Chaperone protein DNAJ-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IET3_LEIDO

TriTrypDb:

LdBPK_200620.1 , LdCL_200010900 , LDHU3_20.0740

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IET3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IET3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	18
GO:0009987	cellular process	1	18
GO:0006458	'de novo' protein folding	3	2
GO:0006950	response to stress	2	7
GO:0009266	response to temperature stimulus	3	7
GO:0009408	response to heat	3	7
GO:0009628	response to abiotic stimulus	2	7
GO:0042026	protein refolding	3	2
GO:0050896	response to stimulus	1	7
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0031072	heat shock protein binding	3	18
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0051082	unfolded protein binding	3	18
GO:0000166	nucleotide binding	3	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.564
CLV_NRD_NRD_1	14	16	PF00675	0.686
CLV_NRD_NRD_1	284	286	PF00675	0.277
CLV_NRD_NRD_1	307	309	PF00675	0.356
CLV_NRD_NRD_1	44	46	PF00675	0.608
CLV_NRD_NRD_1	77	79	PF00675	0.455
CLV_NRD_NRD_1	89	91	PF00675	0.397
CLV_PCSK_KEX2_1	105	107	PF00082	0.546
CLV_PCSK_KEX2_1	14	16	PF00082	0.738
CLV_PCSK_KEX2_1	307	309	PF00082	0.356
CLV_PCSK_KEX2_1	44	46	PF00082	0.608
CLV_PCSK_KEX2_1	77	79	PF00082	0.488
CLV_PCSK_KEX2_1	89	91	PF00082	0.523
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.575
CLV_PCSK_SKI1_1	209	213	PF00082	0.626
CLV_PCSK_SKI1_1	269	273	PF00082	0.341
CLV_PCSK_SKI1_1	476	480	PF00082	0.450
CLV_PCSK_SKI1_1	84	88	PF00082	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_CKS1_1	281	286	PF01111	0.474
DOC_CYCLIN_yClb1_LxF_4	62	67	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.363
DOC_MAPK_DCC_7	428	437	PF00069	0.282
DOC_MAPK_gen_1	474	481	PF00069	0.410
DOC_MAPK_MEF2A_6	428	437	PF00069	0.282
DOC_PP1_RVXF_1	3	10	PF00149	0.565
DOC_PP1_RVXF_1	62	68	PF00149	0.544
DOC_PP2B_LxvP_1	397	400	PF13499	0.360
DOC_USP7_MATH_1	183	187	PF00917	0.724
DOC_USP7_MATH_1	193	197	PF00917	0.590
DOC_USP7_MATH_1	221	225	PF00917	0.655
DOC_USP7_MATH_1	387	391	PF00917	0.322
DOC_USP7_MATH_1	484	488	PF00917	0.486
DOC_USP7_MATH_1	507	511	PF00917	0.586
DOC_USP7_MATH_1	515	519	PF00917	0.787
DOC_USP7_MATH_1	533	537	PF00917	0.596
DOC_USP7_MATH_1	57	61	PF00917	0.614
DOC_WW_Pin1_4	280	285	PF00397	0.474
DOC_WW_Pin1_4	383	388	PF00397	0.473
LIG_14-3-3_CanoR_1	106	114	PF00244	0.607
LIG_14-3-3_CanoR_1	14	22	PF00244	0.794
LIG_14-3-3_CanoR_1	248	252	PF00244	0.285
LIG_14-3-3_CanoR_1	446	454	PF00244	0.641
LIG_14-3-3_CanoR_1	501	506	PF00244	0.514
LIG_14-3-3_CanoR_1	77	87	PF00244	0.496
LIG_BIR_III_4	233	237	PF00653	0.508
LIG_BRCT_BRCA1_1	501	505	PF00533	0.436
LIG_CSL_BTD_1	33	36	PF09270	0.565
LIG_FHA_1	242	248	PF00498	0.396
LIG_FHA_1	300	306	PF00498	0.487
LIG_FHA_1	372	378	PF00498	0.335
LIG_FHA_1	418	424	PF00498	0.442
LIG_FHA_1	78	84	PF00498	0.570
LIG_FHA_2	157	163	PF00498	0.709
LIG_FHA_2	490	496	PF00498	0.643
LIG_HCF-1_HBM_1	379	382	PF13415	0.282
LIG_LIR_Apic_2	436	441	PF02991	0.272
LIG_LIR_Gen_1	112	122	PF02991	0.447
LIG_LIR_Gen_1	456	466	PF02991	0.457
LIG_LIR_Gen_1	59	68	PF02991	0.438
LIG_LIR_Nem_3	112	117	PF02991	0.404
LIG_LIR_Nem_3	456	462	PF02991	0.442
LIG_LIR_Nem_3	59	65	PF02991	0.437
LIG_OCRL_FandH_1	352	364	PF00620	0.422
LIG_PTB_Apo_2	347	354	PF02174	0.437
LIG_SH2_CRK	114	118	PF00017	0.383
LIG_SH2_CRK	459	463	PF00017	0.389
LIG_SH2_CRK	62	66	PF00017	0.495
LIG_SH2_SRC	160	163	PF00017	0.685
LIG_SH2_STAP1	126	130	PF00017	0.500
LIG_SH2_STAP1	538	542	PF00017	0.415
LIG_SH2_STAT5	114	117	PF00017	0.478
LIG_SH2_STAT5	160	163	PF00017	0.649
LIG_SH2_STAT5	311	314	PF00017	0.470
LIG_SH2_STAT5	382	385	PF00017	0.439
LIG_SH2_STAT5	538	541	PF00017	0.410
LIG_SH3_2	319	324	PF14604	0.556
LIG_SH3_3	30	36	PF00018	0.569
LIG_SH3_3	315	321	PF00018	0.510
LIG_SH3_3	334	340	PF00018	0.393
LIG_SH3_3	407	413	PF00018	0.334
LIG_SH3_3	418	424	PF00018	0.305
LIG_SH3_3	460	466	PF00018	0.416
LIG_SUMO_SIM_anti_2	402	407	PF11976	0.393
LIG_SUMO_SIM_par_1	373	379	PF11976	0.335
LIG_TYR_ITIM	457	462	PF00017	0.384
MOD_CDC14_SPxK_1	386	389	PF00782	0.282
MOD_CDK_SPK_2	280	285	PF00069	0.322
MOD_CDK_SPxK_1	280	286	PF00069	0.322
MOD_CDK_SPxK_1	383	389	PF00069	0.282
MOD_CK1_1	16	22	PF00069	0.755
MOD_CK1_1	169	175	PF00069	0.611
MOD_CK1_1	186	192	PF00069	0.713
MOD_CK1_1	219	225	PF00069	0.634
MOD_CK1_1	487	493	PF00069	0.587
MOD_CK1_1	518	524	PF00069	0.555
MOD_CK1_1	536	542	PF00069	0.479
MOD_CK2_1	489	495	PF00069	0.586
MOD_CK2_1	76	82	PF00069	0.446
MOD_CMANNOS	34	37	PF00535	0.697
MOD_GlcNHglycan	16	19	PF01048	0.676
MOD_GlcNHglycan	171	174	PF01048	0.632
MOD_GlcNHglycan	185	188	PF01048	0.665
MOD_GlcNHglycan	189	192	PF01048	0.731
MOD_GlcNHglycan	216	219	PF01048	0.656
MOD_GlcNHglycan	275	278	PF01048	0.360
MOD_GlcNHglycan	294	297	PF01048	0.326
MOD_GlcNHglycan	299	302	PF01048	0.321
MOD_GlcNHglycan	428	431	PF01048	0.394
MOD_GlcNHglycan	447	450	PF01048	0.509
MOD_GlcNHglycan	471	474	PF01048	0.482
MOD_GlcNHglycan	489	492	PF01048	0.423
MOD_GlcNHglycan	517	520	PF01048	0.758
MOD_GSK3_1	121	128	PF00069	0.573
MOD_GSK3_1	14	21	PF00069	0.664
MOD_GSK3_1	183	190	PF00069	0.682
MOD_GSK3_1	193	200	PF00069	0.720
MOD_GSK3_1	216	223	PF00069	0.609
MOD_GSK3_1	247	254	PF00069	0.319
MOD_GSK3_1	269	276	PF00069	0.415
MOD_GSK3_1	344	351	PF00069	0.316
MOD_GSK3_1	371	378	PF00069	0.398
MOD_GSK3_1	383	390	PF00069	0.372
MOD_GSK3_1	441	448	PF00069	0.558
MOD_GSK3_1	514	521	PF00069	0.767
MOD_N-GLC_1	209	214	PF02516	0.635
MOD_N-GLC_1	224	229	PF02516	0.574
MOD_N-GLC_1	238	243	PF02516	0.480
MOD_NEK2_1	251	256	PF00069	0.321
MOD_NEK2_1	348	353	PF00069	0.393
MOD_NEK2_1	371	376	PF00069	0.292
MOD_NEK2_1	527	532	PF00069	0.443
MOD_NEK2_1	534	539	PF00069	0.402
MOD_NEK2_2	417	422	PF00069	0.282
MOD_NEK2_2	57	62	PF00069	0.593
MOD_PIKK_1	507	513	PF00454	0.732
MOD_PKA_1	105	111	PF00069	0.414
MOD_PKA_1	14	20	PF00069	0.589
MOD_PKA_1	77	83	PF00069	0.443
MOD_PKA_2	105	111	PF00069	0.414
MOD_PKA_2	13	19	PF00069	0.754
MOD_PKA_2	166	172	PF00069	0.703
MOD_PKA_2	247	253	PF00069	0.287
MOD_PKA_2	273	279	PF00069	0.369
MOD_PKA_2	28	34	PF00069	0.671
MOD_PKA_2	292	298	PF00069	0.356
MOD_PKA_2	445	451	PF00069	0.688
MOD_PKA_2	76	82	PF00069	0.481
MOD_Plk_1	224	230	PF00069	0.709
MOD_Plk_1	241	247	PF00069	0.357
MOD_Plk_1	251	257	PF00069	0.235
MOD_Plk_4	348	354	PF00069	0.415
MOD_Plk_4	36	42	PF00069	0.647
MOD_Plk_4	371	377	PF00069	0.316
MOD_Plk_4	453	459	PF00069	0.366
MOD_Plk_4	57	63	PF00069	0.492
MOD_ProDKin_1	280	286	PF00069	0.322
MOD_ProDKin_1	383	389	PF00069	0.473
MOD_SUMO_rev_2	100	107	PF00179	0.530
MOD_SUMO_rev_2	108	113	PF00179	0.483
MOD_SUMO_rev_2	92	97	PF00179	0.525
TRG_ENDOCYTIC_2	114	117	PF00928	0.470
TRG_ENDOCYTIC_2	459	462	PF00928	0.458
TRG_ENDOCYTIC_2	62	65	PF00928	0.474
TRG_ER_diArg_1	353	356	PF00400	0.340
TRG_ER_diArg_1	76	78	PF00400	0.482
TRG_ER_diArg_1	88	90	PF00400	0.478
TRG_NES_CRM1_1	242	252	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS2	Leptomonas seymouri	62%	100%
A0A0S4J3B2	Bodo saltans	33%	100%
A0A1X0NLD4	Trypanosomatidae	26%	100%
A0A1X0NWP1	Trypanosomatidae	45%	100%
A0A3R7KX88	Trypanosoma rangeli	43%	100%
A0A3S7WNT6	Leishmania donovani	26%	100%
A0A422N924	Trypanosoma rangeli	27%	100%
A4HS91	Leishmania infantum	26%	100%
A4HYQ6	Leishmania infantum	100%	100%
C9ZI72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZY84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AIB2	Leishmania braziliensis	85%	100%
E9AK75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9AUJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O97016	Leishmania major	26%	100%
Q4QCY5	Leishmania major	95%	100%