Coatomer subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coatomer subunit gamma

Species:

Leishmania donovani

UniProt:

A0A3Q8IEU8_LEIDO

TriTrypDb:

LdBPK_282820.1 , LdCL_280033300 , LDHU3_28.3800

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030126	COPI vesicle coat	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IEU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEU8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0009306	protein secretion	4	1
GO:0032940	secretion by cell	3	1
GO:0035592	establishment of protein localization to extracellular region	4	1
GO:0046903	secretion	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071692	protein localization to extracellular region	5	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.421
CLV_C14_Caspase3-7	415	419	PF00656	0.404
CLV_C14_Caspase3-7	515	519	PF00656	0.386
CLV_C14_Caspase3-7	567	571	PF00656	0.627
CLV_C14_Caspase3-7	633	637	PF00656	0.448
CLV_NRD_NRD_1	174	176	PF00675	0.335
CLV_NRD_NRD_1	505	507	PF00675	0.316
CLV_NRD_NRD_1	85	87	PF00675	0.300
CLV_PCSK_KEX2_1	452	454	PF00082	0.328
CLV_PCSK_KEX2_1	505	507	PF00082	0.316
CLV_PCSK_KEX2_1	513	515	PF00082	0.316
CLV_PCSK_KEX2_1	85	87	PF00082	0.300
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.415
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.335
CLV_PCSK_SKI1_1	176	180	PF00082	0.421
CLV_PCSK_SKI1_1	251	255	PF00082	0.335
CLV_PCSK_SKI1_1	280	284	PF00082	0.312
CLV_PCSK_SKI1_1	356	360	PF00082	0.335
CLV_PCSK_SKI1_1	452	456	PF00082	0.303
CLV_PCSK_SKI1_1	46	50	PF00082	0.358
CLV_PCSK_SKI1_1	526	530	PF00082	0.316
CLV_PCSK_SKI1_1	532	536	PF00082	0.294
CLV_PCSK_SKI1_1	557	561	PF00082	0.520
CLV_PCSK_SKI1_1	608	612	PF00082	0.354
CLV_PCSK_SKI1_1	782	786	PF00082	0.248
CLV_PCSK_SKI1_1	841	845	PF00082	0.262
CLV_Separin_Metazoa	172	176	PF03568	0.404
CLV_Separin_Metazoa	183	187	PF03568	0.352
DEG_APCC_DBOX_1	607	615	PF00400	0.358
DEG_APCC_DBOX_1	855	863	PF00400	0.553
DEG_SCF_FBW7_1	282	287	PF00400	0.409
DOC_CKS1_1	750	755	PF01111	0.496
DOC_MAPK_gen_1	201	210	PF00069	0.302
DOC_MAPK_gen_1	221	230	PF00069	0.117
DOC_MAPK_gen_1	452	458	PF00069	0.323
DOC_MAPK_gen_1	505	511	PF00069	0.316
DOC_MAPK_MEF2A_6	190	198	PF00069	0.368
DOC_MAPK_MEF2A_6	221	230	PF00069	0.321
DOC_MAPK_MEF2A_6	280	288	PF00069	0.316
DOC_MAPK_MEF2A_6	841	848	PF00069	0.459
DOC_MAPK_NFAT4_5	841	849	PF00069	0.523
DOC_PP4_FxxP_1	750	753	PF00568	0.440
DOC_USP7_MATH_1	267	271	PF00917	0.427
DOC_USP7_MATH_1	341	345	PF00917	0.442
DOC_USP7_MATH_1	463	467	PF00917	0.415
DOC_USP7_MATH_1	623	627	PF00917	0.459
DOC_USP7_MATH_1	688	692	PF00917	0.534
DOC_USP7_MATH_1	777	781	PF00917	0.489
DOC_USP7_UBL2_3	388	392	PF12436	0.293
DOC_WD40_RPTOR_TOS_1	743	749	PF00400	0.534
DOC_WW_Pin1_4	280	285	PF00397	0.281
DOC_WW_Pin1_4	598	603	PF00397	0.535
DOC_WW_Pin1_4	749	754	PF00397	0.457
DOC_WW_Pin1_4	93	98	PF00397	0.316
LIG_14-3-3_CanoR_1	175	185	PF00244	0.386
LIG_14-3-3_CanoR_1	207	211	PF00244	0.303
LIG_14-3-3_CanoR_1	221	227	PF00244	0.311
LIG_14-3-3_CanoR_1	275	284	PF00244	0.356
LIG_14-3-3_CanoR_1	310	316	PF00244	0.334
LIG_14-3-3_CanoR_1	335	341	PF00244	0.277
LIG_14-3-3_CanoR_1	46	55	PF00244	0.358
LIG_14-3-3_CanoR_1	514	523	PF00244	0.419
LIG_Actin_WH2_2	286	303	PF00022	0.316
LIG_Actin_WH2_2	333	349	PF00022	0.315
LIG_Actin_WH2_2	397	415	PF00022	0.421
LIG_Actin_WH2_2	490	507	PF00022	0.316
LIG_Actin_WH2_2	546	563	PF00022	0.551
LIG_Actin_WH2_2	800	817	PF00022	0.523
LIG_APCC_ABBA_1	795	800	PF00400	0.473
LIG_BIR_III_2	15	19	PF00653	0.565
LIG_BIR_III_4	593	597	PF00653	0.632
LIG_CSK_EPIYA_1	682	686	PF00017	0.509
LIG_CtBP_PxDLS_1	753	757	PF00389	0.448
LIG_EH1_1	655	663	PF00400	0.534
LIG_eIF4E_1	193	199	PF01652	0.316
LIG_eIF4E_1	858	864	PF01652	0.473
LIG_FHA_1	155	161	PF00498	0.421
LIG_FHA_1	242	248	PF00498	0.390
LIG_FHA_1	252	258	PF00498	0.371
LIG_FHA_1	281	287	PF00498	0.409
LIG_FHA_1	337	343	PF00498	0.312
LIG_FHA_1	449	455	PF00498	0.421
LIG_FHA_1	47	53	PF00498	0.300
LIG_FHA_1	599	605	PF00498	0.541
LIG_FHA_1	674	680	PF00498	0.459
LIG_FHA_1	773	779	PF00498	0.448
LIG_FHA_1	808	814	PF00498	0.558
LIG_FHA_1	824	830	PF00498	0.446
LIG_FHA_2	141	147	PF00498	0.316
LIG_FHA_2	167	173	PF00498	0.421
LIG_FHA_2	346	352	PF00498	0.300
LIG_FHA_2	375	381	PF00498	0.421
LIG_FHA_2	542	548	PF00498	0.551
LIG_FHA_2	565	571	PF00498	0.645
LIG_FHA_2	575	581	PF00498	0.504
LIG_FHA_2	60	66	PF00498	0.306
LIG_FHA_2	631	637	PF00498	0.449
LIG_FHA_2	672	678	PF00498	0.534
LIG_FHA_2	750	756	PF00498	0.501
LIG_GBD_Chelix_1	226	234	PF00786	0.409
LIG_GBD_Chelix_1	285	293	PF00786	0.421
LIG_IRF3_LxIS_1	417	424	PF10401	0.421
LIG_LIR_Apic_2	682	688	PF02991	0.459
LIG_LIR_Apic_2	748	753	PF02991	0.447
LIG_LIR_Gen_1	134	145	PF02991	0.342
LIG_LIR_Gen_1	391	401	PF02991	0.377
LIG_LIR_Gen_1	444	455	PF02991	0.386
LIG_LIR_Gen_1	79	89	PF02991	0.409
LIG_LIR_Nem_3	248	253	PF02991	0.335
LIG_LIR_Nem_3	391	396	PF02991	0.409
LIG_LIR_Nem_3	444	450	PF02991	0.316
LIG_LIR_Nem_3	696	702	PF02991	0.452
LIG_LIR_Nem_3	79	84	PF02991	0.421
LIG_LYPXL_yS_3	193	196	PF13949	0.409
LIG_PCNA_yPIPBox_3	413	421	PF02747	0.421
LIG_PCNA_yPIPBox_3	655	668	PF02747	0.553
LIG_PTB_Apo_2	383	390	PF02174	0.358
LIG_PTB_Apo_2	661	668	PF02174	0.534
LIG_SH2_CRK	250	254	PF00017	0.335
LIG_SH2_CRK	530	534	PF00017	0.316
LIG_SH2_CRK	685	689	PF00017	0.521
LIG_SH2_CRK	699	703	PF00017	0.366
LIG_SH2_CRK	81	85	PF00017	0.409
LIG_SH2_NCK_1	476	480	PF00017	0.316
LIG_SH2_PTP2	701	704	PF00017	0.531
LIG_SH2_SRC	306	309	PF00017	0.438
LIG_SH2_SRC	545	548	PF00017	0.356
LIG_SH2_SRC	685	688	PF00017	0.473
LIG_SH2_SRC	706	709	PF00017	0.518
LIG_SH2_STAP1	393	397	PF00017	0.386
LIG_SH2_STAP1	530	534	PF00017	0.316
LIG_SH2_STAT5	292	295	PF00017	0.300
LIG_SH2_STAT5	306	309	PF00017	0.300
LIG_SH2_STAT5	474	477	PF00017	0.368
LIG_SH2_STAT5	53	56	PF00017	0.300
LIG_SH2_STAT5	530	533	PF00017	0.316
LIG_SH2_STAT5	545	548	PF00017	0.544
LIG_SH2_STAT5	639	642	PF00017	0.448
LIG_SH2_STAT5	701	704	PF00017	0.490
LIG_SH2_STAT5	858	861	PF00017	0.473
LIG_SH2_STAT5	89	92	PF00017	0.316
LIG_SH3_2	171	176	PF14604	0.421
LIG_SH3_3	168	174	PF00018	0.421
LIG_SUMO_SIM_anti_2	507	513	PF11976	0.335
LIG_SUMO_SIM_anti_2	826	831	PF11976	0.473
LIG_SUMO_SIM_par_1	338	344	PF11976	0.316
LIG_SUMO_SIM_par_1	418	424	PF11976	0.327
LIG_SUMO_SIM_par_1	628	634	PF11976	0.534
LIG_SUMO_SIM_par_1	669	674	PF11976	0.497
LIG_SUMO_SIM_par_1	752	759	PF11976	0.492
LIG_TRAF2_1	27	30	PF00917	0.496
LIG_TRAF2_1	765	768	PF00917	0.553
LIG_TYR_ITIM	528	533	PF00017	0.316
LIG_TYR_ITSM	695	702	PF00017	0.489
LIG_UBA3_1	109	116	PF00899	0.335
LIG_UBA3_1	420	425	PF00899	0.362
LIG_UBA3_1	661	668	PF00899	0.534
LIG_UBA3_1	69	75	PF00899	0.334
MOD_CK1_1	119	125	PF00069	0.389
MOD_CK1_1	154	160	PF00069	0.334
MOD_CK1_1	270	276	PF00069	0.335
MOD_CK1_1	362	368	PF00069	0.386
MOD_CK1_1	426	432	PF00069	0.348
MOD_CK1_1	448	454	PF00069	0.409
MOD_CK1_1	500	506	PF00069	0.367
MOD_CK1_1	578	584	PF00069	0.701
MOD_CK2_1	140	146	PF00069	0.316
MOD_CK2_1	166	172	PF00069	0.419
MOD_CK2_1	242	248	PF00069	0.447
MOD_CK2_1	275	281	PF00069	0.316
MOD_CK2_1	345	351	PF00069	0.300
MOD_CK2_1	388	394	PF00069	0.385
MOD_CK2_1	426	432	PF00069	0.387
MOD_CK2_1	541	547	PF00069	0.523
MOD_CK2_1	59	65	PF00069	0.306
MOD_CK2_1	671	677	PF00069	0.512
MOD_CK2_1	724	730	PF00069	0.440
MOD_GlcNHglycan	122	125	PF01048	0.370
MOD_GlcNHglycan	25	28	PF01048	0.430
MOD_GlcNHglycan	362	365	PF01048	0.359
MOD_GlcNHglycan	409	412	PF01048	0.424
MOD_GlcNHglycan	567	570	PF01048	0.657
MOD_GlcNHglycan	577	580	PF01048	0.636
MOD_GlcNHglycan	593	597	PF01048	0.383
MOD_GlcNHglycan	625	628	PF01048	0.230
MOD_GlcNHglycan	712	715	PF01048	0.248
MOD_GlcNHglycan	816	819	PF01048	0.258
MOD_GlcNHglycan	851	854	PF01048	0.282
MOD_GSK3_1	116	123	PF00069	0.300
MOD_GSK3_1	132	139	PF00069	0.259
MOD_GSK3_1	147	154	PF00069	0.306
MOD_GSK3_1	280	287	PF00069	0.409
MOD_GSK3_1	336	343	PF00069	0.324
MOD_GSK3_1	345	352	PF00069	0.309
MOD_GSK3_1	356	363	PF00069	0.375
MOD_GSK3_1	388	395	PF00069	0.341
MOD_GSK3_1	402	409	PF00069	0.290
MOD_GSK3_1	423	430	PF00069	0.378
MOD_GSK3_1	500	507	PF00069	0.303
MOD_GSK3_1	537	544	PF00069	0.485
MOD_GSK3_1	574	581	PF00069	0.639
MOD_GSK3_1	745	752	PF00069	0.268
MOD_GSK3_1	99	106	PF00069	0.386
MOD_N-GLC_1	275	280	PF02516	0.293
MOD_N-GLC_1	769	774	PF02516	0.294
MOD_N-GLC_1	782	787	PF02516	0.192
MOD_NEK2_1	103	108	PF00069	0.300
MOD_NEK2_1	132	137	PF00069	0.323
MOD_NEK2_1	140	145	PF00069	0.305
MOD_NEK2_1	166	171	PF00069	0.402
MOD_NEK2_1	252	257	PF00069	0.349
MOD_NEK2_1	291	296	PF00069	0.320
MOD_NEK2_1	340	345	PF00069	0.303
MOD_NEK2_1	374	379	PF00069	0.421
MOD_NEK2_1	412	417	PF00069	0.376
MOD_NEK2_1	421	426	PF00069	0.386
MOD_NEK2_1	504	509	PF00069	0.306
MOD_NEK2_1	512	517	PF00069	0.309
MOD_NEK2_1	541	546	PF00069	0.523
MOD_NEK2_1	573	578	PF00069	0.732
MOD_NEK2_1	592	597	PF00069	0.542
MOD_NEK2_1	70	75	PF00069	0.386
MOD_NEK2_1	76	81	PF00069	0.300
MOD_NEK2_1	814	819	PF00069	0.426
MOD_NEK2_2	688	693	PF00069	0.565
MOD_NEK2_2	777	782	PF00069	0.489
MOD_PIKK_1	176	182	PF00454	0.325
MOD_PIKK_1	292	298	PF00454	0.382
MOD_PIKK_1	356	362	PF00454	0.358
MOD_PIKK_1	445	451	PF00454	0.386
MOD_PIKK_1	46	52	PF00454	0.335
MOD_PIKK_1	694	700	PF00454	0.509
MOD_PK_1	151	157	PF00069	0.421
MOD_PKA_1	565	571	PF00069	0.722
MOD_PKA_2	206	212	PF00069	0.320
MOD_PKA_2	222	228	PF00069	0.316
MOD_PKA_2	309	315	PF00069	0.364
MOD_PKA_2	504	510	PF00069	0.300
MOD_PKA_2	59	65	PF00069	0.416
MOD_Plk_1	132	138	PF00069	0.306
MOD_Plk_1	140	146	PF00069	0.291
MOD_Plk_1	350	356	PF00069	0.300
MOD_Plk_1	445	451	PF00069	0.386
MOD_Plk_1	537	543	PF00069	0.516
MOD_Plk_1	823	829	PF00069	0.515
MOD_Plk_1	99	105	PF00069	0.421
MOD_Plk_2-3	206	212	PF00069	0.421
MOD_Plk_4	132	138	PF00069	0.304
MOD_Plk_4	151	157	PF00069	0.316
MOD_Plk_4	252	258	PF00069	0.313
MOD_Plk_4	284	290	PF00069	0.404
MOD_Plk_4	341	347	PF00069	0.308
MOD_Plk_4	362	368	PF00069	0.386
MOD_Plk_4	374	380	PF00069	0.374
MOD_Plk_4	392	398	PF00069	0.252
MOD_Plk_4	412	418	PF00069	0.355
MOD_Plk_4	537	543	PF00069	0.487
MOD_Plk_4	639	645	PF00069	0.448
MOD_Plk_4	99	105	PF00069	0.320
MOD_ProDKin_1	280	286	PF00069	0.281
MOD_ProDKin_1	598	604	PF00069	0.525
MOD_ProDKin_1	749	755	PF00069	0.457
MOD_ProDKin_1	93	99	PF00069	0.316
MOD_SUMO_rev_2	755	765	PF00179	0.514
TRG_DiLeu_BaEn_1	823	828	PF01217	0.534
TRG_DiLeu_BaEn_2	247	253	PF01217	0.370
TRG_DiLeu_BaEn_4	12	18	PF01217	0.610
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.335
TRG_ENDOCYTIC_2	129	132	PF00928	0.339
TRG_ENDOCYTIC_2	137	140	PF00928	0.287
TRG_ENDOCYTIC_2	193	196	PF00928	0.300
TRG_ENDOCYTIC_2	250	253	PF00928	0.335
TRG_ENDOCYTIC_2	393	396	PF00928	0.300
TRG_ENDOCYTIC_2	530	533	PF00928	0.301
TRG_ENDOCYTIC_2	699	702	PF00928	0.451
TRG_ENDOCYTIC_2	81	84	PF00928	0.348
TRG_ENDOCYTIC_2	89	92	PF00928	0.279
TRG_ER_diArg_1	504	506	PF00400	0.316
TRG_ER_diArg_1	84	86	PF00400	0.303
TRG_NES_CRM1_1	50	65	PF08389	0.421
TRG_NES_CRM1_1	789	800	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	782	786	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q5	Leptomonas seymouri	81%	100%
A0A0S4IV67	Bodo saltans	49%	100%
A0A1X0NR86	Trypanosomatidae	57%	96%
A0A3R7MHH9	Trypanosoma rangeli	56%	100%
A2VE21	Bos taurus	33%	99%
A4HGW5	Leishmania braziliensis	88%	99%
A4I3Z5	Leishmania infantum	99%	100%
D0A965	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
D4ABY2	Rattus norvegicus	34%	100%
E9B085	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P32074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	93%
P53620	Bos taurus	35%	99%
P87140	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
Q0WW26	Arabidopsis thaliana	35%	98%
Q22498	Caenorhabditis elegans	33%	99%
Q29AE5	Drosophila pseudoobscura pseudoobscura	33%	99%
Q4AEF8	Rattus norvegicus	34%	99%
Q4Q800	Leishmania major	97%	100%
Q54HL0	Dictyostelium discoideum	34%	96%
Q66JI9	Xenopus tropicalis	33%	99%
Q6DKD7	Xenopus laevis	32%	99%
Q6Z382	Oryza sativa subsp. japonica	35%	97%
Q7PVF6	Anopheles gambiae	32%	100%
Q8I0G5	Drosophila melanogaster	33%	98%
Q9I8E6	Takifugu rubripes	33%	99%
Q9PUE4	Danio rerio	32%	99%
Q9QXK3	Mus musculus	34%	99%
Q9QZE5	Mus musculus	34%	99%
Q9UBF2	Homo sapiens	33%	99%
Q9Y678	Homo sapiens	35%	99%
V5DCV8	Trypanosoma cruzi	58%	100%