IEV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.502
CLV_C14_Caspase3-7	163	167	PF00656	0.567
CLV_C14_Caspase3-7	250	254	PF00656	0.547
CLV_C14_Caspase3-7	370	374	PF00656	0.506
CLV_NRD_NRD_1	199	201	PF00675	0.647
CLV_NRD_NRD_1	22	24	PF00675	0.440
CLV_NRD_NRD_1	29	31	PF00675	0.406
CLV_NRD_NRD_1	56	58	PF00675	0.636
CLV_PCSK_KEX2_1	199	201	PF00082	0.647
CLV_PCSK_KEX2_1	22	24	PF00082	0.440
CLV_PCSK_KEX2_1	28	30	PF00082	0.417
CLV_PCSK_KEX2_1	56	58	PF00082	0.644
CLV_PCSK_SKI1_1	165	169	PF00082	0.631
CLV_PCSK_SKI1_1	30	34	PF00082	0.290
CLV_PCSK_SKI1_1	312	316	PF00082	0.623
CLV_PCSK_SKI1_1	64	68	PF00082	0.725
DEG_APCC_DBOX_1	130	138	PF00400	0.493
DEG_APCC_DBOX_1	164	172	PF00400	0.428
DEG_APCC_DBOX_1	63	71	PF00400	0.507
DEG_MDM2_SWIB_1	34	42	PF02201	0.333
DEG_SIAH_1	341	349	PF03145	0.558
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.561
DOC_MAPK_gen_1	173	182	PF00069	0.537
DOC_PP2B_LxvP_1	69	72	PF13499	0.514
DOC_PP4_FxxP_1	138	141	PF00568	0.418
DOC_PP4_FxxP_1	46	49	PF00568	0.333
DOC_WW_Pin1_4	312	317	PF00397	0.439
LIG_14-3-3_CanoR_1	173	178	PF00244	0.460
LIG_14-3-3_CanoR_1	299	303	PF00244	0.526
LIG_14-3-3_CanoR_1	91	99	PF00244	0.492
LIG_CaM_IQ_9	74	90	PF13499	0.440
LIG_Clathr_ClatBox_1	356	360	PF01394	0.490
LIG_FHA_1	256	262	PF00498	0.439
LIG_FHA_1	313	319	PF00498	0.458
LIG_FHA_1	71	77	PF00498	0.514
LIG_FHA_2	130	136	PF00498	0.498
LIG_FHA_2	174	180	PF00498	0.465
LIG_FHA_2	318	324	PF00498	0.460
LIG_FHA_2	368	374	PF00498	0.490
LIG_LIR_Apic_2	135	141	PF02991	0.498
LIG_LIR_Apic_2	44	49	PF02991	0.333
LIG_NRBOX	261	267	PF00104	0.492
LIG_Pex14_2	120	124	PF04695	0.397
LIG_Pex14_2	34	38	PF04695	0.333
LIG_Pex14_2	46	50	PF04695	0.410
LIG_SH2_CRK	52	56	PF00017	0.425
LIG_SH2_SRC	125	128	PF00017	0.507
LIG_SH2_STAT5	125	128	PF00017	0.557
LIG_SH2_STAT5	142	145	PF00017	0.348
LIG_SH2_STAT5	330	333	PF00017	0.469
LIG_SH2_STAT5	35	38	PF00017	0.307
LIG_SH3_2	188	193	PF14604	0.475
LIG_SH3_3	150	156	PF00018	0.528
LIG_SH3_3	185	191	PF00018	0.434
LIG_SH3_3	235	241	PF00018	0.557
LIG_SH3_3	336	342	PF00018	0.535
LIG_Sin3_3	263	270	PF02671	0.353
LIG_SUMO_SIM_par_1	72	77	PF11976	0.516
LIG_TRAF2_1	222	225	PF00917	0.467
LIG_TRAF2_1	278	281	PF00917	0.529
LIG_TRAF2_1	320	323	PF00917	0.546
LIG_TRFH_1	124	128	PF08558	0.452
LIG_TYR_ITIM	2	7	PF00017	0.609
LIG_UBA3_1	265	274	PF00899	0.459
LIG_WW_3	19	23	PF00397	0.652
MOD_CK1_1	349	355	PF00069	0.491
MOD_CK1_1	367	373	PF00069	0.518
MOD_CK1_1	41	47	PF00069	0.382
MOD_CK2_1	173	179	PF00069	0.471
MOD_CK2_1	317	323	PF00069	0.454
MOD_CK2_1	59	65	PF00069	0.460
MOD_DYRK1A_RPxSP_1	312	316	PF00069	0.423
MOD_GlcNHglycan	303	307	PF01048	0.671
MOD_GlcNHglycan	349	352	PF01048	0.757
MOD_GSK3_1	294	301	PF00069	0.476
MOD_GSK3_1	347	354	PF00069	0.560
MOD_GSK3_1	70	77	PF00069	0.495
MOD_NEK2_1	129	134	PF00069	0.439
MOD_NEK2_1	223	228	PF00069	0.513
MOD_NEK2_1	294	299	PF00069	0.537
MOD_NEK2_1	302	307	PF00069	0.518
MOD_NEK2_1	364	369	PF00069	0.512
MOD_PIKK_1	225	231	PF00454	0.473
MOD_PIKK_1	365	371	PF00454	0.417
MOD_PIKK_1	74	80	PF00454	0.453
MOD_PKA_2	21	27	PF00069	0.643
MOD_PKA_2	298	304	PF00069	0.483
MOD_PKB_1	173	181	PF00069	0.474
MOD_PKB_1	57	65	PF00069	0.503
MOD_PKB_1	89	97	PF00069	0.425
MOD_Plk_1	74	80	PF00069	0.468
MOD_Plk_4	3	9	PF00069	0.606
MOD_Plk_4	352	358	PF00069	0.420
MOD_Plk_4	41	47	PF00069	0.333
MOD_ProDKin_1	312	318	PF00069	0.439
TRG_DiLeu_BaEn_1	215	220	PF01217	0.515
TRG_DiLeu_BaEn_1	65	70	PF01217	0.508
TRG_ENDOCYTIC_2	330	333	PF00928	0.469
TRG_ENDOCYTIC_2	4	7	PF00928	0.606
TRG_ENDOCYTIC_2	52	55	PF00928	0.423
TRG_ER_diArg_1	131	134	PF00400	0.500
TRG_ER_diArg_1	172	175	PF00400	0.507
TRG_ER_diArg_1	198	200	PF00400	0.446
TRG_ER_diArg_1	21	23	PF00400	0.667
TRG_ER_diArg_1	27	30	PF00400	0.587
TRG_ER_diArg_1	55	57	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT9	Leptomonas seymouri	42%	100%
A4HM95	Leishmania braziliensis	78%	100%
A4IAV9	Leishmania infantum	99%	100%
E9AEN7	Leishmania major	88%	100%
E9B5U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%