Armadillo-type fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Armadillo-type fold

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IET2_LEIDO

TriTrypDb:

LdBPK_300810.1 , LdCL_300013200 , LDHU3_30.1020

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IET2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IET2

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.457
CLV_C14_Caspase3-7	502	506	PF00656	0.502
CLV_C14_Caspase3-7	76	80	PF00656	0.459
CLV_C14_Caspase3-7	923	927	PF00656	0.610
CLV_MEL_PAP_1	953	959	PF00089	0.738
CLV_NRD_NRD_1	1022	1024	PF00675	0.781
CLV_NRD_NRD_1	1040	1042	PF00675	0.493
CLV_NRD_NRD_1	304	306	PF00675	0.494
CLV_NRD_NRD_1	349	351	PF00675	0.498
CLV_NRD_NRD_1	518	520	PF00675	0.363

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAU2	Bodo saltans	59%	88%
A0A1X0P218	Trypanosomatidae	63%	96%
A0A422P4T6	Trypanosoma rangeli	61%	97%
A4HI31	Leishmania braziliensis	93%	100%
A4I5A7	Leishmania infantum	100%	100%
C6K3W4	Leptomonas seymouri	81%	92%
C9ZQP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9B0K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7M9	Leishmania major	97%	100%
V5BPP6	Trypanosoma cruzi	60%	97%

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