Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEV6_LEIDO

TriTrypDb:

LdBPK_331520.1 , LdCL_330021800 , LDHU3_33.2280

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IEV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.592
CLV_NRD_NRD_1	24	26	PF00675	0.675
CLV_NRD_NRD_1	297	299	PF00675	0.560
CLV_NRD_NRD_1	461	463	PF00675	0.566
CLV_NRD_NRD_1	5	7	PF00675	0.719
CLV_PCSK_FUR_1	3	7	PF00082	0.716
CLV_PCSK_KEX2_1	194	196	PF00082	0.531
CLV_PCSK_KEX2_1	229	231	PF00082	0.641
CLV_PCSK_KEX2_1	24	26	PF00082	0.675
CLV_PCSK_KEX2_1	296	298	PF00082	0.627
CLV_PCSK_KEX2_1	461	463	PF00082	0.566
CLV_PCSK_KEX2_1	5	7	PF00082	0.719
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.500
CLV_PCSK_SKI1_1	201	205	PF00082	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DEG_SCF_FBW7_2	329	335	PF00400	0.678
DEG_SPOP_SBC_1	222	226	PF00917	0.677
DOC_CDC14_PxL_1	258	266	PF14671	0.539
DOC_CDC14_PxL_1	552	560	PF14671	0.501
DOC_CKS1_1	329	334	PF01111	0.695
DOC_MAPK_DCC_7	509	517	PF00069	0.601
DOC_PP2B_LxvP_1	356	359	PF13499	0.654
DOC_PP2B_LxvP_1	81	84	PF13499	0.586
DOC_PP4_FxxP_1	178	181	PF00568	0.603
DOC_USP7_MATH_1	155	159	PF00917	0.629
DOC_USP7_MATH_1	222	226	PF00917	0.677
DOC_USP7_MATH_1	288	292	PF00917	0.574
DOC_USP7_MATH_1	427	431	PF00917	0.730
DOC_USP7_MATH_1	441	445	PF00917	0.600
DOC_WW_Pin1_4	120	125	PF00397	0.724
DOC_WW_Pin1_4	185	190	PF00397	0.554
DOC_WW_Pin1_4	208	213	PF00397	0.651
DOC_WW_Pin1_4	328	333	PF00397	0.697
DOC_WW_Pin1_4	337	342	PF00397	0.659
DOC_WW_Pin1_4	443	448	PF00397	0.654
DOC_WW_Pin1_4	451	456	PF00397	0.585
DOC_WW_Pin1_4	82	87	PF00397	0.575
LIG_14-3-3_CanoR_1	169	178	PF00244	0.631
LIG_14-3-3_CanoR_1	229	233	PF00244	0.523
LIG_14-3-3_CanoR_1	27	32	PF00244	0.533
LIG_14-3-3_CanoR_1	44	49	PF00244	0.713
LIG_14-3-3_CanoR_1	538	543	PF00244	0.527
LIG_BIR_III_4	102	106	PF00653	0.565
LIG_BIR_III_4	343	347	PF00653	0.545
LIG_BRCT_BRCA1_1	187	191	PF00533	0.519
LIG_deltaCOP1_diTrp_1	192	200	PF00928	0.510
LIG_FHA_1	185	191	PF00498	0.647
LIG_FHA_1	216	222	PF00498	0.635
LIG_FHA_1	266	272	PF00498	0.536
LIG_FHA_1	454	460	PF00498	0.668
LIG_FHA_1	570	576	PF00498	0.614
LIG_FHA_2	352	358	PF00498	0.685
LIG_FHA_2	495	501	PF00498	0.469
LIG_LIR_Gen_1	255	265	PF02991	0.539
LIG_LIR_Gen_1	360	369	PF02991	0.620
LIG_LIR_Gen_1	477	484	PF02991	0.482
LIG_LIR_Nem_3	255	261	PF02991	0.527
LIG_LIR_Nem_3	360	364	PF02991	0.703
LIG_LIR_Nem_3	477	482	PF02991	0.479
LIG_LIR_Nem_3	501	507	PF02991	0.468
LIG_LIR_Nem_3	554	558	PF02991	0.487
LIG_LYPXL_yS_3	555	558	PF13949	0.489
LIG_Pex14_2	557	561	PF04695	0.497
LIG_SH2_CRK	106	110	PF00017	0.569
LIG_SH2_CRK	258	262	PF00017	0.523
LIG_SH2_CRK	479	483	PF00017	0.481
LIG_SH2_CRK	553	557	PF00017	0.591
LIG_SH2_PTP2	417	420	PF00017	0.565
LIG_SH2_SRC	417	420	PF00017	0.650
LIG_SH2_SRC	553	556	PF00017	0.563
LIG_SH2_STAP1	479	483	PF00017	0.481
LIG_SH2_STAT5	417	420	PF00017	0.565
LIG_SH3_3	216	222	PF00018	0.672
LIG_SH3_3	384	390	PF00018	0.639
LIG_SH3_3	449	455	PF00018	0.653
LIG_SH3_3	80	86	PF00018	0.582
LIG_SUMO_SIM_par_1	353	360	PF11976	0.633
LIG_SUMO_SIM_par_1	471	477	PF11976	0.463
LIG_TRFH_1	258	262	PF08558	0.505
LIG_TRFH_1	263	267	PF08558	0.513
LIG_TYR_ITIM	415	420	PF00017	0.655
LIG_WRC_WIRS_1	358	363	PF05994	0.700
LIG_WRC_WIRS_1	50	55	PF05994	0.611
MOD_CDK_SPK_2	337	342	PF00069	0.586
MOD_CK1_1	120	126	PF00069	0.665
MOD_CK1_1	170	176	PF00069	0.658
MOD_CK1_1	30	36	PF00069	0.599
MOD_CK1_1	423	429	PF00069	0.623
MOD_CK1_1	432	438	PF00069	0.656
MOD_CK1_1	49	55	PF00069	0.520
MOD_CK1_1	537	543	PF00069	0.555
MOD_CK2_1	120	126	PF00069	0.651
MOD_CK2_1	222	228	PF00069	0.671
MOD_CK2_1	278	284	PF00069	0.628
MOD_CK2_1	315	321	PF00069	0.628
MOD_CK2_1	351	357	PF00069	0.619
MOD_GlcNHglycan	11	14	PF01048	0.649
MOD_GlcNHglycan	150	153	PF01048	0.826
MOD_GlcNHglycan	163	166	PF01048	0.624
MOD_GlcNHglycan	20	23	PF01048	0.558
MOD_GlcNHglycan	206	209	PF01048	0.522
MOD_GlcNHglycan	225	228	PF01048	0.739
MOD_GlcNHglycan	290	293	PF01048	0.585
MOD_GlcNHglycan	405	409	PF01048	0.714
MOD_GlcNHglycan	424	428	PF01048	0.551
MOD_GlcNHglycan	490	493	PF01048	0.479
MOD_GlcNHglycan	78	81	PF01048	0.755
MOD_GSK3_1	116	123	PF00069	0.676
MOD_GSK3_1	163	170	PF00069	0.702
MOD_GSK3_1	204	211	PF00069	0.663
MOD_GSK3_1	213	220	PF00069	0.767
MOD_GSK3_1	315	322	PF00069	0.679
MOD_GSK3_1	423	430	PF00069	0.633
MOD_GSK3_1	435	442	PF00069	0.525
MOD_GSK3_1	453	460	PF00069	0.527
MOD_GSK3_1	494	501	PF00069	0.470
MOD_GSK3_1	534	541	PF00069	0.598
MOD_GSK3_1	565	572	PF00069	0.520
MOD_N-GLC_1	538	543	PF02516	0.558
MOD_NEK2_1	217	222	PF00069	0.677
MOD_NEK2_1	251	256	PF00069	0.670
MOD_NEK2_1	278	283	PF00069	0.655
MOD_NEK2_1	336	341	PF00069	0.602
MOD_NEK2_1	434	439	PF00069	0.607
MOD_NEK2_1	488	493	PF00069	0.478
MOD_NEK2_1	498	503	PF00069	0.490
MOD_NEK2_2	167	172	PF00069	0.575
MOD_PIKK_1	252	258	PF00454	0.592
MOD_PIKK_1	271	277	PF00454	0.613
MOD_PIKK_1	432	438	PF00454	0.675
MOD_PK_1	323	329	PF00069	0.642
MOD_PKA_2	228	234	PF00069	0.543
MOD_PKA_2	319	325	PF00069	0.581
MOD_PKA_2	381	387	PF00069	0.513
MOD_PKA_2	537	543	PF00069	0.555
MOD_PKB_1	25	33	PF00069	0.526
MOD_PKB_1	296	304	PF00069	0.532
MOD_Plk_1	252	258	PF00069	0.566
MOD_Plk_1	538	544	PF00069	0.560
MOD_Plk_2-3	228	234	PF00069	0.576
MOD_Plk_2-3	391	397	PF00069	0.722
MOD_Plk_4	351	357	PF00069	0.632
MOD_Plk_4	429	435	PF00069	0.591
MOD_Plk_4	538	544	PF00069	0.562
MOD_ProDKin_1	120	126	PF00069	0.727
MOD_ProDKin_1	185	191	PF00069	0.545
MOD_ProDKin_1	208	214	PF00069	0.655
MOD_ProDKin_1	328	334	PF00069	0.698
MOD_ProDKin_1	337	343	PF00069	0.659
MOD_ProDKin_1	443	449	PF00069	0.652
MOD_ProDKin_1	451	457	PF00069	0.582
MOD_ProDKin_1	82	88	PF00069	0.573
MOD_SUMO_rev_2	56	63	PF00179	0.714
TRG_ENDOCYTIC_2	258	261	PF00928	0.513
TRG_ENDOCYTIC_2	417	420	PF00928	0.565
TRG_ENDOCYTIC_2	479	482	PF00928	0.481
TRG_ENDOCYTIC_2	555	558	PF00928	0.489
TRG_ER_diArg_1	2	5	PF00400	0.717
TRG_ER_diArg_1	23	25	PF00400	0.572
TRG_ER_diArg_1	296	298	PF00400	0.627
TRG_ER_diArg_1	509	512	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L4	Leptomonas seymouri	40%	100%
A4HLK4	Leishmania braziliensis	68%	100%
A4I915	Leishmania infantum	99%	100%
E9B3Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q444	Leishmania major	88%	100%