Armadillo-type fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Armadillo-type fold

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IET2_LEIDO

TriTrypDb:

LdBPK_300810.1 , LdCL_300013200 , LDHU3_30.1020

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IET2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IET2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.457
CLV_C14_Caspase3-7	502	506	PF00656	0.502
CLV_C14_Caspase3-7	76	80	PF00656	0.459
CLV_C14_Caspase3-7	923	927	PF00656	0.610
CLV_MEL_PAP_1	953	959	PF00089	0.738
CLV_NRD_NRD_1	1022	1024	PF00675	0.781
CLV_NRD_NRD_1	1040	1042	PF00675	0.493
CLV_NRD_NRD_1	304	306	PF00675	0.494
CLV_NRD_NRD_1	349	351	PF00675	0.498
CLV_NRD_NRD_1	518	520	PF00675	0.363
CLV_NRD_NRD_1	59	61	PF00675	0.467
CLV_NRD_NRD_1	799	801	PF00675	0.424
CLV_NRD_NRD_1	868	870	PF00675	0.813
CLV_NRD_NRD_1	895	897	PF00675	0.662
CLV_NRD_NRD_1	919	921	PF00675	0.722
CLV_NRD_NRD_1	959	961	PF00675	0.725
CLV_PCSK_KEX2_1	1022	1024	PF00082	0.719
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.491
CLV_PCSK_KEX2_1	349	351	PF00082	0.505
CLV_PCSK_KEX2_1	518	520	PF00082	0.363
CLV_PCSK_KEX2_1	562	564	PF00082	0.486
CLV_PCSK_KEX2_1	59	61	PF00082	0.467
CLV_PCSK_KEX2_1	868	870	PF00082	0.696
CLV_PCSK_KEX2_1	894	896	PF00082	0.668
CLV_PCSK_KEX2_1	919	921	PF00082	0.722
CLV_PCSK_KEX2_1	959	961	PF00082	0.720
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.486
CLV_PCSK_PC7_1	1036	1042	PF00082	0.651
CLV_PCSK_PC7_1	890	896	PF00082	0.640
CLV_PCSK_SKI1_1	130	134	PF00082	0.491
CLV_PCSK_SKI1_1	241	245	PF00082	0.466
CLV_PCSK_SKI1_1	590	594	PF00082	0.327
CLV_PCSK_SKI1_1	60	64	PF00082	0.489
CLV_PCSK_SKI1_1	718	722	PF00082	0.336
CLV_PCSK_SKI1_1	749	753	PF00082	0.310
CLV_PCSK_SKI1_1	796	800	PF00082	0.437
CLV_PCSK_SKI1_1	974	978	PF00082	0.730
CLV_PCSK_SKI1_1	99	103	PF00082	0.467
CLV_Separin_Metazoa	258	262	PF03568	0.350
DOC_CKS1_1	824	829	PF01111	0.725
DOC_CYCLIN_RxL_1	653	663	PF00134	0.333
DOC_CYCLIN_RxL_1	793	803	PF00134	0.414
DOC_MAPK_gen_1	562	569	PF00069	0.491
DOC_MAPK_gen_1	606	616	PF00069	0.452
DOC_MAPK_MEF2A_6	379	387	PF00069	0.388
DOC_MAPK_MEF2A_6	532	539	PF00069	0.326
DOC_MAPK_MEF2A_6	562	569	PF00069	0.491
DOC_MAPK_MEF2A_6	594	602	PF00069	0.462
DOC_MAPK_MEF2A_6	609	616	PF00069	0.496
DOC_PP1_RVXF_1	204	211	PF00149	0.374
DOC_PP1_RVXF_1	794	800	PF00149	0.404
DOC_PP4_FxxP_1	42	45	PF00568	0.383
DOC_USP7_MATH_1	120	124	PF00917	0.371
DOC_USP7_MATH_1	411	415	PF00917	0.398
DOC_USP7_MATH_1	711	715	PF00917	0.357
DOC_USP7_UBL2_3	609	613	PF12436	0.509
DOC_WW_Pin1_4	169	174	PF00397	0.442
DOC_WW_Pin1_4	538	543	PF00397	0.393
DOC_WW_Pin1_4	608	613	PF00397	0.501
DOC_WW_Pin1_4	802	807	PF00397	0.507
DOC_WW_Pin1_4	811	816	PF00397	0.565
DOC_WW_Pin1_4	823	828	PF00397	0.522
DOC_WW_Pin1_4	835	840	PF00397	0.574
LIG_14-3-3_CanoR_1	121	127	PF00244	0.546
LIG_14-3-3_CanoR_1	532	538	PF00244	0.333
LIG_14-3-3_CanoR_1	606	612	PF00244	0.491
LIG_14-3-3_CanoR_1	705	712	PF00244	0.318
LIG_14-3-3_CanoR_1	735	745	PF00244	0.327
LIG_14-3-3_CanoR_1	800	808	PF00244	0.588
LIG_APCC_ABBA_1	36	41	PF00400	0.331
LIG_BIR_III_2	681	685	PF00653	0.476
LIG_BIR_III_4	128	132	PF00653	0.486
LIG_BRCT_BRCA1_1	122	126	PF00533	0.374
LIG_BRCT_BRCA1_1	213	217	PF00533	0.430
LIG_Clathr_ClatBox_1	224	228	PF01394	0.446
LIG_deltaCOP1_diTrp_1	209	217	PF00928	0.358
LIG_eIF4E_1	394	400	PF01652	0.331
LIG_FHA_1	100	106	PF00498	0.341
LIG_FHA_1	1003	1009	PF00498	0.670
LIG_FHA_1	147	153	PF00498	0.342
LIG_FHA_1	248	254	PF00498	0.374
LIG_FHA_1	286	292	PF00498	0.355
LIG_FHA_1	33	39	PF00498	0.404
LIG_FHA_1	502	508	PF00498	0.441
LIG_FHA_1	534	540	PF00498	0.345
LIG_FHA_1	738	744	PF00498	0.353
LIG_FHA_1	782	788	PF00498	0.540
LIG_FHA_1	824	830	PF00498	0.763
LIG_FHA_1	83	89	PF00498	0.478
LIG_FHA_2	102	108	PF00498	0.381
LIG_FHA_2	131	137	PF00498	0.505
LIG_FHA_2	218	224	PF00498	0.358
LIG_FHA_2	455	461	PF00498	0.481
LIG_HCF-1_HBM_1	847	850	PF13415	0.764
LIG_LIR_Apic_2	40	45	PF02991	0.392
LIG_LIR_Apic_2	847	853	PF02991	0.731
LIG_LIR_Apic_2	977	983	PF02991	0.586
LIG_LIR_Gen_1	209	217	PF02991	0.347
LIG_LIR_Gen_1	278	287	PF02991	0.350
LIG_LIR_Gen_1	37	47	PF02991	0.383
LIG_LIR_Gen_1	546	557	PF02991	0.399
LIG_LIR_Gen_1	650	660	PF02991	0.381
LIG_LIR_LC3C_4	222	226	PF02991	0.455
LIG_LIR_Nem_3	107	111	PF02991	0.354
LIG_LIR_Nem_3	117	122	PF02991	0.398
LIG_LIR_Nem_3	209	213	PF02991	0.368
LIG_LIR_Nem_3	278	282	PF02991	0.331
LIG_LIR_Nem_3	37	42	PF02991	0.391
LIG_LIR_Nem_3	546	552	PF02991	0.416
LIG_LIR_Nem_3	650	655	PF02991	0.435
LIG_LIR_Nem_3	70	75	PF02991	0.349
LIG_LIR_Nem_3	826	831	PF02991	0.621
LIG_PCNA_PIPBox_1	387	396	PF02747	0.339
LIG_PCNA_yPIPBox_3	145	154	PF02747	0.325
LIG_PCNA_yPIPBox_3	767	776	PF02747	0.414
LIG_SH2_CRK	471	475	PF00017	0.345
LIG_SH2_CRK	850	854	PF00017	0.621
LIG_SH2_GRB2like	831	834	PF00017	0.635
LIG_SH2_NCK_1	440	444	PF00017	0.347
LIG_SH2_NCK_1	831	835	PF00017	0.633
LIG_SH2_SRC	75	78	PF00017	0.463
LIG_SH2_SRC	831	834	PF00017	0.635
LIG_SH2_SRC	862	865	PF00017	0.608
LIG_SH2_STAT5	151	154	PF00017	0.352
LIG_SH2_STAT5	177	180	PF00017	0.336
LIG_SH2_STAT5	207	210	PF00017	0.363
LIG_SH2_STAT5	279	282	PF00017	0.337
LIG_SH2_STAT5	29	32	PF00017	0.382
LIG_SH2_STAT5	394	397	PF00017	0.350
LIG_SH2_STAT5	453	456	PF00017	0.316
LIG_SH2_STAT5	753	756	PF00017	0.326
LIG_SH3_1	831	837	PF00018	0.626
LIG_SH3_3	810	816	PF00018	0.662
LIG_SH3_3	831	837	PF00018	0.686
LIG_Sin3_3	554	561	PF02671	0.444
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.344
LIG_SUMO_SIM_par_1	31	41	PF11976	0.360
LIG_SUMO_SIM_par_1	533	538	PF11976	0.318
LIG_TRAF2_1	268	271	PF00917	0.324
LIG_TRAF2_1	389	392	PF00917	0.420
LIG_TRAF2_1	840	843	PF00917	0.812
LIG_UBA3_1	297	306	PF00899	0.352
LIG_UBA3_1	344	353	PF00899	0.341
LIG_UBA3_1	601	609	PF00899	0.333
LIG_WRC_WIRS_1	279	284	PF05994	0.349
MOD_CDK_SPK_2	608	613	PF00069	0.501
MOD_CDK_SPxxK_3	538	545	PF00069	0.379
MOD_CDK_SPxxK_3	804	811	PF00069	0.573
MOD_CDK_SPxxK_3	823	830	PF00069	0.675
MOD_CK1_1	275	281	PF00069	0.311
MOD_CK1_1	322	328	PF00069	0.321
MOD_CK1_1	37	43	PF00069	0.356
MOD_CK1_1	452	458	PF00069	0.348
MOD_CK1_1	499	505	PF00069	0.466
MOD_CK1_1	538	544	PF00069	0.364
MOD_CK1_1	93	99	PF00069	0.475
MOD_CK2_1	101	107	PF00069	0.448
MOD_CK2_1	130	136	PF00069	0.435
MOD_CK2_1	217	223	PF00069	0.351
MOD_CK2_1	287	293	PF00069	0.470
MOD_CK2_1	37	43	PF00069	0.484
MOD_Cter_Amidation	350	353	PF01082	0.510
MOD_Cter_Amidation	917	920	PF01082	0.672
MOD_Cter_Amidation	957	960	PF01082	0.674
MOD_GlcNHglycan	161	164	PF01048	0.390
MOD_GlcNHglycan	293	296	PF01048	0.489
MOD_GlcNHglycan	315	318	PF01048	0.305
MOD_GlcNHglycan	321	324	PF01048	0.289
MOD_GlcNHglycan	396	399	PF01048	0.397
MOD_GlcNHglycan	419	424	PF01048	0.403
MOD_GlcNHglycan	622	625	PF01048	0.305
MOD_GlcNHglycan	723	726	PF01048	0.332
MOD_GlcNHglycan	850	853	PF01048	0.735
MOD_GlcNHglycan	881	884	PF01048	0.793
MOD_GlcNHglycan	922	925	PF01048	0.706
MOD_GlcNHglycan	970	973	PF01048	0.668
MOD_GSK3_1	28	35	PF00069	0.424
MOD_GSK3_1	281	288	PF00069	0.385
MOD_GSK3_1	499	506	PF00069	0.422
MOD_GSK3_1	604	611	PF00069	0.431
MOD_GSK3_1	660	667	PF00069	0.297
MOD_GSK3_1	800	807	PF00069	0.541
MOD_N-GLC_1	157	162	PF02516	0.336
MOD_N-GLC_1	217	222	PF02516	0.471
MOD_N-GLC_1	327	332	PF02516	0.450
MOD_N-GLC_1	496	501	PF02516	0.442
MOD_N-GLC_1	521	526	PF02516	0.502
MOD_N-GLC_2	359	361	PF02516	0.322
MOD_N-GLC_2	402	404	PF02516	0.302
MOD_N-GLC_2	617	619	PF02516	0.317
MOD_N-GLC_2	90	92	PF02516	0.425
MOD_NEK2_1	1004	1009	PF00069	0.602
MOD_NEK2_1	178	183	PF00069	0.414
MOD_NEK2_1	217	222	PF00069	0.502
MOD_NEK2_1	232	237	PF00069	0.346
MOD_NEK2_1	313	318	PF00069	0.308
MOD_NEK2_1	34	39	PF00069	0.411
MOD_NEK2_1	503	508	PF00069	0.478
MOD_NEK2_1	627	632	PF00069	0.384
MOD_NEK2_1	660	665	PF00069	0.297
MOD_NEK2_1	699	704	PF00069	0.311
MOD_NEK2_1	721	726	PF00069	0.324
MOD_NEK2_1	799	804	PF00069	0.583
MOD_NEK2_1	84	89	PF00069	0.277
MOD_NEK2_2	212	217	PF00069	0.369
MOD_PIKK_1	120	126	PF00454	0.480
MOD_PIKK_1	705	711	PF00454	0.311
MOD_PIKK_1	756	762	PF00454	0.399
MOD_PIKK_1	79	85	PF00454	0.320
MOD_PKA_1	800	806	PF00069	0.509
MOD_PKA_2	120	126	PF00069	0.374
MOD_PKA_2	799	805	PF00069	0.600
MOD_PKA_2	911	917	PF00069	0.752
MOD_PKB_1	888	896	PF00069	0.650
MOD_Plk_1	106	112	PF00069	0.235
MOD_Plk_1	146	152	PF00069	0.339
MOD_Plk_1	16	22	PF00069	0.437
MOD_Plk_1	32	38	PF00069	0.258
MOD_Plk_1	499	505	PF00069	0.451
MOD_Plk_1	627	633	PF00069	0.373
MOD_Plk_1	756	762	PF00069	0.399
MOD_Plk_1	93	99	PF00069	0.456
MOD_Plk_4	107	113	PF00069	0.248
MOD_Plk_4	147	153	PF00069	0.479
MOD_Plk_4	212	218	PF00069	0.354
MOD_Plk_4	272	278	PF00069	0.297
MOD_Plk_4	34	40	PF00069	0.342
MOD_Plk_4	449	455	PF00069	0.307
MOD_Plk_4	535	541	PF00069	0.344
MOD_Plk_4	596	602	PF00069	0.358
MOD_Plk_4	64	70	PF00069	0.402
MOD_Plk_4	660	666	PF00069	0.324
MOD_Plk_4	749	755	PF00069	0.304
MOD_Plk_4	761	767	PF00069	0.360
MOD_Plk_4	93	99	PF00069	0.436
MOD_ProDKin_1	169	175	PF00069	0.435
MOD_ProDKin_1	538	544	PF00069	0.384
MOD_ProDKin_1	608	614	PF00069	0.495
MOD_ProDKin_1	802	808	PF00069	0.514
MOD_ProDKin_1	811	817	PF00069	0.566
MOD_ProDKin_1	823	829	PF00069	0.526
MOD_ProDKin_1	835	841	PF00069	0.574
MOD_SUMO_rev_2	123	132	PF00179	0.474
MOD_SUMO_rev_2	371	375	PF00179	0.354
TRG_DiLeu_BaEn_1	272	277	PF01217	0.394
TRG_DiLeu_BaEn_1	293	298	PF01217	0.476
TRG_DiLeu_BaEn_2	227	233	PF01217	0.331
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.340
TRG_ENDOCYTIC_2	1015	1018	PF00928	0.608
TRG_ENDOCYTIC_2	112	115	PF00928	0.521
TRG_ENDOCYTIC_2	279	282	PF00928	0.337
TRG_ENDOCYTIC_2	471	474	PF00928	0.348
TRG_ENDOCYTIC_2	549	552	PF00928	0.426
TRG_ER_diArg_1	1039	1041	PF00400	0.627
TRG_ER_diArg_1	1045	1048	PF00400	0.631
TRG_ER_diArg_1	203	206	PF00400	0.373
TRG_ER_diArg_1	348	350	PF00400	0.494
TRG_ER_diArg_1	517	519	PF00400	0.358
TRG_ER_diArg_1	654	657	PF00400	0.367
TRG_ER_diArg_1	894	896	PF00400	0.668
TRG_ER_diArg_1	959	961	PF00400	0.772
TRG_ER_diArg_1	963	966	PF00400	0.769
TRG_NES_CRM1_1	228	242	PF08389	0.413
TRG_NLS_MonoExtN_4	349	356	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	992	996	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAU2	Bodo saltans	59%	88%
A0A1X0P218	Trypanosomatidae	63%	96%
A0A422P4T6	Trypanosoma rangeli	61%	97%
A4HI31	Leishmania braziliensis	93%	100%
A4I5A7	Leishmania infantum	100%	100%
C6K3W4	Leptomonas seymouri	81%	92%
C9ZQP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9B0K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7M9	Leishmania major	97%	100%
V5BPP6	Trypanosoma cruzi	60%	97%