LeishMANIAdb
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Phosphoinositide-specific phospholipase C, efhand-like/Phosphatidylinositol-specific phospholipase C, X domain/PDZ domain (Also known as DHR or GLGF)/PDZ domain containing protein, putative

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoinositide-specific phospholipase C, efhand-like/Phosphatidylinositol-specific phospholipase C, X domain/PDZ domain (Also known as DHR or GLGF)/PDZ domain containing protein, putative
Gene product:
pdz domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IES3_LEIDO
TriTrypDb:
LdBPK_300680.1 , LdCL_300011900 , LDHU3_30.0870
Length:
730

Annotations

Annotations by Jardim et al.

Phosphodiesterase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote/Amastigote: 51

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IES3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IES3

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0007165 signal transduction 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0035556 intracellular signal transduction 3 12
GO:0044238 primary metabolic process 2 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0065007 biological regulation 1 12
GO:0071704 organic substance metabolic process 2 12
GO:0048015 phosphatidylinositol-mediated signaling 5 1
GO:0048017 inositol lipid-mediated signaling 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008081 phosphoric diester hydrolase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0004435 phosphatidylinositol phospholipase C activity 7 1
GO:0004620 phospholipase activity 5 1
GO:0004629 phospholipase C activity 6 1
GO:0016298 lipase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 209 213 PF00656 0.384
CLV_C14_Caspase3-7 575 579 PF00656 0.567
CLV_C14_Caspase3-7 619 623 PF00656 0.473
CLV_NRD_NRD_1 495 497 PF00675 0.450
CLV_NRD_NRD_1 554 556 PF00675 0.450
CLV_PCSK_KEX2_1 18 20 PF00082 0.807
CLV_PCSK_KEX2_1 313 315 PF00082 0.477
CLV_PCSK_KEX2_1 495 497 PF00082 0.503
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.807
CLV_PCSK_PC1ET2_1 313 315 PF00082 0.477
CLV_PCSK_SKI1_1 132 136 PF00082 0.438
CLV_PCSK_SKI1_1 157 161 PF00082 0.482
CLV_PCSK_SKI1_1 556 560 PF00082 0.545
CLV_PCSK_SKI1_1 689 693 PF00082 0.483
CLV_PCSK_SKI1_1 77 81 PF00082 0.346
DEG_APCC_DBOX_1 116 124 PF00400 0.488
DEG_APCC_DBOX_1 479 487 PF00400 0.344
DEG_APCC_DBOX_1 495 503 PF00400 0.511
DEG_SCF_FBW7_1 367 373 PF00400 0.313
DOC_ANK_TNKS_1 313 320 PF00023 0.453
DOC_CKS1_1 367 372 PF01111 0.361
DOC_CYCLIN_RxL_1 129 140 PF00134 0.461
DOC_CYCLIN_RxL_1 154 164 PF00134 0.464
DOC_MAPK_gen_1 113 122 PF00069 0.401
DOC_MAPK_gen_1 424 431 PF00069 0.459
DOC_MAPK_MEF2A_6 113 122 PF00069 0.417
DOC_MAPK_MEF2A_6 424 431 PF00069 0.436
DOC_MAPK_MEF2A_6 438 445 PF00069 0.214
DOC_MAPK_MEF2A_6 582 590 PF00069 0.472
DOC_MAPK_MEF2A_6 705 712 PF00069 0.480
DOC_MAPK_MEF2A_6 97 104 PF00069 0.387
DOC_MAPK_NFAT4_5 115 123 PF00069 0.426
DOC_MAPK_NFAT4_5 97 105 PF00069 0.461
DOC_PP1_RVXF_1 191 198 PF00149 0.487
DOC_PP2B_LxvP_1 134 137 PF13499 0.499
DOC_USP7_MATH_1 174 178 PF00917 0.302
DOC_USP7_MATH_1 283 287 PF00917 0.542
DOC_USP7_MATH_1 48 52 PF00917 0.534
DOC_USP7_MATH_1 517 521 PF00917 0.477
DOC_USP7_MATH_1 544 548 PF00917 0.519
DOC_USP7_MATH_1 570 574 PF00917 0.601
DOC_USP7_MATH_1 644 648 PF00917 0.524
DOC_USP7_MATH_1 706 710 PF00917 0.493
DOC_USP7_UBL2_3 115 119 PF12436 0.453
DOC_USP7_UBL2_3 25 29 PF12436 0.809
DOC_USP7_UBL2_3 552 556 PF12436 0.518
DOC_WW_Pin1_4 363 368 PF00397 0.319
DOC_WW_Pin1_4 370 375 PF00397 0.319
DOC_WW_Pin1_4 405 410 PF00397 0.285
DOC_WW_Pin1_4 449 454 PF00397 0.285
DOC_WW_Pin1_4 623 628 PF00397 0.639
DOC_WW_Pin1_4 640 645 PF00397 0.400
LIG_14-3-3_CanoR_1 284 292 PF00244 0.503
LIG_14-3-3_CanoR_1 689 699 PF00244 0.475
LIG_Actin_WH2_2 464 482 PF00022 0.361
LIG_BIR_III_4 578 582 PF00653 0.557
LIG_BRCT_BRCA1_1 193 197 PF00533 0.352
LIG_BRCT_BRCA1_1 522 526 PF00533 0.492
LIG_BRCT_BRCA1_1 708 712 PF00533 0.369
LIG_BRCT_BRCA1_2 522 528 PF00533 0.475
LIG_deltaCOP1_diTrp_1 287 296 PF00928 0.446
LIG_FHA_1 122 128 PF00498 0.396
LIG_FHA_1 170 176 PF00498 0.515
LIG_FHA_1 182 188 PF00498 0.437
LIG_FHA_1 283 289 PF00498 0.415
LIG_FHA_1 318 324 PF00498 0.464
LIG_FHA_1 356 362 PF00498 0.418
LIG_FHA_1 538 544 PF00498 0.461
LIG_FHA_1 548 554 PF00498 0.491
LIG_FHA_1 55 61 PF00498 0.630
LIG_FHA_1 672 678 PF00498 0.338
LIG_FHA_2 306 312 PF00498 0.457
LIG_FHA_2 342 348 PF00498 0.339
LIG_FHA_2 552 558 PF00498 0.523
LIG_FHA_2 617 623 PF00498 0.561
LIG_GBD_Chelix_1 379 387 PF00786 0.319
LIG_Integrin_isoDGR_2 610 612 PF01839 0.442
LIG_LIR_Gen_1 152 163 PF02991 0.378
LIG_LIR_Gen_1 194 205 PF02991 0.336
LIG_LIR_Gen_1 215 223 PF02991 0.499
LIG_LIR_Gen_1 286 296 PF02991 0.432
LIG_LIR_Gen_1 39 48 PF02991 0.581
LIG_LIR_Gen_1 628 639 PF02991 0.333
LIG_LIR_Nem_3 152 158 PF02991 0.363
LIG_LIR_Nem_3 184 189 PF02991 0.398
LIG_LIR_Nem_3 194 200 PF02991 0.275
LIG_LIR_Nem_3 215 221 PF02991 0.446
LIG_LIR_Nem_3 293 299 PF02991 0.506
LIG_LIR_Nem_3 356 362 PF02991 0.306
LIG_LIR_Nem_3 39 44 PF02991 0.578
LIG_LIR_Nem_3 523 529 PF02991 0.384
LIG_LIR_Nem_3 628 634 PF02991 0.378
LIG_LIR_Nem_3 84 90 PF02991 0.522
LIG_LYPXL_yS_3 359 362 PF13949 0.285
LIG_PCNA_PIPBox_1 179 188 PF02747 0.483
LIG_PCNA_yPIPBox_3 179 193 PF02747 0.516
LIG_Pex14_2 254 258 PF04695 0.525
LIG_Pex14_2 691 695 PF04695 0.333
LIG_PTB_Apo_2 163 170 PF02174 0.481
LIG_PTB_Apo_2 180 187 PF02174 0.456
LIG_PTB_Phospho_1 180 186 PF10480 0.551
LIG_REV1ctd_RIR_1 524 532 PF16727 0.489
LIG_SH2_CRK 265 269 PF00017 0.388
LIG_SH2_CRK 41 45 PF00017 0.603
LIG_SH2_CRK 704 708 PF00017 0.344
LIG_SH2_CRK 726 730 PF00017 0.354
LIG_SH2_STAT5 186 189 PF00017 0.477
LIG_SH2_STAT5 256 259 PF00017 0.421
LIG_SH2_STAT5 615 618 PF00017 0.338
LIG_SH2_STAT5 726 729 PF00017 0.343
LIG_SH3_1 705 711 PF00018 0.464
LIG_SH3_3 364 370 PF00018 0.379
LIG_SH3_3 705 711 PF00018 0.440
LIG_SUMO_SIM_anti_2 121 129 PF11976 0.459
LIG_SUMO_SIM_anti_2 674 679 PF11976 0.343
LIG_SUMO_SIM_par_1 123 129 PF11976 0.403
LIG_SUMO_SIM_par_1 98 103 PF11976 0.408
LIG_UBA3_1 126 135 PF00899 0.369
MOD_CAAXbox 727 730 PF01239 0.380
MOD_CDK_SPxxK_3 449 456 PF00069 0.285
MOD_CK1_1 227 233 PF00069 0.553
MOD_CK1_1 243 249 PF00069 0.497
MOD_CK1_1 273 279 PF00069 0.399
MOD_CK1_1 366 372 PF00069 0.468
MOD_CK1_1 39 45 PF00069 0.727
MOD_CK1_1 420 426 PF00069 0.520
MOD_CK1_1 520 526 PF00069 0.522
MOD_CK1_1 547 553 PF00069 0.538
MOD_CK1_1 6 12 PF00069 0.797
MOD_CK1_1 623 629 PF00069 0.571
MOD_CK1_1 643 649 PF00069 0.546
MOD_CK1_1 663 669 PF00069 0.459
MOD_CK2_1 104 110 PF00069 0.420
MOD_CK2_1 341 347 PF00069 0.319
MOD_CK2_1 5 11 PF00069 0.783
MOD_CK2_1 75 81 PF00069 0.368
MOD_GlcNHglycan 14 17 PF01048 0.646
MOD_GlcNHglycan 176 179 PF01048 0.339
MOD_GlcNHglycan 208 211 PF01048 0.344
MOD_GlcNHglycan 388 391 PF01048 0.337
MOD_GlcNHglycan 41 44 PF01048 0.617
MOD_GlcNHglycan 517 520 PF01048 0.436
MOD_GlcNHglycan 568 571 PF01048 0.488
MOD_GlcNHglycan 622 625 PF01048 0.492
MOD_GlcNHglycan 692 695 PF01048 0.471
MOD_GlcNHglycan 70 73 PF01048 0.576
MOD_GlcNHglycan 87 90 PF01048 0.305
MOD_GSK3_1 100 107 PF00069 0.377
MOD_GSK3_1 121 128 PF00069 0.495
MOD_GSK3_1 161 168 PF00069 0.425
MOD_GSK3_1 169 176 PF00069 0.456
MOD_GSK3_1 189 196 PF00069 0.305
MOD_GSK3_1 266 273 PF00069 0.374
MOD_GSK3_1 290 297 PF00069 0.409
MOD_GSK3_1 366 373 PF00069 0.412
MOD_GSK3_1 513 520 PF00069 0.438
MOD_GSK3_1 543 550 PF00069 0.464
MOD_GSK3_1 566 573 PF00069 0.467
MOD_GSK3_1 6 13 PF00069 0.753
MOD_GSK3_1 616 623 PF00069 0.489
MOD_GSK3_1 640 647 PF00069 0.545
MOD_N-GLC_1 270 275 PF02516 0.498
MOD_N-GLC_1 640 645 PF02516 0.554
MOD_N-GLC_1 648 653 PF02516 0.492
MOD_N-GLC_1 660 665 PF02516 0.363
MOD_N-GLC_2 106 108 PF02516 0.340
MOD_NEK2_1 102 107 PF00069 0.333
MOD_NEK2_1 126 131 PF00069 0.418
MOD_NEK2_1 169 174 PF00069 0.387
MOD_NEK2_1 292 297 PF00069 0.459
MOD_NEK2_1 417 422 PF00069 0.383
MOD_NEK2_1 479 484 PF00069 0.415
MOD_NEK2_1 548 553 PF00069 0.530
MOD_NEK2_1 629 634 PF00069 0.451
MOD_NEK2_1 648 653 PF00069 0.423
MOD_NEK2_1 75 80 PF00069 0.385
MOD_NEK2_1 85 90 PF00069 0.432
MOD_NMyristoyl 1 7 PF02799 0.618
MOD_PIKK_1 290 296 PF00454 0.355
MOD_PIKK_1 660 666 PF00454 0.480
MOD_PIKK_1 90 96 PF00454 0.446
MOD_PKA_2 283 289 PF00069 0.432
MOD_PKA_2 443 449 PF00069 0.289
MOD_PKA_2 479 485 PF00069 0.361
MOD_PKA_2 605 611 PF00069 0.489
MOD_PKA_2 715 721 PF00069 0.538
MOD_Plk_1 139 145 PF00069 0.504
MOD_Plk_1 490 496 PF00069 0.300
MOD_Plk_1 627 633 PF00069 0.445
MOD_Plk_1 648 654 PF00069 0.575
MOD_Plk_1 687 693 PF00069 0.473
MOD_Plk_2-3 341 347 PF00069 0.428
MOD_Plk_2-3 54 60 PF00069 0.599
MOD_Plk_4 181 187 PF00069 0.431
MOD_Plk_4 270 276 PF00069 0.354
MOD_Plk_4 341 347 PF00069 0.346
MOD_ProDKin_1 363 369 PF00069 0.319
MOD_ProDKin_1 370 376 PF00069 0.319
MOD_ProDKin_1 405 411 PF00069 0.285
MOD_ProDKin_1 449 455 PF00069 0.285
MOD_ProDKin_1 623 629 PF00069 0.628
MOD_ProDKin_1 640 646 PF00069 0.397
MOD_SPalmitoyl_4 1 7 PF01529 0.677
MOD_SUMO_rev_2 307 315 PF00179 0.465
MOD_SUMO_rev_2 398 408 PF00179 0.278
MOD_SUMO_rev_2 497 505 PF00179 0.431
MOD_SUMO_rev_2 530 537 PF00179 0.564
MOD_SUMO_rev_2 575 584 PF00179 0.408
TRG_DiLeu_BaLyEn_6 134 139 PF01217 0.487
TRG_DiLeu_BaLyEn_6 635 640 PF01217 0.481
TRG_ENDOCYTIC_2 265 268 PF00928 0.382
TRG_ENDOCYTIC_2 359 362 PF00928 0.285
TRG_ENDOCYTIC_2 41 44 PF00928 0.601
TRG_ENDOCYTIC_2 704 707 PF00928 0.338
TRG_ENDOCYTIC_2 726 729 PF00928 0.343
TRG_ER_diArg_1 494 496 PF00400 0.440
TRG_ER_diArg_1 604 607 PF00400 0.497
TRG_NES_CRM1_1 477 491 PF08389 0.243
TRG_Pf-PMV_PEXEL_1 248 252 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 77 81 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7S8 Leptomonas seymouri 73% 99%
A0A0S4KHF2 Bodo saltans 42% 100%
A0A1X0P2U3 Trypanosomatidae 46% 100%
A0A3R7MG69 Trypanosoma rangeli 46% 96%
A4HI17 Leishmania braziliensis 86% 100%
A4I594 Leishmania infantum 100% 100%
C9ZQM5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9B0J1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q7P2 Leishmania major 98% 100%
V5AS75 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS