Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-tubulin complex component 4

Species:

Leishmania donovani

UniProt:

A0A3Q8IEU3_LEIDO

TriTrypDb:

LdBPK_301000.1 , LdCL_300015200 , LDHU3_30.1310

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	12
GO:0005737	cytoplasm	2	12
GO:0005815	microtubule organizing center	2	12
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0000923	equatorial microtubule organizing center	3	1
GO:0000930	gamma-tubulin complex	2	1
GO:0005813	centrosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3Q8IEU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IEU3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0007020	microtubule nucleation	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0007051	spindle organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051321	meiotic cell cycle	2	1
GO:0070925	organelle assembly	5	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043015	gamma-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.693
CLV_C14_Caspase3-7	34	38	PF00656	0.699
CLV_MEL_PAP_1	517	523	PF00089	0.301
CLV_NRD_NRD_1	166	168	PF00675	0.511
CLV_NRD_NRD_1	256	258	PF00675	0.400
CLV_NRD_NRD_1	48	50	PF00675	0.645
CLV_NRD_NRD_1	548	550	PF00675	0.301
CLV_NRD_NRD_1	704	706	PF00675	0.547
CLV_NRD_NRD_1	756	758	PF00675	0.765
CLV_PCSK_KEX2_1	166	168	PF00082	0.511
CLV_PCSK_KEX2_1	256	258	PF00082	0.400
CLV_PCSK_KEX2_1	48	50	PF00082	0.628
CLV_PCSK_KEX2_1	548	550	PF00082	0.301
CLV_PCSK_KEX2_1	596	598	PF00082	0.302
CLV_PCSK_KEX2_1	703	705	PF00082	0.405
CLV_PCSK_KEX2_1	756	758	PF00082	0.768
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.302
CLV_PCSK_SKI1_1	102	106	PF00082	0.506
CLV_PCSK_SKI1_1	166	170	PF00082	0.477
CLV_PCSK_SKI1_1	256	260	PF00082	0.390
CLV_PCSK_SKI1_1	340	344	PF00082	0.276
CLV_PCSK_SKI1_1	478	482	PF00082	0.287
CLV_PCSK_SKI1_1	511	515	PF00082	0.344
CLV_PCSK_SKI1_1	530	534	PF00082	0.210
CLV_PCSK_SKI1_1	548	552	PF00082	0.317
CLV_Separin_Metazoa	45	49	PF03568	0.339
DEG_APCC_DBOX_1	256	264	PF00400	0.486
DEG_APCC_DBOX_1	477	485	PF00400	0.501
DEG_APCC_DBOX_1	510	518	PF00400	0.502
DEG_APCC_DBOX_1	519	527	PF00400	0.454
DEG_APCC_DBOX_1	657	665	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DOC_CYCLIN_RxL_1	100	110	PF00134	0.446
DOC_CYCLIN_RxL_1	163	172	PF00134	0.499
DOC_CYCLIN_RxL_1	475	485	PF00134	0.553
DOC_CYCLIN_RxL_1	527	535	PF00134	0.566
DOC_CYCLIN_RxL_1	63	73	PF00134	0.532
DOC_MAPK_DCC_7	325	334	PF00069	0.498
DOC_MAPK_gen_1	48	56	PF00069	0.616
DOC_MAPK_gen_1	703	714	PF00069	0.583
DOC_MAPK_HePTP_8	322	334	PF00069	0.570
DOC_MAPK_MEF2A_6	144	151	PF00069	0.479
DOC_MAPK_MEF2A_6	325	334	PF00069	0.576
DOC_MAPK_MEF2A_6	703	712	PF00069	0.654
DOC_PP1_RVXF_1	100	107	PF00149	0.446
DOC_PP1_RVXF_1	692	698	PF00149	0.476
DOC_PP2B_LxvP_1	20	23	PF13499	0.587
DOC_PP4_FxxP_1	724	727	PF00568	0.731
DOC_USP7_MATH_1	214	218	PF00917	0.714
DOC_USP7_MATH_1	276	280	PF00917	0.607
DOC_USP7_MATH_1	31	35	PF00917	0.689
DOC_USP7_MATH_1	338	342	PF00917	0.498
DOC_USP7_MATH_1	396	400	PF00917	0.542
DOC_USP7_MATH_1	40	44	PF00917	0.688
DOC_USP7_MATH_1	469	473	PF00917	0.564
DOC_USP7_MATH_1	588	592	PF00917	0.544
DOC_USP7_MATH_1	622	626	PF00917	0.486
DOC_USP7_MATH_1	713	717	PF00917	0.685
DOC_USP7_MATH_1	738	742	PF00917	0.788
DOC_WW_Pin1_4	114	119	PF00397	0.491
DOC_WW_Pin1_4	239	244	PF00397	0.467
DOC_WW_Pin1_4	367	372	PF00397	0.586
DOC_WW_Pin1_4	650	655	PF00397	0.562
LIG_14-3-3_CanoR_1	411	419	PF00244	0.561
LIG_14-3-3_CanoR_1	520	524	PF00244	0.515
LIG_14-3-3_CanoR_1	530	538	PF00244	0.573
LIG_14-3-3_CanoR_1	548	554	PF00244	0.517
LIG_14-3-3_CanoR_1	621	627	PF00244	0.576
LIG_14-3-3_CanoR_1	658	662	PF00244	0.562
LIG_14-3-3_CanoR_1	715	724	PF00244	0.732
LIG_14-3-3_CanoR_1	72	78	PF00244	0.459
LIG_14-3-3_CanoR_1	731	738	PF00244	0.741
LIG_14-3-3_CanoR_1	740	745	PF00244	0.642
LIG_14-3-3_CanoR_1	79	86	PF00244	0.428
LIG_Actin_WH2_2	414	429	PF00022	0.548
LIG_AP2alpha_1	598	602	PF02296	0.581
LIG_BRCT_BRCA1_1	218	222	PF00533	0.700
LIG_BRCT_BRCA1_1	413	417	PF00533	0.525
LIG_Clathr_ClatBox_1	481	485	PF01394	0.525
LIG_Clathr_ClatBox_1	661	665	PF01394	0.428
LIG_deltaCOP1_diTrp_1	349	354	PF00928	0.476
LIG_eIF4E_1	509	515	PF01652	0.498
LIG_FHA_1	125	131	PF00498	0.454
LIG_FHA_1	210	216	PF00498	0.687
LIG_FHA_1	232	238	PF00498	0.495
LIG_FHA_1	434	440	PF00498	0.524
LIG_FHA_1	471	477	PF00498	0.547
LIG_FHA_1	527	533	PF00498	0.552
LIG_FHA_1	575	581	PF00498	0.512
LIG_FHA_1	630	636	PF00498	0.493
LIG_FHA_1	675	681	PF00498	0.470
LIG_FHA_2	131	137	PF00498	0.521
LIG_FHA_2	588	594	PF00498	0.581
LIG_FHA_2	651	657	PF00498	0.554
LIG_Integrin_RGD_1	347	349	PF01839	0.276
LIG_LIR_Apic_2	723	727	PF02991	0.740
LIG_LIR_Gen_1	131	139	PF02991	0.442
LIG_LIR_Gen_1	171	182	PF02991	0.440
LIG_LIR_Gen_1	196	203	PF02991	0.514
LIG_LIR_Gen_1	349	360	PF02991	0.478
LIG_LIR_Gen_1	429	439	PF02991	0.480
LIG_LIR_Gen_1	552	560	PF02991	0.520
LIG_LIR_Gen_1	73	80	PF02991	0.552
LIG_LIR_Nem_3	131	135	PF02991	0.411
LIG_LIR_Nem_3	171	177	PF02991	0.380
LIG_LIR_Nem_3	196	201	PF02991	0.410
LIG_LIR_Nem_3	349	355	PF02991	0.472
LIG_LIR_Nem_3	429	435	PF02991	0.490
LIG_LIR_Nem_3	485	491	PF02991	0.539
LIG_LIR_Nem_3	552	557	PF02991	0.562
LIG_LIR_Nem_3	696	700	PF02991	0.457
LIG_LIR_Nem_3	73	77	PF02991	0.476
LIG_MYND_1	367	371	PF01753	0.511
LIG_PCNA_yPIPBox_3	569	579	PF02747	0.525
LIG_PCNA_yPIPBox_3	667	676	PF02747	0.562
LIG_Pex14_2	288	292	PF04695	0.508
LIG_Pex14_2	598	602	PF04695	0.581
LIG_Pex14_2	697	701	PF04695	0.562
LIG_SH2_CRK	509	513	PF00017	0.476
LIG_SH2_CRK	640	644	PF00017	0.524
LIG_SH2_CRK	74	78	PF00017	0.518
LIG_SH2_PTP2	491	494	PF00017	0.487
LIG_SH2_SRC	108	111	PF00017	0.394
LIG_SH2_SRC	491	494	PF00017	0.517
LIG_SH2_STAP1	108	112	PF00017	0.363
LIG_SH2_STAP1	128	132	PF00017	0.415
LIG_SH2_STAP1	233	237	PF00017	0.562
LIG_SH2_STAT3	271	274	PF00017	0.483
LIG_SH2_STAT3	566	569	PF00017	0.487
LIG_SH2_STAT5	179	182	PF00017	0.354
LIG_SH2_STAT5	184	187	PF00017	0.349
LIG_SH2_STAT5	197	200	PF00017	0.366
LIG_SH2_STAT5	233	236	PF00017	0.544
LIG_SH2_STAT5	271	274	PF00017	0.478
LIG_SH2_STAT5	408	411	PF00017	0.586
LIG_SH2_STAT5	488	491	PF00017	0.486
LIG_SH2_STAT5	50	53	PF00017	0.583
LIG_SH2_STAT5	634	637	PF00017	0.479
LIG_SH2_STAT5	700	703	PF00017	0.710
LIG_SH3_1	705	711	PF00018	0.599
LIG_SH3_3	144	150	PF00018	0.494
LIG_SH3_3	398	404	PF00018	0.534
LIG_SH3_3	52	58	PF00018	0.588
LIG_SH3_3	705	711	PF00018	0.727
LIG_SUMO_SIM_par_1	479	485	PF11976	0.569
LIG_SUMO_SIM_par_1	496	502	PF11976	0.493
LIG_SUMO_SIM_par_1	571	577	PF11976	0.501
LIG_SUMO_SIM_par_1	660	665	PF11976	0.519
LIG_SUMO_SIM_par_1	671	677	PF11976	0.505
LIG_TRAF2_1	226	229	PF00917	0.586
LIG_TRAF2_1	80	83	PF00917	0.555
LIG_TYR_ITIM	350	355	PF00017	0.562
LIG_TYR_ITIM	642	647	PF00017	0.562
LIG_UBA3_1	134	140	PF00899	0.370
LIG_UBA3_1	247	254	PF00899	0.377
LIG_UBA3_1	497	504	PF00899	0.581
LIG_WRC_WIRS_1	152	157	PF05994	0.425
LIG_WRC_WIRS_1	8	13	PF05994	0.489
MOD_CK1_1	205	211	PF00069	0.581
MOD_CK1_1	217	223	PF00069	0.645
MOD_CK1_1	531	537	PF00069	0.554
MOD_CK1_1	574	580	PF00069	0.562
MOD_CK1_1	625	631	PF00069	0.553
MOD_CK1_1	7	13	PF00069	0.472
MOD_CK1_1	720	726	PF00069	0.752
MOD_CK1_1	73	79	PF00069	0.498
MOD_CK1_1	739	745	PF00069	0.692
MOD_CK1_1	755	761	PF00069	0.771
MOD_CK2_1	130	136	PF00069	0.500
MOD_CK2_1	276	282	PF00069	0.538
MOD_CK2_1	650	656	PF00069	0.562
MOD_GlcNHglycan	118	121	PF01048	0.509
MOD_GlcNHglycan	12	15	PF01048	0.536
MOD_GlcNHglycan	216	219	PF01048	0.667
MOD_GlcNHglycan	24	27	PF01048	0.612
MOD_GlcNHglycan	37	40	PF01048	0.562
MOD_GlcNHglycan	405	408	PF01048	0.364
MOD_GlcNHglycan	42	45	PF01048	0.346
MOD_GlcNHglycan	543	546	PF01048	0.313
MOD_GlcNHglycan	585	588	PF01048	0.298
MOD_GlcNHglycan	715	718	PF01048	0.676
MOD_GlcNHglycan	719	722	PF01048	0.675
MOD_GlcNHglycan	758	761	PF01048	0.741
MOD_GSK3_1	10	17	PF00069	0.486
MOD_GSK3_1	124	131	PF00069	0.511
MOD_GSK3_1	205	212	PF00069	0.651
MOD_GSK3_1	31	38	PF00069	0.630
MOD_GSK3_1	583	590	PF00069	0.581
MOD_GSK3_1	625	632	PF00069	0.510
MOD_GSK3_1	713	720	PF00069	0.665
MOD_GSK3_1	727	734	PF00069	0.663
MOD_GSK3_1	736	743	PF00069	0.693
MOD_GSK3_1	751	758	PF00069	0.760
MOD_LATS_1	729	735	PF00433	0.626
MOD_N-GLC_1	650	655	PF02516	0.345
MOD_N-GLC_2	627	629	PF02516	0.362
MOD_NEK2_1	130	135	PF00069	0.475
MOD_NEK2_1	151	156	PF00069	0.453
MOD_NEK2_1	169	174	PF00069	0.276
MOD_NEK2_1	177	182	PF00069	0.344
MOD_NEK2_1	419	424	PF00069	0.474
MOD_NEK2_1	426	431	PF00069	0.452
MOD_NEK2_1	499	504	PF00069	0.517
MOD_NEK2_1	526	531	PF00069	0.550
MOD_NEK2_1	559	564	PF00069	0.490
MOD_NEK2_1	607	612	PF00069	0.428
MOD_NEK2_1	70	75	PF00069	0.452
MOD_NEK2_2	338	343	PF00069	0.498
MOD_NEK2_2	629	634	PF00069	0.518
MOD_OFUCOSY	623	629	PF10250	0.353
MOD_PIKK_1	14	20	PF00454	0.651
MOD_PIKK_1	276	282	PF00454	0.538
MOD_PIKK_1	78	84	PF00454	0.557
MOD_PK_1	440	446	PF00069	0.400
MOD_PK_1	740	746	PF00069	0.801
MOD_PKA_2	396	402	PF00069	0.581
MOD_PKA_2	426	432	PF00069	0.493
MOD_PKA_2	460	466	PF00069	0.581
MOD_PKA_2	519	525	PF00069	0.501
MOD_PKA_2	541	547	PF00069	0.525
MOD_PKA_2	657	663	PF00069	0.581
MOD_PKA_2	739	745	PF00069	0.686
MOD_PKA_2	755	761	PF00069	0.735
MOD_PKA_2	78	84	PF00069	0.557
MOD_Plk_1	560	566	PF00069	0.581
MOD_Plk_1	607	613	PF00069	0.562
MOD_Plk_4	151	157	PF00069	0.458
MOD_Plk_4	169	175	PF00069	0.281
MOD_Plk_4	287	293	PF00069	0.445
MOD_Plk_4	313	319	PF00069	0.442
MOD_Plk_4	4	10	PF00069	0.444
MOD_Plk_4	607	613	PF00069	0.487
MOD_Plk_4	629	635	PF00069	0.518
MOD_Plk_4	657	663	PF00069	0.566
MOD_Plk_4	73	79	PF00069	0.496
MOD_ProDKin_1	114	120	PF00069	0.489
MOD_ProDKin_1	239	245	PF00069	0.458
MOD_ProDKin_1	367	373	PF00069	0.586
MOD_ProDKin_1	650	656	PF00069	0.562
MOD_SUMO_for_1	578	581	PF00179	0.553
MOD_SUMO_rev_2	2	7	PF00179	0.553
TRG_DiLeu_BaEn_1	244	249	PF01217	0.415
TRG_DiLeu_BaEn_1	255	260	PF01217	0.367
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.516
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.502
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.531
TRG_ENDOCYTIC_2	352	355	PF00928	0.556
TRG_ENDOCYTIC_2	432	435	PF00928	0.494
TRG_ENDOCYTIC_2	509	512	PF00928	0.476
TRG_ENDOCYTIC_2	567	570	PF00928	0.526
TRG_ENDOCYTIC_2	644	647	PF00928	0.541
TRG_ENDOCYTIC_2	74	77	PF00928	0.503
TRG_ER_diArg_1	165	167	PF00400	0.505
TRG_ER_diArg_1	256	258	PF00400	0.400
TRG_ER_diArg_1	47	49	PF00400	0.622
TRG_ER_diArg_1	547	549	PF00400	0.501
TRG_ER_diArg_1	703	705	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	530	535	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC04	Leptomonas seymouri	65%	95%
A0A0S4JBA6	Bodo saltans	26%	82%
A0A1X0P204	Trypanosomatidae	45%	100%
A0A422P4W6	Trypanosoma rangeli	44%	100%
A4HI49	Leishmania braziliensis	79%	100%
A4I5C5	Leishmania infantum	99%	100%
C9ZQQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7K9	Leishmania major	89%	100%
V5B937	Trypanosoma cruzi	45%	100%