Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IEV1_LEIDO

TriTrypDb:

LdBPK_241020.1 , LdCL_240015200 , LDHU3_24.1190

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.699
CLV_NRD_NRD_1	178	180	PF00675	0.849
CLV_NRD_NRD_1	343	345	PF00675	0.793
CLV_NRD_NRD_1	4	6	PF00675	0.658
CLV_NRD_NRD_1	416	418	PF00675	0.641
CLV_NRD_NRD_1	423	425	PF00675	0.593
CLV_PCSK_KEX2_1	178	180	PF00082	0.870
CLV_PCSK_KEX2_1	19	21	PF00082	0.671
CLV_PCSK_KEX2_1	2	4	PF00082	0.720
CLV_PCSK_KEX2_1	342	344	PF00082	0.778
CLV_PCSK_KEX2_1	416	418	PF00082	0.641
CLV_PCSK_KEX2_1	423	425	PF00082	0.593
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.671
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.684
CLV_PCSK_SKI1_1	416	420	PF00082	0.594
CLV_PCSK_SKI1_1	5	9	PF00082	0.568
CLV_Separin_Metazoa	468	472	PF03568	0.608
DEG_APCC_DBOX_1	3	11	PF00400	0.640
DEG_Nend_UBRbox_1	1	4	PF02207	0.728
DEG_SPOP_SBC_1	254	258	PF00917	0.564
DEG_SPOP_SBC_1	450	454	PF00917	0.629
DOC_CDC14_PxL_1	260	268	PF14671	0.678
DOC_MAPK_gen_1	2	10	PF00069	0.638
DOC_PP2B_LxvP_1	401	404	PF13499	0.686
DOC_PP4_FxxP_1	542	545	PF00568	0.525
DOC_USP7_MATH_1	145	149	PF00917	0.784
DOC_USP7_MATH_1	169	173	PF00917	0.777
DOC_USP7_MATH_1	218	222	PF00917	0.674
DOC_USP7_MATH_1	255	259	PF00917	0.633
DOC_USP7_MATH_1	280	284	PF00917	0.700
DOC_USP7_MATH_1	288	292	PF00917	0.653
DOC_USP7_MATH_1	310	314	PF00917	0.713
DOC_USP7_MATH_1	450	454	PF00917	0.714
DOC_USP7_MATH_1	493	497	PF00917	0.689
DOC_USP7_MATH_1	535	539	PF00917	0.505
DOC_WW_Pin1_4	114	119	PF00397	0.657
DOC_WW_Pin1_4	146	151	PF00397	0.743
DOC_WW_Pin1_4	266	271	PF00397	0.669
DOC_WW_Pin1_4	282	287	PF00397	0.552
DOC_WW_Pin1_4	88	93	PF00397	0.664
LIG_BRCT_BRCA1_1	291	295	PF00533	0.693
LIG_BRCT_BRCA1_1	517	521	PF00533	0.638
LIG_EVH1_1	401	405	PF00568	0.677
LIG_EVH1_2	126	130	PF00568	0.680
LIG_FHA_1	141	147	PF00498	0.567
LIG_FHA_1	254	260	PF00498	0.654
LIG_FHA_1	304	310	PF00498	0.681
LIG_FHA_1	460	466	PF00498	0.620
LIG_FHA_1	508	514	PF00498	0.643
LIG_FHA_1	72	78	PF00498	0.484
LIG_FHA_2	100	106	PF00498	0.537
LIG_FHA_2	23	29	PF00498	0.654
LIG_FHA_2	292	298	PF00498	0.704
LIG_FHA_2	407	413	PF00498	0.628
LIG_LIR_Gen_1	257	268	PF02991	0.617
LIG_LIR_Gen_1	324	334	PF02991	0.646
LIG_LIR_Nem_3	128	133	PF02991	0.608
LIG_LIR_Nem_3	257	263	PF02991	0.624
LIG_LIR_Nem_3	28	34	PF02991	0.621
LIG_MYND_1	231	235	PF01753	0.674
LIG_NRBOX	105	111	PF00104	0.574
LIG_PTB_Apo_2	157	164	PF02174	0.693
LIG_PTB_Phospho_1	157	163	PF10480	0.693
LIG_SH2_CRK	260	264	PF00017	0.685
LIG_SH2_PTP2	393	396	PF00017	0.660
LIG_SH2_SRC	393	396	PF00017	0.660
LIG_SH2_STAT5	393	396	PF00017	0.709
LIG_SH3_2	466	471	PF14604	0.695
LIG_SH3_3	115	121	PF00018	0.714
LIG_SH3_3	129	135	PF00018	0.567
LIG_SH3_3	153	159	PF00018	0.678
LIG_SH3_3	177	183	PF00018	0.680
LIG_SH3_3	264	270	PF00018	0.586
LIG_SH3_3	399	405	PF00018	0.688
LIG_SH3_3	463	469	PF00018	0.682
LIG_SH3_3	485	491	PF00018	0.714
LIG_SUMO_SIM_anti_2	102	112	PF11976	0.535
LIG_SUMO_SIM_par_1	207	213	PF11976	0.603
LIG_SUMO_SIM_par_1	6	12	PF11976	0.642
LIG_TRFH_1	260	264	PF08558	0.685
LIG_WW_3	182	186	PF00397	0.681
LIG_WW_3	405	409	PF00397	0.638
MOD_CK1_1	190	196	PF00069	0.764
MOD_CK1_1	210	216	PF00069	0.456
MOD_CK1_1	242	248	PF00069	0.770
MOD_CK1_1	258	264	PF00069	0.625
MOD_CK1_1	284	290	PF00069	0.773
MOD_CK1_1	291	297	PF00069	0.718
MOD_CK1_1	373	379	PF00069	0.681
MOD_CK1_1	437	443	PF00069	0.626
MOD_CK1_1	464	470	PF00069	0.614
MOD_CK1_1	482	488	PF00069	0.641
MOD_CK1_1	492	498	PF00069	0.628
MOD_CK2_1	22	28	PF00069	0.685
MOD_CK2_1	291	297	PF00069	0.716
MOD_CK2_1	406	412	PF00069	0.666
MOD_CK2_1	451	457	PF00069	0.634
MOD_CK2_1	79	85	PF00069	0.566
MOD_CK2_1	99	105	PF00069	0.377
MOD_GlcNHglycan	127	130	PF01048	0.710
MOD_GlcNHglycan	192	195	PF01048	0.765
MOD_GlcNHglycan	244	247	PF01048	0.730
MOD_GlcNHglycan	367	370	PF01048	0.778
MOD_GlcNHglycan	372	375	PF01048	0.719
MOD_GlcNHglycan	459	462	PF01048	0.597
MOD_GlcNHglycan	476	480	PF01048	0.786
MOD_GlcNHglycan	491	494	PF01048	0.622
MOD_GlcNHglycan	499	502	PF01048	0.586
MOD_GlcNHglycan	537	540	PF01048	0.587
MOD_GSK3_1	183	190	PF00069	0.731
MOD_GSK3_1	242	249	PF00069	0.709
MOD_GSK3_1	254	261	PF00069	0.634
MOD_GSK3_1	266	273	PF00069	0.656
MOD_GSK3_1	278	285	PF00069	0.694
MOD_GSK3_1	457	464	PF00069	0.593
MOD_GSK3_1	475	482	PF00069	0.655
MOD_GSK3_1	489	496	PF00069	0.597
MOD_GSK3_1	507	514	PF00069	0.549
MOD_GSK3_1	515	522	PF00069	0.581
MOD_LATS_1	18	24	PF00433	0.668
MOD_N-GLC_1	437	442	PF02516	0.562
MOD_N-GLC_2	337	339	PF02516	0.630
MOD_NEK2_1	347	352	PF00069	0.650
MOD_NEK2_1	451	456	PF00069	0.640
MOD_NEK2_2	255	260	PF00069	0.635
MOD_PIKK_1	183	189	PF00454	0.729
MOD_PIKK_1	511	517	PF00454	0.632
MOD_PIKK_1	71	77	PF00454	0.552
MOD_PIKK_1	79	85	PF00454	0.481
MOD_PKA_2	246	252	PF00069	0.691
MOD_Plk_1	437	443	PF00069	0.561
MOD_Plk_1	515	521	PF00069	0.606
MOD_Plk_4	255	261	PF00069	0.683
MOD_Plk_4	273	279	PF00069	0.527
MOD_Plk_4	437	443	PF00069	0.625
MOD_Plk_4	451	457	PF00069	0.578
MOD_ProDKin_1	114	120	PF00069	0.660
MOD_ProDKin_1	146	152	PF00069	0.744
MOD_ProDKin_1	266	272	PF00069	0.672
MOD_ProDKin_1	282	288	PF00069	0.552
MOD_ProDKin_1	88	94	PF00069	0.656
TRG_DiLeu_BaEn_1	105	110	PF01217	0.523
TRG_ENDOCYTIC_2	260	263	PF00928	0.687
TRG_ENDOCYTIC_2	393	396	PF00928	0.660
TRG_ER_diArg_1	178	180	PF00400	0.664
TRG_ER_diArg_1	219	222	PF00400	0.625
TRG_ER_diArg_1	3	5	PF00400	0.607
TRG_ER_diArg_1	341	344	PF00400	0.758
TRG_ER_diArg_1	416	418	PF00400	0.610
TRG_NLS_MonoExtN_4	423	428	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.535
TRG_PTS1	544	547	PF00515	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDF6	Leishmania braziliensis	59%	100%
E9AH58	Leishmania infantum	99%	100%
E9AWU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAN3	Leishmania major	88%	100%