Hsp33 protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IES4_LEIDO

TriTrypDb:

LdBPK_301670.1 , LdCL_300022000 , LDHU3_30.2330

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IES4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IES4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0042026	protein refolding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051082	unfolded protein binding	3	12
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.480
CLV_C14_Caspase3-7	213	217	PF00656	0.387
CLV_NRD_NRD_1	176	178	PF00675	0.585
CLV_NRD_NRD_1	200	202	PF00675	0.420
CLV_NRD_NRD_1	256	258	PF00675	0.499
CLV_NRD_NRD_1	36	38	PF00675	0.368
CLV_NRD_NRD_1	365	367	PF00675	0.404
CLV_NRD_NRD_1	427	429	PF00675	0.254
CLV_PCSK_KEX2_1	176	178	PF00082	0.585
CLV_PCSK_KEX2_1	200	202	PF00082	0.461
CLV_PCSK_KEX2_1	238	240	PF00082	0.390
CLV_PCSK_KEX2_1	256	258	PF00082	0.372
CLV_PCSK_KEX2_1	36	38	PF00082	0.349
CLV_PCSK_KEX2_1	365	367	PF00082	0.437
CLV_PCSK_KEX2_1	427	429	PF00082	0.326
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.390
CLV_PCSK_SKI1_1	184	188	PF00082	0.428
CLV_PCSK_SKI1_1	256	260	PF00082	0.400
CLV_PCSK_SKI1_1	28	32	PF00082	0.470
CLV_PCSK_SKI1_1	365	369	PF00082	0.472
CLV_PCSK_SKI1_1	7	11	PF00082	0.340
DEG_APCC_DBOX_1	256	264	PF00400	0.386
DOC_CKS1_1	270	275	PF01111	0.381
DOC_MAPK_DCC_7	201	211	PF00069	0.461
DOC_MAPK_gen_1	42	50	PF00069	0.497
DOC_MAPK_gen_1	5	13	PF00069	0.412
DOC_MAPK_MEF2A_6	5	13	PF00069	0.354
DOC_PP1_RVXF_1	16	23	PF00149	0.433
DOC_PP2B_LxvP_1	11	14	PF13499	0.393
DOC_PP2B_LxvP_1	142	145	PF13499	0.529
DOC_PP2B_LxvP_1	169	172	PF13499	0.468
DOC_PP4_FxxP_1	373	376	PF00568	0.397
DOC_USP7_MATH_1	129	133	PF00917	0.362
DOC_USP7_MATH_1	149	153	PF00917	0.605
DOC_USP7_MATH_1	182	186	PF00917	0.490
DOC_USP7_MATH_1	409	413	PF00917	0.546
DOC_USP7_MATH_1	449	453	PF00917	0.543
DOC_WW_Pin1_4	269	274	PF00397	0.445
DOC_WW_Pin1_4	298	303	PF00397	0.413
DOC_WW_Pin1_4	444	449	PF00397	0.614
LIG_14-3-3_CanoR_1	200	207	PF00244	0.426
LIG_14-3-3_CanoR_1	21	25	PF00244	0.372
LIG_14-3-3_CanoR_1	443	448	PF00244	0.490
LIG_14-3-3_CanoR_1	451	456	PF00244	0.536
LIG_14-3-3_CanoR_1	77	85	PF00244	0.335
LIG_Actin_WH2_2	6	23	PF00022	0.442
LIG_deltaCOP1_diTrp_1	181	187	PF00928	0.467
LIG_FHA_1	112	118	PF00498	0.493
LIG_FHA_1	307	313	PF00498	0.420
LIG_FHA_1	4	10	PF00498	0.418
LIG_FHA_1	85	91	PF00498	0.323
LIG_FHA_2	383	389	PF00498	0.387
LIG_FHA_2	77	83	PF00498	0.388
LIG_LIR_Apic_2	372	376	PF02991	0.407
LIG_LIR_Gen_1	127	138	PF02991	0.412
LIG_LIR_Gen_1	435	442	PF02991	0.416
LIG_LIR_Gen_1	49	58	PF02991	0.316
LIG_LIR_Gen_1	59	68	PF02991	0.298
LIG_LIR_Nem_3	127	133	PF02991	0.451
LIG_LIR_Nem_3	164	170	PF02991	0.523
LIG_LIR_Nem_3	181	186	PF02991	0.427
LIG_LIR_Nem_3	266	270	PF02991	0.318
LIG_LIR_Nem_3	435	439	PF02991	0.397
LIG_LIR_Nem_3	49	53	PF02991	0.328
LIG_LIR_Nem_3	59	63	PF02991	0.284
LIG_MAD2	121	129	PF02301	0.418
LIG_NRBOX	137	143	PF00104	0.501
LIG_PCNA_yPIPBox_3	392	403	PF02747	0.526
LIG_Pex14_1	183	187	PF04695	0.460
LIG_REV1ctd_RIR_1	387	396	PF16727	0.474
LIG_SH2_CRK	196	200	PF00017	0.476
LIG_SH2_SRC	170	173	PF00017	0.389
LIG_SH2_STAT3	103	106	PF00017	0.471
LIG_SH2_STAT5	170	173	PF00017	0.566
LIG_SH2_STAT5	198	201	PF00017	0.427
LIG_SH2_STAT5	98	101	PF00017	0.349
LIG_SH3_2	113	118	PF14604	0.380
LIG_SH3_3	110	116	PF00018	0.410
LIG_SH3_3	267	273	PF00018	0.294
LIG_SH3_3	357	363	PF00018	0.445
LIG_SH3_3	400	406	PF00018	0.492
LIG_SUMO_SIM_par_1	328	334	PF11976	0.393
LIG_TRAF2_1	79	82	PF00917	0.410
LIG_WW_3	405	409	PF00397	0.454
MOD_CDK_SPxxK_3	444	451	PF00069	0.460
MOD_CK1_1	185	191	PF00069	0.446
MOD_CK1_1	202	208	PF00069	0.400
MOD_CK1_1	23	29	PF00069	0.430
MOD_CK1_1	331	337	PF00069	0.390
MOD_CK1_1	401	407	PF00069	0.495
MOD_CK1_1	416	422	PF00069	0.474
MOD_CK1_1	444	450	PF00069	0.561
MOD_CK2_1	451	457	PF00069	0.527
MOD_CK2_1	63	69	PF00069	0.411
MOD_CK2_1	76	82	PF00069	0.295
MOD_Cter_Amidation	425	428	PF01082	0.326
MOD_GlcNHglycan	151	154	PF01048	0.714
MOD_GlcNHglycan	25	28	PF01048	0.271
MOD_GlcNHglycan	293	296	PF01048	0.507
MOD_GlcNHglycan	298	301	PF01048	0.543
MOD_GlcNHglycan	309	312	PF01048	0.561
MOD_GlcNHglycan	333	336	PF01048	0.406
MOD_GlcNHglycan	403	406	PF01048	0.339
MOD_GlcNHglycan	415	418	PF01048	0.332
MOD_GlcNHglycan	443	446	PF01048	0.586
MOD_GlcNHglycan	65	68	PF01048	0.438
MOD_GSK3_1	185	192	PF00069	0.433
MOD_GSK3_1	3	10	PF00069	0.383
MOD_GSK3_1	409	416	PF00069	0.458
MOD_GSK3_1	449	456	PF00069	0.693
MOD_N-GLC_1	189	194	PF02516	0.311
MOD_NEK2_1	20	25	PF00069	0.500
MOD_NEK2_1	31	36	PF00069	0.336
MOD_NEK2_1	40	45	PF00069	0.385
MOD_NEK2_1	413	418	PF00069	0.478
MOD_NEK2_1	441	446	PF00069	0.530
MOD_NEK2_1	53	58	PF00069	0.256
MOD_NEK2_1	63	68	PF00069	0.328
MOD_NEK2_2	182	187	PF00069	0.440
MOD_NEK2_2	189	194	PF00069	0.340
MOD_NEK2_2	409	414	PF00069	0.526
MOD_PIKK_1	449	455	PF00454	0.517
MOD_PIKK_1	53	59	PF00454	0.419
MOD_PKA_2	199	205	PF00069	0.373
MOD_PKA_2	20	26	PF00069	0.371
MOD_PKA_2	391	397	PF00069	0.443
MOD_PKA_2	41	47	PF00069	0.401
MOD_PKA_2	76	82	PF00069	0.351
MOD_PKB_1	5	13	PF00069	0.354
MOD_Plk_1	189	195	PF00069	0.285
MOD_Plk_1	7	13	PF00069	0.342
MOD_Plk_1	81	87	PF00069	0.348
MOD_Plk_2-3	241	247	PF00069	0.568
MOD_Plk_4	129	135	PF00069	0.507
MOD_Plk_4	182	188	PF00069	0.502
MOD_Plk_4	328	334	PF00069	0.393
MOD_Plk_4	398	404	PF00069	0.536
MOD_Plk_4	81	87	PF00069	0.326
MOD_ProDKin_1	269	275	PF00069	0.456
MOD_ProDKin_1	298	304	PF00069	0.422
MOD_ProDKin_1	444	450	PF00069	0.624
MOD_SUMO_rev_2	244	252	PF00179	0.548
TRG_DiLeu_BaEn_1	293	298	PF01217	0.445
TRG_DiLeu_BaEn_4	81	87	PF01217	0.375
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.477
TRG_ENDOCYTIC_2	196	199	PF00928	0.379
TRG_ER_diArg_1	176	178	PF00400	0.580
TRG_ER_diArg_1	199	201	PF00400	0.455
TRG_ER_diArg_1	255	257	PF00400	0.438
TRG_ER_diArg_1	35	37	PF00400	0.356
TRG_ER_diArg_1	364	366	PF00400	0.416
TRG_ER_diArg_1	4	7	PF00400	0.441
TRG_ER_diArg_1	427	429	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI4	Leptomonas seymouri	63%	89%
A0A0S4J763	Bodo saltans	24%	100%
A0A1X0P2N8	Trypanosomatidae	38%	100%
A0A422P4Y1	Trypanosoma rangeli	37%	100%
A4HIB0	Leishmania braziliensis	78%	100%
A4I5J4	Leishmania infantum	99%	100%
C9ZQT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7C7	Leishmania major	94%	100%
V5DQR0	Trypanosoma cruzi	35%	100%