Pumilio-family RNA binding repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IET5_LEIDO

TriTrypDb:

LdBPK_331210.1 , LdCL_330018300 , LDHU3_33.1850

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IET5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IET5

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.641
CLV_C14_Caspase3-7	697	701	PF00656	0.668
CLV_C14_Caspase3-7	712	716	PF00656	0.487
CLV_NRD_NRD_1	154	156	PF00675	0.770
CLV_NRD_NRD_1	337	339	PF00675	0.772
CLV_NRD_NRD_1	789	791	PF00675	0.538
CLV_NRD_NRD_1	94	96	PF00675	0.542
CLV_PCSK_KEX2_1	337	339	PF00082	0.772
CLV_PCSK_KEX2_1	675	677	PF00082	0.527
CLV_PCSK_KEX2_1	789	791	PF00082	0.538
CLV_PCSK_KEX2_1	94	96	PF00082	0.542
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.510
CLV_PCSK_PC7_1	333	339	PF00082	0.796
CLV_PCSK_SKI1_1	676	680	PF00082	0.540
CLV_PCSK_SKI1_1	704	708	PF00082	0.657
CLV_PCSK_SKI1_1	711	715	PF00082	0.506
CLV_PCSK_SKI1_1	769	773	PF00082	0.498
CLV_PCSK_SKI1_1	791	795	PF00082	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DEG_SPOP_SBC_1	803	807	PF00917	0.735
DOC_ANK_TNKS_1	20	27	PF00023	0.780
DOC_ANK_TNKS_1	695	702	PF00023	0.713
DOC_CKS1_1	129	134	PF01111	0.770
DOC_CKS1_1	209	214	PF01111	0.661
DOC_MAPK_DCC_7	112	122	PF00069	0.754
DOC_MAPK_gen_1	711	720	PF00069	0.658
DOC_MAPK_gen_1	786	794	PF00069	0.581
DOC_MAPK_MEF2A_6	466	474	PF00069	0.468
DOC_PP2B_LxvP_1	223	226	PF13499	0.770
DOC_PP4_FxxP_1	444	447	PF00568	0.447
DOC_PP4_FxxP_1	66	69	PF00568	0.776
DOC_USP7_MATH_1	116	120	PF00917	0.814
DOC_USP7_MATH_1	138	142	PF00917	0.894
DOC_USP7_MATH_1	210	214	PF00917	0.805
DOC_USP7_MATH_1	224	228	PF00917	0.708
DOC_USP7_MATH_1	251	255	PF00917	0.766
DOC_USP7_MATH_1	69	73	PF00917	0.827
DOC_USP7_MATH_1	694	698	PF00917	0.740
DOC_USP7_MATH_2	132	138	PF00917	0.752
DOC_USP7_UBL2_3	156	160	PF12436	0.765
DOC_USP7_UBL2_3	462	466	PF12436	0.468
DOC_USP7_UBL2_3	610	614	PF12436	0.387
DOC_WW_Pin1_4	128	133	PF00397	0.765
DOC_WW_Pin1_4	190	195	PF00397	0.642
DOC_WW_Pin1_4	202	207	PF00397	0.662
DOC_WW_Pin1_4	208	213	PF00397	0.658
DOC_WW_Pin1_4	429	434	PF00397	0.519
DOC_WW_Pin1_4	443	448	PF00397	0.385
DOC_WW_Pin1_4	466	471	PF00397	0.468
DOC_WW_Pin1_4	57	62	PF00397	0.791
DOC_WW_Pin1_4	644	649	PF00397	0.486
DOC_WW_Pin1_4	72	77	PF00397	0.720
LIG_14-3-3_CanoR_1	775	780	PF00244	0.558
LIG_14-3-3_CanoR_1	94	102	PF00244	0.547
LIG_BRCT_BRCA1_1	194	198	PF00533	0.711
LIG_BRCT_BRCA1_1	377	381	PF00533	0.730
LIG_CSL_BTD_1	691	694	PF09270	0.688
LIG_CtBP_PxDLS_1	447	451	PF00389	0.412
LIG_eIF4E_1	458	464	PF01652	0.387
LIG_FHA_1	467	473	PF00498	0.468
LIG_FHA_1	679	685	PF00498	0.797
LIG_FHA_2	125	131	PF00498	0.755
LIG_FHA_2	272	278	PF00498	0.758
LIG_FHA_2	700	706	PF00498	0.724
LIG_FHA_2	73	79	PF00498	0.547
LIG_IBAR_NPY_1	179	181	PF08397	0.675
LIG_IBAR_NPY_1	300	302	PF08397	0.710
LIG_LIR_Apic_2	314	320	PF02991	0.633
LIG_LIR_Apic_2	442	447	PF02991	0.440
LIG_LIR_Apic_2	64	69	PF02991	0.775
LIG_LIR_Apic_2	768	773	PF02991	0.486
LIG_LIR_Apic_2	776	782	PF02991	0.476
LIG_LIR_Gen_1	124	132	PF02991	0.740
LIG_LIR_Gen_1	437	448	PF02991	0.412
LIG_LIR_Gen_1	579	589	PF02991	0.387
LIG_LIR_Gen_1	616	627	PF02991	0.461
LIG_LIR_Gen_1	758	767	PF02991	0.387
LIG_LIR_Gen_1	78	83	PF02991	0.556
LIG_LIR_Nem_3	130	136	PF02991	0.808
LIG_LIR_Nem_3	196	202	PF02991	0.654
LIG_LIR_Nem_3	437	443	PF02991	0.404
LIG_LIR_Nem_3	452	458	PF02991	0.410
LIG_LIR_Nem_3	579	585	PF02991	0.387
LIG_LIR_Nem_3	595	600	PF02991	0.387
LIG_LIR_Nem_3	616	622	PF02991	0.461
LIG_LIR_Nem_3	64	70	PF02991	0.713
LIG_LIR_Nem_3	740	746	PF02991	0.555
LIG_LIR_Nem_3	758	763	PF02991	0.275
LIG_LIR_Nem_3	78	82	PF02991	0.523
LIG_LIR_Nem_3	98	103	PF02991	0.630
LIG_LYPXL_S_1	66	70	PF13949	0.721
LIG_LYPXL_yS_3	67	70	PF13949	0.716
LIG_MYND_3	117	121	PF01753	0.704
LIG_NRBOX	459	465	PF00104	0.387
LIG_NRP_CendR_1	836	837	PF00754	0.717
LIG_PCNA_yPIPBox_3	457	466	PF02747	0.387
LIG_PCNA_yPIPBox_3	594	606	PF02747	0.393
LIG_Pex14_2	440	444	PF04695	0.387
LIG_SH2_CRK	317	321	PF00017	0.765
LIG_SH2_CRK	50	54	PF00017	0.777
LIG_SH2_CRK	619	623	PF00017	0.510
LIG_SH2_CRK	779	783	PF00017	0.494
LIG_SH2_GRB2like	743	746	PF00017	0.503
LIG_SH2_NCK_1	317	321	PF00017	0.765
LIG_SH2_NCK_1	50	54	PF00017	0.737
LIG_SH2_PTP2	770	773	PF00017	0.591
LIG_SH2_SRC	218	221	PF00017	0.668
LIG_SH2_STAP1	410	414	PF00017	0.447
LIG_SH2_STAP1	743	747	PF00017	0.503
LIG_SH2_STAT3	2	5	PF00017	0.751
LIG_SH2_STAT3	260	263	PF00017	0.675
LIG_SH2_STAT3	458	461	PF00017	0.387
LIG_SH2_STAT3	600	603	PF00017	0.387
LIG_SH2_STAT3	746	749	PF00017	0.387
LIG_SH2_STAT5	261	264	PF00017	0.673
LIG_SH2_STAT5	458	461	PF00017	0.387
LIG_SH2_STAT5	600	603	PF00017	0.387
LIG_SH2_STAT5	628	631	PF00017	0.468
LIG_SH2_STAT5	746	749	PF00017	0.387
LIG_SH2_STAT5	770	773	PF00017	0.470
LIG_SH2_STAT5	777	780	PF00017	0.517
LIG_SH3_3	105	111	PF00018	0.729
LIG_SH3_3	790	796	PF00018	0.505
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.456
LIG_SUMO_SIM_anti_2	445	453	PF11976	0.330
LIG_SUMO_SIM_anti_2	667	673	PF11976	0.535
LIG_SUMO_SIM_par_1	445	453	PF11976	0.412
LIG_SUMO_SIM_par_1	482	487	PF11976	0.414
LIG_TRAF2_1	575	578	PF00917	0.387
LIG_UBA3_1	511	516	PF00899	0.447
LIG_UBA3_1	581	587	PF00899	0.447
MOD_CDK_SPxxK_3	644	651	PF00069	0.503
MOD_CK1_1	184	190	PF00069	0.823
MOD_CK1_1	193	199	PF00069	0.638
MOD_CK1_1	254	260	PF00069	0.788
MOD_CK1_1	3	9	PF00069	0.708
MOD_CK1_1	328	334	PF00069	0.716
MOD_CK1_1	369	375	PF00069	0.724
MOD_CK1_1	432	438	PF00069	0.580
MOD_CK1_1	548	554	PF00069	0.487
MOD_CK1_1	72	78	PF00069	0.585
MOD_CK1_1	807	813	PF00069	0.857
MOD_CK2_1	124	130	PF00069	0.752
MOD_CK2_1	443	449	PF00069	0.566
MOD_CK2_1	610	616	PF00069	0.423
MOD_CK2_1	699	705	PF00069	0.747
MOD_Cter_Amidation	153	156	PF01082	0.773
MOD_GlcNHglycan	13	16	PF01048	0.748
MOD_GlcNHglycan	134	139	PF01048	0.778
MOD_GlcNHglycan	150	153	PF01048	0.892
MOD_GlcNHglycan	227	230	PF01048	0.707
MOD_GlcNHglycan	30	33	PF01048	0.730
MOD_GlcNHglycan	342	345	PF01048	0.778
MOD_GlcNHglycan	371	374	PF01048	0.828
MOD_GlcNHglycan	42	45	PF01048	0.839
MOD_GlcNHglycan	425	428	PF01048	0.437
MOD_GlcNHglycan	504	507	PF01048	0.417
MOD_GlcNHglycan	547	550	PF01048	0.456
MOD_GlcNHglycan	676	679	PF01048	0.577
MOD_GSK3_1	124	131	PF00069	0.842
MOD_GSK3_1	134	141	PF00069	0.759
MOD_GSK3_1	186	193	PF00069	0.741
MOD_GSK3_1	24	31	PF00069	0.767
MOD_GSK3_1	283	290	PF00069	0.812
MOD_GSK3_1	311	318	PF00069	0.797
MOD_GSK3_1	371	378	PF00069	0.756
MOD_GSK3_1	423	430	PF00069	0.552
MOD_GSK3_1	466	473	PF00069	0.477
MOD_GSK3_1	57	64	PF00069	0.764
MOD_GSK3_1	610	617	PF00069	0.491
MOD_GSK3_1	674	681	PF00069	0.620
MOD_GSK3_1	68	75	PF00069	0.570
MOD_GSK3_1	688	695	PF00069	0.765
MOD_GSK3_1	802	809	PF00069	0.828
MOD_GSK3_1	9	16	PF00069	0.838
MOD_N-GLC_1	340	345	PF02516	0.777
MOD_NEK2_1	271	276	PF00069	0.696
MOD_NEK2_1	315	320	PF00069	0.819
MOD_NEK2_1	423	428	PF00069	0.490
MOD_NEK2_1	545	550	PF00069	0.452
MOD_NEK2_1	627	632	PF00069	0.508
MOD_NEK2_1	674	679	PF00069	0.575
MOD_NEK2_1	82	87	PF00069	0.674
MOD_NEK2_2	699	704	PF00069	0.704
MOD_PIKK_1	13	19	PF00454	0.633
MOD_PIKK_1	169	175	PF00454	0.766
MOD_PIKK_1	193	199	PF00454	0.634
MOD_PIKK_1	254	260	PF00454	0.703
MOD_PIKK_1	283	289	PF00454	0.856
MOD_PIKK_1	315	321	PF00454	0.768
MOD_PIKK_1	397	403	PF00454	0.627
MOD_PIKK_1	93	99	PF00454	0.626
MOD_PK_1	614	620	PF00069	0.519
MOD_PKA_2	17	23	PF00069	0.711
MOD_PKA_2	230	236	PF00069	0.789
MOD_PKA_2	245	251	PF00069	0.784
MOD_PKA_2	328	334	PF00069	0.716
MOD_PKA_2	785	791	PF00069	0.587
MOD_PKA_2	93	99	PF00069	0.536
MOD_Plk_1	134	140	PF00069	0.807
MOD_Plk_1	3	9	PF00069	0.651
MOD_Plk_1	484	490	PF00069	0.503
MOD_Plk_1	577	583	PF00069	0.503
MOD_Plk_4	181	187	PF00069	0.762
MOD_Plk_4	311	317	PF00069	0.784
MOD_Plk_4	577	583	PF00069	0.503
MOD_Plk_4	614	620	PF00069	0.569
MOD_Plk_4	62	68	PF00069	0.796
MOD_Plk_4	730	736	PF00069	0.436
MOD_ProDKin_1	128	134	PF00069	0.767
MOD_ProDKin_1	190	196	PF00069	0.641
MOD_ProDKin_1	202	208	PF00069	0.659
MOD_ProDKin_1	429	435	PF00069	0.519
MOD_ProDKin_1	443	449	PF00069	0.391
MOD_ProDKin_1	466	472	PF00069	0.468
MOD_ProDKin_1	57	63	PF00069	0.790
MOD_ProDKin_1	644	650	PF00069	0.486
MOD_ProDKin_1	72	78	PF00069	0.717
MOD_SUMO_for_1	609	612	PF00179	0.412
MOD_SUMO_rev_2	161	169	PF00179	0.660
MOD_SUMO_rev_2	393	400	PF00179	0.596
MOD_SUMO_rev_2	611	615	PF00179	0.387
MOD_SUMO_rev_2	708	716	PF00179	0.695
TRG_DiLeu_BaEn_2	418	424	PF01217	0.387
TRG_DiLeu_BaEn_2	755	761	PF01217	0.468
TRG_ENDOCYTIC_2	302	305	PF00928	0.773
TRG_ENDOCYTIC_2	50	53	PF00928	0.758
TRG_ENDOCYTIC_2	619	622	PF00928	0.509
TRG_ENDOCYTIC_2	67	70	PF00928	0.700
TRG_ER_diArg_1	337	339	PF00400	0.776
TRG_ER_diArg_1	93	95	PF00400	0.547
TRG_NES_CRM1_1	477	489	PF08389	0.468
TRG_NES_CRM1_1	579	595	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.744
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2G5	Trypanosomatidae	48%	91%
A0A3R7N6T6	Trypanosoma rangeli	49%	100%
A4HLH0	Leishmania braziliensis	87%	100%
A4I8Y0	Leishmania infantum	100%	100%
D0A4X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9B3U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q475	Leishmania major	97%	100%
V5BZN6	Trypanosoma cruzi	48%	100%