Haloacid dehalogenase-like hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IEU6_LEIDO

TriTrypDb:

LdBPK_281490.1 , LdCL_280019600 , LDHU3_28.1880

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IEU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	31
GO:0016787	hydrolase activity	2	31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.480
CLV_NRD_NRD_1	15	17	PF00675	0.651
CLV_NRD_NRD_1	378	380	PF00675	0.291
CLV_NRD_NRD_1	81	83	PF00675	0.281
CLV_PCSK_FUR_1	78	82	PF00082	0.349
CLV_PCSK_KEX2_1	15	17	PF00082	0.492
CLV_PCSK_KEX2_1	278	280	PF00082	0.265
CLV_PCSK_KEX2_1	80	82	PF00082	0.269
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.309
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.290
CLV_PCSK_SKI1_1	278	282	PF00082	0.296
CLV_PCSK_SKI1_1	52	56	PF00082	0.313
CLV_PCSK_SKI1_1	71	75	PF00082	0.194
DEG_APCC_DBOX_1	51	59	PF00400	0.530
DEG_SCF_FBW7_1	124	131	PF00400	0.501
DEG_SPOP_SBC_1	116	120	PF00917	0.508
DEG_SPOP_SBC_1	397	401	PF00917	0.463
DOC_CKS1_1	125	130	PF01111	0.497
DOC_CKS1_1	92	97	PF01111	0.677
DOC_CKS1_1	99	104	PF01111	0.717
DOC_MAPK_DCC_7	358	368	PF00069	0.421
DOC_MAPK_gen_1	15	22	PF00069	0.690
DOC_MAPK_gen_1	358	368	PF00069	0.491
DOC_MAPK_gen_1	78	85	PF00069	0.543
DOC_MAPK_MEF2A_6	360	368	PF00069	0.447
DOC_MAPK_MEF2A_6	90	99	PF00069	0.673
DOC_USP7_MATH_1	116	120	PF00917	0.715
DOC_USP7_MATH_1	126	130	PF00917	0.701
DOC_USP7_MATH_1	149	153	PF00917	0.555
DOC_USP7_MATH_1	266	270	PF00917	0.567
DOC_USP7_MATH_1	397	401	PF00917	0.742
DOC_WW_Pin1_4	112	117	PF00397	0.675
DOC_WW_Pin1_4	124	129	PF00397	0.592
DOC_WW_Pin1_4	91	96	PF00397	0.621
DOC_WW_Pin1_4	98	103	PF00397	0.671
LIG_14-3-3_CanoR_1	238	242	PF00244	0.490
LIG_14-3-3_CanoR_1	255	262	PF00244	0.566
LIG_14-3-3_CanoR_1	379	387	PF00244	0.597
LIG_14-3-3_CanoR_1	71	79	PF00244	0.505
LIG_BRCT_BRCA1_1	256	260	PF00533	0.549
LIG_BRCT_BRCA1_1	381	385	PF00533	0.293
LIG_EVH1_1	124	128	PF00568	0.497
LIG_FHA_1	138	144	PF00498	0.652
LIG_FHA_1	238	244	PF00498	0.548
LIG_FHA_1	248	254	PF00498	0.447
LIG_FHA_1	282	288	PF00498	0.380
LIG_FHA_1	298	304	PF00498	0.528
LIG_FHA_1	49	55	PF00498	0.479
LIG_FHA_1	87	93	PF00498	0.618
LIG_FHA_2	324	330	PF00498	0.488
LIG_FHA_2	99	105	PF00498	0.710
LIG_IBAR_NPY_1	27	29	PF08397	0.339
LIG_LIR_Gen_1	177	186	PF02991	0.504
LIG_LIR_Nem_3	177	182	PF02991	0.504
LIG_LIR_Nem_3	240	244	PF02991	0.521
LIG_LIR_Nem_3	258	264	PF02991	0.491
LIG_MYND_3	363	367	PF01753	0.433
LIG_NRBOX	54	60	PF00104	0.545
LIG_Pex14_1	221	225	PF04695	0.509
LIG_SH2_CRK	206	210	PF00017	0.541
LIG_SH2_CRK	29	33	PF00017	0.354
LIG_SH2_GRB2like	206	209	PF00017	0.562
LIG_SH2_NCK_1	158	162	PF00017	0.545
LIG_SH2_NCK_1	206	210	PF00017	0.587
LIG_SH2_STAP1	166	170	PF00017	0.530
LIG_SH2_STAP1	179	183	PF00017	0.468
LIG_SH2_STAP1	50	54	PF00017	0.551
LIG_SH2_STAT5	206	209	PF00017	0.510
LIG_SH2_STAT5	301	304	PF00017	0.581
LIG_SH2_STAT5	50	53	PF00017	0.474
LIG_SH3_3	120	126	PF00018	0.511
LIG_SH3_3	17	23	PF00018	0.704
LIG_SH3_3	96	102	PF00018	0.694
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.515
LIG_TRAF2_1	217	220	PF00917	0.497
MOD_CDK_SPxxK_3	103	110	PF00069	0.530
MOD_CK1_1	106	112	PF00069	0.717
MOD_CK1_1	115	121	PF00069	0.710
MOD_CK1_1	130	136	PF00069	0.583
MOD_CK1_1	237	243	PF00069	0.539
MOD_CK1_1	274	280	PF00069	0.540
MOD_CK1_1	3	9	PF00069	0.452
MOD_CK1_1	308	314	PF00069	0.485
MOD_CK1_1	43	49	PF00069	0.481
MOD_CK2_1	224	230	PF00069	0.526
MOD_CK2_1	242	248	PF00069	0.464
MOD_CK2_1	267	273	PF00069	0.498
MOD_CK2_1	98	104	PF00069	0.705
MOD_GlcNHglycan	112	115	PF01048	0.711
MOD_GlcNHglycan	132	135	PF01048	0.624
MOD_GlcNHglycan	297	300	PF01048	0.309
MOD_GlcNHglycan	313	316	PF01048	0.246
MOD_GSK3_1	106	113	PF00069	0.717
MOD_GSK3_1	115	122	PF00069	0.687
MOD_GSK3_1	124	131	PF00069	0.563
MOD_GSK3_1	267	274	PF00069	0.544
MOD_GSK3_1	36	43	PF00069	0.507
MOD_N-GLC_1	116	121	PF02516	0.530
MOD_N-GLC_1	137	142	PF02516	0.492
MOD_N-GLC_2	328	330	PF02516	0.191
MOD_NEK2_1	148	153	PF00069	0.491
MOD_NEK2_1	247	252	PF00069	0.499
MOD_NEK2_1	289	294	PF00069	0.536
MOD_NEK2_1	323	328	PF00069	0.484
MOD_NEK2_1	342	347	PF00069	0.542
MOD_NEK2_1	36	41	PF00069	0.475
MOD_NEK2_1	86	91	PF00069	0.431
MOD_PIKK_1	53	59	PF00454	0.472
MOD_PKA_1	379	385	PF00069	0.450
MOD_PKA_2	237	243	PF00069	0.497
MOD_PKA_2	254	260	PF00069	0.547
MOD_Plk_1	166	172	PF00069	0.555
MOD_Plk_1	247	253	PF00069	0.386
MOD_Plk_1	266	272	PF00069	0.389
MOD_Plk_1	289	295	PF00069	0.513
MOD_Plk_1	323	329	PF00069	0.497
MOD_Plk_2-3	215	221	PF00069	0.545
MOD_Plk_2-3	267	273	PF00069	0.396
MOD_Plk_4	119	125	PF00069	0.534
MOD_Plk_4	177	183	PF00069	0.485
MOD_Plk_4	267	273	PF00069	0.578
MOD_Plk_4	3	9	PF00069	0.707
MOD_Plk_4	36	42	PF00069	0.483
MOD_ProDKin_1	112	118	PF00069	0.674
MOD_ProDKin_1	124	130	PF00069	0.594
MOD_ProDKin_1	91	97	PF00069	0.628
MOD_ProDKin_1	98	104	PF00069	0.672
MOD_SUMO_for_1	287	290	PF00179	0.380
MOD_SUMO_rev_2	210	218	PF00179	0.559
MOD_SUMO_rev_2	282	289	PF00179	0.562
TRG_ENDOCYTIC_2	179	182	PF00928	0.457
TRG_ENDOCYTIC_2	29	32	PF00928	0.341
TRG_ER_diArg_1	15	17	PF00400	0.496
TRG_ER_diArg_1	81	83	PF00400	0.418
TRG_NLS_MonoExtC_3	359	364	PF00514	0.391
TRG_NLS_MonoExtN_4	357	364	PF00514	0.391
TRG_NLS_MonoExtN_4	78	84	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	29%	100%
A0A0N0P7W9	Leptomonas seymouri	24%	100%
A0A0N1I1D8	Leptomonas seymouri	30%	100%
A0A0N1ILU0	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	66%	100%
A0A1X0NRL0	Trypanosomatidae	26%	100%
A0A1X0NYN3	Trypanosomatidae	30%	100%
A0A1X0NYY3	Trypanosomatidae	29%	100%
A0A1X0P2Q4	Trypanosomatidae	38%	100%
A0A3Q8IDX0	Leishmania donovani	28%	85%
A0A3Q8IGR3	Leishmania donovani	28%	100%
A0A3R7M7Z1	Trypanosoma rangeli	26%	100%
A0A3S7X1G8	Leishmania donovani	32%	100%
A0A422MX56	Trypanosoma rangeli	26%	100%
A0A422N4F0	Trypanosoma rangeli	30%	100%
A4HGI1	Leishmania braziliensis	27%	90%
A4HGI6	Leishmania braziliensis	30%	83%
A4HGI9	Leishmania braziliensis	27%	100%
A4HGJ0	Leishmania braziliensis	31%	91%
A4I3L4	Leishmania infantum	29%	85%
A4I3L6	Leishmania infantum	32%	100%
A4I3L7	Leishmania infantum	100%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	83%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8C8	Leishmania major	95%	100%
Q4Q8C9	Leishmania major	29%	100%
Q4Q8D1	Leishmania major	29%	83%
V5BGL5	Trypanosoma cruzi	33%	100%
V5D8D2	Trypanosoma cruzi	27%	100%