Gluconokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gluconokinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IES5_LEIDO

TriTrypDb:

LdBPK_281190.1 , LdCL_280016500 , LDHU3_28.1490

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IES5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IES5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	6
GO:0006082	organic acid metabolic process	3	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	6
GO:0009987	cellular process	1	6
GO:0016052	carbohydrate catabolic process	4	6
GO:0016054	organic acid catabolic process	4	6
GO:0016310	phosphorylation	5	6
GO:0019520	aldonic acid metabolic process	4	6
GO:0019521	D-gluconate metabolic process	5	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0032787	monocarboxylic acid metabolic process	6	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	6
GO:0044262	obsolete cellular carbohydrate metabolic process	3	6
GO:0044275	obsolete cellular carbohydrate catabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0044282	small molecule catabolic process	3	6
GO:0046176	aldonic acid catabolic process	5	6
GO:0046177	D-gluconate catabolic process	6	6
GO:0046395	carboxylic acid catabolic process	5	6
GO:0071704	organic substance metabolic process	2	6
GO:0072329	monocarboxylic acid catabolic process	6	6
GO:1901575	organic substance catabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0046316	gluconokinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.454
CLV_NRD_NRD_1	202	204	PF00675	0.558
CLV_NRD_NRD_1	43	45	PF00675	0.399
CLV_PCSK_KEX2_1	17	19	PF00082	0.454
CLV_PCSK_KEX2_1	202	204	PF00082	0.558
CLV_PCSK_KEX2_1	43	45	PF00082	0.398
CLV_PCSK_SKI1_1	137	141	PF00082	0.491
CLV_PCSK_SKI1_1	21	25	PF00082	0.422
CLV_PCSK_SKI1_1	47	51	PF00082	0.376
DEG_APCC_DBOX_1	46	54	PF00400	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.644
DEG_ODPH_VHL_1	24	37	PF01847	0.489
DEG_SPOP_SBC_1	139	143	PF00917	0.466
DOC_USP7_MATH_1	139	143	PF00917	0.466
DOC_USP7_MATH_2	112	118	PF00917	0.578
DOC_WW_Pin1_4	144	149	PF00397	0.583
DOC_WW_Pin1_4	151	156	PF00397	0.528
DOC_WW_Pin1_4	178	183	PF00397	0.420
DOC_WW_Pin1_4	185	190	PF00397	0.400
LIG_14-3-3_CanoR_1	137	146	PF00244	0.547
LIG_Actin_WH2_2	131	147	PF00022	0.469
LIG_BRCT_BRCA1_1	158	162	PF00533	0.448
LIG_Clathr_ClatBox_1	164	168	PF01394	0.401
LIG_FHA_1	116	122	PF00498	0.498
LIG_FHA_1	139	145	PF00498	0.491
LIG_FHA_2	6	12	PF00498	0.462
LIG_LIR_Apic_2	183	189	PF02991	0.456
LIG_LIR_Gen_1	159	169	PF02991	0.485
LIG_LIR_Gen_1	70	80	PF02991	0.450
LIG_LIR_Nem_3	159	165	PF02991	0.508
LIG_LIR_Nem_3	69	75	PF02991	0.434
LIG_MYND_1	194	198	PF01753	0.471
LIG_MYND_2	124	128	PF01753	0.552
LIG_SH2_CRK	186	190	PF00017	0.469
LIG_SH2_STAT5	174	177	PF00017	0.439
LIG_SH2_STAT5	186	189	PF00017	0.467
LIG_SH2_STAT5	55	58	PF00017	0.520
LIG_SH3_3	192	198	PF00018	0.531
LIG_SH3_3	20	26	PF00018	0.445
LIG_SUMO_SIM_par_1	117	123	PF11976	0.557
MOD_Cter_Amidation	200	203	PF01082	0.495
MOD_GlcNHglycan	158	161	PF01048	0.448
MOD_GlcNHglycan	182	185	PF01048	0.441
MOD_GlcNHglycan	2	5	PF01048	0.651
MOD_GlcNHglycan	39	42	PF01048	0.414
MOD_GlcNHglycan	76	79	PF01048	0.467
MOD_GSK3_1	110	117	PF00069	0.435
MOD_GSK3_1	123	130	PF00069	0.388
MOD_GSK3_1	140	147	PF00069	0.412
MOD_GSK3_1	156	163	PF00069	0.676
MOD_GSK3_1	174	181	PF00069	0.298
MOD_GSK3_1	185	192	PF00069	0.465
MOD_GSK3_1	62	69	PF00069	0.476
MOD_GSK3_1	95	102	PF00069	0.452
MOD_NEK2_1	94	99	PF00069	0.520
MOD_NEK2_2	160	165	PF00069	0.441
MOD_PIKK_1	99	105	PF00454	0.473
MOD_PKA_2	196	202	PF00069	0.484
MOD_Plk_4	123	129	PF00069	0.437
MOD_Plk_4	31	37	PF00069	0.517
MOD_ProDKin_1	144	150	PF00069	0.588
MOD_ProDKin_1	151	157	PF00069	0.525
MOD_ProDKin_1	178	184	PF00069	0.422
MOD_ProDKin_1	185	191	PF00069	0.400
MOD_SUMO_rev_2	77	83	PF00179	0.530
TRG_DiLeu_BaEn_1	131	136	PF01217	0.412
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.469
TRG_ER_diArg_1	16	18	PF00400	0.450
TRG_ER_diArg_1	202	204	PF00400	0.496
TRG_ER_diArg_1	42	44	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIM9	Leptomonas seymouri	52%	100%
A0A1X0NYC5	Trypanosomatidae	32%	95%
A0A3R7MBD0	Trypanosoma rangeli	43%	100%
A4HGF4	Leishmania braziliensis	72%	100%
A4I3I5	Leishmania infantum	97%	100%
B0BML1	Xenopus tropicalis	35%	100%
P46859	Escherichia coli (strain K12)	35%	100%
Q54PI5	Dictyostelium discoideum	31%	100%
Q5T6J7	Homo sapiens	34%	100%